Levels and dynamic changes of serum fibroblast growth factor 23 in hypophosphatemic rickets/osteomalacia

作     者：XIA Wei-bo JIANG Yan LI Mei XING Xiao-ping WANG Ou HU Ying-ying ZHANG Hua-bing LIU Huai-cheng MENG Xun-wu ZHOU Xue-ying 

作者机构：Department of EndocrinologyKey Laboratory of EndocrinologyMinistry of HealthPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2010年第123卷第9期

页      面：1158-1162页

核心收录：

学科分类：10[医学] 

基　　金：This study was supported by National Natural Science Foundation of China (NSFC) (No. 30370781) and Doctoral Fund of Ministry of Education of China (No. 20040023055) The authors state that there are no conflicts of interest in this study 

主　　题：fibroblast growth factor 23 hypophosphatemia rickets osteomalacia 

摘      要：Background Hypophosphatemic rickets/osteomalacia is a group of diseases characterised by defective mineralization of bone due to hypophosphatemia and low 1,25-dihydroxy vitamin D. To explore the role of fibroblast growth factor 23 （FGF-23） in the regulation of phosphate homeostasis, we measured the circulating concentrations of this growth factor in healthy individuals and in patients with hypophosphatemic rickets/osteomalacia. Methods Nineteen patients with hypophosphatemic rickets/osteomalacia were included in hypophosphatemic group （HP, 12 female and 7 male, mean age was 30 years）, and 19 healthy age-matched individuals served as the control group. Full length FGF-23 fragments were measured by two-site enzyme-linked immunosorbent *** Mean FGF-23 concentrations were significantly higher in the HP group （（87.4±43.6） pg/ml） compared with the control group （（19.2±6.16） pg/ml; P 〈0.001）. In 1 patient with tumour-induced osteomalacia, serum FGF-23 concentrations were 84.1 pg/ml; these concentrations were normalized 2 hours after a hemangiopericytoma resection （7.8 pg/ml）. Subsequently, serum 1,25（OH）2 vitamin D3 concentrations significantly increased from 21.3 pg/ml to 89.3 pg/ml, and serum phosphorus levels were normalized. Conclusions Serum FGF-23 concentrations were markedly elevated in patients with hypophosphatemic rickets. FGF-23 plays an important role in the pathogenesis of hypophosphatemic rickets/osteomalacia.