Pediatric acute myeloid leukemia patients with i(17)(q10)mimicking acute promyelocytic leukemia:Two case reports

作     者：Hong-Xia Yan Wei-Hua Zhang Jin-Quan Wen Yan-He Liu Bao-Juan Zhang A-Duo Ji 

作者机构：Department of HealthcareRainbow Hospital of XianyangXianyang 721000Shaanxi ProvinceChina Department of Pediatric Intensive Care UnitRainbow Hospital of XianyangXianyang 721000Shaanxi ProvinceChina Department of Pediatric Hematology/OncologyRainbow Hospital of XianyangXianyang 721000Shaanxi ProvinceChina Department of Pediatric Hemato-logy/OncologyRainbow Hospital of XianyangXianyang 721000Shaanxi ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第16期

页      面：5446-5455页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Shaanxi Natural Science Foundation No.2020SF-004 

主　　题：Chromosome i(17)(q10) Gene mutations Acute promyelocytic leukemia Acute myeloid leukemia Case report 

摘      要：BACKGROUND Chromosome i(17)(q10)abnormality is mainly associated with chronic myeloid leukemia(CML),myelodysplastic syndrome/myeloproliferative tumors(MDS/MPD),and acute myeloid leukemia(AML).The role of i(17)(q10)in AML is still unknown,the differences between AML and acute promyelocytic leukemia(APL)-like AML with i(17)(q10)need more *** study aimed to investigate the clinical characteristics and laboratory evidence of 2 AML cases with i(17)(q10),similar to APL *** SUMMARY Both pediatric patients were males;case 1 had newly diagnosed AML,and case 2 showed relapsed tumor after 1 year of drug *** marrow cell morphology,chromosome karyotype analysis,Fully-instrumented submersible housing test,immunological assays,molecular biological methods,and blood tumor panoramic gene test were ***-trans retinoic acid(ATRA)combined with arsenic acid(As2O3)were used in the first course of *** marrow was dominated by abnormal promyelocytic *** test revealed i(17)(q10)*** phenotype mainly included positive expressions of CD9,CD13,CD33,and *** 1 suffered intracranial hemorrhage after re-chemotherapy and died on *** case 2,on D145 and D265,bone marrow promyelocytic granulocytes accounted for 2%.Flow cytometric residual lesion detection showed no abnormal immunophenotype *** copy number of WT1 gene in two cases were 1087 and 1010,respectively,and the expression rates were 55.29% and 59.5%,*** ATRA,As2O3,and chemotherapy may be ineffective in treating APL-like AML with i(17)(q10)but without t(15;17)and PML-RARA fusion gene.