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General anesthetic agents induce neurotoxicity through astrocytes

Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： yanchang yang Tiantian Liu Jun Li Dandan yan Yuhan Hu Pin Wu Fuquan Fang Patrick M.McQuillan Wenxin Hang Jianhang leng Zhiyong Hu Department of Anesthesiology The First Affiliated Hospital Zhejiang University School of Medicine Department of Anesthesiology Ningbo Women and Children's Hospital 3. Department of Anesthesiology Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College 4. Cell Biology Department Yale University 5. Department of Anesthesiology Penn State Hershey Medical Centre Penn State College of Medicine 6. Department of Central Laboratory Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial transmitters. Few studies, however, have focused on the effects of general anesthetic agents on neuroglia or astrocytes. Astrocytes can also be an important target of general anesthetic agents as they exert not only sedative, analgesic, and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive dysfunction. Here, we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes, and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes, in addition to acting on the receptors on their surface, which not only affect Ca2+signaling, inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes, but are even involved in the regulation of the pro-and anti-inflammatory processes of astrocytes. These would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons, other neuroglia, and vascular cells. In this review, we summarize how general anesthetic agents act on neurons via astrocytes, and explore potential mechanisms of action of general anesthetic agents on the nervous system. We hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents N-methyl-D-aspartate receptor neuron neurotoxicity perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

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MiR-24-3p Attenuates Doxorubicin-induced Cardiotoxicity via the Nrf2 Pathway in Mice

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Current Medical Science 2022年第1期42卷 48-55页

作者： Di FAN Hong-bin CHEN yan leng Shi-jun yanG Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430060China Department of Pulmonary and Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhan 430060China.

Objective:The nuclear factor erythroid 2(NFE2)-related factor 2(Nrf2)is associated with doxorubicin(DOX)-induced cardiac injury.It has been reported that microRNA-24-3p(miR-24-3p)may regulate the Keapl by mRNA degradation,whereas Keapl can suppress the activation of Nrf2.However,the role of miR-24-3p in DOX-related cardiotoxicity remains unclear.

关键词： miR-24-3p Ros doxorubicin nuclear factor erythroid 2-related factor 2 apoptosis

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A high precision two-axis GMR angular sensor manufactured by post-annealing

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Science China(Information Sciences) 2024年第6期67卷 465-466页

作者： Zitong ZHOU Zhiqiang CAO Shaohua yan Xiaolong WANG Libo XIE Shiyang LU Dapeng ZHU Qunwen leng Weisheng ZHAO School of Integrated Circuit Science and Engineering Beihang University Beihang Qingdao Microelectronics Research Institute Beihang University National Key Lab of Spintronics Institute of International InnovationBeihang University

Angle sensors are widely used in numerous fields such as industry,military,medical care,and the Internet of Things(IoT)[1].Magnetoresistance angle sensors have become a mainstream approach for angle measurement becaus... 详细信息

关键词： Annealing

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Ultrafast laser state active controlling based on anisotropic quasi-1D material

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Light(Science & Applications) 2024年第4期13卷 717-726页

作者： Zixin yang Qiang Yu Jian Wu Haiqin Deng yan Zhang Wenchao Wang Tianhao Xian Luyi Huang Junrong Zhang Shuai Yuan Jinyong leng Li Zhan Zongfu Jiang Junyong Wang Kai Zhang Pu Zhou College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China. Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China. i-Lab&Key Laboratory of Nanodevices and Applications&Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China. School of Applied and Engineering Physics Cornell UniversityIthacaNY 14853USA. State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China. Shanghai Key Lab of Modern Optical System University of Shanghai for Science and TechnologyShanghai 200093China

Laser state active controlling is challenging under the influence of inherent loss and other nonlinear effects in ultrafast systems.Seeking an extension of degree of freedom in optical devices based on low-dimensional materials may be a way forward.Herein,the anisotropic quasi-one-dimensional layered material Ta2PdS6 was utilized as a saturable absorber to modulate the nonlinear parameters effectively in an ultrafast system by polarization-dependent absorption.The polarization-sensitive nonlinear optical response facilitates the Ta2PdS6-based mode-lock laser to sustain two types of laser states,i.e.,conventional soliton and noise-like pulse.The laser state was switchable in the single fiber laser with a mechanism revealed by numerical simulation.Digital coding was further demonstrated in this platform by employing the laser as a codable light source.This work proposed an approach for ultrafast laser state active controlling with low-dimensional material,which offers a new avenue for constructing tunable on-fiber devices.

