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Safety and efficacy of balloon angioplasty compared to stent-basedstrategies with pulmonary vein stenosis:A systematic review and meta-analysis

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World Journal of Cardiology 2023年第2期15卷 64-75页

作者： Pradyumna Agasthi Srilekha Sridhara Pattara Rattanawong Nithin Venepally Chieh-Ju Chao Hasan Ashraf Sai Harika Pujari Mohamed allam Diana Almader-Douglas yamini alla Amit Kumar Farouk Mookadam Douglas L Packer David R Holmes Jr Donald J Hagler Floyd David Fortuin Reza Arsanjani Department of Cardiovascular Diseases Mayo ClinicScottsdaleAZ 85259United States Department of Internal Medicine Banner Heart HospitalMesaAZ 85054United States Library Services Mayo ClinicPhoenixAZ 85054United States Department of Medicine Bronx Lebanon HospitalBronxNY 10457United States Department of Cardiovascular Diseases Mayo ClinicRochesterMN 55905United States

BACKGROUND Pulmonary vein stenosis(PVS)is an uncommon but known cause of morbidity and mortality in adults and children and can be managed with percutaneous revascularization strategies of pulmonary vein balloon angioplasty(PBA)or pulmonary vein stent implantation(PSI).AIM To study the safety and efficacy outcomes of PBA vs PSI in all patient categories with *** We performed a literature search of all studies comparing outcomes of patients evaluated by PBA vs PSI for *** selected all published studies comparing PBA vs PSI for PVS with reported outcomes of restenosis and procedure-related complications in all patient *** adults,PVS following atrial fibrillation ablation and in children PVS related to congenital etiology or post-procedural PVS following total or partial anomalous pulmonary venous return repair were *** patient-centered outcomes were risk of restenosis requiring re-intervention and procedural-related *** metaanalysis was performed by computing odds ratios(ORs)using the random effects model based on underlying statistical *** Eight observational studies treating 768 severe PVS in 487 patients met our inclusion *** age range of patients was 6 months to 70 years and 67%were *** primary outcome of the re-stenosis requiring re-intervention occurred in 196 of 325 veins in the PBA group and 111 of 443 veins in the PSI *** to PSI,PBA was associated with a significantly increased risk of re-stenosis(OR 2.91,95%CI:1.15-7.37,P=0.025,I2=79.2%).Secondary outcomes of the procedurerelated complications occurred in 7 of 122 patients in the PBA group and 6 of 69 in the PSI *** were no statistically significant differences in the safety outcomes between the two groups(OR:0.94,95%CI:0.23-3.76,P=0.929,I^(2)=0.0%).CONCLUSION Across all patient categories with PVS,PSI is associated with reduced risk of re-intervention and is as safe as PBA and should be considered first-line ther

关键词： Pulmonary veins Pulmonary vein stenosis Constriction Balloon angioplasty Stents Drugeluting stents

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Simultaneous determination of steroid drugs in the ointment via magnetic solid phase extraction followed by HPLC-UV

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Journal of Pharmaceutical Analysis 2018年第4期8卷 250-257页

作者： Yadollah yamini Meysam Safari Maryam Shamsayei Department of Chemistry Tarbiat Modares University Department of Chemical Engineering Kermanshah University of Technology

