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Repairing whole facial nerve defects with xenogeneic acellular nerve grafts in rhesus monkeys

Neural Regeneration Research 2022年第5期17卷 1131-1137页

作者： Guo-Chen Zhu Da-Jiang xiao Bi-Wen Zhu Yan XIAO Department of Otorhinolaryngology-Head and Neck Surgery Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical UniversityWuxiJiangsu ProvinceChina Department of Otorhinolaryngology-Head and Neck Surgery Affiliated Wuxi Clinical College of Nantong UniversityWuxiJiangsu ProvinceChina College of Animal Science&Technology Zhongkai University of Agriculture and EngineeringGuangzhouGuangdong ProvinceChina Department of Pathology Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical UniversityWuxiJiangsu ProvinceChina

Acellular nerve allografts conducted via chemical extraction have achieved satisfactory results in bridging whole facial nerve defects clinically,both in terms of branching a single trunk and in connecting multiple branches of an extratemporal segment.However,in the clinical treatment of facial nerve defects,allogeneic donors are limited.In this experiment,we exposed the left trunk and multiple branches of the extratemporal segment in six rhesus monkeys and dissected a gap of 25 mm to construct a monkey model of a whole left nerve defect.Six monkeys were randomly assigned to an autograft group or a xenogeneic acellular nerve graft group.In the autograft group,the 25-mm whole facial nerve defect was immediately bridged using an autogenous ipsilateral great auricular nerve,and in the xenogeneic acellular nerve graft group,this was done using a xenogeneic acellular nerve graft with trunk-branches.Examinations of facial symmetry,nerve-muscle electrophysiology,retrograde transport of labeled neuronal tracers,and morphology of the regenerated nerve and target muscle at 8 months postoperatively showed that the faces of the monkey appeared to be symmetrical in the static state and slightly asymmetrical during facial movement,and that they could actively close their eyelids completely.The degree of recovery from facial paralysis reached House-Brackmann grade II in both groups.Compound muscle action potentials were recorded and orbicularis oris muscles responded to electro-stimuli on the surgical side in each monkey.Fluoro Gold-labeled neurons could be detected in the facial nuclei on the injured side.Immunohistochemical staining showed abundant neurofilament-200-positive axons and soluble protein-100-positive Schwann cells in the regenerated nerves.A large number of mid-graft myelinated axons were observed via methylene blue staining and a transmission electron microscope.Taken together,our data indicate that xenogeneic acellular nerve grafts from minipigs are safe and effective for repairing whole facial nerve defects in

关键词： acellular nerve compound muscle action potentials facial nerve defect facial symmetry monkey nerve graft nerve regeneration retrograde labeling test synaptophysin xenogeneic

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Serosurvey for SARS-CoV-2 among blood donors in Wuhan,China from September to December 2019

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Protein & Cell 2023年第1期14卷 28-36页

作者： Le Chang Lei Zhao Yan XIAO Tingting Xu Lan Chen yan Cai xiaojing Dong Conghui Wang Xia xiao Lili Ren Lunan Wang National Center for Clinical Laboratories Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Beijing Engineering Research Center of Laboratory Medicine Beijing HospitalBeijing 100730China Department of Laboratory Wuhan Blood CenterWuhan 430030China Confirmation Laboratory for Transfusion Transmitted Disease Institute of Blood Transfusion of Hubei ProvinceWuhan 430030China National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Quality Control Wuhan Blood CenterWuhan 430030China Graduate School Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

The emerging of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)caused COVID-19 pandemic.The first case of COVID-19 was reported at early December in 2019 in Wuhan City,China.To examine specific antibodies against SARS-CoV-2 in biological samples before December 2019 would give clues when the epidemic of SARS-CoV-2 might start to circulate in populations.We obtained all 88,517 plasmas from 76,844 blood donors in Wuhan between 1 September and 31 December 2019.We first evaluated the pan-immunoglobin(pan-Ig)against SARS-CoV-2 in 43,850 samples from 32,484 blood donors with suitable sample quality and enough volume.Two hundred and sixty-four samples from 213 donors were pan-Ig reactive,then further tested IgG and IgM,and validated by neutralizing antibodies against SARS-CoV-2.Two hundred and thirteen samples(from 175 donors)were only pan-Ig reactive,8(from 4 donors)were pan-Ig and IgG reactive,and 43(from 34 donors)were pan-Ig and IgM reactive.Microneutralization assay showed all negative results.In addition,213 screened reactive donors were analyzed and did not show obviously temporal or regional tendency,but the distribution of age showed a difference compared with all tested donors.Then we reviewed SARS-CoV-2 antibody results from these donors who donated several times from September 2019 to June 2020,partly tested in a previous published study,no one was found a significant increase in S/CO of antibodies against SARS-CoV-2.Our findings showed no SARS-CoV-2-specific antibodies existing among blood donors in Wuhan,China before 2020,indicating no evidence of transmission of COVID-19 before December 2019 in Wuhan,China.

