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Determining the protective effects of Ma-Mu-Ran Antidiarrheal Capsules against acute DSS-induced enteritis using 16S rRNA gene sequencing and fecal metabolomics

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Chinese Journal of Natural Medicines 2022年第5期20卷 364-377页

作者： ZHENG Si-Li ZHANG Dong-Ning du AN yan-Fen HUANG Fang HAN Lin-Tao MO Guo-yan Pharmacy Faculty Hubei University of Chinese MedicineWuhan 430065China College of Basic Medical Sciences Hubei University of Chinese MedicineWuhan 430065China Xinjiang Uygur Pharmaceutical Co. Ltd.UrumqiXinjiang 830026China

Ma-Mu-Ran Antidiarrheal Capsules(MMRAC)is traditional Chinese medicine that has been used to treat diarrhea caused by acute enteritis(AE)and bacillary dysentery in Xinjiang(China)for many ***,the potential therapeutic mechanism of MMRAC for AE and its regulatory mechanism on host metabolism is *** study used fecal metabolomics profiling with GC/MS and 16S rRNA gene sequencing analysis to explore the potential regulatory mechanisms of MMRAC on a dextran sulfate sodium salt(DSS)-induced mouse model of *** metabolomics-based analyses were performed to detect the differentially expressed metabolites and metabolic *** 16S rRNA gene sequencing analysis was used to assess the altered gut microbes at the genus level and for functional ***,Pearson correlation analysis was used to integrate differentially expressed metabolites and altered bacterial *** results revealed that six intestinal bacteria and seven metabolites mediated metabolic disorders(i.e.,metabolism of amino acid,carbohydrate,cofactors and vitamins,and lipid)in AE ***,ten altered microbes mediated the differential expression of eight metabolites and regulated these metabolisms after MMRAC ***,these findings demonstrate that AE is associated with metabolic disorders and microbial ***,we present that MMRAC exerts protective effects against AE by improving host metabolism through the intestinal flora.

关键词： Acute enteritis Ma-Mu-Ran Antidiarrheal Capsules 16S rRNA sequencing Fecal metabolomics Gut microbiota

Identification and spatial pattern analysis of alpine timberline by remote sensing methods in Yarlung Zangpo Grand Canyon

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Journal of Mountain Science 2021年第9期18卷 2304-2314页

作者： ZHU Bei WANG Shi-yan SU Wei CHEN Kai-qi LIU Chang du yan-liang WANG Liang HAN Zhen ZOU Jiang-xiang State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin Beijing 100038China China Institute of Water Resources and Hydropower Research Beijing 100038China College of Hebei Agricultural University Huanghua 061100China Appraisal Center for Environment and Engineering Ministry of Environmental ProtectionBeijing 100012China

As an important ecotone,the alpine timberline is the boundary between closed-canopy montane forest and alpine vegetation,and is highly sensitive to global and regional climate *** provided a way to identify and extract the alpine timberline in Yarlung Zangpo Grand Canyon Nature Reserve by using remote sensing data and spatial analysis based on land use/land cover classification and NDVI distribution *** DEM data,the influence of slope and aspect on the distribution of alpine timberline was *** results showed that the alpine timberline in Yarlung Zangpo Grand Canyon is transitional timberline,with the upper boundary approximately distributed at the elevation of 3422-4373 m,the lower boundary at approximately 3270-4164 m,with a width of about 110-280 *** timberline was mainly distributed on steep and very steep slopes ranging from 25°to 45°.The maximum elevation of both the upper and lower boundaries occurred on steep *** distribution of alpine timberline varies with aspects,with sunny slopes having a higher boundary than shady slopes.