The copper-coated iron oxide nanoparticles with core-shell were produced by deposition of a Cu shell on Fe3 O4 NPs through reduction of Cu2 tions in solution using NaB H4. Subsequently, the organosulfur compound, bis-（2,4,4-trimethylpentyl）-dithiophosphinic acid（b-TMP-DTPA）, was used to form self-assembled monolayer in order to modify sorbent＇s surface via covalent bonding between Cu and thiol（–SH）terminal groups. The prepared magnetic nanoparticles were characterized by using Fourier transform infrared（FT-IR） spectroscopy, scanning electron microscopy（SEM）, transmission electron microscope（TEM）, vibrating sample magnetometer（VSM） and thermo gravimetric analysis（TGA）. Then, the application of this new sorbent was investigated to extract the steroid drugs in ointment samples with the aid of ultrasound. An external magnetic field was applied to collect the magnetic nanoparticles（MNPs）. The extracted analytes were desorbed using acetonitrile. The obtained extraction solution was analyzed by HPLC-UV. The main affecting factors on the extraction efficiency including p H, sonication time, amount of sorbent, salt concentration, and desorption conditions were optimized in detail. Under the optimum conditions, good linearity was obtained in the range of 2.5–250.0 mg/L with reasonable linearity（R24 0.99） and the limits of detection（LODs） ranged between 0.5 and 1.0 mg/L（based on S/N ？ 3）.Repeatability（intra-day precision） based on five replicates and preconcentration factors were calculated to be 3.6%–4.7% and 87–116, respectively. Relative recoveries in ointment samples at two spiked levels of the target analytes were obtained in the range of 90.0%–103.2%. The results illustrated that the Fe3 O4@Cu@ b-TMP-DTPA NPs have the capability of extraction of steroid drugs from ointment samples.

关键词： Magnetic nanoparticles Steroid drug Ointment High performance liquid chromatography Self-assembled monolayer

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Key networks to create disaster resilient Smart Cities Mission: A case for remodeling India’s Smart Cities Mission to include disaster resilience

Resilient Cities and Structures

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Resilient Cities and Structures 2024年第4期3卷 52-62页

作者： yamini Meduri R.Singh Geetha Manoharan Assistant Professor ICFAI Business SchoolICFAI Foundation for Higher EducationIndia Research Scholar SR UniversityIndia Assistant Professor School of BusinessSR UniversityIndia

Amidst a concerning surge in urban losses attributed to disasters,this research paper explores the intricate relationship between urban development,disaster mitigation,and resilience emphasizing the significance of addressing disaster vulnerability in urban settings,where a substantial portion of the population faces risks stemming from high population density,limited resilience,and inadequate coping *** study advocates for the integration of disaster resilience principles into the Smart Cities Mission of India,placing particular emphasis on the necessity of developing infrastructure,establishing early warning systems,and fostering community engagement to bolster urban ***,the paper draws comparisons and parallels between the components of smart cities,mitigation strategies,and disaster resilience,illuminating their interconnectedness and potential *** conclusion,the study recommends the incorporation of essential network elements to establish a Smart Cities Mission that is resilient to disasters,ultimately aiming to safeguard urban communities from the adverse impacts of future calamities.

关键词： Disaster resilience Smart city mission Disaster mitigation Disaster management

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Extraction and determination of trace amounts of chlorpromazine in biological fluids using magnetic solid phase extraction followed by HPLC

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Journal of Pharmaceutical Analysis 2014年第4期4卷 279-285页

作者： Yadollah yamini Mohammad Faraji Department of Chemistry Tarbiat Modares UniversityP.O.Box 14115-175TehranIran Faculty of Food Industry and Agriculture Department of Food Science & TechnologyStandard Research Institute(SRI)KarajP.O.Box 31745-139Iran

A simple, rapid and sensitive method termed as magnetic solid phase extraction （MSPE） combined with high-performance liquid chromatography-ultraviolet detector （HPLC-UV） has been proposed for the determination of trace amounts of chlorpromazine （CPZ） in water, urine and plasma samples. The separation and determination was performed on a C18 column under the optimal chromatographic conditions. Several factors influencing the extraction efficiency of CPZ, such as pH, surfactant and adsorbent amounts, ionic strength, extraction time, sample volume and desorption conditions, were studied and optimized. Under the optimal MSPE conditions, the extraction percentage of CPZ was 74%, 27% and 16% in water, urine and plasma samples, respectively. The limits of detection （LODs） of the proposed approach were 0.1, 5.0 and 10ng/mL in water, urine and plasma samples, respectively. The relative standard deviations （RSDs） based on five replicate determinations at 10 ng/mL level of CPZ was 1.2%. Good linear behaviors over the investigated concentration ranges （0.25-300 ng/mL） with good coefficient of determination, R2 〉 0.9998, were obtained. Good spike recoveries with relative errors less than 9.0% were obtained when applying the proposed method to water, urine and plasma samples.

