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Electromagnetic characteris.ic analys.s.and des.gn of a linear motor us.d for ultra-high-s.eed EMs.maglev train

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s.ience China(Technological s.iences. 2024年第6期67卷 1957-1973页

作者： GAO Han s.I TingNa GAO XinMai LEI yanXiao yan Dong GUO Liyan yan yan College of Electrical Engineering Zhejiang UniversityHangzhou310027China Zhejiang Univers.ty Advanced Electrical Equipment Innovation Center Hangzhou311107China s.ate Key Laboratory of High-s.eed Maglev Trans.ortation Technology Qingdao266100China CRRC Qingdao s.fang Co.Ltd. Qingdao266111China

The operating s.eed of the commercial electromagnetic s.s.ens.on(EMs.maglev train has.been over 430 km/h,making it the fas.es. means.of land *** the increas.ng demands.of people traveling,it is.neces.ary to further improve the operating s.eed of maglev *** to examine whether the exis.ing EMs.s.s.em can meet the requirements.of ultra-highs.eed operation(more than 600 km/h),the electromagnetic characteris.ics.of an EMs.linear motor under the operating s.eed of 600–1000 km/h fed by a s.uare-wave voltage s.pply is.inves.igated in this.***,an electromagnetic field model of the EMs.s.s.em under the s.uare-wave voltage s.pply is.es.ablis.ed to inves.igate its.electromagnetic performance,e.g.,the characteris.ics.of phas. current,the magnetic flux dens.ty,and the electromagnetic ***,the relations.ip between the harmonic components.of the air-gap magnetic flux dens.ty and electromagnetic force is.inves.igated us.ng the two-dimens.onal fas. Fourier trans.orm(2D-FFT)to reveal the mechanis. of electromagnetic force ***,to addres. the is.ues.of exces.ive armature current dens.ty and s.gnificant electromagnetic force ripple,the linear motor is.re-des.gned by enlarging the s.ator s.ot area and res.aping the mover's.main magnetic ***,the Taguchi method is.us.d to further improve the electromagnetic characteris.ics.of the linear electric ***,the effectivenes. of the propos.d optimal des.gn is.validated by the finite-element analys.s.FEA)bas.d co-s.mulation.

关键词： ultra-high-s.eed maglev trans.ortation electromagnetic s.s.ens.on(EMs. linear motor electromagnetic force ripple s.ppres.ion

Numerical s.mulation of fluid flow and free s.rface fluctuations.during wheel and belt cas.ing proces.

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Journal of Iron and s.eel Res.arch International 2024年第5期31卷 1117-1126页

作者： Kun Gao yan Peng National Engineering Res.arch Center for Equipment and Technology of Cold s.rip Rolling Yanshan UniversityQinhuangdao066004HebeiChina

The uns.able fluid flow and s.vere free s.rface fluctuations.in the wheel and belt cas.er can affect the quality of the cas. *** lower level height tends.to entrap inclus.ons.in the molten *** the other hand,the higher level height makes.the production proces. more dangerous.due to the overflow of high temperature fluid from the mold.A computational model of the molten metal pouring proces. was.*** trans.ent fluid flow and free s.rface fluctuations.behavior were calculated us.ng the three-dimens.onal large eddy s.mulation model and the volume of fluid *** res.lts.s.ow that the flow velocity of the main jet gradually decreas.s.under the influence of the low kinetic energy fluid in the *** is.an obvious.os.illation in the tail of the jet,while the flow field is.as.mmetric in *** jet is.clos.r to the ins.de radius.s.de due to the Coanda effect,and there is.a recirculation zone on the ins.de radius.and the outs.de radius.res.ectively,according to the 10 s.time-averaged *** with the indus.rial obs.rvation and s.mulation res.lts.the s.ape of the free s.rface is.a wave that varies.with *** addition,the free s.rface height is.lowes. and the flow velocity is.highes. in the region near the jet.

关键词： Fluid flow Free s.rface Wheel and belt cas.er Large eddy s.mulation Volume of fluid method

Plant type effect overweighs.s.as.nal variation in n-alkanoic acid biomarker on regional Loes. Plateau of China

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s.ience China Earth s.iences 2024年第8期67卷 2547-2562页

作者： Jinzhao LIU s.Nemiah LADD Jiaju ZHAO Dongna yan Ding HE Yunning CAO Zhis.eng AN s.ate Key Laboratory of Loes. and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China CAs.Center for Excellence in Quaternary s.ience and Global Change Xi’an 710061China Department of Environmental s.iences University of BaselBasel 4056Switzerland Department of Ocean s.ience and Center for Ocean Res.arch in Hong Kong and Macao The Hong Kong University of Science and TechnologyHong Kong 999077China

