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Performance Characterization of Visible Light Communication Based on GaN High-Voltage LED/PD

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ZTE Communications 2024年第4期22卷 46-52页

作者： LU Meixin JIANG Zitong FANG Li yan yiqun yan Jiabin Nanjing University of Posts and Telecommunications Nanjing 210003China

While considerable research has been conducted on the structural principles,fabrication techniques,and photoelectric properties of high-voltage light-emitting diodes(LEDs),their performance in light communication remains underexplored.A high-voltage seriesconnected LED or photodetector(HVS-LED/PD)based on the gallium nitride(GaN)integrated photoelectronic chip is presented in this ***-quantum wells(MQW)diodes with identical structures are integrated onto a single chip through wafer-scale micro-fabrication techniques and connected in series to construct the HVS-LED/*** advantages of the HVS-LED/PD in communication are explored by testing its performance as both a light transmitter and a *** series connection enhances the device's 3 dB bandwidth,allowing it to increase from 1.56 MHz to a minimum of 2.16 MHz when functioning as an LED,and from 47.42 kHz to at least 85.83 kHz when operating as a *** results demonstrate that the light communication performance of HVS-LED/PD is better than that of a single GaN MQW diode with bandwidth and transmission quantity,which enriches the research of GaN-based high-voltage devices.

关键词： high-voltage LEDs high-voltage PDs GaN MQW diode array communication characterization visible light communication

Prognostic analysis of patients suffering from intrahepatic cholangiocarcinoma

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The Chinese-German Journal of Clinical Oncology 2011年第3期10卷 150-152页

作者： Zhong Chen Jianjun yan Liang Huang yiqun yan Department of Hepatobiliary Surgery Jinan Military Hospital Jinan 250031 China Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

Objective： The outcome of surgical treatment of patients with intrahepatic cholangiocarcinoma （ICC） is poor. This study was designed to analyze prognostic factors after surgical procedure for ICCs. Methods： A retrospective clinical analysis was made in 183 cases of ICC, admitted to Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China, from December 1996 to July 2003. Fifteen clinicopathologic factors that could possibly influence survival were selected. A multivariate analysis of these individuals was performed using the Cox Proportional Hazards Model. Results： The accumulative 1-, 3-and 5-year survival rates of the patients were 51.3%, 21.6% and 11.8% respectively. The statistical analysis showed that surgical procedure, lymph node metastasis, serum level of CA19-9 and pathological differentiation grade affected postoperative survival significantly, but transfusion, postoperative radiotherapy and chemotherapy, diameter of tumor, serum level of AFP, cirrhosis, preoperative total serum bilirubin level （TBIL）, ratio of albumin to globulin （A/G）, sex and age were not significant factors influencing postoperative survival. Conclusion： Major hepatectomy with systematic lymph node dissection may be recommended for the surgical treatment of ICC. Aggressive treatment and prevention on postoperative intrahepatic recurrence and lymph node metastasis are important strategy to improve the survival for ICC.

关键词： intrahepatic cholangiocarcinoma (ICC) surgical procedures operative prognosis

Treatment Strategy for Post-Hepatectomy Recurrent Hepatocellular Carcinoma: A Single Center Experience with 556 Consecutive Cases in China

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Journal of Cancer Therapy 2020年第7期11卷 389-400页

作者： Jing Li Liang Huang Caifeng Liu Maixuan Qiu Jianjun yan Shaohua Wei yiqun yan Department of General Surgery The Second Affiliated Hospital of Soochow University Suzhou China Department of Hepatic Surgery Shanghai Eastern Hepatobiliary Surgery Hospital Shanghai China