关键词： Chlorpromazine Magnetic solid phaseextraction

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A Distributed Mechanism for Handling of Adaptive/Intelligent Selfish Misbehaviour at MAC Layer in Mobile Ad Hoc Networks

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Journal of Computer Science & Technology 2009年第3期24卷 472-481页

作者： Raja Gunasekaran Vaidheyanathan Rhymend Uthariaraj Uamapathy yamini Rajagopalan Sudharsan Selvaraj Sujitha Priyadarshini Department of Information Technology Anna University Ramanujan Computing Centre Anna University

Medium access control （MAC） protocols such as IEEE 802.11 are used in wireless networks for sharing of the wireless medium. The random nature of the protocol operation together with the inherent difficulty of monitoring in the open poses significant challenges. All nodes are expected to comply with the protocol rules. But, some nodes in order to gain greater benefits misbehave by not complying with the rules. One such selfish misbehavior is waiting for smaller back-off intervals when compared to the other nodes in the same subnet. Such selfish misbehavior is being tackled in this paper. A diagnosis scheme and a penalty scheme are being proposed for overcoming such selfish-misbehavior at MAC layer of mobile ad hoc networks which could be extended to other types of networks also.

关键词： WLANs MAC layer DCF contention backoff

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Natural history of children with mild Crohn’s disease

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World Journal of Gastroenterology 2019年第30期25卷 4235-4245页

作者： yamini Sharma Athos Bousvaros Enju Liu Julia Bender Stern Department of Gastroenterology and Hepatology Inflammatory Bowel Disease Center Boston Children’s Hospital

BACKGROUND There is a small and poorly studied population of patients with mild and limited Crohn’s disease(CD),who either spontaneously enter remission and can discontinue therapy,or be maintained on milder anti-inflammatory *** To identify a group of children with mild CD who were not escalated to immunomodulators(azathioprine,mercaptopurine,or methotrexate)or biologics(infliximab or adalimumab)within the first two years after their Crohn’s diagnosis and outline the natural history and phenotypic features of these *** In a retrospective chart review of the inflammatory bowel disease database at Boston Children’s Hospital we reviewed all the mild CD patient’s clinic visits,laboratory studies,and procedures for the duration of time they were followed at the *** were included if they had clear diagnosis of Crohn’s disease,and they were not escalated to immunosuppressive therapies for at least 2 years after the date of *** mild CD patients were compared to controls diagnosed at a similar time,that were treated with immunomodulators or *** that was abstracted included:Age at diagnosis,sex,disease location utilizing the Paris classification,medical treatment,surgical treatment,endoscopic findings,histology,and *** also analyzed differences in the phenotypic features between those with mild CD and those with moderate to severe *** Out of 1205 patients with CD diagnosed between 1990 and 2013,we identified 29 patients that met the inclusion criteria,and they were matched with 58 *** were no significant differences between the disease behaviors at presentation,with approximately 90%of patients in each group having inflammatory ***,patients with mild disease were more likely to have disease limited to the colon(31%vs 12%,P=0.03).In contrast,patients with moderate to severe disease(aka control group)were more likely to have ileocolonic disease(70%vs 45%in the mild grou

关键词： Crohn’s disease Colitis Aminosalicylates Antibiotics Immunosuppression Inflammatory bowel disease Child Pediatric

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Natural compounds as potential inhibitors of SARS-CoV-2 main protease: An insilico study