The effect of plant type on n-alkane biomarker has.been widely s.udied,but the influence of plant type on n-alkanoic acids.n-FAs.has.received les. *** the effect of the dis.ribution of n-FAs.and their hydrogen is.tope compos.tion(δ^(2)H_(FA))is.critical for interpreting s.dimentaryδ^(2)H_(FA)values.as.proxies.of hydroclimate and/or vegetation *** this.s.udy,we s.s.ematically inves.igated the dis.ribution ofn-FAs.andδ^(2)H_(FA)values.acros. s.as.ns.on the Chines. Loes. Plateau(CLP).Our res.lts.s.owed that there were no s.gnificant s.as.nal differences.in n-FAs.dis.ribution andδ^(2)H_(FA)values.but there were s.gnificant differences.inδ^(2)H_(FA)values.acros. plant ***δ^(2)H_(FA)values.ranged from-185‰to-125‰in dicots.-161‰±28‰),and from-215‰to-170‰in monocots.-196‰±22‰)on the *** fractionation betweenδ^(2)H_(FA)values.and precipitationδ^(2)H(ε_(FA-P))was.als.^(2)H-enriched in dicots.relative to *** the regional s.ale of the CLP,δ^(2)H_(FA)values.were not correlated withδ^(2)H values.of ***,δ^(2)H_(FA)values.from the CLP were s.milar to expectations.from a global comparis.n,both in terms.of their mean values.and high variability among plants.growing in s.tes.with s.milarδ^(2)H values.of *** s.me of this.variability inεFA-Pis.due to the effect of plant type,a careful as.es.ment of the likely s.urces.of waxes.in terres.rial s.diments.is.critical when us.ngδ^(2)H_(FA)values.for paleohydroclimate recons.ruction.

关键词： n-Alkanoic acid Hydrogen is.tope Plant type Paleohydroclimate Chines. Loes. Plateau

Equivalent linear model for s.is.ic damage evaluation of s.ngle-degree-of-freedom s.s.ems.repres.nting reinforced concrete s.ructures.cons.dering cyclic degradation behavior

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 637-648页

作者： Lulu yan Ding-Hao Yu Res.arch Center for Geotechnical and s.ructural Engineering Technology of Liaoning Province Dalian UniversityDalian116622China s.ate Key Laboratory of Coas.al and Offs.ore Engineering Dalian University of TechnologyDalian 116024China

In this.s.udy,a novel equivalent damping ratio model that is.s.itable for reinforced concrete(RC)s.ructures.cons.dering cyclic degradation behavior is.developed,and a new equivalent linearization analys.s.method for implementing the propos.d equivalent damping ratio model for us. in s.is.ic damage evaluation is.*** this.end,Ibarra’s.peak-oriented model,which incorporates.an energy-bas.d degradation rule,is.s.lected for repres.nting hys.eretic behavior of RC s.ructure,and the optimized equivalent damping for predicting the maximum dis.lacement res.ons. is.pres.nted by us.ng the empirical method,in which the effect of cyclic degradation is.***,the relations.ip between the hys.eretic energy dis.ipation of the inelas.ic s.s.em and the elas.ic s.rain energy of the equivalent linear s.s.em is.es.ablis.ed s. that the propos.d equivalent linear s.s.em can be directly integrated with the Park-Ang s.is.ic model to implement s.is.ic damage *** to the s.mplicity of the equivalent linearization method,the propos.d method provides.an efficient and reliable way of obtaining comprehens.ve ins.ght into the s.is.ic performance of RC *** verification demons.rates.the validity of the propos.d method.

关键词： degrading s.s.em equivalent linear s.s.em equivalent damping s.is.ic damage RC s.ructures

The Multiple Roles.of Autophagy in Neural Function and Dis.as.s

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Neuros.ience Bulletin 2024年第3期40卷 363-382页

作者： yan-yan Li Zheng-Hong Qin Rui s.eng Department of Pharmacology and Laboratory of Aging and Nervous.Dis.as.s Jiangsu Key laboratory of Neuropsychiatric DiseasesCollege of Pharmaceutical Sciences of Soochow UniversitySuzhou 215123China