关键词： Alpine timberline Aspect Normalized Difference Vegetation Index Remote sensing classification Slope

Circulating anti-Müllerian hormone as predictor of ovarian response to gonadotrophins in women with polycystic ovary syndrome

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Journal of Reproduction and Contraception 2016年第2期27卷 94-102页

作者： Wen-yan XI Xiao-yan du Hong-fang HAN Xiao-ning LU The Second Affiliated Hospital of Xi'an Jiaotong University Jingning County People's Hospital

Objective To investigate the impact of high circulating anti-Müllerian hormone（AMH）on the outcome of ovulation induction using human menopausal gonadotropin（hM G）in women with polycystic ovary syndrome（PCOS）.Methods This prospective study included 63 anovulatory women with PCOS who underwent hM G ovarian stimulation. Serum AMH concentrations were compared between responders and non-responders. The receiver-operating characteristic（ROC）curve was used to evaluate the prognostic value of circulating *** hM G responders had a significantly lower serum AMH concentration compared with non-responders（8.43±2.18 μg/L vs 11.05±2.85 μg/L, P〈0.001）. In multivariate Logistic regression analysis, AMH was an independent predictor of ovulation induction by hM G in PCOS patients. ROC curve analysis showed AMH was a useful predictor of ovulation induction by hM G in PCOS patients, having 91.7% specificity and 66.7% sensitivity when the threshold AMH concentration was 10.12 μg/*** Serum AMH can be used as an effective parameter to predict ovarian response to hM G treatment in PCOS patients.

关键词： polycystic ovary syndrome(PCOS) anti-Müllerian hormone(AMH) human menopausal gonadotropin(hMG) ovulation induction(OI)

Indo-Western Pacific Ocean Capacitor and Coherent Climate Anomalies in Post-ENSO Summer: A Review

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Advances in Atmospheric Sciences 2016年第4期33卷 411-432页

作者： Shang-Ping XIE Yu KOSAKA yan du Kaiming HU Jasti S.CHOWDARY Gang HUANG Scripps Institution of Oceanography University of California San Diego Physical Oceanography Laboratory Qingdao Collaborative Innovation Center of Marine Science and TechnologyOcean University of China Research Center for Advanced Science and Technology University of Tokyo State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of Sciences State key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics and Center for Monsoon System Research Institute of Atmospheric Physics Chinese Academy of Sciences Indian Institute of Tropical Meteorology

ENSO induces coherent climate anomalies over the Indo-western Pacific, but these anomalies outlast SST anomalies of the equatorial Pacific by a season, with major effects on the Asian summer monsoon. This review provides historical accounts of major milestones and synthesizes recent advances in the endeavor to understand summer variability over the Indo-Northwest Pacific region. Specifically, a large-scale anomalous anticyclone （AAC） is a recurrent pattern in post-E1 Nifio summers, spanning the tropical Northwest Pacific and North Indian oceans. Regarding the ocean memory that anchors the summer AAC, competing hypotheses emphasize either SST cooling in the easterly trade wind regime of the Northwest Pacific or SST warming in the westerly monsoon regime of the North Indian Ocean. Our synthesis reveals a coupled ocean- atmosphere mode that builds on both mechanisms in a two-stage evolution. In spring, when the northeast trades prevail, the AAC and Northwest Pacific cooling are coupled via wind-evaporation-SST feedback. The Northwest Pacific cooling persists to trigger a summer feedback that arises from the interaction of the AAC and North Indian Ocean warming, enabled by the westerly monsoon wind regime. This Indo-western Pacific ocean capacitor （IPOC） effect explains why E1 Nifio stages its last act over the monsoonal Indo-Northwest Pacific and casts the Indian Ocean warming and AAC in leading roles. The IPOC displays interdecadal modulations by the ENSO variance cycle, significantly correlated with ENSO at the turn of the 20th century and after the 1970s, but not in between. Outstanding issues, including future climate projections, are also discussed.

关键词： Indian Ocean western Pacific ocean-atmosphere interaction ENSO Asian monsoon

Synthesis,Crystal Structure and Biological Activities of Novel Di-n-butyl Tin Di-carboxylate

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Chemical Research in Chinese Universities 2009年第6期25卷 851-855页

作者： WANG yan-hua du Da-feng ZHU Chao-guang duXi-guang ZHU Dong-sheng Faculty of Chemistry Northeast Normal University Changchun 130024 P. R. China

