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Development of annulus fibrosus tissue construct with hydrogel coils containing pre-conditioned mesenchymal stem cell

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Journal of Materials Science & Technology 2021年第4期63卷 27-34页

作者： Yon Jin Chuah Yingnan Wu Mei Ling Shirlynn Cheong yan qing chia Ching Ann Tee Hwan Tak Hee Chenjie Xu Yuejun Kang Dong-An Wang School of Chemical and Biomedical Engineering Nanyang Technological University62 Nanyang Drive637459Singapore Lee Kong chian School of Medicine Nanyang Technological University59 Nanyang Drive636921Singapore Pinnacle Spine&Scoliosis Centre 3 Mount ElizabethMount Elizabeth Medical Centre228510Singapore Faculty of Materials and Energy Institute for Clean Energy and Advanced MaterialsSouthwest UniversityChongqing 400715China Department of Biomedical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina National Dental Centre of Singapore 5 Second Hospital Ave168938Singapore

Low back pain associated with degenerative disc diseases has been a major health concern that brings suffering to the patients physically and *** existing therapeutic strategies provide shortterm relief of symptoms rather than treatment of the underlying *** of an engineered tissue for disc regeneration is still in its infancy due to the limited autologous healthy disc cell source from the *** is also challenging to mimic the complexity of micro-architecture in the native disc tissue that determine their unique structural *** date,simple tissue models that mimic the annulus fibrosus(AF)micro-environment for understanding the potential of mesenchymal stem cells(MSCs)in AF tissue engineering are still *** this study,the assembly of a coiled hydrogel microfiber has shown its capability to encapsulate MSCs and create an engineered tissue model that mimics the multiple lamellae of native *** this model,we investigated the potential of MSCs that were previously induced by ascorbic acid(AA).Compared to non-induced MSCs,AA-induced MSCs exhibited significant increase in AF-associated biomarkers during later development in the engineered AF tissue model and also encouraged collagen accumulation through the down-regulated catabolic gene MMP1 and upregulated anti-catabolic gene ***,AA-induced MSCs exhibited a Col2/Col1 ratio closer to that of a native AF *** results suggested that AA-induced MSCs could be a potential cell source for AF tissue engineering and this established tissue model may provide a simple tool for successful AF tissue engineering strategies in the future.

关键词： closer stem strategies

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Recent geomagnetic storms observed by Macao Science Satellite-1

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Earth and Planetary Physics 2024年第4期8卷 565-569页

作者： qing yan HongBo Yao Macao Institute of Space Technology and Application Macao University of Science and TechnologyMacao 999078China

Geomagnetic storms are rapid disturbances of the Earth’s *** are related to many geophysical phenomena and have large influences on human *** and studying geomagnetic storms is thus of great significance to both scientific research and geomagnetic hazards *** Macao Science Satellite-1(MSS-1)project includes two high-precision Chinese geomagnetic satellites successfully launched on May 21,*** main purpose of MSS-1 is to accurately measure the Earth’s magnetic ***,we analyze early MSS-1 geomagnetic field measurements and report observations of two recent geomagnetic storms that occurred on March 24,2024 and May 11,*** also calculate the related geoelectric fields as an initial step towards a quantitative assessment of geomagnetic hazards.

关键词： Macao Science Satellite-1 geomagnetic storms satellite magnetics electromagnetic induction geoelectric fields

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Numerical simulation on directional solidification and heat treatment processes of turbine blades

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China Foundry 2024年第5期21卷 476-490页

作者： Ye-yuan Hu Ju-huai Ma qing-yan Xu School of Materials Science and Engineering Tsinghua UniversityKey Laboratory for Advanced Materials Processing TechnologyMinistry of EducationBeijing 100084China

Study on turbine blades is crucial due to their critical role in ensuring the efficient and reliable operation of aircraft ***-based single crystal superalloys are extensively used in the hot manufacturing of turbine blades due to their exceptional high-temperature mechanical *** hot manufacturing of single crystal blades involves directional solidification and heat *** manufacturing of these blades is time-consuming,capital-intensive,and often insufficient to meet industrial *** simulation techniques have gained widespread acceptance in blade manufacturing research due to their low energy consumption,high efficiency,and rapid turnaround *** article introduces the modeling and simulation of hot manufacturing in single crystal *** discussion outlines the prevalent mathematical models employed in numerical simulations related to blade hot *** encapsulates the advancements in research concerning macro to micro-level numerical simulation techniques for directional solidification and heat treatment ***,potential future trajectories for the numerical simulation of single crystal blade hot manufacturing are also discussed.

