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Synthesis and in vitro-Anti-hepatitis B Virus Activities of Several Ethyl 5-Hydroxy-1H-indole-3-carboxylates

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Chemical Research in Chinese Universities 2006年第5期22卷 577-583页

作者： ZHAO Chun-shen ZHAO yan-fang CHAI Hui-fang GONG Ping Liaoning Province Key Laboratory of Innovative Medicine Research and Design Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of ethyl 5-hydroxyindole-3-earboxylates 6a-10r was designed and synthesized. The structures of all the compounds were confirmed by IR, ^1H NMR, and MS and their anti-hepatitis B virus （HBV） activities were evaluated in 2.2.15 cells. Among them, compound 7g { ethyl 5-hydroxy-2- [ （ 3-methoxyphenylsulfinyl ） methyl ] -1-methyl-4- [ （4-methylpiperazin-1-yl） methyl ]-1H-indole-3-carboxylate} displays a significant anti-HBV activity, which is more potent than the positive control lamivudine.

关键词： Ethyl 5-hydroxy-1H-indole-3-carboxylates Synthesis Anti-hepatitis B virus activity

“Cutting effect” of organoclay platelets in compatibilizing immiscible polypropylene/polystyrene blends

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第11期9卷 1614-1620页

作者： yan ZHU Hai-yun MA Li-fang TONG Zheng-ping fang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Institute of Polymer Composites Zhejiang University Hangzhou 310027 China Department of Blochemical and Chemical Engineermg Ningbo Institute of Technology Zhejiang University Ningbo 315100 China

In this work, polypropylene (PP)/polystyrene (PS) blends with different organoclay concentrations were prepared via melt compounding. Differing from the results of previous reports, the organoclay platelets are mostly located in the dispersed PS phase instead of the interface. The dimensions of the dispersed PS droplets are greatly reduced and apparent compatibilization effect still exists, which cannot be explained by the traditional compatibilization mechanism. A novel compatibilization mecha- nism, "cutting" to apparently compatibilize the immiscible PP/PS blends was proposed. The organoclay platelets tend to form a special "knife-like structure" in the PS domain under the shear stress of the continuous PP phase during compounding. The "clay knife" can split the dispersed PS domain apart and lead to the dramatic reduction of the dispersed domain size.

关键词： Compatibilization Organoclay Polymer blends Polypropylene (PP) Polystyrene (PS)

Parametric Narrow-Band InISAR 3D Imaging Based on Compressed Sensing

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Chinese Journal of Electronics 2020年第3期29卷 508-514页

作者： WANG Baoping ZHANG yan fang yang SONG Zuxun Science and Technology on UAV Laboratory Northwestern Polytechnical University School of Electronic and Information Northwestern Polytechnical University

For muti-scatter point target and undersampled data, tradintional imaging method has a poor precision for imaging result and spin angular *** view of the above problems, this paper proposes a narrow-band Interferometric inverse synthetic aperture radar(InISAR) 3-dimensional(3D) Compressed sensing imaging method based on the joint spin angle velocity error parameter estimation. First, a sparse model of narrow-band spin target is constructed. Then, the image entropy is used as the criterion function to search the optimal angle velocity by the joint reconstruction ***, the image of the target is obtained by interference processing. The simulation results show that compared with the traditional method, the estimation of spin angular velocity and the imaging result are more accurate in proposed method.

关键词： InISAR 3D imaging Narrow-band Spin angular velocity Compressed sensing Joint reconstruction iteration

Kinetic model of vibration screening for granular materials based on biological neural network

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Particuology 2024年第5期88卷 98-106页

作者： Zhan Zhao yan Zhang fang Qin Mingzhi Jin School of Agricultural Engineering Jiangsu UniversityZhenjiang212013China Shandong Academy of Agricultural Machinery Sciences Ji'nan250100China

