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Chinese Journal of Structural Chemistry 2007年第2期26卷 172-176页

作者： MO Wen-yan HE hong-wu College of Chemistry Central China Normal University Wuhan 430079 China

The title compound, 3-[2-（4-fluoro-phenyl）-ethyl]-5-methyl-4-hydroxyl-4-methyl- 7-methylsulfanyl-3,4-dihydro-pyrido[4,3-d]pyrimidine-8-carbonitrile, has been prepared and detemined by single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P1 with a = 6.8754（8）, b = 10.2617（12）, c = 13.3491（16） A, α = 93.163（2）, β = 96.704（2）, γ = 102.421（2）°, V= 910.35（19）A^3, Z= 2, Mr= 370.44, Dc= 1.351 g/cm^3,μ = 0.203 mm^-1,F（000） = 388, the final R = 0.0573 and wR = 0.1497. X-ray analysis reveals that the pyridine and pyrimidine rings are almost coplanar.

关键词： pyrido[4,3-d]pyrimidine synthesis crystal structure biological activities

Analysis of subscription characteristics and user mobility in different types of MMORPGs

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The Journal of China Universities of Posts and Telecommunications 2009年第6期16卷 121-128页

作者： PENG Hui SUN yan-li wu hong School of Economics and Management Beijing University of Posts and Telecommunications Beijing 100876 China

Massively multiplayer online role-playing game（MMORPG） is one of the fastest-growing segments of the online game *** subscription refers to game accounts logged in during a certain period of *** user mobility explains the dynamics of subscriber size *** article explores the subscription characteristics and user mobility in different types of *** is found that subscription characteristics in different types of MMORPGs are marked by *** one hand,the curve of competition-based game subscription is linear,and the stability period is short,therefore it is necessary for the game operators to introduce new versions *** the other hand,the gradient rate of subscription in the community-based game is slow at first and then fast,and the stability period is long,hence it will take the game operator a long cycle to launch a new *** difference of subscription curve is caused by the fact that user mobility in competition-based game is higher than in the community-based game,as attractiveness of community-based game can maintain a longer period due to network *** purpose of the study is to help the game operator to understand the development stage and features of the game and to make effective decisions to attract more players.

关键词： virtual reality online game subscription characteristics user mobility subscription curve life cycle MMORPG

On hot deformation behavior and workability characteristic of 42CrMo4 steel based on microstructure and processing map

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Journal of Iron and Steel Research International 2023年第3期30卷 537-547页

作者： Min Qi hong-yan wu Ying Dong Lin-xiu Du State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

In order to determine the safe region of 42CrMo4 steel during hot working and obtain excellent workability,the hot deformation behavior at the temperatures of 850-1150℃and the strain rates of 0.01-10 s^(-1)was investigated through single-pass compression test of *** observing and analyzing the true stress-strain curves,the conclusion may be drawn that the flow stress value increases with the decrease in deformation temperature and the increase in strain *** temperature and reducing strain rate are conductive to dynamic recrystallization(DRX)nucleating and growing,but adiabatic heating caused by higher strain rate can also promote *** the Zener-Hollomon(Z)value and dynamic recrystallized grain size(D_(DRX))have completely opposite trends with deformation condition parameters,the expression of Z value and DDRX can be determined as:D_(DRx)=15,567.645Z^(-02174).The processing map and instability map constructed at a strain of 0.9 show that the suitable window for hot working with a true strain of 0.9 is in the temperature range of 970-1150℃and strain rate range of 0.01-0.25 s^(-1),as well as at the temperature of 1150℃ and strain rate range of 0.25-10 s^(-1).The instability phenomenon appears in the process interval of 850-1096℃ and 0.22-10 s^(-1).

关键词： Hot deformation behavior Dynamic recrystallization Microstructure evolution Constitutive relationship Processing map

Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-yang 1 binding

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World Journal of Gastroenterology 2017年第48期23卷 8500-8511页

作者： Wei Sun hong-yan wu Song Chen Institute of Infectious Diseases Southwest HospitalThe Third Military Medical University Nuclear Medicine Department the First Affiliated HospitalChongqing Medical University

AIM To investigated the mechanism of the association between the TBX21 T-1993 C promoter polymorphism and autoimmune hepatitis type 1(AIH-1) *** In vivo,In vivo,and reporter analyses were performed to determine the function of transcription factors binding to the T-1993 C element of the TBX21 promoter in human CD4+ T and B cell lines. Flow cytometry and quantitative real-time PCR were used to analyze T-box transcription factor(T-bet) and interferon-γ(IFN-γ) expressions in CD4+ T cells,B cells and monocytes from the peripheral blood of AIH-1 patients including 5-1993 TC and 15-1993 TT genotype carriers,and healthy controls including 10-1993 TC and 25-1993 TT genotype carriers. Furthermore,a range of biochemical indices was measured simultaneously in the blood of AIH-1 *** TBX21-1993 C allele created a strong Yin-yang 1(YY1)-binding site and decreased transcriptional activity of TBX21 promoter in human CD4+ T and B *** levels of T-bet and IFN-γ were detected in the circulating CD4+ T cells and B cells of AIH-1 patients carrying the TBX21-1993 TT genotype compared with the patients carrying the-1993 TC genotype and controls with the-1993 TC genotype. T-bet expression levels of circulating T cells and B cells were positively correlated with AIH-1 disease activity. Knockdown of YY1 with si RNA caused increased expression of T-bet and IFN-γ in peripheral blood mononuclear cells in AIH-1 patients. CONCLUSION The repression of TBX21 expression by high-affinity binding of YY1 to the-1993 C allele may contribute to a decreased development of AIH-1 via suppression of type 1 immunity.

