Energy consumption and environmental impact considerations of machining processes are viewed as important issues for the global trends towards sustainable manufacturing. The existing research of reducing energy consum...
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Energy consumption and environmental impact considerations of machining processes are viewed as important issues for the global trends towards sustainable manufacturing. The existing research of reducing energy consumption and environmental impacts of machining processes greatly focuses on design and planning activities, but is reasonably sparse for production operation activities. This paper explores a systematic methodology that incorporates energy consumption and environmental impact considerations into the production operation of machining processes. Firstly, the framework of the methodology is proposed to establish the generic procedures for integrating the above considerations in production operation activities. As the two key issues of the framework, the profile index value matrix is determined by valuing the individual quantity of energy consumption and environmental impacts of machining each job on each machine, and the multi-criteria models are constructed by the operational methods. Furthermore, with the guideline of the framework, the specific formulations are modeled by two sub-models for the parallel machine scheduling problem, in which makespan and energy consumption are the optimizing objectives as well as the constraints of environmental impact considerations. The specific formulations provide a practical method to integrate energy consumption and environmental impact considerations into the scheduling activity, and also can serve as a reference to other activities in the production operation. The case study for a batch of jobs, including seven kinds of gears in the machining shop floor, is presented to demonstrate the application of the specific formulations of the methodology. The proposed methodology provides potential opportunities for reducing energy consumption and environmental impacts in machining processes, and helps production managers in decision-making on the issues of energy consumption and environmental impacts in the production operat
BACKGROUND Chromosome i(17)(q10)abnormality is mainly associated with chronic myeloid leukemia(CML),myelodysplastic syndrome/myeloproliferative tumors(MDS/MPD),and acute myeloid leukemia(AML).The role of i(17)(q10)in ...
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BACKGROUND Chromosome i(17)(q10)abnormality is mainly associated with chronic myeloid leukemia(CML),myelodysplastic syndrome/myeloproliferative tumors(MDS/MPD),and acute myeloid leukemia(AML).The role of i(17)(q10)in AML is still unknown,the differences between AML and acute promyelocytic leukemia(APL)-like AML with i(17)(q10)need more *** study aimed to investigate the clinical characteristics and laboratory evidence of 2 AML cases with i(17)(q10),similar to APL *** SUMMARY Both pediatric patients were males;case 1 had newly diagnosed AML,and case 2 showed relapsed tumor after 1 year of drug *** marrow cell morphology,chromosome karyotype analysis,Fully-instrumented submersible housing test,immunological assays,molecular biological methods,and blood tumor panoramic gene test were ***-trans retinoic acid(ATRA)combined with arsenic acid(As2O3)were used in the first course of *** marrow was dominated by abnormal promyelocytic *** test revealed i(17)(q10)*** phenotype mainly included positive expressions of CD9,CD13,CD33,and *** 1 suffered intracranial hemorrhage after re-chemotherapy and died on *** case 2,on D145 and D265,bone marrow promyelocytic granulocytes accounted for 2%.Flow cytometric residual lesion detection showed no abnormal immunophenotype *** copy number of WT1 gene in two cases were 1087 and 1010,respectively,and the expression rates were 55.29% and 59.5%,*** ATRA,As2O3,and chemotherapy may be ineffective in treating APL-like AML with i(17)(q10)but without t(15;17)and PML-RARA fusion gene.
作者：
he LeiLUO YichenZHANG yangyan Tengfeiliu JunqiuCollege of Material
Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of EducationKey Laboratory of Organosilicon Material Technology of Zhejiang ProvinceHangzhou Normal UniversityHangzhou310036P.R.China
Dysfunction of ion channels,often caused by mutations in natural proteins,can lead to various *** artificial analogs have shown great promise to substitute the abnormal ***,we report a supramolecular potassium channel...
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Dysfunction of ion channels,often caused by mutations in natural proteins,can lead to various *** artificial analogs have shown great promise to substitute the abnormal ***,we report a supramolecular potassium channel that forms through the self-assembly of pyrene-crown ether conjugated by intermolecularπ-π*** self-assembled dimer of this channel was optimized and calculated to have a binding energy of−27.4 kcal/mol(1 kcal=4.18 kJ).Evidence for the formation of an active ion channel by PC5 was confirmed using a planar lipid bilayer(BLM)workstation,while no such activity was observed for *** K+/Na+selectivity was reversed in the reduced form,R-PC5,due to the elimination of the planar structure of PC5,resulting in R-PC5 functioning as a Na+***,incorporating the pyrene group facilitates imaging in living cells,providing a potentially viable method for investigating the behaviors of artificial ion channels in living systems.
Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication,...
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Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication, and portable/wearable electronic *** this work, a nacre-inspired multifunctional heterocyclic aramid(HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper withlarge-scale, high strength, super toughness, and excellent tolerance tocomplex conditions is fabricated through the strategy of HA/MXenehydrogel template-assisted in-situ assembly of PPy. Benefiting from the"brick-and-mortar" layered structure and the strong hydrogen-bondinginteractions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa),outstanding toughness (57.6 MJ m−3), exceptional foldability, and structural stability against ultrasonication. By using the template effect ofHA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly,the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dBat an ultra-thin thickness (25.4 μm) and a high specific EMI SE of 17,204.7 dB cm2g−1. In addition, the papers also have excellent applicationsin electromagnetic protection, electro-/photothermal de-icing, thermal therapy, and fire safety. These findings broaden the ideas for developinghigh-performance and multifunctional MXene-based films with enormous application potential in EMI shielding and thermal management.
