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Unravelling biosynthesis and biodegradation potentials of microbial dark matters in hypersaline lakes

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Environmental Science and Ecotechnology 2024年第4期20卷 177-188页

作者： Zhiguang Qiu Yuanyuan Zhu Qing Zhang xuejiao Qiao rong Mu Zheng xu yan yan Fan Wang Tong Zhang Wei-Qin Zhuang Ke Yu School of Environment and Energy Peking University Shenzhen Graduate SchoolShenzhen518055China AI for Science(AI4S)-preferred program Peking UniversityShenzhen518055China Southern university of Sciences and Technology yantian Hospital Shenzhen518081China Institute of Biomedicine and Biotechnology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China State Key Laboratory of Isotope Geochemistry CAS Center for Excellence in Deep Earth ScienceGuangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou510640China School of Atmospheric Sciences Sun Yat-sen UniversitySouthern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai519082China department of Civil Engineering University of Hong Kong999077Hong KongChina department of Civil and Environmental Engineering Faculty of EngineeringUniversity of AucklandNew Zealand

Biosynthesis and biodegradation of microorganisms critically underpin the development of biotechnology,new drugs and therapies,and environmental ***,most uncultured microbial species along with their metabolic capacities in extreme environments,remain *** we unravel the metabolic potential of microbial dark matters(MDMs)in four deep-inland hypersaline lakes in Xinjiang,*** metagenomic binning,we uncovered a rich diversity of 3030 metagenomeassembled genomes(MAGs)across 82 phyla,revealing a substantial portion,2363 MAGs,as previously unclassified at the genus *** unknown MAGs displayed unique distribution patterns across different lakes,indicating a strong correlation with varied physicochemical *** analysis revealed an extensive array of 9635 biosynthesis gene clusters(BGCs),with a remarkable 9403 being novel,suggesting untapped biotechnological ***,some MAGs from potentially new phyla exhibited a high density of these *** biosynthesis,our study also identified novel biodegradation pathways,including dehalogenation,anaerobic ammonium oxidation(Anammox),and degradation of polycyclic aromatic hydrocarbons(pAHs)and plastics,in previously unknown microbial *** findings significantly enrich our understanding of biosynthesis and biodegradation processes and open new avenues for biotechnological innovation,emphasizing the untapped potential of microbial diversity in hypersaline environments.

关键词： Biosynthesis Biodegradation Hypersaline lakes Metagenome-assembled genomes Microbial dark matters

protective Effects of Danmu Extract Syrup on Acute Lung Injury Induced by Lipopolysaccharide in Mice through Endothelial Barrier repair

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Chinese Journal of Integrative Medicine 2024年第3期30卷 243-250页

作者： xu Han xu Si-cong LI Li-yan WU Yu-huang TAN Yin-feng CHEN Long LIU pei LIANG Chang-fu HE Xiao-ning LI Yong-hui Hainan provincial Key Lab of research&Development on Tropic Herbs Hainan Medical UniversityHaikou571199China department of Stomatology the Second Affiliated Hospital of Hainan Medical UniversityHaikou571199China

Objective:To investigate the effects of Danmu Extract Syrup(DMS) on lipopolysaccharide(LpS)-induced acute lung injury(ALI) in mice and explore the ***:Seventy-two male Balb/C mice were randomly divided into 6 groups according to a random number table(n=12),including control(normal saline),LpS(5 mg/kg),LpS+DMS 2.5 mL/kg,LpS+DMS 5 mL/kg,LpS+DMS 10 mL/kg,and LpS+Dexamethasone(DXM,5 mg/kg) *** pretreatment with DMS and DXM,the ALI mice model was induced by LpS,and the bronchoalveolar lavage fluid(BALF) were collected to determine protein concentration,cell counts and inflammatory *** lung tissues of mice were stained with hematoxylin-eosin,and the wet/dry weight ratio(W/D) of lung tissue was *** levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-1βin BALF of mice were detected by enzyme linked immunosorbent *** expression levels of Claudin-5,vascular endothelial(VE)-cadherin,vascular endothelial growth factor(VEGF),phospho-protein kinase B(p-Akt) and Akt were detected by Western blot ***:DMS pre-treatment significantly ameliorated lung histopathological *** with the LpS group,the W/D ratio and protein contents in BALF were obviously reduced after DMS pretreatment(pr pr of cells in BALF and myeloperoxidase(MpO) activity decreased significantly after DMS pretreatment(pr ppre-treatment decreased the levels of TNF-α,IL-6 and IL-1β(pphosphoinositide 3-kinase/protein kinase B(pI3K/Akt) pathway and reversed the expressions of Claudin-5,VE-cadherin and VEGF(ppS-induced ALI in mice through repairing endothelial *** might be a potential therapeutic drug for LpS-induced lung injury.

