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Dynamic single-cell mapping unveils Epstein-Barr virusimprinted T-cell exhaustion and on-treatment response

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4985-4997页

作者： Miao-Zhen qiu Chaye Wang Zhiying Wu Qi Zhao Zhibin Zhao Chun-Yu Huang Wenwei Wu li-Qiong yang Zhi-Wei Zhou Yu Zheng Hong-ming Pan Zexian liu Zhao-Lei Zeng Hui-yan Luo feng Wang feng-Hua Wang Si-Yu yang Meng-xing Huang Zhexiaon lian Haiyan zhang rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center510060 GuangzhouChina Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical Sciences510060 GuangzhouChina Department of Experimental Research Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University510060 GuangzhouChina Medical Research Institute Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Endoscopy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University510060 GuangzhouChina Department of Gastric Surgery Sun Yat-sen University Cancer Center510060 GuangzhouChina Department of Internal Medical Oncology Zhejiang University School of MedicineSir Run Run Shaw HospitalHangzhouChina Cancer Centre Faculty of Health SciencesUniversity of MacaoMacao SARChina MOE Frontier Science Centre for Precision Oncology University of MacaoMacao SARChina

Epstein-Barr virus(EBV)-associated gastric cancer(GC)manifests an intriguing immunotherapy ***,the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains *** study aimed to finely characterize the dynamic tumour immune contexture of human EBV(+)GC treated with immunochemotherapy by longitudinal scRNA-seg and paired scTCR/***(+)GC exhibits an inflamed-immune phenotype with increased T-cell and B-cell infiltration.

关键词： chemotherapy treatment EBV

Variable phenotypes and outcomes associated with the MMACHC c.482G>A mutation:follow-up in a large CblC disease cohort

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World Journal of Pediatrics 2024年第8期20卷 848-858页

作者： Sheng-nan Wu Hui-Shu E Yue Yu Shi-Ying ling li-li liang Wen-Juan qiu Hui-Wen zhang rui-Xue Shuai Hai-yan Wei Chi-Ju yang Peng Xu Xi-Gui Chen Hui Zou Ji-Zhen feng Ting-Ting Niu Hai-li Hu Kai-Chuang zhang De-Yun Lu Zhu-Wen Gong Xia Zhan Wen-Jun Ji Xue-Fan Gu Yong-xing Chen lian-Shu Han Department of Endocrinology and Metabolism Henan Key Laboratory of Children’s Genetics and Metabolic DiseasesChildren’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s HospitalZhengzhou Children’s HospitalNo.255 Gangdu StreetZhengzhouChina Department of Pediatric Endocrinology and Genetics Fujian Children’s HospitalFuzhouChina The Center for Pediatric liver Diseases Children’s HospitalFudan UniversityShanghaiChina Department of Pediatric Endocrinology/Genetics Shanghai Institute for Pediatric ResearchXinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityNo.1665 Kongjiang RoadShanghaiChina Department of Pediatrics Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Center of Neonatal Disease Screening Jining Maternal and Child Health Care HospitalJiningChina Center of Neonatal Disease Screening Jinan Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Shijiazhuang Maternal and Child Health Care HospitalShijiazhuangChina Center of Neonatal Disease Screening Shandong Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Hefei Maternal and Child Health Care HospitalHefeiChina