Objective:To investigate morphokinetic characteristics of embryos displaying either reverse cleavage or direct cleavage during the first,second or third cleavage ***:A total of 167 in vitro fertilization and/or intrac...
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Objective:To investigate morphokinetic characteristics of embryos displaying either reverse cleavage or direct cleavage during the first,second or third cleavage ***:A total of 167 in vitro fertilization and/or intracytoplasmic sperm injection treatment cycles undertaken by 167 women[aged(35.0±4.6)years]were included for reverse cleavage analysis,and a total of 167 in vitro fertilization and/or intracytoplasmic sperm injection treatment cycles undertaken by 167 women[aged(33.8±4.3)years]were included for direct cleavage analysis in this *** a sibling-embryo design,morphokinetic profiles(both before and after the onset of abnormal event)of embryos displaying reverse cleavage(n=241)or direct cleavage(n=244)were compared with their unaffected siblings(the controls)in the first,second and third cell cycles(n=32,n=142,n=562;n=195,n=412,n=205,respectively),at different developmental stages up to day ***:Direct cleavage embryos demonstrated significantly delayed cleavage rates prior to the event regardless of developmental stage of the occurrence,while reverse cleavage embryos showed similar cleavage rates to their unaffected *** event,direct cleavage embryos sped up cleavage rates while reverse cleavage embryos slowed ***:Altered morphokinetic profiles are displayed by direct cleavage embryos both before and after their occurrence and reverse cleavage embryos after the occurrence,which could potentially confound morphokinetic comparisons if not separated from their unaffected sibling *** study is warranted in order to fully understand the biological mechanisms of such events.
Dear Editor,Time-lapse videography of human embryos allows for the easy visualization of the embryos without removing them from the protective environment of the incubator[1],the measurement of various morphokinetic(q...
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Dear Editor,Time-lapse videography of human embryos allows for the easy visualization of the embryos without removing them from the protective environment of the incubator[1],the measurement of various morphokinetic(quantitative)parameters[2],and the identification of abnormalities of growth(qualitative parameters)such as direct cleavage[3],reverse cleavage[4]and intercellular contact of blastomeres[5].
Multiple cortical areas including the primary somatosensory cortex(S1) are activated during itch signal processing, yet cortical representation of itch perception remains unknown. Using novel miniature two-photon micr...
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Multiple cortical areas including the primary somatosensory cortex(S1) are activated during itch signal processing, yet cortical representation of itch perception remains unknown. Using novel miniature two-photon microscopic imaging in free-moving mice, we investigated the coding of itch perception in *** found that pharmacological inactivation of S1 abolished itch-induced scratching behavior, and the itch-induced scratching behavior could be well predicted by the activity of a fraction of layer 2/3 pyramidal neurons, suggesting that a subpopulation of S1 pyramidal neurons encoded itch perception, as indicated by immediate subsequent scratching behaviors. With a newly established optogenetics-based paradigm that allows precisely controlled pruritic stimulation, we found that a small fraction of S1 neurons exhibited an ignition-like pattern at the detection threshold of itch perception. Our study revealed the neural mechanism underlying itch perceptual coding in S1, thus paving the way for the study of cortical representation of itch perception at the single-neuron level in freely moving animals.
The first example of Nd@C3N4-photoredox/chlorine dual catalyzed alkylation with unactivated alkanes as the alkyl sources has been developed,which allows for the synthesis of various 4-alkylated cyclic sulfonyl *** thi...
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The first example of Nd@C3N4-photoredox/chlorine dual catalyzed alkylation with unactivated alkanes as the alkyl sources has been developed,which allows for the synthesis of various 4-alkylated cyclic sulfonyl *** this process,chlorine functions as both a redox and hydrogen atom transfer *** synergism of the reversible Nd2+/Nd3+and Clˉ/Cl˙redox pairs significantly enhances overall photocatalytic *** in vitro anticancer activity of 4-alkylated products was evaluated by using the CCK8assay against both human choroidal melanoma （MUM-2B） and lung cancer （A549） *** 3da showed approximately triple the potency of 5-fluorouracil.
CpG oligodeoxynucleotides （CpG ODN） as adjuvant have been extensively studied in recent years. Phosphodiester CpG ODN （PO CpG ODN） can perfectly mimic bacterial DNA in enhancing immune response but are vulnerable ...
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CpG oligodeoxynucleotides （CpG ODN） as adjuvant have been extensively studied in recent years. Phosphodiester CpG ODN （PO CpG ODN） can perfectly mimic bacterial DNA in enhancing immune response but are vulnerable to nucleases in vivo. This study aimed to evaluate the immunostimulatory potential arid safety of phosphodiester CpG ODN encapsulated in nonphospholipid liposomes. BALB/c mice were immunized intramuscularly with different formulations of liposomes, CpG ODN and hepatitis B surface antigen （HBsAg）. The results demonstrated that the encapsulated PO CpG ODN were protected against rapid degradation in vivo and retained their adjuvant activity. PO CpG ODN encapsulated with HBsAg in liposomes induced strong Th1-biased or Th1/Th2 mixed humoral immune response in mice with the magnitude similar to their phosphothioate equivalent in the same formulation. High IFN-gamma production induced by this formulation confirmed the generation of strong cellular immune response. Additionally, co-delivery of HBsAg arid PO CpG ODN improved the immune response over that obtained with separate delivery. Safety experiment showed that liposome-encapsulaed PO CpG ODN and HBsAg caused mild systemic and moderate local adverse reaction. In conclusion, our data shows that PO CpG ODN encapsulated in liposomes fully exhibit their Th1-type adjuvant activity arid act as a potential adjuvant for vaccines.
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