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Determining the protective effects of Ma-Mu-Ran Antidiarrheal Capsules against acute DSS-induced enteritis using 16S rRNA gene sequencing and fecal metabolomics

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Chinese Journal of Natural Medicines 2022年第5期20卷 364-377页

作者： ZHENG Si-Li ZHANG Dong-Ning DU AN yan-Fen HUANG fang HAN Lin-Tao mo Guo-yan Pharmacy Faculty Hubei University of Chinese MedicineWuhan 430065China College of Basic Medical Sciences Hubei University of Chinese MedicineWuhan 430065China Xinjiang Uygur Pharmaceutical Co. Ltd.UrumqiXinjiang 830026China

Ma-Mu-Ran Antidiarrheal Capsules(MMRAC)is traditional Chinese medicine that has been used to treat diarrhea caused by acute enteritis(AE)and bacillary dysentery in Xinjiang(China)for many ***,the potential therapeutic mechanism of MMRAC for AE and its regulatory mechanism on host metabolism is *** study used fecal metabolomics profiling with GC/MS and 16S rRNA gene sequencing analysis to explore the potential regulatory mechanisms of MMRAC on a dextran sulfate sodium salt(DSS)-induced mouse model of *** metabolomics-based analyses were performed to detect the differentially expressed metabolites and metabolic *** 16S rRNA gene sequencing analysis was used to assess the altered gut microbes at the genus level and for functional ***,Pearson correlation analysis was used to integrate differentially expressed metabolites and altered bacterial *** results revealed that six intestinal bacteria and seven metabolites mediated metabolic disorders(i.e.,metabolism of amino acid,carbohydrate,cofactors and vitamins,and lipid)in AE ***,ten altered microbes mediated the differential expression of eight metabolites and regulated these metabolisms after MMRAC ***,these findings demonstrate that AE is associated with metabolic disorders and microbial ***,we present that MMRAC exerts protective effects against AE by improving host metabolism through the intestinal flora.

关键词： Acute enteritis Ma-Mu-Ran Antidiarrheal Capsules 16S rRNA sequencing Fecal metabolomics Gut microbiota

Bubble Tree ConVergence for the Harmonic Sequence of Harmonic Surfaces in CP^n

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1277-1286页

作者： Xiao Huan mo fang SUN Key Laboratory of Pure and Applied Mathematics School of Mathematical Sciences Peking University Beijing 100871 P. R. China

We show that any harmonic sequence determined by a harmonic map from a compact Riemannian surface M to CP^n has a terminating holomorphic （or anti-holomorphic） map from M to CP^n, or a ＂bubble tree limit＂ consisti... 详细信息

关键词： bubble tree harmonic sequence non-isotropic energy identity

PVDF-based solid-state battery

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Chinese Journal of Structural Chemistry 2024年第8期43卷 5-7页

作者： Biao fang Runwei mo School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai200030China

With the rapid development of electric vehicle and energy storage industries,solid-state batteries have attracted widespread attention due to their excellent safety and high energy *** with tradi-tional organic liquid electrolytes,solid electrolytes can effectively avoid safety issues such as combustion,leakage or even ***-state electrolytes mainly include inorganic and organic solid-state electro-lytes.

关键词： battery density. state

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双壁波纹钢管混凝土构件短柱轴压力学性能

哈尔滨工业大学学报 2025年第1期57卷 56-64页

作者：路博崔燕方勇王玉银李豪哈尔滨工业大学土木工程学院哈尔滨150090 结构工程灾变与控制教育部重点实验室(哈尔滨工业大学) 哈尔滨150090 深圳市市政设计研究院有限公司广东深圳518029

为改善空心钢筋混凝土柱(HRC)的使用与受力性能,提出一种双壁波纹钢管混凝土(CFDCST)构件。本文共进行了4个大尺寸双壁波纹钢管混凝土短柱与2个空心钢筋混凝土短柱的轴压试验,关键试验参数为试件类型与波纹钢管类型。分析构件的破坏模式... 详细信息

为改善空心钢筋混凝土柱(HRC)的使用与受力性能,提出一种双壁波纹钢管混凝土(CFDCST)构件。本文共进行了4个大尺寸双壁波纹钢管混凝土短柱与2个空心钢筋混凝土短柱的轴压试验,关键试验参数为试件类型与波纹钢管类型。分析构件的破坏模式,对比不同参数下构件的承载力、峰值应变、延性系数等关键力学指标,获得荷载-波纹钢管应变关系曲线以揭示试件的约束机理并验证外波纹钢管类型的影响。试验结果表明:外波纹钢管可为夹层混凝土提供约束作用,且螺旋角越小,外波纹钢管的约束作用越强;内波纹钢管则主要为夹层混凝土内壁提供有效支撑,以保持截面的完整性。名义约束效应系数与空心率相近时,由于咬口滑移影响,大螺旋角双壁波纹钢管混凝土比小螺旋角双壁波纹钢管混凝土的峰值应力、峰值应变与延性系数分别降低15.5%、21.8%与16.7%。在总用钢量相近的情况下,小螺旋角双壁波纹钢管混凝土柱的承载力、峰值应变与延性系数分别比空心钢筋混凝土柱提高10.6%、36.2%与50.0%。基于试验结果,检验了3种典型承载力公式的适用性,并提出了相应设计建议。