Background The aim of this study was to characterize the variable phenotypes and outcomes associated with the methylmalonic aciduria and homocystinuria type C protein gene(MMACHC)c.482G>A mutation in 195 Chinese cases with CblC *** We carried out a national,retrospective multicenter study of 195 Chinese patients with CblC disease attributable to the MMACHC c.482G>A variant either in a homozygous or compound heterozygous *** control group consisted of 200 patients diagnosed with CblC disease who did not possess the c.482G>A *** features,including disease onset,symptoms,biochemical metabolites,gene mutation,and follow-up outcomes were reviewed and analyzed in *** median follow-up period spanned 3 years and 8 months,with a range of 1 year and 2 months to 12 years and 10 *** Among 195 patients carrying the c.482G>A variant,125(64.1%)cases were diagnosed by newborn screening(NBS),60(30.8%)cases were detected due to disease onset,and 10(5.1%)cases were identified from sibling *** hundred and seventeen(93.6%)individuals who were diagnosed by NBS,and nine patients who came from sibling diagnoses remained asymptomatic in this *** 69 symptomatic patients of the c.482G>A group,more patients presented with later onset,and the top six common clinical symptoms at disease onset were developmental delay(59.4%),lower limb weakness and poor exercise tolerance(50.7%),cognitive decline(37.7%),gait instability and abnormal posture(36.2%),seizures(26.1%),and psychiatric and behavioral disturbances(24.6%).In the 159 symptomatic patients lacking c.482G>A variants,the most frequently observed clinical manifestations at disease onset included developmental delay(81.8%),lethargy and feeding difficulty(62.9%),lower limb weakness and poor exercise tolerance(54.7%),prolonged neonatal jaundice(51.6%),vomiting(47.2%),and seizures(32.7%).Before treatment,the levels of blood propionylcarnitine,propionylcarnitine/acetylcarnitine ratio

关键词： c.482G>A CblC disease MMACHC gene Newborn screening Outcome

Centralized isolation of Helicobacter pylori from multiple centers and transport condition influences

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World Journal of Gastroenterology 2015年第3期21卷 944-952页

作者： Ya-nan Gong You-ming li Ning-Min yang Hong-zhang li feng Guo Lang lin Qun-Ying Wang Jia-Kun zhang Zi-Zhong Ji Ji-Bo Mao Jun-liang Mao Zheng-Chao Shi Wu-Heng Tang Xin-Jian Zhu Wei Shao Xiao-feng zhang xing-Hua Wang Yue-feng Tong Mi-Zu Jiang Guang-Lan Chen Zhi-Yong Wang Hui-Min Tu Guo-Fa Jiang Jian-Sheng Wu Xu-Peng Chen qiu-Long Ding Hong Ouyang feng-Zhe Jin yan-li Xu Jian-Zhong zhang State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital College of MedicineZhejiang University Zhiyuan Medical Inspection Institute Co. Ltd. Sanmen People’s Hospital The First People’s Hospital of Xiaoshan District The First People’s Hospital of Cangnan Jinhua Municipal Central Hospital The First People’s Hospital of Pingyang The First Hospital of Jiaxing Zhoushan Hospital The First People’s Hospital of Wenling rui’an People’s Hospital Maternal and Child Health Hospital of Zhoushan City Shangyu People’s Hospital People’s Hospital of Putuo District Zhoushan Hangzhou First People’s Hospital Qingtian People’s Hospital The First People’s Hospital of Yongkang The Children’s Hospital Zhejiang University School of Medicine lishui People’s Hospital The Affiliated Hospital of Hangzhou Normal University Wuxi No.4 Hospital Affiliated to Suzhou University Jinhua Wenrong Hospital The First Affiliated Hospital of Wenzhou Medical College Yueqing People’s Hospital Tiantai People’s Hospital lin’an people’s Hospital rui’an City TCM Hospital Medical College of Hebei University of Engineering

AIM:To evaluate the efficacy of centralized culture and possible influencing ***:From January 2010 to July 2012,66452 patients with suspected Helicobacter pylori(***) infection from 26 hospitals in Zhejiang and Jiangsu Provinces in China underwent gastrointestinal *** mucosal biopsies were taken from the antrum for *** biopsies were transported under natural environmental temperature to the central laboratory in Hangzhou city and divided into three groups based on their transport time:5,24 and 48 *** culture results were reported after 72 h and the positive culture rates were analyzed by a χ2 *** additional 5736 biopsies from ***-positive patients(5646 rapid urease test-positive and 90 14C-urease breath test-positive) were also cultured for quality control in the central laboratory ***:The positive culture rate was 31.66%(21036/66452) for the patient samples and 71.72%(4114/5736) for the ***-positive quality control *** the 5 h transport group,the positiveculture rate was 30.99%(3865/12471),and 32.84%(14960/45553) in the 24 h transport *** contrast,the positive culture rate declined significantly in the 48 h transport group(26.25%; P lined from 36.67%(1462/3987) to 24.12%(1799/7459).When the temperature exceeded 24℃,the positive culture rate decreased significantly,especially in the 48 h transport group(23.17%).CONCLUSION:Transportation of specimens within 24 h and below 24℃ is reasonable and acceptable for centralized culture of multicenter *** samples.

