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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei mei yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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自卸半挂车液压系统的设计

液压与气动 2013年第7期37卷 54-56页

作者：石固欧梅彦利承德石油高等专科学校河北承德067000

目前自卸半挂车普遍存在卸料不净、运输效率低、、影响道路环保、运输货物易受污染等诸多问题,为此设计出一种新型自卸半挂车的液压系统,提出了自卸车举升、中停、限位、下降、过载保护、篷布开启与闭合的先进技术及主要元件的设计方法... 详细信息

目前自卸半挂车普遍存在卸料不净、运输效率低、、影响道路环保、运输货物易受污染等诸多问题,为此设计出一种新型自卸半挂车的液压系统,提出了自卸车举升、中停、限位、下降、过载保护、篷布开启与闭合的先进技术及主要元件的设计方法,为物料的运输提供了保障。

关键词：自卸半挂车液压系统设计

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基于图论的电网脆性仿真

系统仿真学报 2007年第18期19卷 4104-4106,4110页

作者：闫丽梅张江陈娟大庆石油学院电气信息工程学院大庆石油管理局电力总公司供电公司黑龙江大庆163453

系统的脆性分析的关键是要建立脆性模型。图论针对网络系统可以描述出系统脆性传播的方向和权重。提出了基于图论理论的系统脆性模型建立的方法和步骤。针对7节点电力系统进行了理论的建模和分析,求出了分层的电力系统脆性模型和脆性源... 详细信息

系统的脆性分析的关键是要建立脆性模型。图论针对网络系统可以描述出系统脆性传播的方向和权重。提出了基于图论理论的系统脆性模型建立的方法和步骤。针对7节点电力系统进行了理论的建模和分析,求出了分层的电力系统脆性模型和脆性源。证明了此方法对于网络系统分析的有效性。

关键词：图论系统脆性脆性源分层脆性传播模型

Levels and dynamic changes of serum fibroblast growth factor 23 in hypophosphatemic rickets/osteomalacia

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Chinese Medical Journal 2010年第9期123卷 1158-1162页

作者： XIA Wei-bo JIANG yan li mei XING Xiao-ping WANG Ou HU Ying-ying ZHANG Hua-bing liU Huai-cheng MENG Xun-wu ZHOU Xue-ying Department of Endocrinology Key Laboratory of EndocrinologyMinistry of HealthPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China

Background Hypophosphatemic rickets/osteomalacia is a group of diseases characterised by defective mineralization of bone due to hypophosphatemia and low 1,25-dihydroxy vitamin D. To explore the role of fibroblast growth factor 23 （FGF-23） in the regulation of phosphate homeostasis, we measured the circulating concentrations of this growth factor in healthy individuals and in patients with hypophosphatemic rickets/osteomalacia. Methods Nineteen patients with hypophosphatemic rickets/osteomalacia were included in hypophosphatemic group （HP, 12 female and 7 male, mean age was 30 years）, and 19 healthy age-matched individuals served as the control group. Full length FGF-23 fragments were measured by two-site enzyme-linked immunosorbent *** Mean FGF-23 concentrations were significantly higher in the HP group （（87.4±43.6） pg/ml） compared with the control group （（19.2±6.16） pg/ml; P 〈0.001）. In 1 patient with tumour-induced osteomalacia, serum FGF-23 concentrations were 84.1 pg/ml; these concentrations were normalized 2 hours after a hemangiopericytoma resection （7.8 pg/ml）. Subsequently, serum 1,25（OH）2 vitamin D3 concentrations significantly increased from 21.3 pg/ml to 89.3 pg/ml, and serum phosphorus levels were normalized. Conclusions Serum FGF-23 concentrations were markedly elevated in patients with hypophosphatemic rickets. FGF-23 plays an important role in the pathogenesis of hypophosphatemic rickets/osteomalacia.