Background: Treatment strategy for recurrent hepatocellular carcinoma (HCC) remains scantily defined. This study was aimed to establish a treatment strategy to manage post-hepatectomy recurrent HCC and report the clinical outcomes. Methods: From January 2006 to December 2016, 556 consecutive patients who developed post-hepatectomy HCC recurrence were enrolled in the study. The patients were clinically stratified and treated according to a strategy established by a multi-disciplinary team. Clinical data and survival times were collected prospectively and analyzed retrospectively. Results: According to the strategy, there were 298 (53.6%), 214 (38.5%), 32 (5.7%) and 12 (2.2%) patients stratified into Early, Intermediate, Advanced and Terminal stages, respectively. In Early stage patients, 164 (55.0%) received curative treatment in the form of repeat resection or local ablation, 134 (45.0%) received transarterial chemoembolization (TACE), and the 1-, 3-, and 5-year overall survival (OS) rates were 82.0%, 46.8% and 37.3%, respectively. In Intermediate stage patients, 207 (96.7%) received TACE, 7 (3.3%) radiotherapy, and the 1-, 3-, and 5-year OS rates were 73.2%, 31.8% and 15.9%, respectively. In Advanced stage patients, 22 patients received sorafenib, 10 radiotherapy, and the mean survival time (MST) was 25.1 ± 3.1 months. All the 12 patients in Terminal stage received the best supportive treatment, and the MST was 6.5 ± 3.4 months. Clinical stages and duration of disease-free interval were independent factors relating to overall survival. Conclusions:

关键词： Post-Hepatectomy Recurrent Hepatocellular Carcinoma Clinical Classification Treatment Strategy Clinical Outcomes

对成人肝血管瘤自然发展进程及生长方式的新认识：队列研究

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中华肝胆外科杂志 2015年第11期21卷 721-725页

作者：朱倩乔国梁晏建军严以群湖北省荆门市第一人民医院肝胆外科 448000 第二军医大学东方肝胆外科医院肝外科上海

目的探索成人肝血管瘤的自然发展进程和生长方式。方法从2010年4月至2013年3月，236例未接受过治疗的肝血管瘤成人患者纳入本研究。随访观察肝血管瘤的自然发展进程及出现的并发症。结果236例肝血管瘤直径0．6—19．2cm不等，中位大小4... 详细信息

目的探索成人肝血管瘤的自然发展进程和生长方式。方法从2010年4月至2013年3月，236例未接受过治疗的肝血管瘤成人患者纳入本研究。随访观察肝血管瘤的自然发展进程及出现的并发症。结果236例肝血管瘤直径0．6—19．2cm不等，中位大小4．5cm。在3—266个月的随访期间（中位时间为48个月），61％的患者肝血管瘤增大，23．7％的血管瘤大小无变化，8．5％的肝血管瘤缩小。30岁前为肝血管瘤患者肿瘤生长高峰（0．46±0．41cm／年），50岁以后肿瘤生长速度明显降低（0．21±0．40cm／年）。小于2．0cm的肝血管瘤生长速度最慢（0．16±0．42cm／年），8．0～10．0cm的肝血管瘤生长最快（0．80±0．62cm／年），大于10．0cm的肝血管瘤生长速度则明显变缓（0．47±0．91cm／年）。随访显示9例患者出现明显的与肿瘤相关的症状，没有发现肿瘤相关并发症。结论绝大多数肝血管瘤均有增大发展趋势，但极少引起并发症。所有肝血管瘤患者均可安全地进行随访。对于症状明显的肝血管瘤患者，手术是最佳治疗方案。

关键词：肝血管瘤自然进程生长方式治疗指征手术

巴塞罗那分期A期及B期肝细胞癌自发破裂的危险因素及预后

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中华肝胆外科杂志 2015年第2期21卷 81-85页

作者：朱倩乔国梁晏建军严以群湖北省荆门市第一人民医院肝胆外科 448000 第二军医大学东方肝胆外科医院肝外科上海

目的探索巴塞罗那分期（BCLC）A期及B期肝细胞癌自发破裂的危险因素及其肝切除手术预后.方法将2002年4月至2006年11月收治的89例BCLC A期及B期肝癌自发破裂患者纳入病例组.根据年龄、性别及BCLC分期随机选取同期未发生破裂的171例肝... 详细信息