关键词： Centralized isolation Helicobacter pylori Influenc

Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates

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Virologica Sinica 2021年第5期36卷 879-889页

作者： yan-feng Yao Ze-Jun Wang Ren-Di Jiang Xue Hu Hua-Jun zhang Yi-Wu Zhou Ge Gao Ying Chen Yun Peng Mei-Qin liu Ya-nan zhang Juan Min Jia Lu Xiao-Xiao Gao Jing Guo Cheng Peng Xu-rui Shen Qian li Kai Zhao lian yang Xin Wan Bo zhang Wen-Hui Wang Jia Wu Peng Zhou xing-Lou yang Shuo Shen Chao Shan Zhi-ming Yuan Zheng-li Shi Center for Biosafety Mega-Science Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Wuhan Institute of Biological Products Co.Ltd Jiangxia DistrictWuhan 430024China University of Chinese Academy of Sciences Beijing 100049China Department of Forensic Medicine Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430074China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so ***,there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the disease causative *** is the most effective approach to eradicate a *** tests of safety and efficacy in animals are pivotal for developing a vaccine and before the vaccine is applied to human *** we evaluated the safety,immunogenicity,and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human *** data showed that the inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in mice and non-human primates,and subsequently provided partial(in low dose)or full(in high dose)protection of challenge in the tested *** addition,passive serum transferred from vaccine-immunized mice could also provide full protection from SARS-CoV-2 infection in *** results warranted positive outcomes in future clinical trials in humans.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Inactivated vaccine Transgenic mouse Non-human primate

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)

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Research in Astronomy and Astrophysics 2012年第9期12卷 1197-1242页

作者： Xiang-Qun Cui Yong-Heng Zhao Yao-Quan Chu Guo-Ping li Qi li li-Ping zhang Hong-Jun Su Zheng-qiu Yao Ya-nan Wang Xiao-Zheng xing Xin-nan li Yong-Tian Zhu Gang Wang Bo-Zhong Gu A-li Luo Xin-Qi Xu Zhen-Chao zhang Gen-Rong liu Hao-Tong zhang De-Hua yang Shu-Yun Cao Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei feng Xue-Fei Gong Yong-Hui Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua li yan li Ye-Ping li Guan-Qunliu Zhi-Gang liu Huo-ming Shi Zheng-Hong Tang Qing-Sheng Tao Xiang-yan Yuan Chao Zhai Jing zhang yan-Xia zhang Yong zhang ming Zhao Fang Zhou Guo-Hua Zhou Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China yzhao @ *** nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Tecfinologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects.

关键词： techniques: wide field telescope - active optics - multi fiber - spectroscopy survey - data reduction

Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao Dong li Shao-lin Xiong yan-qiu zhang yang Su Wei Chen Yi Zhao Xiao-Bo li Jia-Cong liu Wen-Xi Peng rui Qiao Xin-Qiao li Xiang-yang Wen li-ming Song Shi-Jie Zheng Xin-Ying Song Xiao-Yun Zhao Yue Huang Shuang-nan zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen yan-Qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-Wei Guo Jian-Jian He Bin li Chao li Chao-yang li Gang li Jian-Hui li Lu li Qing-Xin li yan-Guo li Jing liang Xiao-Hua liang Jin-Yuan liao Xiao-Jing liu Ya-Qing liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-li Shi Jing-yan Shi Gong-xing Sun Xi-Lei Sun You-li Tuo Chen-Wei Wang Hui Wang Jin Wang Jin-Zhou Wang Ping Wang Wen-Shuai Wang Hong Wu Sheng-Lun Xie yan-Bing Xu Yu-Peng Xu Wang-Chen Xue Sheng yang Min Yao Jian-Ying Ye Qi-Bin Yi Chao-Yue zhang Da-li zhang Fan zhang Fei zhang Hong-Mei zhang Kai zhang Peng zhang Xiao-Lu zhang Zhen zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA yan ZHU Dong Shan CHEN Ren Bo SHI nan nan liU Si Hong FAN Yi Pin WU Gui Hui yanG Pu Ye BAI Jiang feng CHEN Hong CHEN li Ying feng Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG qiu Hua HUANG Shao Zhen JI liang JIN Hai Hao LEI Xiao li Chun yan li Min Qing li Qun Tang li Xian Yong liU Hong De liU Jin Ping liU zhang MA Yu Ting MAO Ya MO liu Fen NA Hui WANG Jing Wei SONG Fang li SUN Sheng WANG Dong Ting WANG ming Xuan WANG Xiao yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO yan Hua XIE Hai Jun XU Hong ming XU Shou Fang XUE rui Xia yanG Chun yanG Kai Jun YUAN Sheng li zhang Gong Qi zhang Jin Bo zhang lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing zhang Hua Min WANG yan Ping WANG Yong yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-lin Xiong Xiang-yang Wen Xin-Qiao li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan liao yan-qiu zhang Yue Huang Lu li xing Wen Fei zhang Jing Duan Chen-Wei Wang Dong-li Shi Peng zhang Qi-Bin Yi Chao-yang li yan-Bing Xu Xiao-Hua liang Ya-Qing liu Da-li zhang Xi-Lei Sun Fan zhang Gang Chen Huan-Yu Wang Sheng yang Xiao-Jing liu Min Gao Mao-Shun li Jin-Zhou Wang xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong liu xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke zhang Can Chen Xiong-Tao yang Dong-Jie Hou Yu-Sa Wang rui Qiao Xiang Ma Xiao-Bo li Ping Wang Xin-Ying Song li-ming Song Shi-Jie Zheng Bing li Hong-Mei zhang Yue Zhu Wei Chen Jian-Jian He Zhen zhang Jin Hou Hong-Jun Wang yan-Chao Hao Xiang-Yu Wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du rui Gao Xiao-Fei Lan yan-Guo li Gang li Xu-Fang li Fang-Jun Lu Hong Lu Bin Meng feng Shi Hui Wang Hui-Zhen Wang Yu-Peng Xu Jia-Wei yang Xue-Juan yang Shuang-nan zhang Chao-Yue zhang Cheng-Mo zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

SiS低激发态势能曲线和光谱性质的全电子组态相互作用方法研究

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物理学报 2014年第11期63卷 201-209页

作者：李瑞张晓美李奇楠罗旺金明星徐海峰闫冰齐齐哈尔大学理学院齐齐哈尔161006 吉林大学原子与分子物理研究所长春130012

基于全电子的相关一致极化4-ζ(aug-cc-pwCVQZ-DK)基组,采用高精度的多参考组态相互作用方法计算了SiS自由基与最低的解离极限Si(3Pg)+S(3Pg)对应的18个Λ-S电子态的势能曲线.计算中考虑了标量相对论效应以及Si(2s22p6)和S(2s22p6)内壳... 详细信息

基于全电子的相关一致极化4-ζ(aug-cc-pwCVQZ-DK)基组,采用高精度的多参考组态相互作用方法计算了SiS自由基与最低的解离极限Si(3Pg)+S(3Pg)对应的18个Λ-S电子态的势能曲线.计算中考虑了标量相对论效应以及Si(2s22p6)和S(2s22p6)内壳层电子产生的关联效应.基于计算的势能曲线,拟合出了束缚态的光谱参数,包括平衡核间距Re,绝热激发能Te,振动常数ωe和ωeχe,平衡转动常数Be;并分析了束缚态在不同键长位置处的电子组态.计算了18个Λ-S态的电偶极矩函数,阐明了电子态的组态变化对电偶极矩的影响.给出了包含b3Π和A1Π态的自旋-轨道矩阵元随核间距变化的曲线,分析了邻近的电子激发态对b3Π和A1Π态的扰动.计算了A1Π—X1Σ+和E1Σ+—X1Σ+跃迁的跃迁偶极矩和Franck-Condon因子,讨论了A1Π和E1Σ+的最低五个振动能级的辐射寿命.

关键词： SiS 组态相互作用方法势能曲线光谱参数