关键词： single crystal blades Ni-based superalloy directional solidification heat treatment numerical simulation

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Cut-off value of glycated hemoglobin A1c for detecting diabetic retinopathy in the Chinese population

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World Journal of Diabetes 2024年第7期15卷 1531-1536页

作者： yan Wen qing Wang Department of Endocrinology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND Glycated hemoglobin A1c(HbA1c)is considered the most suitable for diabetes mellitus diagnosis due to its accuracy and ***,the effect of HbA1c on diabetic retinopathy(DR)in the Han and Korean populations in Jilin,China,remains *** To determine the best cut-off of HbA1c for diagnosing DR among the *** This cross-sectional study included 1933 participants from the yanbian area of Jilin Province,*** investigators employed a questionnaire-based survey,physical examination,laboratory tests,and fundus photography for the *** best cut-off value for HbA1c was established via the receiver operating characteristic *** factors associated with HbA1c-associated risk factors were determined via linear *** The analysis included 887 eligible Chinese Han and Korean participants,591 of whom were assigned randomly to the training set and 296 to the validation *** prevalence of DR was 3.27% in the total ***1c of 6.2% was the best cut-off value in the training set,while it was 5.9% in the validation *** both Chinese Han and Korean populations,an HbA1c level of 6.2% was the best cut-off *** optimal cut-off values of fasting blood glucose(FBG)≥7 mmol/L and<7 mmol/L were 8.1% and 6.2% respectively in Han populations,while those in Korean populations were 6.9%and 5.3%,***,body mass index,and FBG were determined as the risk factors impacting HbA1c *** HbA1c may serve as a useful diagnostic indicator for *** HbA1c level of 6.2% may be an appropriate cut-off value for DR detection in the Chinese population.

关键词： Diabetic retinopathy Glycated hemoglobin A1c Cut-off value Age Body mass index Fasting blood glucose

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Model Parameters Identification and Backstepping Control of Lower Limb Exoskeleton Based on Enhanced Whale Algorithm

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 100-114页

作者： yan Shi Jiange Kou Zhenlei Chen Yixuan Wang qing Guo School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Aeronautics and Astronautics University of Electronic Science and Technology of ChinaChengdu 611731China

Exoskeletons generally require accurate dynamic models to design the model-based controller conveniently under the human-robot interaction ***,due to unknown model parameters such as the mass,moment of inertia and mechanical size,the dynamic model of exoskeletons is difficult to ***,an enhanced whale optimization algorithm(EWOA)is proposed to identify the exoskeleton model ***,the periodic excitation trajectories are designed by finite Fourier series to input the desired position demand of exoskeletons with mechanical physical *** a backstepping controller based on the identified model is adopted to improve the human-robot wearable comfortable performance under cooperative ***,the proposed Model parameters identification and control are verified by a two-DOF exoskeletons *** knee joint motion achieves a steady-state response after 0.5 ***,the position error of hip joint response is less than 0.03 rad after 0.9 *** addition,the steady-state human-robot interaction torque of the two joints is constrained within 15 N·*** research proposes a whale optimization algorithm to optimize the excitation trajectory and identify model ***,an enhanced mutation strategy is adopted to avoid whale evolution’s unsatisfactory local optimal value.