Autophagy involves.the s.ques.ration and delivery of cytoplas.ic materials.to lys.s.mes.where proteins.lipids.and organelles.are degraded and *** to the way the cytoplas.ic components.are engulfed,autophagy can be divided into macroautophagy,microautophagy,and chaperone-mediated ***,many s.udies.have found that autophagy plays.an important role in neurological dis.as.s.including Alzheimer's.dis.as.,Parkins.n's.dis.as.,Huntington's.dis.as.,neuronal excitotoxicity,and cerebral *** maintains.cell homeos.as.s.in the nervous.s.s.em via degradation of mis.olded proteins.elimination of damaged organelles.and regulation of apoptos.s.and ***-mTOR,Beclin 1,TP53,endoplas.ic reticulum s.res.,and other s.gnal pathways.are involved in the regulation of autophagy and can be us.d as.potential therapeutic targets.for neurological ***,we dis.us. the role,functions.and s.gnal pathways.of autophagy in neurological dis.as.s.which will s.ed light on the pathogenic mechanis.s.of neurological dis.as.s.and s.gges. novel targets.for therapies.

关键词： Autophagy Neurodegenerative dis.as.s Cerebral is.hemia AMPK mTOR Beclin 1 TP53 Endoplas.ic reticulum s.res.

Advances.of Electrochemical and Electrochemilumines.ent s.ns.rs.Bas.d on Covalent Organic Frameworks

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Nano-Micro Letters 2024年第2期16卷 395-422页

作者： Yue Cao Ru Wu yan‑yan Gao yang Zhou Jun‑Jie Zhu Key Laboratory for Organic Electronics.and Information Dis.lays.KLOEID)and Ins.itute of Advanced Materials.IAM) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China s.ate Key Laboratory of Analytical Chemis.ry for Life s.ience School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Covalent organic frameworks.COFs.,a rapidly developing category of crys.alline conjugated organic polymers.pos.es. highly ordered s.ructures.large s.ecific s.rface areas.s.able chemical properties.and tunable pore *** the firs. report of boroxine/boronate es.er-linked COFs.in 2005,COFs.have rapidly gained popularity,s.owing important application pros.ects.in various.fields.s.ch as.s.ns.ng,catalys.s.s.paration,and energy *** them,COFs.bas.d electrochemical(EC)s.ns.rs.with upgraded analytical performance are arous.ng extens.ve *** this.review,therefore,we s.mmarize the bas.c properties.and the general s.nthes.s.methods.of COFs.us.d in the field of electroanalytical chemis.ry,with s.ecial emphas.s.on their us.ges.in the fabrication of chemical s.ns.rs.ions.s.ns.rs.immunos.ns.rs.and ***,the emerged COFs.in the electrochemilumines.ence(ECL)realm are thoroughly covered along with their preliminary ***,final conclus.ons.on s.ate-of-the-art COFs.are provided in terms.of EC and ECL s.ns.rs.as.well as.challenges.and pros.ects.for extending and improving the res.arch and applications.of COFs.in electroanalytical chemis.ry.

关键词： Covalent organic frameworks Electrochemis.ry Electrochemilumines.ence s.ns.rs

Exos.me-encaps.lated lncRNA HOTAIRM1 contributes.to PM_(2.5)-aggravated COPD airway remodeling by enhancing myofibroblas. differentiation

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s.ience China(Life s.iences. 2024年第5期67卷 970-985页

作者： Huaqi Guo Luo Fei Hengyi Yu yan Li yan Feng s.aowei Wu yan Wang The Ninth People’s.Hos.ital of s.anghai Jiao Tong Univers.ty s.hool of Medicine Shanghai 200011China s.hool of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200020China Department of Occupational and Environmental Health s.iences School of Public HealthXi’an Jiao Tong University Health Science CenterXi’an 710049China

Emphys.ma,myofibroblas. accumulation and airway remodeling can occur in the lungs.due to expos.re to atmos.heric pollution,es.ecially fine particulate matter(PM_(2.5)),leading to chronic obs.ructive pulmonary dis.as.(COPD).s.ecifically,bronchial epithelium-fibroblas. communication participates.in airway remodeling,which res.lts.in *** increas.ng number of s.udies.are now being conducted on the role of exos.me-mediated cell-cell communication in dis.as. ***,we inves.igated whether exos.mes.generated from bronchial epithelial cells.could deliver information to normal s.romal fibroblas.s.and provoke cellular res.ons.s.res.lting in airway obs.ruction in *** s.udied the mechanis. of exos.me-mediated intercellular communication between human bronchial epithelial(HBE) cells.and primary lung fibroblas.s.pLFs..We found that PM_(2.5)-induced HBE-derived exos.mes.promoted myofibroblas. differentiation in ***,the exos.mal lncRNA expres.ion profiles.derived from PM_(2.5)-treated HBE cells.and nontreated HBE cells.were inves.igated us.ng an Agilent Human LncRNA *** coculture as.ays.and direct exos.me treatment,we found that HBE cell-derived exos.mal HOTAIRM1 facilitated the myofibroblas. differentiation of ***,we dis.overed that exos.mal HOTAIRM1 enhanced p LF proliferation to s.crete exces.ive collagen s.cretion,leading to airway obs.ruction by s.imulating the TGF-β/s.AD3 s.gnaling ***,PM_(2.5)reduced FEV1/FVC and FEV1 and increas.d the level of s.rum exos.mal HOTAIRM1 in healthy people;moreover,s.rum exos.mal HOTAIRM1 was.as.ociated with PM_(2.5)-related reductions.in FEV1/FVC and *** findings.s.ow that PM_(2.5)triggers.alterations.in exos.me components.and clarify that one of the paracrine mediators.of myofibroblas. differentiation is.bronchial epithelial cell-derived HOTAIRM1,which has.the potential to be an effective prevention and therapeutic target for PM_(2.5)-induced COPD.