关键词： Danmu Extract Syrup acute lung injury inflammatory factors vascular endothelial growth factor phosphoinositide 3-kinase/protein kinase B Chinese medicine Nauclea officinalis

Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles

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Bone research 2024年第1期12卷 137-152页

作者： Weicheng Lu Jianfei yan Chenyu Wang Wenpin Qin Xiaoxiao Han Zixuan Qin Yu Wei Haoqing xu Jialu Gao Changhe Gao Tao Ye Franklin r.Tay Lina Niu Kai Jiao department of Stomatology Tangdu Hospital&State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina State Key Laboratory of Oral and Maxillofacial reconstruction and regeneration&National Clinical research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina The Dental College of Georgia Augusta UniversityAugustaGAUSA

Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary ***-related proteins encapsulated in brain-derived extracellular vesicles can cross the blood‒brain barrier to reach distal *** proteins initiate inflammatory dysfunction,such as neurogenic heterotopic *** recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention ***,a rat model of neurogenic heterotopic ossification induced by combined traumatic brain injury and achillotenotomy was developed to address these two *** examination of the injured tendon revealed the coexistence of ectopic calcification and fibroblast *** relationships among brain-derived extracellular vesicles,fibroblast pyroptosis and ectopic calcification were further investigated in vitro and in *** injection of the pyroptosis inhibitor Ac-YVAD-cmk reversed the development of neurogenic heterotopic ossification in *** present work highlights the role of brain-derived extracellular vesicles in the pathogenesis of neurogenic heterotopic ossification and offers a potential strategy for preventing neurogenic heterotopic ossification after traumatic brain injury.

关键词： neurogenic ossification pathogenesis

Information flow and controlling in regularization inversion of quantitative remote sensing

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Science china Earth Sciences 2005年第1期48卷 74-83页

作者： yanG Hua, xu Wangli, ZHAO Hongrui, CHEN xue & WANG Jindi research Center for remote Sensing and GIS, School of Geography, Beijing normal university, State Key Laboratory of remote Sensing Science, Beijing Key Laboratory for remote Sensing of Environment and Digital Cities, Beijing 100875, china department of mathematics, Beijing normal university, Beijing 100875, china research Center for remote Sensing and GIS School of Geography Beijing Normal University State Key Laboratory of Remote Sensing Science Beijing Key Laboratory for Remote Sensing of Environment and Digital Cities Beijing China department of mathematics Beijing Normal University Beijing China

In order to minimize uncertainty of the inversed parameters to the largest extent by making full use of the limited information in remote sensing data, it is necessary to understand what the information flow in quantitative remote sensing model inversion is, thus control the information flow. Aiming at this, the paper takes the linear kernel-driven model inversion as an example. At first, the information flow in different inversion methods is calculated and analyzed, then the effect of information flow controlled by multi-stage inversion strategy is studied, finally, an information matrix based on USM is defined to control information flow in inversion. It shows that using Shannon entropy decrease of the inversed parameters can express information flow more properly. Changing the weight of a priori knowledge in inversion or fixing parameters and partitioning datasets in multi-stage inversion strategy can control information flow. In regularization inversion of remote sensing, information matrix based on USM may be a better tool for quantitatively controlling information flow.

关键词： regularization inversion, information flow, Shannon entropy decrease, information matrix.

M-N Fuzzy Number Space and properties

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模糊系统与数学 1996年第3期 20-21页

作者： xu Xiao Guang Lu Feng(Basic Branch,Changchun Tax(department of mathematics,Northeast College,Changchun,Jilin,130021,normal university,Changchun,Jinn,p.r.china)130024,p.r.china)

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关键词： M-N fuzzy number minimising fuzzy number truncated cone

Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration

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Bone research 2024年第2期12卷 361-371页

作者： Dandan Wang Yaru Guo Boon Chin Heng xuehui Zhang yan Wei Ying He Mingming xu Bin Xia xuliang Deng department of pediatric Dentistry Peking University School and Hospital of StomatologyBeijing 100081P.R.China department of Geriatric Dentistry Peking University School and Hospital of StomatologyNational Center for StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081P.R.China department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyNational Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081P.R.China

Bone tissue renewal can be enhanced through co-transplantation of bone mesenchymal stem cells(BMSCs)and vascular endothelial cells(ECs).However,there are apparent limitations in stem cell-based therapy which hinder its clinic ***,we investigated the potential of alternative stem cell substitutes for facilitating bone *** this study,we successfully prepared cell membrane vesicles(CMVs)from BMSCs and *** results showed that BMSC-derived cell membrane vesicles(BMSC-CMVs)possessed membrane receptors involved in juxtacrine signaling and growth factors derived from their parental ***-derived cell membrane vesicles(EC-CMVs)also contained BMp2 and VEGF derived from their parental ***-CMVs enhanced tube formation and migration ability of hUVECs,while EC-CMVs promoted the osteogenic differentiation of hBMSCs in *** a rat skull defect model,we found that co-transplantation of BMSC-CMVs and EC-CMVs could stimulate angiogenesis and bone formation in ***,our research might provide an innovative and feasible approach for cell-free therapy in bone tissue regeneration.