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 155-163页

作者： Amaresh Mishra yamini Pathak Anuj Kumar Surabhi Kirti Mishra Vishwas Tripathi School of Biotechnology Gautam Buddha UniversityGreater Noida-201310India Bioinformatics Laboratory Uttarakhand Council for BiotechnologyBiotech BhawanPantnagarU.S.NagarUttarakhand-263145India Advanced Centre for Computational and Applied Biotechnology Uttarakhand Council for BiotechnologyDehradun-248007India School of Biotechnology Jawaharlal Nehru UniversityNew DelhiIndia

Objective:To explore natural compounds as potential inhibitors against main protease(Mpro)of ***:In the current study,systematic molecular docking analysis was conducted using AutoDock 4.2 to determine the binding affinities and interactions between natural compounds and *** natural compounds were further validated using a combination of molecular dynamic(MD)simulations and molecular mechanic Poisson-Boltzmann surface area(MM/PBSA)free energy c alculation ***:Out of twenty natural compounds,four natural metabolites namely,amentoflavone,guggulsterone,puerarin,and piperine were found to have strong interaction with Mpro of SARS-CoV-2 based on docking *** MD simulations,all four natural compounds bound to Mpro at 50 ns and MM/G/P/BSA free energy calculations showed that all four shortlisted ligands had stable and favorable energies with strong binding to Mpro ***:Guggulsterone is a potential inhibitor of COVID-19 main protease *** in vitro and pre-clinical studies are needed.

关键词： SARS-CoV-2 COVID-19 Amentoflavone Guggulsterone Puerarin Piperine

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Effect of sharing health messages on antenatal care behavior among women involved in microfinance-based self-help groups in Bihar India

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Global Health Research and Policy 2020年第1期5卷 406-413页

作者： Monika Walia Laili Irani Indrajit Chaudhuri yamini Atmavilas Niranjan Saggurti Population Council Zone 5AGround Floor India Habitat CentreLodi RoadNew DelhiDelhi 110003India Project Concern International 38Okhla Phase 3 RdOkhla Phase IIIOkhla Industrial AreaNew DelhiDelhi 110020India Bill&Melinda Gates Foundation Capital Court5th FloorOlof Palme MargMunirkaDelhiIndia

Background:Bihar state in India has one of the highest rates of maternal and infant mortality in South ***-based self-help groups(SHGs),involving rural women,are being utilized to improve maternal and child health practice and reduce *** members receive information on key maternal and child health practices as well as encouragement for their *** study measures the association of health messaging to SHG members with their antenatal care(ANC)***:The study was conducted in eight districts of Bihar in 2016.A three-stage cluster sampling design(with a random selection of blocks,villages,and SHGs)selected the sample of 1204 SHG members who had an infant child;of these,597 women were members of SHGs that received dedicated sessions on health messages,while 607 women belonged to SHGs that did *** examine the impact of the health intervention on ANC practice,radius caliper method of propensity score matching controlled for various socio-demographic characteristics between the two ***:Most of the interviewed women(91.5%)belonged to a scheduled caste or *** 44%of SHG members exposed to the health intervention were engaged in some occupation,compared to 35%of those not exposed to the *** matching unexposed SHG women with exposed SHG women,no significant differences were found in their socio-demographic *** suggest that exposure to a health intervention is associated with increased likelihood of at least four ANC visits by SHG women(ATE=7.2,95%CI:0.76-13.7,p<0.05),consumption of iron-folic acid for at least 100 days(ATE=8.7,95%CI:5.0-12.5,p<0.001)and complete ANC(ATE=3.6,95%CI:2.3-4.9,p<0.001),when compared to women not exposed to the health ***:The study shows that sharing health messages in microfinance-based SHGs is associated with significant increase in ANC *** the results suggest the potential of microfinance-based SHGs for improved mat

关键词： Self-help group(SHG) Antenatal care(ANC) Propensity score matching(PSM) Health integration Health messaging ANC outcomes Bihar India

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Hollow fiber-based liquid phase microextraction followed by analytical instrumental techniques for quantitative analysis of heavy metal ions and pharmaceuticals