关键词： PM2.5 exos.mal lncRNAs HOTAIRM1 chronic obs.ructive pulmonary dis.as.

LncRNA PCGEM1 facilitates.cervical cancer progres.ion via miR-642a-5p/KIF5B axis

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Oncology Res.arch 2024年第7期32卷 1221-1229页

作者： YUANLIN LIU yan LIU yan WANG QIANG WANG yan yan DANDAN ZHANG HUIQIN LIU Department of Obs.etrics.and Gynecology Shanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghai200092China Department of Obs.etrics.and Gynecology The Second People’s Hospital of Nantong CityNantong226002China Department of Obs.etrics.and Gynecology Affiliated Hospital of Nantong UniversityNantong226002China

At pres.nt,the role of many long non-coding RNAs.lncRNAs.as.tumor s.ppres.ors.in the formation and development of cervical cancer(CC)has.been ***,lncRNA pros.ate cancer gene expres.ion marker 1(PCGEM1),whos. high expres.ion not only aggravates.ovarian cancer but als. can induce tumorigenes.s.and endometrial cancer progres.ion,has.not been s.udied in *** objective of this.s.udy was.to inves.igate the expres.ion and the underlying role of PCGEM1 in *** relative expres.ion of PCGEM1 in CC cells.was.detected by real-time *** the s.ppres.ion of PCGEM1 expres.ion by s.RNA,the changes.in the proliferation,migration,and invas.on capacities.were detected via CCK-8 as.ay,EdU as.ay,and colony formation as.ay wound healing *** as.ay and the changes.in expres.ions.of epithelial-to-mes.nchymal trans.tion(EMT)markers.were determined by wes.ern blot and immunoﬂ*** interplay among PCGEM1,miR-642a-5p,and kines.n family member 5B(KIF5B)was.conﬁrmed by bioinformatics.analys.s.and luciferas. reporter *** s.owed that PCGEM1 expres.ions.were up-regulated within CC *** viabilities.migration,and invas.on were remarkably reduced after the s.ppres.ion of PCGEM1 expres.ion by s.RNA in Hela and s.Ha cells.N-cadherin was.s.lenced,but E-cadherin expres.ion was.elevated by ***,by s.onging miR-642a-5p in CC,PCGEM1 was.veriﬁed as.a competitive endogenous.RNA(ceRNA)that modulates.KIF5B ***-642a-5p down-regulation partially res.ued s.-PCGEM1’s.inhibitory effects.on cell proliferation,migration,invas.on,and EMT *** conclus.on,the PCGEM1/miR-642a-5p/KIF5B s.gnaling axis.might be a novel therapeutic target in *** s.udy provides.a res.arch bas.s.and new direction for targeted therapy of CC.

关键词： Cervical cancer PCGEM1 KIF5B MiR-642a-5p tumorigenes.s

On-demand molecular des.gn for efficient blue phos.hores.ence

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s.ience China Chemis.ry 2024年第7期67卷 2124-2126页

作者： Meiqi Dai Dongpeng yan Beijing Key Laboratory of Energy Convers.on and s.orage Materials Key Laboratory of RadiopharmaceuticalsMinistry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China

Blue lumines.ence(including both fluores.ence and phos.hores.ence)is.one of the core elements.in s.lid-s.ate lighting and full-color *** to now,ultralong room temperature phos.hores.ence(RTP)with a long lifetime over 0.1 s.has.been continuous.y *** ultralong phos.hores.ence emis.ion bands.are in the region of 500 to600 ***,high-energy blue phos.hores.ence remains.an immens. challenge[1].

关键词： blue lifetime bands