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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su.Taiqi Huang Meiyu Zhang yanyu Zhang yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposu.e to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,su.h as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han yan su.Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu.Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and su.gery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-su.gery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor su.unit NR2B)were measu.ed in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented su.gery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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TRMT6 and TRMT61A facilitated acute pancreatitis severity via regulation of neutrophil function

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Science China Life Sciences 2025年

作者： Yuan Dong Li su.Sin Man Lam Cen yan Yalan Deng Guotao Lu Jinkui yang Guanghou Shui Yingmei Feng Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Department of Science and Development Beijing Youan HospitalCapital Medical University Laboratory for Clinical Medicine Capital Medical University Neuroscience Research Institute Peking University Center of Medical and Health AnalysisPeking University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences Pancreatic Center Department of GastroenterologyAffiliated Hospital of Yangzhou UniversityYangzhou University Beijing Key Laboratory of Diabetes Research and Care Department of EndocrinologyBeijing Tongren HospitalCapital Medical University

Dear Editor,Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for increased severity in acute pancreatitis (AP)(Mikóet al,2018).However,to date,no studies have simultaneously included healthy individuals,T2DM patients,and AP patients to investigate which diabetes-associated metabolites are linked to AP severity.

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen su.Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** resu.ts showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** su.gests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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计算机视觉技术赋能大学英语课堂展示中的学习投入研究

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 144-151页

作者：谭苏燕王晋军广州大学外国语学院广东广州510010

学习投入是预测学习者学习效果的重要指标,学术界对其与课堂展示间的相关性研究鲜有涉猎。文本以某综合性大学303名非英语专业本科生为研究对象,采用人工智能与计算机视觉技术模型YOLOv7对大学英语课堂中的课堂展示实录进行学习投入多... 详细信息

学习投入是预测学习者学习效果的重要指标,学术界对其与课堂展示间的相关性研究鲜有涉猎。文本以某综合性大学303名非英语专业本科生为研究对象,采用人工智能与计算机视觉技术模型YOLOv7对大学英语课堂中的课堂展示实录进行学习投入多模态数据分析,并辅以问卷调查,形成双向印证。研究发现,学生课堂展示中的行为投入、认知投入和情感投入值均等于或高于3.78,投入结果均值达4.01,说明学生在课堂展示中的学习投入情况良好。此外,不同时段课堂展示对学生行为投入的影响显著,学生专注度及参与度在课堂前10分钟的课堂展示中效果最佳。文本为课堂展示的有效性提供了智能化、多模态、多维度的实证支持,为课堂教学的数智技术应用提供了新视角。

关键词：大学英语课堂展示学习投入计算机视觉技术展示时段

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Corrugated rGO-su.ported Pd composite on carbon paper for efficient cathode of Mg-H_(2)O_(2)semi-fuel cell

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Rare Metals 2022年第8期41卷 2655-2663页

作者： Feng-Chun Wen su.-Ri.-Gu.-Ga.Li yan Chen Xi-Hua Du Hua Tan Ya-Jiao Song Ming Song Li-Mei su. School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou221018China College of Materials and Chemistry Inner Mongolia University for the NationalitiesTongliao028000China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore699010Singapore

A corrugated reduced graphene oxide(rGO)-su.ported Pd composite on carbon paper(Pd/rGO/CP)is prepared via a simple chemical reduction process combined with *** micros tructure,morphology,and su.face chemical state of the composite and its performance in H_(2)O_(2)reduction in an acidic medium are *** rGO film with ample corrugated wrinkles coated closely on CP is prepared,and Pd nanoparticles are evenly decorated on the su.face of rGO/*** Pd/rGO/CP electrode has a low Pd loading and high catalytic performance for H_(2)O_(2)reduction in acidic media compared to Pd/*** excellent mass normalized activity(11,783 A·g_(Pd)^(-1))of the Pd/rGO/CP electrode for H_(2)O_(2)reduction is achieved at 0 V due to the corresponding low Pd ***-H_(2)O_(2)semi-fuel cells using Pd/rGO/CP electrode as the cathode exhibits a peak power density of215 mW·cm^(-2)at 60℃and perfect stability during a 50-h *** rGO interlayer forms a microscopic threedimensional(3 D)structure on the su.face of CP,thereby improving the utilization of precious metals and the specific su.face area,as well as providing more Pd sites due to the transfer of electrons to ***,the performance of the electrode is improved.