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Journal of Pharmaceutical Analysis 2020年第2期10卷 109-122页

作者： Wajid Ali Khan Muhammad Balal Arain Yadollah yamini Nasrullah Shah Tasneem Gul Kazi Stig Pedersen-Bjergaard Mohammad Tajik Department of Chemistry Abdul Wali Khan University Mardan23200KPKPakistan Department of Chemistry University of Karachi75270KarachiPakistan Department of Chemistry Tarbiat Modares UniversityP.O.Box 14115-175TehranIran National Center of Excellence in Analytical Chemistry University of SindhJamshoro76080SindhPakistan School of Pharmacy University of OsloOsloNorway

Hollow-fiber liquid-phase microextraction(HF-LPME)and electromembrane extraction(EME)are miniaturized extraction techniques,and have been coupled with various analytical instruments for trace analysis of heavy metals,drugs and other organic compounds,in recent ***-LPME and EME provide high selectivity,efficient sample cleanup and enrichment,and reduce the consumption of organic sol-vents to a few micro-liters per ***-LPME and EME are compatible with different analytical in-struments for chromatography,electrophoresis,atomic spectroscopy,mass spectrometry,and electrochemical ***-LPME and EME have gained significant popularity during the recent *** review focuses on hollow fiber based techniques(especially HF-LPME and EME)of heavy metals and pharmaceuticals(published 2017 to May 2019),and their combinations with atomic spectroscopy,UV-VIS spectrophotometry,high performance liquid chromatography,gas chromatography,capillary elec-trophoresis,and voltammetry.

关键词： Hollow fiber liquid phase microextraction Electromembrane extraction Heavy metals Pharmaceuticals Instrumental techniques

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Nanomagnet-facilitated pharmaco-compatibility for cancer diagnostics:Underlying risks and the emergence of ultrasmall nanomagnets

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Journal of Pharmaceutical Analysis 2022年第3期12卷 365-379页

作者： Divya S.Parimi yamini Gupta Sreekar Marpu Chandra S.Bhatt Tharun K.Bollu Anil K.Suresh Bionanotechnology&Sustainable Laboratory Department of Biological SciencesSchool of Engineering and Applied SciencesSri Ramaswamy Memorial(SRM)UniversityAmaravati522503India Department of Chemistry University of North TexasDentonTX76201USA Department of Biotechnology Faculty of Science and HumanitiesSri Ramaswamy Memorial(SRM)Institute of Science and TechnologyChennai603203India

Cancer therapy is a fast-emerging biomedical paradigm that elevates the diagnostic and therapeutic potential of a nanovector for identification,monitoring,targeting,and post-treatment response *** of superparamagnetic iron oxide nanoparticles(SPION)are of tremendous significance in cancer therapy because of their inherited high surface area,high reactivity,biocompatibility,superior contrast,and magnetic and photo-inducibility *** addition to a brief introduction,we summarize various progressive aspects of nanomagnets pertaining to their production with an emphasis on sustainable biomimetic ***-synthesis particulate and surface alterations in terms of pharmaco-affinity,liquid accessibility,and biocompatibility to facilitate cancer therapy are *** parameters including particle contrast,core-fusions,surface area,reactivity,photosensitivity,photodynamics,and photothermal properties,which facilitate diverse cancer diagnostics,are *** also elaborate on the concept of magnetism to selectively focus chemotherapeutics on tumors,cell sorting,purification of bioentities,and elimination of ***,while addressing the toxicity of nanomaterials,the advent of ultrasmall nanomagnets as a healthier alternative with superior properties and compatible cellular interactions is *** summary,these discussions spotlight the versatility and integration of multitasking nanomagnets and ultrasmall nanomagnets for diverse cancer theragnostics.

关键词： Nanomagnets Biomimetics Utrasmall-SPIONs Magnetization Core-fusion Cancer theragnostics

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