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Numerical analysis of matrix swelling and its effect on microstructure of digital coal and its associated permeability during CO_(2)-ECBM process based on X-ray CT data

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Petroleum Science 2023年第1期20卷 87-101页

作者： hui-huang Fang Zhang-Fei Wang Shu-Xun Sang yan-hui huang School of Earth and Environment Anhui University of Science and TechnologyHuainanAnhui232001China Institute of Energy Hefei Comprehensive National Science CenterHefeiAnhui230000China Low Carbon Energy Institute China University of Mining and TechnologyXuzhouJiangsu221008China School of Resources and Geosciences China University of Mining and TechnologyXuzhouJiangsu221116China Jiangsu Key Laboratory of Coal-based Greenhouse Gas Control and Utilization China University of Mining and TechnologyXuzhouJiangsu221008China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China

Matrix swelling effect will cause the change of microstructure of coal reservoir and its permeability,which is the key factor affecting the engineering effect of CO_(2)-ECBM *** Sihe and Yuwu collieries are taken as research ***,visualization reconstruction of coal reservoir is ***,the evolution of the pore/fracture structures under different swelling contents is ***,the influence of matrix phase with different swelling contents on permeability is ***,the mechanism of swelling effect during the CO_(2)-ECBM process is further *** results show that the intra-matrix pores and matrix-edge fractures are the focus of this study,and the contacting area between matrix and pore/fracture is the core area of matrix *** number of matrix particles decreases with the increase of size,and the distribution of which is isolated with small size and interconnected with large *** swelling effect of matrix particles with larger size has a great influence on the pore/fracture *** number of connected pores/fractures is limited and only interconnected in a certain *** the increase of matrix swelling content,the number,porosity,width,fractal dimension,surface area and volume of pores/fractures decrease,and their negative contribution to absolute permeability increases from 0.368% to 0.633% and 0.868%-1.404%,*** the increase of swelling content,the number of intra-matrix pores gradually decreases and the pore radius becomes shorter during the CO_(2)-ECBM *** matrix continuously expands to the connected fractures,and the width of connected fractures gradually *** the influence of matrix swelling,the bending degree of fluid flow increases gradually,so the resistance of fluid migration increases and the permeability gradually *** study shows that the matrix swelling effect is the key factor affecting CBM recovery,and the application of this effec

关键词： Matrix swelling CO_(2)-ECBM Absolutely permeability Numerical analysis X-ray CT Qinshui Basin

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Coupling mechanism of THM fields and SLG phases during the gas extraction process and its application in numerical analysis of gas occurrence regularity and effective extraction radius

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Petroleum Science 2022年第3期19卷 990-1006页

作者： hui-huang Fang Chun-Shan Zheng Ning Qi Hong-Jie Xu hui-Hu Liu yan-hui huang Qiang Wei Xiao-Wei Hou Lei Li Shuai-Liang Song State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainanAnhui 232001China Institute of Energy Hefei Comprehensive National Science CenterHefeiAnhui 230000China School of Earth and Environment Anhui University of Science and TechnologyHuainanAnhui 232001China Great Institute of Standardization China National Institute of Standardization's High Quality and Green Development Innovation R&D BaseJinanShandong 250101China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China School of Resources and Civil Engineering Suzhou UniversitySuzhouJiangsu 234000China School of Resources and Environmental Engineering Hefei University of TechnologyHefeiAnhui 230009China The Third Exploration Team of Shandong Coalfield Geologic Bureau TaianShandong 250102China Shandong Provincial Lunan Geo-engineering Exploration Instituts JiningShandong 272100China

The analysis of the coupling mechanism of thermal-hydraulic-mechanical(THM)fields,and solid-liquidgas(SLG)phases during gas extraction process is of profound significance to explore its numerical application in the gas occurrence regularity and its effective extraction *** this study,the Hudi coal mine in Qinshui basin is taken as the research area,the influencing factors of gas occurrence were analyzed,the differences in overburden load for gas pressure distribution and the factors influencing the effective extraction radius were further discussed by using the COMSOL *** results show that the derivation of mathematical model in gas extraction shows that the process is a process the THM fields restrict each other,and the SLG phases influence each *** longer the extraction time,the larger the influencing range of borehole,and the better the extraction *** larger the diameter of borehole,the larger the effective extraction radius,and the influence on gas extraction effect is smaller in the early stage and larger in the late *** borehole arrangement should be flexibly arranged according to the actual extraction *** higher the porosity,the higher the permeability,the better the gas extraction *** larger the overburden load of reservoir,the stronger the effective stress,which will result in the more severe the strain,and the closure of pore and fracture,which in turn will lead to the decrease of permeability and slow down the gas *** relationship among extraction time,borehole diameter,negative pressure of gas extraction,permeability with effective extraction radius is *** study has important theoretical and practical significance for clarifying and summarizing the gas occurrence regularity and its engineering practice.