关键词：组合结构空心钢筋混凝土波纹钢管双壁构件约束机理

Synthesis, Crystal Structure and Biological Activities of 3-[2-(4-Fluoro-phenyl)-ethyl]-5-methyl-4-hydroxyl-4-methyl-7-methylsulfanyl-3,4-dihydro-pyrido[4,3-d]pyrimidine-8-carbonitrile

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Chinese Journal of Structural Chemistry 2007年第2期26卷 172-176页

作者： mo Wen-yan HE Hong-Wu College of Chemistry Central China Normal University Wuhan 430079 China

The title compound, 3-[2-（4-fluoro-phenyl）-ethyl]-5-methyl-4-hydroxyl-4-methyl- 7-methylsulfanyl-3,4-dihydro-pyrido[4,3-d]pyrimidine-8-carbonitrile, has been prepared and detemined by single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P1 with a = 6.8754（8）, b = 10.2617（12）, c = 13.3491（16） A, α = 93.163（2）, β = 96.704（2）, γ = 102.421（2）°, V= 910.35（19）A^3, Z= 2, Mr= 370.44, Dc= 1.351 g/cm^3,μ = 0.203 mm^-1,F（000） = 388, the final R = 0.0573 and wR = 0.1497. X-ray analysis reveals that the pyridine and pyrimidine rings are almost coplanar.

关键词： pyrido[4,3-d]pyrimidine synthesis crystal structure biological activities

Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu Wen-Chang Jia Jing Wen Xue-Lin Cheng yan Han Ming-Hui Peng Jing Zhou Yao Liu Sun-fang Jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

Type-2 Fuzzy Control for Driving State and Behavioral Decisions of Unmanned Vehicle

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 178-186页

作者： Xuanming Zhao Hong mo Kefu yan Lingxi Li College of Electric and Information Engineering Changsha University of Science and TechnologyChangsha 410114China Department of Electrical and Computer Engineering Purdue School of Engineering and TechnologyIndiana University-Purdue University IndianapolisIndiana 46202-5132 USA

In this paper, interval type-2 fuzzy sets, fuzzy comprehensive evaluation and the fuzzy control rules are synthesized to realize the control of unmanned vehicle in driving state and behavioral decisions. Compared to the type-1 fuzzy set, type-2 fuzzy sets have more advantages in handling the model based on uncertainties, linguistic information because the membership functions are fuzzy sets. Different membership functions are established for each factor when the unmanned vehicle is driving at different speed intervals. In addition, a new evaluation method is developed to analyze unmanned vehicle’s driving state. Finally, a set of dynamic fuzzy rules are sorted out, which can be applied to the unmanned vehicle’s behavioral decision-making and provide a new idea to related research.

关键词： Fuzzy comprehensive evaluation fuzzy control interval type-2 fuzzy sets unmanned vehicle

Benchmark solutions of large-strain cavity contraction for deep tunnel convergence in geomaterials

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第3期12卷 596-607页

作者： Pin-Qiang mo Yong fang Hai-Sui Yu State Key Laboratory for Geomechanics and Deep Underground Engineering School of Mechanics and Civil EngineeringChina University of Mining and TechnologyXuzhou221116China Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu610031China School of Civil Engineering University of LeedsLeedsLS29JTUK

To provide precise prediction of tunnelling-induced deformation of the surrounding geomaterials,a framework for derivation of rigorous large-strain solutions of unified spherical and cylindrical cavity contraction is presented for description of confinement-convergence responses for deep tunnels in *** the tunnelling-induced large deformation,logarithmic strains are adopted for cavity contraction analyses in linearly elastic,non-associated mohr-Coulomb,and brittle Hoek-Brown *** with approximate solutions,the approximation error indicates the importance of release of small-strain restrictions for estimating tunnel convergence profiles,especially in terms of the scenarios with high stress condition and stiffness degradation under large *** ground reaction curve is therefore predicted to describe the volume loss and stress relaxation around the tunnel *** stiffness of circular lining is calculated from the geometry and equivalent modulus of the supporting structure,and a lining installation factor is thus introduced to indicate the time of lining installation based on the prediction of spherical cavity contraction around the tunnel opening *** study also provides a general approach for solutions using other sophisticated geomaterial models,and serves as benchmarks for analytical developments in consideration of nonlinear large-deformation behaviour and for numerical analyses of underground excavation.

关键词： Convergence-confinement method(CCM) Cavity contraction analysis Tunnel convergence

White-light emission and tunable room temperature phosphorescence of dibenzothiophene

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Science China Chemistry 2018年第4期61卷 397-401页

作者： Xiaoyu fang Dongpeng yan Beijing Key Laboratory of Energy Conversion and Storage Materials College of Chemistry Beijing Normal University State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology

molecular materials exhibiting room temperature phosphorescence(RTP) have received much attention during last few years. It has been known that different stacking fashions(e.g., formation of polymorph) and aggregation/crystal states could largely influence the RTP efficiency. However, whether the crystal morphology or shape could play a key role in modulation of the RTP has not been detected yet. In this work, we report that the dibenzothiophene(DBT) with the same molecular stacking fashion but different crystal morphologies can present alternated RTP performances. By modulation of the fluorescence and phosphorescence dual emission, a direct warm-white color light-emitting has also been successfully achieved. moreover, the RTP emission can be further tuned through hybridization with β-cyclodextrin in different ratios, with the longest lifetime of 0.43 s.

关键词： molecular crystal white-light emission room temperature phosphorescence hybrid