关键词： severe acute respiratory syndrome coronavirus 2 coronavirus disease 2019 seroprevalence neutralizing antibodies blood donors

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Advances in the genetic etiology of premature ovarian insufficiency

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Science China(Life Sciences) 2023年第7期66卷 1705-1707页

作者： Qi Guo xiao-yan Liang Center of Reproductive Medicine The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Guangdong Engineering Technology Research Center of Fertility Preservation Guangzhou510080China

Premature ovarian insufficiency(POI),defined as the loss of ovarian function in women before the age of 40 years,is a challenging reproductive issue that affects hundreds of millions of people globally with compromised fertility and a higher risk of cardiovascular disease.POI is highly heterogeneous in etiology,including genetic,infectious,metabolic,environmental,iatrogenic,and immunological factors.

关键词： insufficiency etiology cardiovascular

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A lightweight global awareness deep network model for flame and smoke detection

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Optoelectronics Letters 2023年第10期19卷 614-622页

作者： xiao Bowei yan Chunman School of Physics and Electronic Engineering Northwest Normal UniversityLanzhou730070China

Aiming at the trouble of low detection accuracy and the problem of large model size,this paper proposes a lightweight flame-and-smoke detection model depending on global awareness of images.The proposed method replaces the Conv+BatchNorm+SiLU(CBS)module of original you only look once version 5(YOLOv5)in the backbone with DSConv+BatchNorm+SiLU(DBS),and the C3 module with GC3,and thus constructs a lightweight backbone network.Besides,involution(InvC3)module is proposed to enhance the global modeling ability and compress the model size,and a module using adaptive receptive fields,named FConv,is proposed to enhance the model’s perception capacity for foreground complex flame-and-smoke information in feature maps.Experimental results show that the proposed model increases the mean average precision of all categories at 0.5 IOU(mAP@0.5)to 70.8%,the mAP@0.5:0.95 to 39.7%,reduces the number of parameters to 3.57M and the amount of calculation to 7.4 giga floating-point operations per second(GFLOPs)under the premise of ensuring the detection speed.It has been verified that the model can achieve high-precision real-time detection of flame and smoke.

关键词： smoke backbone replace

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Demyelinating neuropathy in patients with hepatitis B virus: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1766-1771页

作者： xiao-xiao yan Jin Huang Jing Lin Department of Neurology The Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325000Zhejiang ProvinceChina

BACKGROUND Hepatitis B rarely leads to demyelinating neuropathy,despite peripheral neuropathy being the first symptom of hepatitis B infection.CASE SUMMARY A 64-year-old man presented with sensorimotor symptoms in multiple peripheral nerves.Serological testing showed that these symptoms were due to hepatitis B.After undergoing treatment involving intravenous immunoglobulin and an antiviral agent,there was a notable improvement in his symptoms.CONCLUSION Although hepatitis B virus(HBV)infection is known to affect hepatocytes,it is crucial to recognize the range of additional manifestations linked to this infection.The connection between long-term HBV infection and demyelinating neuropathy has seldom been documented;hence,prompt diagnostic and treatment are essential.The patient's positive reaction to immunoglobulin seems to be associated with production of the antigen-antibody immune complex.

关键词： Hepatitis B virus infection Extrahepatic manifestations Demyelinating neuropathy Intravenous immunoglobulin Electroneuromyography Case report

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Evaluation of Smoking Cessation Intervention Effectiveness in Smoking Cessation Clinics-China,2019–2021

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China CDC weekly 2023年第21期5卷 469-474页

作者： Li Xie Yongfu yan yan yang Yi Nan Lin xiao Tobacco Control Office Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Since 2014,the Chinese government has advocated for the development of smoking cessation clinics(SCCs)within each provincial-level administrative division(PLAD).What is added by this report?In the 2019–2021 period,the self-reported 7-day point prevalence of abstinence rates(PPAR)at 1-month and 3-month follow-up were 26.2%and 23.5%,respectively.What are the implications for public health practice?The interventions implemented by SCCs in this investigation proved to be successful.It is imperative to employ extensive tobacco control strategies in order to enhance the motivation of smokers to seek assistance for cessation from SCCs.