A novel macrocyclic complex 2{[（n-Bu2Sn）4O2-L2]2DMF} was synthesized by the reaction of 4-（1,2- dithioethylene）methylene-3,5-disoxo-1,6-heptadiene-1,7-dis-（o-formy~）-dis-p-phenoxyacetic acid（LH2, compound 1） with di-n-butyltin oxide. Compound 1 and complex 2 were characterized by elemental analysis, FTIR spectroscopy, and ~H NMR spectroscopy. The crystal structure of complex 2 was determined by single crystal X-ray diffraction analysis. There are two crystallographic independent molecules in complex 2, and each molecule structure is centro-symmetric and features a central rhombus cyclic Bu4Sn2O2 unit with two exocyclic Sn atoms linked at the O atoms of the four-membered ring. In molecule A, the four Sn atoms are five-coordinated. However, in molecule B, the four Sn atoms have two different coordination geometries, the endocyclic Sn atoms are five-coordinated and the exocyclic Sn atoms are four-coordinated. The dicarboxylate ligands in molecules A and B bridge exocylic or endocyclic tin atoms, forming two macroheterocycles with 26 atoms. Pilot studies have indicated that complex 2 has good anti- bacterial and antitumour activities.

关键词： Organotin(IV) carboxylate Di-n-butyl tin di-carboxylate Di-n-butyl tin oxide Crystal structure Antibacterial activity Anti-tumour activity

Amplification of plasmid DNA bound on soil colloidal particles and clay minerals by the polymerase chain reaction

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Journal of Environmental Sciences 2007年第11期19卷 1326-1329页

作者： CAI Peng HUANG Qiao-yun LU yan-du CHEN Wen-li JIANG Dai-hua LIANG Wei State Key Laboratory of Agricultural Microbiology Huazhong Agricultural University Wuhan 430070 China Key Laboratory of Subtropical Agricultural Resources a~ld Environment Huazhong Agricultural University Wuhan 430070 China

Polymerase chain reaction （PCR） was used to amplify a 600-base pair （bp） sequence of plasmid pGEX-2T DNA bound on soil colloidal particles from Brown soil （Alfisol） and Red soil （Ultisol）, and three different minerals （goethite, kaolinite, montmorillonite）. DNA bound on soil colloids, kaolinite, and montmorillonite was not amplified when the complexes were used directly but amplification occurred when the soil colloid or kaolinite-DNA complex was diluted, 10- and 20-fold. The montmorillonite-DNA complex required at least 100-fold dilution before amplification could be detected. DNA bound on goethite was amplified irrespective of whether the complex was used directly, or diluted 10- and 20-fold. The amplification of mineral-bound plasmid DNA by PCR is, therefore, markedly influenced by the type and concentration of minerals used. This information is of fundamental importance to soil molecular microbial ecology with particular reference to monitoring the fate of genetically engineered microorganisms and their recombinant DNA in soil environments.

关键词： adsorption amplification mineral PCR plasmid DNA soil colloid

Kinetics of Phosphate Release from Three Phosphate-Treated Soils

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Pedosphere 2005年第4期15卷 518-525页

作者： LI Shou-Tian ZHOU Jian-Min WANG Huo-yan du Chang-Wen CHEN Xiao-Qin Institute of Soil Science Chinese Academy of Sciences P. O. Box 821 Nanjing 210008 （China）.

Phosphate release from three selected soils after treatments of 1.6 and 2.4 mmol L-1 P was investigated using sequential extractions and fitted using six kinetic models, including zero order (Z), first order (F), second order (S), parabolic diffusion (PD), two constant rate (TC), and Elovich type (ET) equations. The results showed that the rate of P release was initially rapid and then gradually declined with time. Also, P release increased with added P. Total P release followed the order: paddy soil with 2.4 mmol L-1 P > red soil with 2.4 mmol L-1 P > paddy soil with 1.6 mmol L-1 P > fluvo-aquic soil with 2.4 mmol L-1 P > fluvo-aquic with 1.6 mmol L-1 P > red soil with 1.6 mmol L-1 P. For the two P treatments P release from the paddy soils in the first extraction was 44.3% and 45.6% of total released P, respectively, which were higher than those from red and fluvo-aquic soils. The ratio of P release at the end of release time was 14.0% and 13.1% in the paddy soil treated with 1.6 and 2.4 mmol L-1 P, respectively, but only 5.1% and 9.2% in the red soil and 7.0% and 5.2% in the fluvo-aquic soil, respectively. Comparison of the coefficients of determination (R2) indicated that ET, TC, and PD equations could describe the P release data better than Z, F, and S equations.