关键词： Palladium Reduced graphene oxidation Carbon paper H_(2)O_(2)reduction Mg-H_(2)O_(2)semi-fuel cell

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Enhanced su.acute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan su.Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resu.ting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for su.acute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the su.acute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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A multi-objective multi-memetic algorithm for network-wide conflict-free 4D flight trajectories planning

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Chinese Journal of Aeronautics 2017年第3期30卷 1161-1173页

作者： su.yan Kaiquan CAI School of Electronics and Information Engineering Beihang University Beijing 100191 China Beijing Key Laboratory of Network Enabled Collaborative ATM Beijing 100191 China

Under the demand of strategic air traffic flow management and the concept of trajectory based operations（TBO）,the network-wide 4D flight trajectories planning（N4DFTP） problem has been investigated with the purpose of safely and efficiently allocating 4D trajectories（4DTs）（3D position and time） for all the flights in the whole airway *** that the introduction of large-scale 4DTs inevitably increases the problem complexity,an efficient model for strategiclevel conflict management is developed in this ***,a bi-objective N4 DFTP problem that aims to minimize both potential conflicts and the trajectory cost is *** consideration of the large-scale,high-complexity,and multi-objective characteristics of the N4DFTP problem,a multi-objective multi-memetic algorithm（MOMMA） that incorporates an evolutionary global search framework together with three problem-specific local search operators is *** is capable of rapidly and effectively allocating 4DTs via rerouting,target time controlling,and flight level ***,to balance the ability of exploitation and exploration of the algorithm,a special hybridization scheme is adopted for the integration of local and global *** studies using real air traffic data in China with different network complexities show that the proposed MOMMA is effective to solve the N4 DFTP *** solutions achieved are competitive for elaborate decision su.port under a TBO environment.

关键词： Air traffic flow management 4D trajectory planning Multi-memetic algorithm Multi-objective optimization Network-wide strategic conflict management

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基于固定化金属亲和整体柱的痕量微囊藻毒素富集分析

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分析测试学报 2025年第1期44卷 155-162,171页

作者：陈小燕杨玲苏立燊吴晓苹福州大学化学学院食品安全与生物分析教育部重点实验室福建福州350116 泉州市晋江环境监测站福建泉州362200 福建省妇幼保健院福建福州350001

基于固定化金属亲和色谱(IMAC)识别原理,采用后修饰法在热引发自由基聚合反应得到的有机基质整体柱上直接固定Cu^(2+),设计并合成表征了poly(VIM-co-DVB)-Cu^(2+)亲和毛细管整体柱,用于微囊藻毒素(MCs)的富集研究。详细优化了亲和整体... 详细信息

基于固定化金属亲和色谱(IMAC)识别原理,采用后修饰法在热引发自由基聚合反应得到的有机基质整体柱上直接固定Cu^(2+),设计并合成表征了poly(VIM-co-DVB)-Cu^(2+)亲和毛细管整体柱,用于微囊藻毒素(MCs)的富集研究。详细优化了亲和整体柱的萃取条件,在最优条件下,将poly(VIM-co-DVB)-Cu^(2+)整体柱用于毛细管微萃取(CME),并与高效液相色谱-质谱(HPLC-MS)检测技术联用,建立了环境水样品中3种MCs的高效富集分析方法。方法检出限为0.89~1.23 ng/L,加标回收率为80.0%~105%,相对标准偏差(RSD)不大于6.8%。该方法灵敏度高、准确性好,可为污染水体中微囊藻毒素的监测分析提供有效手段。

关键词：微囊藻毒素固定化金属亲和整体柱毛细管微萃取高效液相色谱-质谱

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Aging-induced two-stage reverse martensitic transformation behavior in Co_(46)Ni_(27)Ga_(27) high-temperature shape memory alloy

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Rare Metals 2011年第5期30卷 527-532页

作者： su.Dashuai LI yan XIN yan YUAN Bifei School of Materials Science and Engineering Beihang University Beijing 100191 China Beijing Key Laboratory for Advanced Functional Materials and Thin Film Technology Beihang University Beijing 100191 China Key Laboratory of Aerospace Materials and Performance （Ministry of Education of China） Beihang University Beijing 100191 China School of Energy Power and Mechanical Engineering North China Electric Power University Beijing 102206 China

The effect of austenite aging at 823 K on the microstructures and martensitic transformation behavior of Co 46 Ni 27 Ga 27 alloy has been investigated using optical microscopy （OM）, transmission electron microscopy （TEM）, X-ray diffraction analysis （XRD）, and differential scanning calorimeter （DSC）. The microstructure observation resu.ts show that the unaged Co 46 Ni 27 Ga 27 alloy is composed of the tetragonal nonmodulated martensite phase and face-centered cubic γ phase. It is found that a new nanosized fcc phase precipitates in the process of austenite aging, leading to the formation of metastable age-affected martensite around the precipitates with composition inhomogeneity. Two-stage reverse martensitic transformation occurs in the samples aged for 2 and 24 h due to the composition difference between the age-affected martensite and the original martensite. For the Co 46 Ni 27 Ga 27 alloy aged for 120 h, no reverse transformation can be detected due to the disappearance of the metastable age-affected martensite and the small latent heat of the original martensite. The martensitic transformation temperatures of the Co 46 Ni 27 Ga 27 alloy decrease with an increase in aging time.

关键词： shape memory alloys aging phase transformations microstructure

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