关键词： Gas occurrence regularity Effective extraction radius THM fields and SLG phases Numerical simulation COMSOL Multiphysics Hudi coal mine

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Lie Symmetry and Conserved Quantity of Three-Order Lagrangian Equations for Non-conserved Mechanical System

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Communications in Theoretical Physics 2006年第2期45卷 350-352页

作者： MA Shan-Jun yanG Xue-hui yan Rong huang Pei-Tian College of Physics and Communication Electronics Jiangxi Normal University Nanchang 330027 China

Based on the infinitesimal and one parameter transformation, the problem of Lie symmetry of three-order Lagrangian equations has been studied. Under Lie transformation, the sufficient and necessary condition which kee... 详细信息

关键词： three-order Lagrangian equation Lie symmetry conserved quantity

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Spatial Variability of Micronutrients in Rice Grain and Paddy Soil

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Pedosphere 2009年第6期19卷 748-755页

作者： WANG Lin, WU Jia-Ping 2 , LIU yan-Xuan, huang hui-Qing and FANG Qian-Fang College of Environment and Natural Resources, Zhejiang University, Hangzhou 310029 (China) [a]College of Environment and Natural Resources Zhejiang University Hangzhou 310029 (China)

Consumption of rice is the main source of micronutrients to human in Asia. A paddy field with unknown anthro- pogenic contamination in Deqing County, Zhejiang Province, China was selected to characterize the spatial variability and distribution of micronutrients in rice grain and soil. A total of 96 paired soil and rice grain samples were collected at harvest. The micronutrients in the soil samples were extracted by diethylenetriamine pentaacetic acid （DTPA）. The mean micronutrient concentrations in rice grain were 3.85 μg Cu g^-1, 11.6 μg Fe g^-1, 39.7 μg Mn g^-1 and 26.0 μg Zn g^-1 The mean concentrations were 2.54μg g^-1 for DTPA-Cu, 133.5μg g^-1 for DTPA-Fe, 30.6μg g^-1 for DTPA-Mn, and 0.84μg g^-1 for DTPA-Zn. Semivariograms showed that measured micronutrients in rice grain were moderately dependent, with a range distance of about 110 m. The concentrations of the DTPA-extractable micronutrients all displayed strong spatial dependency, with a range distance of about 60 m. There was some resemblance of spatial structure between soil pH and the grain Cu, Fe, Mn, and Zn. By analogy, similar spatial variation was observed between soil organic matter （SOM） and DTPA-extractable table micronutrients in the soil. Kriging estimated maps of the attributes showed the spatial distributions of the variables in the field, which is beneficial for better understanding the spatial variation of micronutrients and for potentially refining agricultural management practices at a field scale.

关键词： correlation dependency kriging soil properties

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点星网与度量空间的映像

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数学学报（中文版） 2019年第6期62卷 865-878页

作者：林寿黄燕晖张静宁德师范学院数理学院宁德352100 闽南师范大学数学与统计学院漳州363000

拓扑空间X的覆盖列{Pi}i∈N被称为空间X的点星网,若x∈X,则{st(x,Pi)}i∈N是x在X中的网.本文刻画具有cs有限cs覆盖列的点星网的空间,并将其表示为度量空间在确定映射下的像.在假设集族性质β满足适当的条件下,证明对拓扑空间X下述条件... 详细信息

拓扑空间X的覆盖列{Pi}i∈N被称为空间X的点星网,若x∈X,则{st(x,Pi)}i∈N是x在X中的网.本文刻画具有cs有限cs覆盖列的点星网的空间,并将其表示为度量空间在确定映射下的像.在假设集族性质β满足适当的条件下,证明对拓扑空间X下述条件相互等价:(1) X具有β且cs覆盖列的点星网.(2)X具有β且sn覆盖列的点星网.(3)X是Cauchy sn对称空间且具有σ-β的cs网.(4) X是Cauchy sn对称空间且具有σ-β的sn网.(5) X是度量空间的序列覆盖、π且σ-β映像.(6) X是度量空间的1序列覆盖、紧且σ-β映像.这些工作以局部有限集族与点有限集族为特例,拓展了从基到cs网的研究,丰富了映射与空间的相互分类思想.