目的探索巴塞罗那分期（BCLC）A期及B期肝细胞癌自发破裂的危险因素及其肝切除手术预后.方法将2002年4月至2006年11月收治的89例BCLC A期及B期肝癌自发破裂患者纳入病例组.根据年龄、性别及BCLC分期随机选取同期未发生破裂的171例肝癌患者作为对照组.回顾性分析肝癌破裂患者的临床资料和预后.结果多因素分析显示,高血压[优势比（HR）7.38,95％ CI：1.91 ～ 28.58,P＜0.05]、肝硬化（HR6.04,95％ CI：2.83 ～ 12.88,P＜0.05）以及肿瘤位于Ⅱ、Ⅲ、Ⅵ段（HR 5.03,95％ CI：2.70～6.37,P＜0.05）是肝癌自发破裂的独立危险因素.病例组术后中位生存时间和中位无瘤生存时间（范围）分别为12（1 ～78）个月和4（0 ～78）个月.病例组1、3、5年总体生存率分别为66.3％、23.4％、10.1％,无瘤生存率分别为57.0％、16.8％、4.5％.对照组分别为85.4％、63.2％、46.3％和65.7％、39.2％、27.5％（P ＜0.05）.根治性切除是影响肝癌自发破裂预后的独立危险因素（总体生存：HR0.32,95％ CI：0.08 ～0.61,P＜0.05;无瘤生存：HR0.12,95％ CI：0.01 ～0.73,P＜0.05）.结论肿瘤部位、高血压及肝硬化是影响肝细胞癌自发破裂的重要危险因素.BCLC A期及B期肝细胞癌破裂患者应行一期肝切除术.

关键词：肝细胞癌破裂危险因素预后

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可切除肝门部胆管癌预后影响因素分析

中华肝胆外科杂志 2014年第9期20卷 662-666页

作者：朱倩乔国梁晏建军严以群湖北省荆门市第一人民医院肝胆外科 448000 第二军医大学东方肝胆外科医院肝外一科上海200438

目的研究对肝门部胆管癌预后影响最大的CA19-9的截点值,探索手术切除肝门部胆管癌患者的预后因素.方法回顾性分析2003年4月至2009年1月于东方肝胆外科医院手术治疗的168例肝门部胆管癌患者资料.单因素分析其CA19-9水平对判断预后最有... 详细信息

目的研究对肝门部胆管癌预后影响最大的CA19-9的截点值,探索手术切除肝门部胆管癌患者的预后因素.方法回顾性分析2003年4月至2009年1月于东方肝胆外科医院手术治疗的168例肝门部胆管癌患者资料.单因素分析其CA19-9水平对判断预后最有价值的截点,后行多因素分析,得出独立预后因素.结果术前CA19-9水平对预后判断最有价值的截点值为150 kU/L（P＜0.001）.单因素分析显示年龄、肿瘤大小、分化程度、Bismuth-Corlette分型、门静脉侵犯、肝动脉侵犯、术前减黄、淋巴结转移及切缘均会影响肝门部胆管癌的预后.多因素分析证实只有淋巴结转移、切缘及CA19-9是影响肝门部胆管癌预后的独立危险因素.结论 CA19-9水平是影响肝门部胆管癌预后的独立因素,其对预后判断最有价值的截点是150 kU/L.结合术前CA19-9水平不仅有助于肝门部胆管癌患者的术前分期评估,而且有助于决定是否行腹腔探查并推断肝门部胆管癌的预后.

关键词：肝门部胆管癌糖链抗原19-9,截点淋巴结转移切缘影响因素,预后

大鼠肝卵圆细胞中matrilin-2的表达及其意义

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中国普通外科杂志 2010年第1期19卷 61-64页

作者：陈中晏建军黄亮严以群第二军医大学东方肝胆外科医院肝外一科上海200438

目的探讨大鼠肝脏再生过程中肝卵圆细胞matrilin-2的表达及其意义。方法利用大鼠部分肝切除(PH)或2-乙酰氨基芴灌胃+/部分肝切除(2-AAF/PH)建立大鼠肝脏再生模型,并设正常对照组。应用免疫组织化学和RT-PCR方法研究肝脏组织中matrilin-... 详细信息

目的探讨大鼠肝脏再生过程中肝卵圆细胞matrilin-2的表达及其意义。方法利用大鼠部分肝切除(PH)或2-乙酰氨基芴灌胃+/部分肝切除(2-AAF/PH)建立大鼠肝脏再生模型,并设正常对照组。应用免疫组织化学和RT-PCR方法研究肝脏组织中matrilin-2表达情况。结果免疫组化发现正常对照组及PH组肝脏组织中只有极少量的matrilin-2表达位于胆管血管周围及肝窦状隙内,而在2-AAF/PH模型中可见matrilin-2表达位于门静脉周围的肝窦状隙内,RT-PCR发现2-AAF/PH组肝卵圆细胞中matrilin-2mRNA高表达,而PH组及正常对照组成熟肝细胞中无matrilin-2mRNA表达。结论matrilin-2是肝卵圆细胞在肝脏再生过程中产生的重要的细胞外基质蛋白,与肝卵圆细胞的增殖分化过程有密切关系。