关键词： TBX21 Single nucleotide polymorphism Yin-yang 1 T helper cells B cells Autoimmune hepatitis

Localization of Frames

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Journal of Mathematical Research and Exposition 2010年第1期30卷 78-86页

作者： yan hong wu Department of Mathematics and LPMC Nankai University Tianjin 300071 P. R. China

Grochenig and Balan, Casazza, Heil, and Landau introduced the concepts of localization. The concepts were used to Gabor frames, wavelet frames and sampling theorem in recent years. Here they are applied to the frame of exponential windows with the conclusion that the frame of exponential windows is a Banach frame for a kind of Banach spaces, and the conclusion is also obtained about the relationship between frame bounds, frame density, measure and density of indexing set.

关键词： frame localization Banach frame density.

On the reverse leakage current of Schottky contacts on free-standing GaN at high reverse biases

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Chinese Physics B 2017年第2期26卷 403-405页

作者： Yong Lei Jing Su hong-yan wu Cui-hong yang Wei-Feng Rao Department of Materials Physics School of Physics and Optoelectronic Engineering Nanjing University of Information Science and Technology Nanjing 210044 China

In this work, a dislocation-related tunneling leakage current model is developed to explain the temperature-dependent reverse current–voltage（I–V –T） characteristics of a Schottky barrier diode fabricated on free-standing GaN substrate for reverse-bias voltages up to-150 V. The model suggests that the reverse leakage current is dominated by the direct tunneling of electrons from Schottky contact metal into a continuum of states associated with conductive dislocations in GaN epilayer.A reverse leakage current ideality factor, which originates from the scattering effect at metal/GaN interface, is introduced into the model. Good agreement between the experimental data and the simulated I–V curves is obtained.

关键词： homoepitaxial GaN Schottky contact leakage current tunneling dislocations ideality factor

Temperature Dependence of Abnormal Fano Resonance in Photon-Assisted Transport Through a Side-Coupled Quantum Dot

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Communications in Theoretical Physics 2008年第3期49卷 767-770页

作者： SONG hong-yan wu Liu-Po SHI Yao-Ming ZHOU Shi-Ping Department of Physics Shanghai University Shanghai 200444 China

We investigate transport through a perfect quantum wire with a side-coupled quantum dot under an ac field. Time-averaged complex conductance is formulated by using the nonequilibrium Green function （NGF） method. We find that the electron-photon interaction together with the quantum interference of electron wave function can lead to anti-resonance in the conductance, which is then useful for tuning coherence and phases of electrons. Meanwhile, we study the temperature dependence of the conductance. Interestingly, a peak-structure can be developed at the Fano resonance levels with increasing temperatures.

关键词： Fano resonance photon-assisted tunneling quantum dot

Global-local combined features to detect pain intensity from facial expression images with attention mechanism

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Journal of Electronic Science and Technology 2024年第3期22卷 80-93页

作者： Jiang wu Yi Shi Shun yan hong-Mei yan yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China MOE Key Laboratory for Neuroinformation School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China College of Engineering University of California at Santa BarbaraSanta Barbara93106USA

The estimation of pain intensity is critical for medical diagnosis and treatment of *** the development of image monitoring technology and artificial intelligence,automatic pain assessment based on facial expression and behavioral analysis shows a potential value in clinical *** paper reports a framework of convolutional neural network with global and local attention mechanism(GLA-CNN)for the effective detection of pain intensity at four-level thresholds using facial expression ***-CNN includes two modules,namely global attention network(GANet)and local attention network(LANet).LANet is responsible for extracting representative local patch features of faces,while GANet extracts whole facial features to compensate for the ignored correlative features between *** the end,the global correlational and local subtle features are fused for the final estimation of pain *** under the UNBC-McMaster Shoulder Pain database demonstrate that GLA-CNN outperforms other state-of-the-art ***,a visualization analysis is conducted to present the feature map of GLA-CNN,intuitively showing that it can extract not only local pain features but also global correlative facial *** study demonstrates that pain assessment based on facial expression is a non-invasive and feasible method,and can be employed as an auxiliary pain assessment tool in clinical practice.

关键词： Attention Convolutional neural network Facial expression Pain intensity

A new anthraquinone glycoside from seeds of Cassia obtusifolia

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Chinese Chemical Letters 2008年第9期19卷 1083-1085页

作者： Li Ying Tang Zhu Ju Wang Mei hong Fu yan He hong Wei wu Lu Qi Huang Institute of Traditional Chinese Materia Medica Chinese Academy of Medical Sciences Beijing 100700 China

A new anthraquinone glycoside 1, along with a known anthraquinone glycoside aurantio-obmsin-6-O-β-D-glucopyranoside 2, were isolated from the seeds of Cassia obtusifolia. On the basis of spectral and chemical evidences, the structure of 1 was established as 1-demethylaurantio-obtusin-2-O-β-D-glucopyranoside. Moreover, the 13C NMR of 2 was assigned totally and correctly for the first time based on the two-dimensional NMR.

关键词： ~assia obtusifolia Anthraquinone glycoside 1-Demethylaurantio-obtusin-2-O-β-D-glucopyranoside

Effective field theory of the Majorana dark matter

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Chinese Physics C 2019年第4期43卷 63-68页

作者： Hua-Yong Han hong-yan wu Si-Bo Zheng CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Department of Physics Chongqing University School of Physics Peking University

We revisit the thermal Majorana dark matter from the viewpoint of the minimal effective field theory. In this framework, analytical results for dark matter annihilation into Standard Model particles are derived. The dark matter parameter space, subject to the latest LUX, Panda X-Ⅱ and Xenon-1 T limits, is presented in a model-independent way. Applications to the singlet-doublet and MSSM are presented.

关键词： dark matter effective field theory Majorana