The kinetic model is the theoretical basis for optimizing the structure and operation performance of vibration screening *** this paper,a biological neurodynamic equation and neural connections were established according to the motion and interaction properties of the material under vibration *** material feeding to the screen and the material passing through apertures were considered as excitatory and inhibitory inputs,respectively,and the generated stable neural activity landscape was used to describe the material distribution on the 2D screen *** dynamic process of material vibration screening was simulated using discrete element method(DEM).By comparing the similarity between the material distribution established using biological neural network(BNN)and that obtained using DEM simulation,the optimum coefficients of BNN model under a certain screening parameter were determined,that is,one relationship between the BNN model coefficients and the screening operation parameters was *** screening parameters were randomly selected,and the corresponding relationships were established as a ***,with straw/grain ratio,aperture diameter,inclination angle,vibration strength in normal and tangential directions as inputs,five independent adaptive neuro-fuzzy inference systems(ANFIS)were established to predict the optimum BNN model coefficients,*** training results indicated that ANFIS models had good stability and *** flexibility and adaptability of the proposed BNN method was demonstrated by modeling material distribution under complex feeding conditions such as multiple regions and non-uniform rate.

关键词： Kinetic model Material distribution Vibration screening Biological neural network DEM simulation Adaptive neuro-fuzzy inference systems

Coordinated Chance-constrained Optimization of Multi-energy Microgrid System for Balancing Operation Efficiency and Quality-of-service

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Journal of Modern Power Systems and Clean Energy 2020年第5期8卷 853-862页

作者： Sidun fang Tianyang Zhao yan Xu Tianguang Lu School of Electrical and Electronics Nanyang Technological UniversitySingaporeSingapore School of Engineering and Applied Sciences Harvard UniversityCambridgeUSA

To enhance the flexible interactions among multiple energy carriers,i.e.,electricity,thermal power and gas,a coordinated programming method for multi-energy microgrid(MEMG)system is *** energy requirements for both residential and parking loads are managed simultaneously,i.e.,electric and thermal loads for residence,and charging power and gas filling requirements for parking *** proposed model is formulated as a two-stage joint chance-constrained programming,where the first stage is a day-ahead operation problem that provides the hourly generation,conversion,and storage towards the minimization of operation cost considering the forecasting error of photovoltaic output and load ***,the second stage is an on-line scheduling which adjusts the energy scheme in hourly time-scale considering the *** have demonstrated the validity of the proposed method,i.e.,collecting the flexibilities of thermal system,gas system,and parking vehicles to facilitate the operation of electrical *** analysis shows that the proposed scheme can achieve a compromise between the operation efficiency and service quality.

关键词： Multi-energy microgrid system operation efficiency quality-of-service joint chance-constrained programming

Burning products of TA15 titanium alloy by friction oxygen concentration method

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Rare Metals 2018年第11期37卷 952-960页

作者： Nan sui Guang-Bao Mi Meng-Qi yan Jing-Xia Cao Xu Huang Aviation Key Laboratory of Science and Technology on Advanced Titanium Alloys AECC Beijing Institute of Aeronautical Materials

The microstructural characteristics, elemental distribution law and microscopic formation mechanism of the burning products of TA15 titanium alloy were investigated by friction oxygen concentration method, associated with in situ observation, X-ray diffraction(XRD),scanning electron microscopy(SEM) and energy-dispersive spectroscopy(EDS) analyses, providing the thoughts to improve fireproof property. The results show that, when the friction contact pressure(p) is 0.20 MPa and oxygen concentration of premixed air flow(c) is 60 vol%, TA15 titanium alloy produces violent sparks and presents dazzling white light during combustion. The generated products after burning are mainly TiOand small amount of AlOoxides. Four distinct zones form from the combustion surface to the alloy matrix, and they are in the sequence of combustion zone, fusion zone, heat-affected zone and transition zone. Further, combustion zone is composed of TiOand A1203 compounds, containing obvious cracks. In the fusion zone, discontinuous oxygenrich Al-based solid solution forms, and the elemental distribution has strong volatility. In the heat-affected zone,there are abundant of Ti-based solid solution and small amount of Al-and Mo-based solid solution. Transition zone is made of lamellar structure. Two technical approaches are given to prevent oxygen diffusion inside the reaction zone and reaction-affected zone. On the one hand,the content of Al is designed as the upper limit of alloy composition; on the other hand, fireproof coatings are deposited on the surface of the alloy.