关键词： polarization fiber controlling

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General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain

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Zoological Research 2024年第3期45卷 691-703页

作者： Wen-Xin Hang yan-Chang yang Yu-Han Hu Fu-Quan Fang Lang Wang Xing-Hua Qian Patrick M.McQuillan Hui Xiong Jian-Hang leng Zhi-Yong Hu Department of Anesthesiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Cell Biology Yale UniversityNew HavenCT 06520USA Department of Neurology of the First Affiliated Hospital Interdisciplinary Institute of Neuroscience and TechnologySchool of Brain Science and Brain MedicineZhejiang University School of MedicineHangzhouZhejiang 310027China Department of Anesthesiology Jiaxing Maternity and Childcare Health HospitalJiaxingZhejiang 314009China Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPA 17033USA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang 310006China

General anesthetic agents can impact brain function through interactions with neurons and their effects on glial cells.Oligodendrocytes perform essential roles in the central nervous system,including myelin sheath formation,axonal metabolism,and neuroplasticity regulation.They are particularly vulnerable to the effects of general anesthetic agents resulting in impaired proliferation,differentiation,and apoptosis.Neurologists are increasingly interested in the effects of general anesthetic agents on oligodendrocytes.These agents not only act on the surface receptors of oligodendrocytes to elicit neuroinflammation through modulation of signaling pathways,but also disrupt metabolic processes and alter the expression of genes involved in oligodendrocyte development and function.In this review,we summarize the effects of general anesthetic agents on oligodendrocytes.We anticipate that future research will continue to explore these effects and develop strategies to decrease the incidence of adverse reactions associated with the use of general anesthetic agents.

关键词： Oligodendrocytes General anesthetic agents Neurotoxicity Central nervous system Perioperative neurocognitive disorders

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Evaluation of the injection and plugging ability of a novel epoxy resin in cement cracks

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Petroleum Science 2024年第2期21卷 1211-1220页

作者： Guang-Yao leng Wei yan Hai-Mu Ye Er-Dong Yao Ji-Bin Duan Zheng-Xian Xu Ke-Pei Li Jing-Ru Zhang Zhong Li State Key Laboratory of Petroleum Resource&Prospecting China University of Petroleum(Beijing)Beijing102249China CNPC Liaohe Oilfield Gas Storage Co.LTD Panjin124000LiaoningChina CNOOC Research Institute Co. Ltd.Beijing100028China

Sustained casing pressure(SCP)is a crucial issue in the oil and gas production lifecycle.Epoxy resins,exhibiting exceptional compressive strength,ductility,and shear bonding strength,have the potential to form reliable barriers.The injectivity and sealing capacity of the epoxy resin is crucial parameters for the success of shallow remediation operations.This study aimed to develop and assess a novel solid-free resin sealant as an alternative to Portland cement for mitigating fluid leakage.The investigation evaluated the viscosity,compressive strength,and brittleness index of the epoxy resin sealant,as well as its tangential and normal shear strengths in conjunction with casing steel.The flow characteristics and sealing abilities of conventional cement and epoxy resin were comparatively analyzed in cracks.The results showed that the application of a viscosity reducer facilitated control over the curing time of the epoxy resin,ranging from 1.5 to 6 h,and reduced the initial viscosity from 865.53 to 118.71 m Pa,s.The mechanical properties of the epoxy resin initially increased with a rise in curing agent content before experiencing a minor decrease.The epoxy resin containing 30%curing agent exhibited optimal mechanical properties.After a 14-day curing period,the epoxy resin's compressive strength reached81.37 MPa,2.12 times higher than that of cement,whereas the elastic modulus of cement was 2.99 times greater than that of the epoxy resin.The brittleness index of epoxy resin is only 3.42,demonstrating high flexibility and toughness.The tangential and normal shear strengths of the epoxy resin exceeded those of cement by 3.17 and 2.82 times,respectively.In a 0.5 mm-wide crack,the injection pressure of the epoxy resin remained below 0.075 MPa,indicating superior injection and flow capabilities.Conversely,the injection pressure of cement surged dramatically to 2.61 MPa within 5 min.The breakthrough pressure of0.5 PV epoxy resin reached 7.53 MPa,decreasing the crack's permeability to 0.02 D,a mere 9.49%of the permeabilit