关键词： fibroblast growth factor 23 hypophosphatemia rickets osteomalacia

Glycopeptide vaccine based on DNA Supramolecular Hydrogels

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Glycopeptide vaccine based on DNA Supramolecular Hydrogels

Identification of HIV-1 Genotypic Resistance in Patients on First-line Antiretroviral Therapy Using Polymerase Chain Reaction and Sequencing

中国化学会第三届全国糖化学会议

作者： Hongguo Hu Zhan-Yi Sun Yu Shao Yijie Wang Bo-Dou Zhang Dongsheng liu yan-mei li Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology(Ministry of Education) Key Laboratory of Organic Optoelectronics and Molecular Engineering(Ministry of Education) Department of Chemistry Tsinghua University

In recent years,cancer immunotherapy,one of the most promising ways for the treatment of cancer,has been widely developed. However,it is very hard to construct a wide antigenadaptive,easy-handling,biodegradable system which can recruit and activate antigen presenting cells(APCs).Herein,we developed an injectable DNA supramolecular hydrogel vaccine(DSHV) system which containing tumor-associated antigen MUC1 glycopeptide and immunostimulant CpG. By self-assembly conveniently,the injectable,biocompatible DSHV can mimic the function of lymph node(LN) where the APCs are recruited and activated,and then strong adaptive immune response and anti-tumor effect were elicited in *** DSHV system could serve as a general platform for cancer immunotherapy.

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国际感染病学（电子版） 2013年第4期2卷 169-175页

作者： Jiang Xiao yan-mei li Ying-xiu Huang Wen Zhang Wen-jing Su Wei Zhang Ning Han Di yang Xin li Gui-ju Gao Hong-xin Zhao Center for Infectious Diseases Beijing Ditan HospitalCapital Medical University

Objective The aim of the study was to evaluate the characteristics of HIV drug-genotypic resistance among patients taking first-line ARV regimens using polymerase chain reaction and sequencing,and guide to design optimal ARV regimens for these *** HIV reverse transcriptase-encoded gene was amplified with RT-PCR and amplified PCR products were aligned and comparatively analyzed with HIV resistance database to find drug-resistance *** Twenty-eight PCR products were amplified and sequenced successfully in 30 serum samples of recruited HIV-infected patients with virologic *** resistance rate was 96%,mutations in NRT region were found in 26 patients(93%),while mutations in NNRT region were found in 27 patients(96%).M184V was the most common mutation(86%),K65R was selected in 14%of recruited individuals and TAMs occurred in 50%of patients,which resulted in resistance to NRTIs.Y181C and V179D were the most common mutations in NNRTIs and prevalence was 43%(12/28)and 36%(10/28),respectively,which resulted in cross-resistance to NNRTIs due to low-genetic *** Virologic failure may occur in long-term administration of first-line ARV regimens,and drugresistance mutations can be found in these patients,which resulted in resistance to first-line ARV *** emphasized that HIV viral load assay and resistance assay were important tools to guide healthcare workers to design an optimal second-line ARV regimens for HAART-experienced individuals with virologic failure.

关键词： HIV HAART Mutation Resistance PCR

Experience of clinical pharmaceutical care carried out in pediatric respiratory department

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Experience of clinical pharmaceutical care carried out in pe...

Revision of genera in Asterinales

两岸三地药理学与临床药理学术会议

作者： DU Xiao-ming JIAN ling-yan ZHAO li-mei (Shengjing Hospital of China Medical University, Shenyang 110004, China)

Objective To discuss the role of clinical pharmacists in providing pharmaceutical care in pediatric respiratory *** Supply pharmaceutical information,participate in clinical rounds,provide the rationalization proposal,help doctors to formulate correctly dose regimen,enhance medication efficiency;establish medicine record for the patient,record the drugs which were used,provide pharmaceutical care for the patient such as disease propaganda,medicine-use education,medicine consultation and so *** Promote rational administration,enhance the security of medical practice,the clinical pharmacists’work ob- tains the doctors’approval;improve the medication compliance,reduce patients’economy and spiritual bur- den,and obtain the patients’*** The pharmaceutical care carried out in pediatric respiratory department can help reduce the incidence of medication errors,cut down the medication cost,shorten the time of patients to be hospitalized,raise the medication efficiency,and promote the doctor-patient relation- ship *** a word the clinical pharmacists are indispensable.

关键词： pharmaceutical care clinical pharmacists rational drug use

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Fungal Diversity 2014年第5期68卷 1-68页