关键词： Parameter identification Enhanced whale optimization algorithm(EWOA) Backstepping Human-robot interaction Lower limb exoskeleton

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Influence of friction-lubrication characteristics varying with rolling speed on instability of chatter and slip in cold tandem rolling process

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Journal of Iron and Steel Research International 2024年第4期31卷 894-908页

作者： yan-li Xin Zhi-ying Gao Bo Tian qing-dong Zhang School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

In the high-speed cold tandem rolling process of thin plate,chatter or slip instability gives rise to the deterioration of equipment and product *** instability behavior is closely related to interfacial friction-lubrication con-dition which is generally characterized by the friction ***,with higher and higher speed requirements,the commonly used model of friction coefficient is no longer applicable and accurate.A novel approach is suggested to calculate the speed-dependent friction coefficient,in which the viscosity-pressure-temperature effects of the lubricant,surface roughness states of work rolls and rolled piece are comprehensively involved and the mixed flm lubrication theory is ***,the influences of friction coefficient on the instability of slip and chatter are investigated for a five-stand cold tandem rolling *** one side,the critical friction coefficient for each stand is determined by calculating the corresponding slip factor;on the other hand,the friction coefficient varying with rolling speed is combined with the model of theoretical critical rolling speed presented under constant friction coefficient,so that the speed threshold is ***,the stable and unstable regions corresponding to the rear three stands are individually discussed,and the technical strategies are proposed to suppress both slip and chatter frequently occurring in the actual rolling process.

关键词： Cold tandem rolling:Oil film thickness Speed-dependent friction coefficient-Slip:Chatter

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Impact of climate and human activity on NDVI of various vegetation types in the Three-River Source Region, China

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Journal of Arid Land 2024年第8期16卷 1080-1097页

作者： LU qing KANG Haili ZHANG Fuqing XIA Yuanping yan Bing Research Center of Resource and Environment Economics East China University of TechnologyNanchang 330013China Jiangxi Key Laboratory of Watershed Ecological Process and Information East China University of TechnologyNanchang 330013China School of Surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China Nanchang Key Laboratory of Landscape Process and Territorial Spatial Ecological Restoration East China University of TechnologyNanchang 330013China Institute of Energy Research Jiangxi Academy of SciencesNanchang 330096China

The Three-River Source Region(TRSR)in China holds a vital position and exhibits an irreplaceable strategic importance in ecological preservation at the national *** the basis of an in-depth study of the vegetation evolution in the TRSR from 2000 to 2022,we conducted a detailed analysis of the feedback mechanism of vegetation growth to climate change and human activity for different vegetation *** the growing season,the spatiotemporal variations of normalized difference vegetation index(NDVI)for different vegetation types in the TRSR were analyzed using the Moderate Resolution Imaging Spectroradiometer(MODIS)-NDVI data and meteorological data from 2000 to *** addition,the response characteristics of vegetation to temperature,precipitation,and human activity were assessed using trend analysis,partial correlation analysis,and residual *** indicated that,after in-depth research,from 2000 to 2022,the TRSR's average NDVI during the growing season was *** preliminary ranking of the average NDVI for different vegetation types was as follows:shrubland(0.5762)>forest(0.5443)>meadow(0.4219)>highland vegetation(0.2223)>steppe(0.2159).The NDVI during the growing season exhibited a fluctuating growth trend,with an average growth rate of 0.0018/10a(P<0.01).Notably,forests displayed a significant development trend throughout the growing season,possessing the fastest rate of change in NDVI(0.0028/10a).Moreover,the upward trends in NDVI for forests and steppes exhibited extensive spatial distributions,with significant increases accounting for 95.23%and 93.80%,*** sensitivity to precipitation was significantly enhanced in other vegetation types other than highland *** contrast,steppes,meadows,and highland vegetation demonstrated relatively high vulnerability to temperature fluctuations.A further detailed analysis revealed that climate change had a significant positive impact on the TRSR from 2000 to 2022,particularly in its

关键词： growing season normalized difference vegetation index(NDVI) highland vegetation trend analysis partial correlation analysis residual analysis contribution rate

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Effects of iron oxide on crystallization behavior and spatial distribution of spinel in stainless steel slag

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 292-300页

作者： Zihang yan qing Zhao Chengzhi Han Xiaohui Mei Chengjun Liu Maofa Jiang Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

