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Risk Assessment of Debris Flows Along the Karakoram Highway (Kashgar‑Khunjerab Section) in the Context of Climate Change

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International Journal of Disaster Risk Science 2023年第4期14卷 586-599页

作者： yamei li Qiang Zou Jiansheng Hao lijun Su State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China China-Pakistan Joint Research Center on Earth Sciences Islamabad 45320Pakistan Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

The Karakoram highway(KKH)is renowned for its complex natural environment and geological *** climate changes drastically and directly infuences the frequency and magnitude of debris fows in this region,resulting in signifcant casualties and economic ***,the risk assessment of debris fows along the KKH in the context of climate change has been rarely ***,in this study we used the debris fow data,historical meteorological data and future climate prediction data to assess the debris fow risk of the study region during the baseline period(2009–2018),2025s(2021–2030),2035s(2031–2040)and 2045s(2041–2050)under the Representative Concentration Pathway 8.5 *** results show that the risk of debris fows increases with climate change,with the highest risk level in the *** diferent parts of this highway,the upper reaches of the Ghez River and the second half of Tashkorgan-Khunjerab are the sections with the highest *** fndings are helpful for debris fow prevention and can ofer coping strategies for the existing line of the *** also provide some reference for the renovation,improvement,operation,and maintenance of the KKH.

关键词： Climate change Debris fows Karakoram highway Risk assessment

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Silica supported potassium oxide catalyst for dehydration of 2-picolinamide to form 2-cyanopyridine

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Chinese Chemical Letters 2019年第2期30卷 494-498页

作者： yamei li Yujun Zhao Shengping Wang Xinbin Ma Key Laboratory for Green Chemical Technology School of Chemical Engineering and TechnologyTianjin UniversityCollaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The dehydration of 2-picolinamide to produce 2-cyanopyridine was investigated thoroughly using silica supported potassium oxide as a heterogeneous catalyst. Both large specific surface area and pore size of SiO_2 (B) contributed to the favorable catalytic performance for the synthesis of 2-CP. In addition, the yield of 2-CP showed the linear relationship with the amounts of medium basicity of the catalysts,demonstrating that medium basic sites were the active sites of silica supported potassium oxide catalysts. The catalysts were further characterized by XRD and FT-IR to clarify the active species. The results indicated the Si—O—K group produced by the reaction of K_2CO_3 with Si—OH was the active species, which was further evidenced by the adjustment of the amount of Si—OH by silylation and hydroxylation procedure.

关键词： 2-Picolinamide 2-Cyanopyridine Dehydration Potassium oxide

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Structural change of molybdenum sulfide facilitates the electrocatalytic hydrogen evolution reaction at neutral pH as revealed by in situ Raman spectroscopy

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Chinese Journal of Catalysis 2018年第3期39卷 401-406页

作者： yamei li Ryuhei Nakamura Biofunctional Catalyst Research Team RIKEN Center for Sustainable Resource Science (CSRS) 2‐1 Hirosawa Wako Saitama 351‐0198 Japan Earth‐life Science Institute (ELSI) Tokyo Institute of Technology 2‐12‐1‐I7E Ookayama Meguro‐ku Tokyo 152‐8550 Japan

Molybdenum sulfides are promising electrocatalysts for the hydrogen evolution reaction(HER).Sand Mo‐related species have been proposed as the active site for forming adsorbed hydrogen to initiate the HER;however,the nature of the interaction between Mo centers and S ligands is ***,the development of cost‐effective water‐splitting systems using neutral water as a proton source for H2evolution is highly desirable,whereas the mechanism of the HER at neutral pH is rarely ***,the structural change in the Mo?Mo and S?S species in a synthesized molybdenum sulfide was monitored at neutral pH using in situ electrochemical Raman *** of the potential dependent Raman spectra revealed that the band assigned to a terminal S?S species emerged along with synchronized changes in the frequency of the Mo?Mo,Mo3?μ3S,and Mo?S vibrational *** indicates that Mo?Mo bonds and terminal S?S ligands play synergistic roles in facilitating hydrogen evolution,likely via the internal reorganization of trinuclear Mo3?thio *** nature and role of metal‐ligand interactions in the HER revealed in this study demonstrated a mechanism that is distinct from those reported previously in which the S or Mo sites function independently.