作者： Sinang Hongsanan yan-mei li Jian-Kui liu Tina Hofmann meike Piepenbring Jayarama D.Bhat Saranyaphat Boonmee Mingkhuan Doilom Chonticha Singtripop Qing Tian Ausana Mapook Xiang-Yu Zeng Ali H.Bahkali Jian-Chu Xu Peter E.Mortimer Xia-Hai Wu Jun-Bo yang Kevin D.Hyde Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Institute of Excellence in Fungal Research Chiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East Asia NodeHeilongtanKunming 650201People’s Republic of China International Fungal Research and Development Centre Key Laboratory of Resource Insect Cultivation and Utilization State Forestry AdministrationKunmingPeople’s Republic of China Herbario UCH Centro de Investigaciones Micológicas(CIMi)Universidad Autónoma de Chiriquí0427 DavidChiriquíPanama Department of Mycology Institute of EcologyEvolutionand DiversityGoethe University Frankfurt am MainBiologicumMax-von-Laue-Str.1360438 Frankfurt am MainGermany Formerly at Department of Botany Goa UniversityGoa 403206India College of Science Botany and Microbiology DepartmentKing Saud UniversityRiyadh 1145Saudi Arabia Germplasm Bank of Wild Species in Southwest China Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina

The order Asterinales comprises a single family,*** this study,types or specimens of 41 genera of Asterinaceae are re-examined and re-described and illustrated by *** genera,namely Asterina(type genus),Asterinella,Asterotexis,Batistinula,Cirsosia,Echidnodella,Halbania,Lembosia,Meliolaster,Parasterinopsis,Platypeltella,Prillieuxina,Schenckiella(=Allothyrium),Trichasterina,Trichopeltospora,Uleothyrium and Vizellopsis,are maintained within ***,Lembosiella,Lembosina,Morenoina,and Thyriopsi s are transferred to Aulographaceae based on morphological and molecular *** is transferred to Micropeltidaceae,while Lembosiopsis is transferred to *** and Placosoma are morphologically close to taxa in Parmulariaceae,where they are *** is placed in Teratosphaeriaceae,while Asterodothis,Asterinema,Dothidasteromella,Leveillella,Petrakina and Stephanotheca are transferred to Dothideomycetes,genera incertae ***,Macowaniella,Maheshwaramyces,Parasterinella,and Vishnumyces are treated as doubtful genera,because of lack of morphological and molecular ***,Asterolibertia,Neostomella,Placoasterina,and Symphaster are synonyms of Asterina based on morphology,while Trichamelia,Viegasia,and Yamamotoa are synonyms of *** characteristics of each family are discussed and a phylogenetic tree is included.

关键词： Asterina Asterinaceae Aulographaceae Lembosiaceae morphology type species taxonomy

阿帕替尼联合放化疗治疗复发伴转移宫颈癌的近期疗效及预后影响因素

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中国临床研究 2020年第10期33卷 1396-1399页

作者：付玉齐亮严丽梅中国医科大学附属盛京医院妇产科辽宁沈阳110004

目的分析阿帕替尼联合放化疗治疗复发伴转移宫颈癌患者的近期疗效及预后影响因素。方法选取2011年10月至2016年10月收治的98例宫颈癌术后出现复发转移的女性患者作为研究对象,进行回顾性研究。根据所实施的治疗方案分为联合组及对照组... 详细信息

目的分析阿帕替尼联合放化疗治疗复发伴转移宫颈癌患者的近期疗效及预后影响因素。方法选取2011年10月至2016年10月收治的98例宫颈癌术后出现复发转移的女性患者作为研究对象,进行回顾性研究。根据所实施的治疗方案分为联合组及对照组各49例,对照组采用常规化疗和放疗治疗,联合组在对照组基础上采用阿帕替尼联合治疗。比较两组患者近期疗效、毒副反应,同时采用单因素分析和多因素Cox回归分析复发伴转移宫颈癌患者预后的相关因素。结果疗程结束后1个月评价,联合组患者治疗后临床总有效率(93.88%)明显高于对照组(77.55%,P0.05);所有宫颈癌术后复发伴转移患者的随访时间为2~36个月,3年总生存率为53.06%(52/98),其中对照组患者3年生存率为44.90%(22/49),联合组患者3年生存率为61.22%(30/49)。经单因素分析得出,肿瘤直径、淋巴转移数、脉管内肿瘤以及临床分期与复发伴转移宫颈癌患者预后相关(P3个及出现脉管内肿瘤均为复发伴转移宫颈癌患者预后的独立危险因素(P<0.05,P<0.01)。结论阿帕替尼联合放化疗治疗复发伴转移宫颈癌患者的近期疗效有明显提高。复发伴转移宫颈癌患者预后与淋巴转移数、脉管内肿瘤以及临床分期存在密切关系,因此治疗过程中需注意以上影响预后的因素。

关键词：阿帕替尼放疗化疗复发伴转移宫颈癌近期疗效预后