Chromium plays a vital role in stainless steel due to its ability to improve the corrosion resistance of the ***,the re-lease of chromium from stainless steel slag(SSS)during SSS stockpiling causes detrimental environmental *** prevent chromium pollution,the effects of iron oxide on crystallization behavior and spatial distribution of spinel were investigated in this *** results revealed that FeO was more conducive to the growth of spinels compared with Fe2O3 and *** were found to be mainly distrib-uted at the top and bottom of *** amount of spinel phase at the bottom decreased with the increasing FeO content,while that at the top *** average particle size of spinel in the slag with 18wt%FeO content was 12.8μ***,no notable structural changes were observed with a further increase in FeO *** other words,the spatial distribution of spinel changed when the content of iron oxide varied in the range of 8wt%to 18wt%.Finally,less spinel was found at the bottom of slag with a FeO content of 23wt%.

关键词： stainless steel slag spinel chromium waste remediation ferrous oxide

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Introducing hydroxyl groups to tailor the d-band center of Ir atom through side anchoring for boosted ORR and HER

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Journal of Energy Chemistry 2024年第3期90卷 144-151,I0005页

作者： qing Lv Meiping Li Xiaodong Li Xingru yan Zhufeng Hou Changshui Huang Science Center for Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringInstitute of Frontier and Interdisciplinary ScienceShandong UniversityJinan 250100ShandongChina Institute of Chemistry Chinese Academy of ScienceBeijing 100191China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina

Tuning the coordination atoms of central metal is an effective means to improve the electrocatalytic activity of atomic ***,iridium(Ir) is proposed to be asymmetrically anchored by sp-N and pyridinic N of hydrogen-substituted graphdiyne(HsGDY),and coordinated with OH as an Ir atomic catalyst(Ir_(1)-N-HsGDY).The electron structures,especially the d-band center of Ir atom,are optimized by these specific coordination ***,the as-synthesized Ir_(1)-N-HsGDY exhibits excellent electrocatalytic performances for oxygen reduction and hydrogen evolution reactions in both acidic and alkaline *** from the unique structure of HsGDY,IrN_(2)(OH)_(3) has been developed and demonstrated to act as the active site in these electrochemical *** those indicate the fresh role of the sp-N in graphdiyne in producing a new anchor way and contributing to promote the electrocatalytic activity,showing a new strategy to design novel electrochemical catalysts.

关键词： Oxygen reduction reaction D-band center Graphdiyne Hydroxyl group Electrocatalysis

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PVP/PAN-derived porous carbon fiber for zinc-ion hybrid supercapacitors

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Rare Metals 2024年第7期43卷 3066-3073页

作者： Shu-Hua yang Wen-qing Fu yan-Wei Cui Bing-Qiang Cao Materials Center for Energy and Photoelectrochemical Conversion School of Material Science and EngineeringUniversity of JinanJinan 250022China

Porous carbon fibers are promising cathodes for zinc-ion hybrid supercapacitors(ZHSs)owing to their abundant active sites,great conductivity,and stable physical and chemical ***,designing a proper preparation technique to regulate the microstructure of carbon fibers still remains a great ***,a poly vinylpyrrolidone/po-lyacry lonitrile(PVP/PAN)-derived porous carbon fiber is developed via the PVP/PAN blend electrospinning and hydrothermal selective PVP removal *** hydrothermal selective PVP removal strategy can effectively avoid a cross-linking between PVP and PAN during the traditional stabilization at air *** PVP/PAN-derived porous carbon fiber,the sufficient micropores provide abundant space for the Zn^(2+)storage,whereas the proper mesopores contribute to the fast ion *** hierarchical porous structures endow ZHSs with high specific capacity and high-rate *** ZHS assembled with the optimal PVP/PAN-derived porous carbon fiber(PVP-PANC-0.8)displays an outstanding specific capacity of 208 mAh·g^(-1),high rate capability(49.5%)from 0.5 to 5 A·g^(-1),and 72.25%capacity retention after 10,000 cycles at 0.5 A·g^(-1).

关键词： Zinc-ion hybrid supercapacitors Porous carbon fibers Hierarchical porous structures Electrospinning

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