关键词：肝再生 Matrilin-2 肝卵圆细胞大鼠

Misdiagnosis of Patients with Solitary Liver Metastasis as the First Finding for Hospitalization（以单个肝占位为首发表现的转移性肝癌的误诊分析）

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The Chinese-German Journal of Clinical Oncology 2003年第2期2卷 87-89,121页

作者： yanyiqun yanJianjun HUANGLiang ZHOUFeiguo WUMengchao TheFirstDepartmentofHepaticSurgeryofEasternHepatobiliarySurgeryHospital SecondMilitaryMedicalUniversityShanghai200438China

目的探讨以单个肝占位为首发表现的转移性肝癌的误诊原因和治疗。方法回顾性总结分析1年半来治疗10例患者的临床资料。结果 10例患者入院后确诊为转移性肝癌，肝脏转移灶均为单发，肿瘤直径在4．5～12．4cm，平均(7．8±2．5)cm。2例... 详细信息

目的探讨以单个肝占位为首发表现的转移性肝癌的误诊原因和治疗。方法回顾性总结分析1年半来治疗10例患者的临床资料。结果 10例患者入院后确诊为转移性肝癌，肝脏转移灶均为单发，肿瘤直径在4．5～12．4cm，平均(7．8±2．5)cm。2例来自胃癌，7例来自结直肠癌，1例来自恶性淋巴瘤，门诊有6例误诊为原发性肝癌，误诊率高达60％。9例患者均同期行肝转移癌切除及胃肠道肿瘤切除术，手术顺利，无1例出现手术并发症。结论以单个肝占位为首发表现的转移肝癌发病率低，容易误诊，医师对本病认识不足以及临床思维的局限是导致误诊的主要原因。同期切除肝转移灶和原发灶肿瘤可取得良好疗效。Objective To summarize the experience of diagnosis for solitary liver metastasis as the patient' s first finding for hospitalization and the cause of misdiagnosis for this kind of *** From July 2000 to March 2002, 10 cases of solitary space occupying lesion in liver as the first clinical finding were admitted to our department. Besides the routine blood test after admission, serum AFP, CEA and CA-199 were determined in all patients. Colonoscopy was performed on the patients suspected with primary cancer in colon or *** The diagnosis of hepatic metastasis was finally made in all patients after admission, based on the findings of the primary tumor in other organs. The metastatic tumor was from gastric cancer in 2 cases, from colorectal cancer in 7 cases and from malignant lymphoma in 1 case. The diameters of the metastatic tumor ranged from 4.5 to 12.4 cm with a mean diameter of 7.8 ± 2.5cm. The misdiagnosis rate in outpatient department was 60%. In 9 patients, the liver metastatic tumors and the primary tumors were resected at the same time. All of them recovered and discharged *** Because of its low morbility, the solitary liver metastasis can be easily misdiagnosed if the patients only have a single space occupying lesion in liver as the first finding when they come to hospital. Fully recognition of the disease and complete imaging examinations are both necessory to make a correct diagnosis. The treatment for these patients is, if possible, to resect the liver metastatasis and the primary tumor simultaneously.

关键词：肝脏转移癌误诊原因分析临床表现手术治疗

Reactivation of hepatitis C virus replication in a patient undergoing hepatectomy for hepatocellular carcinoma

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Journal of Medical Colleges of PLA(China) 2012年第5期27卷 306-310页

作者： Liu Caifeng Li Jing Huang Liang yan yiqun Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China

*** Hepatocellular carcinoma (HCC) is one of the most common neoplasms encountered,and its incidence is increasing worldwide because of the increasing prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection [1,2].Patients with HBV or HCV-related HCC suffer not only from malignancy but also chronic virus *** follows that treatments for HCC could also affect the activity of virus replication,a factor that has important implication for hepatitis *** previous studies [3,4],high incidences (28％ and 21％ respectively) of HBV reactivation were observed in HBV-related HCC patients undergoing liver *** far,there have been very few reports concerning reactivation of HCV replication in HCV-related HCC patients undergoing liver *** we present the case of a patient with HCV-related HCC underwent liver resection and experienced postoperative liver failure duo to HCV reactivation.

关键词：丙型肝炎病毒病毒复制切除术癌病 C型激活恶性肿瘤病毒感染