关键词： smoke motivation has

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Empirical Likelihood for Partially Linear Errors-in-variables Models with Longitudinal Data

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Acta Mathematicae Applicatae Sinica 2022年第3期38卷 664-683页

作者： Li yan xiao-yan TAN Xia CHEN School of Mathematics and Statistics Shaanxi Normal UniversityXi’an 710119China

Empirical likelihood inference for partially linear errors-in-variables models with longitudinal data is investigated.Under regularity conditions,it is shown that the empirical log-likelihood ratio at the true parameters converges to the standard Chi-squared distribution.Furthermore,we consider some estimates of the unknown parameter and the resulting estimators are shown to be asymptotically normal.Some simulations and a real data analysis are given to illustrate the performance of the proposed method.

关键词： empirical likelihood measurement error confidence regions coverage probability longitudinal data

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A simple image-based method for online moisture content estimation of iron ore green pellets

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Journal of Iron and Steel Research(International) 2023年第5期30卷 851-863页

作者： Shu-yi Zhou xiao-yan Liu College of Electrical and Information Engineering Hunan UniversityChangsha 410082HunanChina Innovation Institute of Industrial Design and Machine Intelligence Quanzhou-Hunan University Quanzhou 362006FujianChina

Moisture content(MC)is an important quality metric of iron ore green pellets in pelletizing process in ironmaking industry.Current image-based methods for MC estimation may result in big errors for gray-scale pellet images captured under various lighting conditions.We proposed a simple image-based method to improve the MC estimation accuracy by illumination correction and linear regression modeling.Firstly,the illumination of the pellet image was transformed into the reference illumination by use of a color checker chart and piecewise linear interpolation,so that the influence of different illuminations could be greatly reduced.By experimental analysis,it was found that MC is approximately adversely proportional to the average intensity of the transformed images.A simple model for MC prediction was then established by linear fitting.Experiments demonstrated that the proposed method has good robustness to different lighting conditions and achieves the best performance in metrics of mean square error,mean absolute error and maximum absolute error in comparison with five state-of-art MC estimating methods.Application on a working disk pelletizer shows that the proposed method can predict well the change of moisture content with time,and its computing efficiency can satisfy the requirement for online MC monitoring during the pelletizing process.

关键词： Green pellet Moisture content Image processing Pelletizing process

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阎小萍“合和”论痹诊疗风湿病经验

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中华中医药杂志 2021年第8期36卷 4745-4748页

作者：靖卫霞阎小萍(指导) 北京中医药大学第三附属医院北京100029 中日友好医院北京100029

文章用“合和”二字总结概括了阎小萍教授诊疗风湿病的经验。从疾病的病因——杂合而致,到阎教授常采用的合药、合方以及“五连环”“综合强化序贯”疗法,均做了较为详尽的阐述。治法上以“和”为主,“因而和之,是谓圣度”,治疗目的也... 详细信息

文章用“合和”二字总结概括了阎小萍教授诊疗风湿病的经验。从疾病的病因——杂合而致,到阎教授常采用的合药、合方以及“五连环”“综合强化序贯”疗法,均做了较为详尽的阐述。治法上以“和”为主,“因而和之,是谓圣度”,治疗目的也是求“和”,“谨察阴阳所在而调之,以平为期”。期望通过文章可窥阎教授治疗痹病之一二,以飨读者。

关键词：合和痹病经验阎小萍风湿病

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Gut microbiome:New perspectives for type 2 diabetes prevention and treatment

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World Journal of Clinical Cases 2023年第31期11卷 7508-7520页

作者： Shu-xiao Li yan Guo School of Clinical Medicine Changchun University of Traditional Chinese MedicineChangchun 130000Jilin ProvinceChina

Type 2 diabetes mellitus(T2DM),which is distinguished by increased glucose levels in the bloodstream,is a metabolic disease with a rapidly increasing incidence worldwide.Nevertheless,the etiology and characteristics of the mechanism of T2DM remain unclear.Recently,abundant evidence has indicated that the intestinal microbiota is crucially involved in the initiation and progression of T2DM.The gut microbiome,the largest microecosystem,engages in material and energy metabolism in the human body.In this review,we concentrated on the correlation between the gut flora and T2DM.Meanwhile,we summarized the pathogenesis involving the intestinal flora in T2DM,as well as therapeutic approaches aimed at modulating the gut microbiota for the management of T2DM.Through the analysis presented here,we draw attention to further exploration of these research directions.

关键词： Microbial metabolites Intestinal flora Probiotics Insulin resistance Type 2 diabetes

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