关键词： Sustained casing pressure Epoxy resin sealant Curing agent Viscosity reducer Mechanical properties Crack sealing

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基于双分支点流语义先验的路面病害分割模型

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智能系统学报 2024年第1期19卷 153-164页

作者：庞荣杨燕冷雄进张朋刘言西南交通大学计算机与人工智能学院四川成都611756 可持续城市交通智能化教育部工程研究中心四川成都611756 招商局重庆公路工程检测中心有限公司重庆400067 国家山区公路工程技术研究中心重庆400067

针对基于深度学习的真实路面病害图像识别算法主要面临的复杂道路背景与病害前景比例不同、病害尺度小等导致的类别严重不平衡、路面病害与道路的几何结构特征对比不明显导致其不易识别等问题,本文提出一种基于双分支语义先验网络,用于... 详细信息

针对基于深度学习的真实路面病害图像识别算法主要面临的复杂道路背景与病害前景比例不同、病害尺度小等导致的类别严重不平衡、路面病害与道路的几何结构特征对比不明显导致其不易识别等问题,本文提出一种基于双分支语义先验网络,用于指导自注意力骨干特征网络挖掘背景与病害前景的复杂关系,运用高效自注意力机制和互协方差自注意力机制分别对二维空间和特征通道进行语义特征提取,并引入语义局部增强模块提高局部特征聚合能力。本文提出了一种新的稀疏主体点流模块,并与传统特征金字塔网络相结合,进一步缓解路面病害的类别不平衡问题;构建了一个真实场景的道路病害分割数据集,并在该数据集和公开数据集上与多个基线模型进行对比实验,实验结果验证了本模型的有效性。

关键词：语义先验信息高效注意力机制互协方差注意力机制稀疏主体点流类别不平衡语义分割路面病害深度学习

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3~6岁儿童在迷你独裁者游戏中的分配行为:群体身份的作用

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学前教育研究 2024年第6期 73-82页

作者：陈燕张晶季燕冷英刘昌南京师范大学心理学院南京210097 南通大学教育科学学院南通226000

本文采用迷你独裁者博弈范式,考察在自我利益与他人利益冲突情境下,任务伙伴的群体身份对儿童分配行为的影响。比较在劣势(利他的不平等)博弈和优势(利己的不平等)博弈中,儿童对内群体成员(朋友)和外群体成员(陌生人)的分配行为。结果发... 详细信息

本文采用迷你独裁者博弈范式,考察在自我利益与他人利益冲突情境下,任务伙伴的群体身份对儿童分配行为的影响。比较在劣势(利他的不平等)博弈和优势(利己的不平等)博弈中,儿童对内群体成员(朋友)和外群体成员(陌生人)的分配行为。结果发现,群体身份影响分配行为,儿童对朋友比对陌生人表现出更多的平等分配行为;而这种内群体偏向作用主要在优势博弈中起作用,并且随着年龄增长而减弱。儿童对劣势不平等厌恶的程度高于优势不平等,当面对陌生人时,两种厌恶程度的差异随年龄增长而减弱。在教育过程中,首先应尊重不平等厌恶的客观发展规律,因势利导促进儿童平等分配意识的发展;其次,充分利用同伴资源,培养儿童的分享意识。

关键词：儿童分配行为迷你独裁者游戏群体身份

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circRNA SIPA1L1修饰牙髓干细胞来源外泌体促血管生成能力的机制