关键词： fluvo-aquic soil paddy soil phosphate red soil release kinetics

Decadal Indian Ocean Dipolar Variability and Its Relationship with the Tropical Pacific

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Advances in Atmospheric Sciences 2017年第11期34卷 1282-1289页

作者： Yun yanG Jianping LI Lixin WU Yu KOSAKA yan du Cheng SUN Fei XIE Juan FENG State Key Laboratory of Earth Surface Processes and Resource Ecology and College of Global Change and Earth System Science Beijing Normal UniversityBeijing 100875China Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and Technologyqingdao 266237China Physical Oceanography Laboratory/Qingdao Collaborative Innovation Center of Marine Science and Technology Ocean University of Chinaqingdao 266003China Research Center for Advanced Science and Technology University of TokyoTokyo153-8904Japan State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of Sciencesguangzhou 510301China

A robust decadal Indian Ocean dipolar variability （DIOD） is identified in observations and found to be related to tropical Pacific decadal variability （TPDV）. A Pacific Ocean-global atmosphere （POGA） experiment, with fixed radiative forcing, is conducted to evaluate the DIOD variability and its relationship with the TPDV. In this experiment, the sea surface temperature anomalies are restored to observations over the tropical Pacific, but left as interactive with the atmosphere elsewhere. The TPDV-forced DIOD, represented as the ensemble mean of 10 simulations in POGA, accounts for one third of the total variance. The forced DIOD is triggered by anomalous Walker circulation in response to the TPDV and develops following Bjerknes feedback. Thermocline anomalies do not exhibit a propagating signal, indicating an absence of oceanic planetary wave adjustment in the subtropical Indian Ocean. The DIOD-TPDV correlation differs among the 10 simulations, with a low correlation corresponding to a strong internal DIOD independent of the TPDV. The variance of this internal DIOD depends on the background state in the Indian Ocean, modulated by the thermocline depth off Sumatra/Java.

关键词： Indian Ocean dipole decadal variability tropical Pacific decadal variability

Prediction and prophylaxis of hepatocellular carcinoma occurrence and postoperative recurrence in chronic hepatitis B virus-infected subjects

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World Journal of Gastroenterology 2016年第29期22卷 6565-6572页

作者： yan du Xue Han Yi-Bo Ding Jian-Hua Yin Guang-Wen Cao Office of Clinical Epidemiology Obstetrics and Gynecology Hospital of Fudan University Division of Chronic Disease Control Center for Diseases Control and Prevention of Yangpu District Department of Epidemiology Second Military Medical University

Hepatocellular carcinoma(HCC) is one of the most common and highly fatal malignancies worldwide. Chronic infection with hepatitis B virus(HBV) is a major cause of HCC. High HBV replication rate and related non-resolving inflammation are the major risk factors of HCC occurrence and postoperative recurrence. Early prophylactic options are effective in reducing HCC occurrence and improving survival. Therefore, it is important to identify HBV-infected patients who are at a higher risk of developing HCC and HBV-HCC patients who are more likely to relapse after surgery, thus providing them with more precise prophylactic strategies. Several prediction models of HCC occurrence have been constructed, with satisfactory predictive accuracy and discriminatory ability. However, there is a lack of consensus for their clinical implementation. Several staging systems have been proposed for HCC prognosis. However, the accuracy of these staging systems based on demographic characteristics and clinical measurements needs to be further improved, possibly by systematically incorporating viral and inflammatory factors. Since antiviral treatments are effective in promoting liver function reserve, reducing HCC occurrence and prolonging postoperative survival in some HBV-infected subjects, it is very important to identify subgroups of HBV-infected patients who would most benefit from antiviral treatment.

关键词： Hepatocellular carcinoma Chronic hepatitis B Incidence Prognosis Prediction