关键词： cs有限集族 cs覆盖点星网序列覆盖映射 σ-cs映射

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Novel functional proteins interact with midkine in hepatic cancer cells

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Hepatobiliary & Pancreatic Diseases International 2012年第3期11卷 272-277页

作者： Qiang yan, hui-Lian huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (yan Q and Zheng SS) [a] Department of Hepatobiliary and Pancreatic Surgery Huzhou Central Hospital Huzhou 313000 China [b] Huzhou Key Laboratory of Molecular Medicine Affiliated Central Hospital of Huzhou Teachers College Huzhou 313000 China [c] Division of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with ***: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma.

关键词： midkine yeast two-hybrid interaction hepatic cancer cell

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi huang Meiyu Zhang yanyu Zhang yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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(ω)性质的判定

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数学的实践与认识 2019年第22期49卷 231-237页

作者：闫慧凰曹小红长治学院数学系山西长治046011 陕西师范大学数学与信息科学学院陕西西安710119

利用新定义的谱集,刻画了Hilbert空间上有界线性算子满足(ω1)性质和(ω)性质的等价条件.另外,利用该谱集,对算子函数的(ω)性质进行了判定.

关键词： (ω1)性质 (ω)性质本质逼近点谱

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Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus:A case report

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World Journal of Diabetes 2025年第1期16卷 204-210页

作者： Fang Chen Bo An Wen-Cheng An Gang Fu Wei huang hui-Xian yan Department of Endocrinology Beijing Haidian HospitalBeijing 100080China Department of Nephrology Beijing Haidian HospitalBeijing Haidian Section of Peking University Third HospitalBeijing 100080China

BACKGROUND Treating diabetes in dialysis patients remains a challenge,with many hypoglycemic drugs requiring dose adjustments or avoidance in these *** SUMMARY This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes(T2DM)who had struggled to control her blood sugar for more than a *** had a history of high blood pressure for 30 years,had undergone continuous ambulatory peritoneal dialysis for more than two years,was 163 cm tall,weighed 77 kg,and had a body mass index of 28.98 kg/*** intensive insulin therapy at a daily dose of 150 units,adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin *** one month of follow-up,the fasting plasma glucose was 6-8 mmol/L,and the 2-hour postprandial glucose was 8-12 mmol/*** To our knowledge,this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose ***,a novel glucokinase activator primarily metabolized by the liver,exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney *** has a high plasma protein binding rate and may not be cleared by peritoneal dialysis,potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.

关键词： Dorzagliatin Type 2 diabetes mellitus Peritoneal dialysis Glucokinase activator Glucose control Case report

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Systemic thrombosis with prothrombin Belgrade mutation in a Chinese patient:A case report

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World Journal of Clinical Cases 2025年第10期13卷 35-39页

作者： yan-Feng Wu yan huang Bao-hui Weng Shan Deng Li-Ya Pan Zhen Li Department of Neurology Liuzhou Worker’s HospitalLiuzhou 545007Guangxi Zhuang Autonomous RegionChina Department of Neurology Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Thrombophilia contributes to a significant increased risk of venous thromboembolism and can be either inherited or *** thrombophilia may arise from various gene mutations,some of which have not even been adequately reported or poorly *** studies reported a rare and novel missense mutation in the prothrombin gene(***596Gln),known as prothrombin *** mechanisms and therapeutic strategies associated with prothrombin Belgrade mutation have not been fully *** SUMMARY We present the case of a 26-year-old woman with recurrent systemic thrombosis induced by prothrombin Belgrade *** patient suffered from cerebral venous sinus thrombosis that rapidly progressed to systemic thrombosis,alongside a family history of cerebral thrombosis,and no traditional risk factors or abnormal coagulation ***-genome sequencing detected a novel and rare heterozygous prothrombin missense mutation,c.1787G>T(***596Gln),which was responsible for the major etiology of the systemic *** This case strengthens our understanding about hereditary basis of thrombophilia and provokes considerations for therapeutic options on prothrombin Belgrade mutation.

关键词： Arg596Gln Belgrade mutation Thrombophilia Prothrombin Case report

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