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实用医学杂志 2024年第9期40卷 1211-1217页

作者：刘景冷春涛王艳新疆医科大学第五附属医院口腔科乌鲁木齐830011

目的探究环状RNA(circRNA)信号诱导增殖相关蛋白1样蛋白1(SIPA1L1)修饰的人牙髓干细胞(hDPSC)来源外泌体(Exo)对人脐静脉内皮细胞(HUVEC)血管生成能力的影响及机制。方法从牙髓组织分离培养hDPSC,将circSIPA1L1过表达质粒载体转染至hD... 详细信息

目的探究环状RNA(circRNA)信号诱导增殖相关蛋白1样蛋白1(SIPA1L1)修饰的人牙髓干细胞(hDPSC)来源外泌体(Exo)对人脐静脉内皮细胞(HUVEC)血管生成能力的影响及机制。方法从牙髓组织分离培养hDPSC,将circSIPA1L1过表达质粒载体转染至hDPSC后,分离Exo并进行鉴定。将HUVEC分为对照组、hDPSC Exo组、circSIPA1L1-hDPSC Exo组,培养48 h后,Matrigel基质胶血管形成实验检测血管形成能力,qRT-PCR和Western blot测定血管内皮细胞生长因子(VEGF)、血管内皮细胞生长因子受体2(VEGFR2)、胎盘生长因子(PGF)的表达水平。结果从未转染的hDPSC与转染circSIPA1L1的hDPSC中成功分离出Exo,且相较于h DPSC来源的Exo,转染circSIPA1L1的hDPSC来源的Exo中circSIPA1L1相对表达量显著上调(P <0.05)。与hDPSC Exo组比较,circSIPA1L1-hDPSC Exo组HUVEC的管样结构形成数目显著增加(P <0.05),VEGF、VEGFR2、PGF mRNA与蛋白相对表达量也显著上调(P<0.05)。结论 circRNA SIPA1L1修饰hDPSC来源的Exo能够促进血管生成,其机制可能与上调VEGF、VEGFR2、PGF的表达水平有关。

关键词：牙髓干细胞环状RNA 信号诱导增殖相关蛋白1样蛋白1 外泌体血管生成

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基于代谢组学方法的混合香精香料差异性物质鉴定与品质分析

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分析测试学报 2024年第2期43卷 226-235页

作者：冷月胡芸张进李博岩谢锋贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室贵州贵阳550025 贵州中烟工业有限责任公司技术中心贵州贵阳550009 贵州省分析测试研究院贵州贵阳550000

使用气相色谱-质谱和代谢组学分析方法,研究了4种混合香精香料的多批次样本中的特征性和差异性物质,并对样本的品质一致性进行分析评价。从A、B、C、D 4种混合香精香料中分别鉴定出49、32、48、39种物质,其中乙酸乙酯、乙酰丙酸乙酯、... 详细信息

使用气相色谱-质谱和代谢组学分析方法,研究了4种混合香精香料的多批次样本中的特征性和差异性物质,并对样本的品质一致性进行分析评价。从A、B、C、D 4种混合香精香料中分别鉴定出49、32、48、39种物质,其中乙酸乙酯、乙酰丙酸乙酯、异戊酸异戊酯、麦芽酚、二丙二醇、乙酸、4-氧代戊酸及5-羟甲基-2-呋喃甲醛8种物质是共有的主要风味组分。A与C型样本风味成分较为相似,果香与花香特征的酯类物质含量最为丰富,B型中具有酸香特征的酸类物质含量较高,D型中酮类致香物质最多。主成分分析与偏最小二乘判别分析能够识别混合香精香料中的特征性与差异性物质。根据变量投影重要性及统计结果筛选出的苹果酸二乙酯、反式-橙花叔醇、乙基麦芽酚等40种物质可用于4种香精香料的品质判断。不同类型样本的物质组成差异明显,同类型不同批次样本间特征物质的质量波动较小、品质一致性较好。

关键词：混合香精香料差异性物质品质分析气相色谱-质谱代谢组学

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