关键词： Friction oxygen concentration method TA15 titanium alloy Burning products Microstructure Titanium fire

Room-Temperature Phosphorescent Organic-Doped Inorganic Frameworks Showing Wide-Range and Multicolor LongPersistent Luminescence

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Research 2021年第1期2021卷 1413-1423页

作者： Guowei Xiao Bo Zhou Xiaoyu fang Dongpeng yan Beijing Key Laboratory of Energy Conversion and Storage Materials College of Chemistry Beijing Normal UniversityBeijing 100875China College of Chemistry Key Laboratory of RadiopharmaceuticalsMinistry of EducationBeijing Normal UniversityBeijing 100875China College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Long-persistent luminescence based on purely inorganic and/or organic compounds has recently attracted much attention in a wide variety of fields including illumination,biological imaging,and information ***,simultaneously tuning the static and dynamic afterglow performance still presents a *** this work,we put forward a new route of organic-doped inorganic framework to achieve wide-range and multicolor ultralong room-temperature phosphorescence(RTP).Through a facile hydrothermal method,phosphor(tetrafluoroterephthalic acid(TFTPA))into the CdCO_(3)(or Zn_(_(2))(OH)_(2)CO_(3))host matrix exhibits an excitation-dependent colorful RTP due to the formation of diverse molecular aggregations with multicentral *** RTP lifetime of the doped organic/inorganic hybrids is greatly enhanced(313 times)compared to the pristine *** high RTP quantum yield(43.9%)and good stability guarantee their easy visualization in both ambient and extreme conditions(such as acidic/basic solutions and an oxygen environment).Further codoped inorganic ions(Mn_(2)+and Pb_(2)+)afford the hybrid materials with a novel time-resolved tunable afterglow emission,and the excitation-dependent RTP color is highly adjustable from dark blue to red,covering nearly the whole visible spectrum and outperforming the current stateof-the-art RTP ***,this work not only describes a combined codoping and multicentral strategy to obtain statically and dynamically tunable long-persistent luminescence but also provides great opportunity for the use of organicinorganic hybrid materials in multilevel anticounterfeiting and multicolor display applications.

关键词： inorganic excitation luminescence

Optimization of micellar electrokinetic capillary chromatography method using central composite design for the analysis of components in yangwei granule

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第3期12卷 193-200页

作者： Shu-fang WANG Hai-yan fang Hai-bin QU Pharmaceutical Informatics Institute Zhejiang University Hangzhou 310058 China

Central composite design(CCD),together with multiple linear regression,was successfully used to optimize the electrophoretic buffer system of micellar electrokinetic capillary chromatography(MEKC) for the determination of albiflorin,paeoniflorin,liquiritin,and glycyrrhizic acid in the traditional Chinese medicine(TCM) prescription,yangwei *** of sodium deoxycholate(SDC) and borate,and proportions of ammonia,acetonitrile,and methanol were *** total resolutions of peaks between the analytes and their adjacent peaks in real samples were integrated into the evaluation index of separation *** optimum electrophoretic buffer contained 80 mmol/L SDC,20 mmol/L borate,5%(v/v) methanol,0.5%(v/v) ammonia,and 5%(v/v) *** correlation coefficients(R 2 ) between the peak areas and the corresponding concentrations of analytes were greater than *** limits of detection(LODs) (S/N=3) of the analytes were 0.97-4.00μg/*** results indicate the superiority of CCD in optimizing the separation conditions of complex samples such as TCM prescriptions.

关键词： Micellar electrokinetic capillary chromatography Traditional Chinese medicine Central composite design yangwei granule

Reconstructing Local Volatility Using Total Variation

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Acta Mathematica Sinica,English Series 2017年第2期33卷 263-277页

作者： Rui yan ZHANG fang fang XU Jian Chao HUANG School of Mathematical Sciences University of the Chinese Academy of Sciences College of Mathematics and Systems Science Shandong University of Science and Technology Department of Mathematics Shanghai Jiao Tong University

The aim of this paper is to identify the volatility function in Dupire＇s equation from given option prices. This inverse problem is formulated as an infinite-dimensional minimization problem with PDE constraints. The computational cost of solving the discretized problem on a fine discretization level is expensive. A multi-grid method is proposed to explore the hierarchical structures of discretized problems on different levels. Computational examples are presented to demonstrate the efficiency of our method.

关键词： Volatility smile Dupire's equation finite difference optimization multigrid method