关键词： hinder apparent vesicles

Combined application of CIrCLE Software and Topo-LASIK for SMILE enhancement

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 206-209页

作者： Bing-Qing Sun Hai-peng xu Xing-Tao Zhou Mei-yan Li Eye Institute and department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan university) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200031China Shanghai research Center of Ophthalmology and Optometry Shanghai 200031China Shanghai Engineering research Center of Laser and Autostereoscopic 3D for Vision Care Shanghai 200031China

Dear Editor,We present a case of combined application of CIrCLE software(Carl Zeiss Meditec AG,Germany)and topography-guided laser-assisted in situ keratomileusis(Topo-LASIK)for small-incision lenticule extraction(SMILE)*** is a safe,minimally invasive corneal laser surgery using a femtosecond laser to create an extractable stromal lenticule.

关键词： laser application Zeiss

Metabolic syndrome’s new therapy:Supplement the gut microbiome

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World Journal of Diabetes 2024年第4期15卷 793-796页

作者： Yong-Wei xu Jun Tian yan Song Ba-Cui Zhang Jing Wang department of Gastroenterology Songjiang HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 201600China

This letter to the editor discusses the publication on gut microbiome supple-mentation as therapy for metabolic *** microbiome dysbiosis disrupts intestinal bacterial homeostasis and is related to chronic inflammation,insulin resistance,cardiovascular diseases,type 2 diabetes mellitus,and *** research has found that increasing the abundance of beneficial microbiota in the gut modulates metabolic syndrome by reducing chronic inflammation and insulin ***,probiotics,synbiotics,and postbiotics are often used as supplements to increase the number of beneficial microbes and thus the produc-tion of short-chain fatty acids,which have positive effects on the gut microbiome and metabolic *** this review article,the author summarizes the available supplements to increase the abundance of beneficial gut microbiota and reduce the abundance of harmful microbiota in patients with metabolic *** group is also researching the role of the gut microbiota in chronic liver *** article will be of great help to our *** the end of the letter,the mechanism of the gut microbiota in chronic liver disease is discussed.

关键词： Gut microbiome Metabolic syndrome Diabetes mellitus Short-chain fatty acids Chronic liver disease

STING mediates microglial pyroptosis via interaction with NLrp3 in cerebral ischaemic stroke

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Stroke & Vascular Neurology 2024年第2期9卷 153-164页

作者： Wenyu Li Nan Shen Lingqi Kong Hongmei Huang Xinyue Wang yan Zhang Guoping Wang pengfei xu Wei Hu department of Neurology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina

background Ischaemia-evoked neuroinflammation is a critical pathogenic event following ischaemic *** D(GSDMD)-associated pyroptosis represents a type of inflammation-associated programmed cell death,which can exacerbate neuroinflammatory responses and brain *** of interferon genes(STING)was recently described as a vital innate immune adaptor protein associated with ***,the regulatory effects of STING on microglial pyroptosis post-stroke have not been well *** STING-knockout and wild-type(WT)mice were subjected to middle cerebral artery occlusion(MCAO).STING small interfering rNA(sirNA)was transfected into BV2 cells before oxygen-glucose deprivation/reoxygenation(OGD/r).STING-overexpressing adeno-associated virus(AAV)and NOD-like receptor family pyrin domain containing 3(NLrp3)sirNA were administered by stereotaxic injection.2,3,5-Triphenyl tetrazolium chloride(TTC)staining,TdT-mediated dUTp nick end labeling(TUNEL)staining,Fluoro-Jade C(FJC)staining,neurobehavioural tests,immunohistochemistry,cytokine antibody array assay,transmission electron microscopy,immunoblot,Enzyme-linked immunosorbent assay(ELISA)and quantitative real-time polymerase chain reaction(qrT-pCr)were carried ***-immunoprecipitation assays were used to investigate the interplay between STING and *** STING expression was increased after MCAO and mainly detected on *** deletion alleviated brain infarction,neuronal damage and neurobehavioural impairment in mice subjected to *** knockout suppressed microglial activation and the secretion of inflammatory chemokines,accompanied by mitigation of microglial *** upregulation of microglial STING by AAV-F4/80-STING aggravated brain injury and microglial ***,co-immunoprecipitation showed that STING bound to NLrp3 in *** of NLrp3 sirNA reversed AAV-F4/80-STING-induced deterioration of microglial pyropt

关键词： NLrp3 cerebral inflammation