关键词： Hydrogen evolution reaction Molybdenum sulfide Electrocatalyst In‐situ Raman spectroscopy Artificial photosynthesis Clean energy

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Determining antimicrobial resistance profiles and identifying novel mutations of Neisseria gonorrhoeae genomes obtained by multiplexed MinION sequencing

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Science China(life Sciences) 2020年第7期63卷 1063-1070页

作者： Chi Zhang Feng Wang Cansheng Zhu Leshan Xiu yamei li li li Bo liu Yizhun li Yaling Zeng Boyang Guo Junping Peng NHC Key Laboratory'of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176China Shenzhen Center for Chronic Disease Control Shenzhen 518020China Department of STD Laboratory Shaanxi Provincial Institute for Skin Disease and STD ControlXi'an 710003China

Gonorrhea is one of the most common sexually transmitted diseases worldwide. To cure infection and prevent transmission,timely and appropriate antimicrobial therapy is necessary. Unfortunately, Neisseria gonorrhoeae, the etiological agent of gonorrhea, has acquired nearly all known mechanisms of antimicrobial resistance(AMR), thereby compromising the efficacy of antimicrobial therapy. Treatment failure resulting from AMR has become a global public health concern. Whole-genome sequencing is an effective method to determine the AMR characteristics of N. gonorrhoeae. Compared with next-generation sequencing, the MinION sequencer(Oxford Nanopore Technologies(ONT)) has the advantages of long read length and portability. Based on a pilot study using MinION to sequence the genome of N. gonorrhoeae, we optimized the workflow of sequencing and data analysis in the current study. Here we sequenced nine isolates within one flow cell using a multiplexed sequencing strategy. After hybrid assembly with Illumina reads, nine integral circular chromosomes were obtained. By using the online tool Pathogenwatch and a BLAST-based workflow, we acquired complete AMR profiles related to seven classes of antibiotics. We also evaluated the performance of ONT-only assemblies. Most AMR determinants identified by ONT-only assemblies were the same as those identified by hybrid assemblies. Moreover, one of the nine assemblies indicated a potentially novel antimicrobial-related mutation located in mtrR which results in a frame-shift, premature stop codon, and truncated *** addition, this is the first study using the MinION sequencer to obtain complete genome sequences of N. gonorrhoeae strains which are epidemic in China. This study shows that complete genome sequences and antimicrobial characteristics of *** can be obtained using the MinION sequencer in a simple and cost-effective manner, with hardly any knowledge of bioinformatics required. More importantly, this strategy provid

关键词： nanopore sequencing MinION sequencer Neisseria gonorrhoeae whole-genome sequencing antimicrobial resistance

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Genetic Variations and Nonalcoholic Fatty liver Disease:Field Synopsis,Systematic Meta-Analysis,and Epidemiological Evidence

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Biomedical and Environmental Sciences 2024年第7期37卷 762-773页

作者： yamei li Xiang Xiao Jie Wang Yixu liu Xiongfeng Pan Haibin Yu Jiayou Luo Miyang Luo Department of Epidemiology and Health Statistics School of Public HealthUniversity of South ChinaHengyang 421001HunanChina Department of Maternal and Child Health Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina Supervision and Inspection Department of Shanghai Healthcare Security Bureau Shanghai 200003China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410008HunanChina

Objective To systematically summarize the published literature on the genetic variants associated with nonalcoholic fatty liver disease(NAFLD).Methods literature from Web of Science,PubMed,and Embase between January 1980 and September 2022 was systematically ***-analyses of the genetic variants were conducted using at least five data *** epidemiologic credibility of the significant associations was graded using the Venice *** Based on literature screening,399 eligible studies were included,comprising 381 candidate gene association,16 genome-wide association,and 2 whole-exome sequencing *** identified 465 genetic variants in 173 genes in candidate gene association studies,and 25 genetic variants in 17 genes were included in the *** meta-analysis identified 11 variants in 10 genes that were significantly associated with NAFLD,with cumulative epidemiological evidence of an association graded as strong for two variants in two genes(HFE,TNF),moderate for four variants in three genes(TM6SF2,GCKR,and ADIPOQ),and weak for five variants in five genes(MBOAT7,PEMT,PNPLA3,LEPR,and MTHFR).Conclusion This study identified six variants in five genes that had moderate to strong evidence of an association with NAFLD,which may help understand the genetic architecture of NAFLD risk.

关键词： Nonalcoholic fatty liver disease Genetic association study Genetic variant Systematic review Meta-analysis

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Comparative transcriptome analysis between rhesus macaques(Macaca mulatta) and crab-eating macaques(M. fascicularis)

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Zoological Research 2024年第2期45卷 299-310页

作者： Yu-Xiang Mao yamei li Zikun Yang Ning Xu Shilong Zhang Xuankai Wang Xiangyu Yang Qiang Sun Yafei Mao Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science&Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Genetic Evolution&Animal Models Chinese Academy of SciencesKunmingYunnan 650201China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China Zhiyuan College Shanghai Jiao Tong UniversityShanghai 200240China Center for Genomic Research International Institutes of MedicineFourth Affiliated HospitalZhejiang UniversityYiwuZhejiang 322000China

Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques(Macaca mulatta, MMU)and crab-eating macaques(M. fascicularis, MFA) serve as crucial nonhuman primate biomedical models with different phenotypes. To date, however, large-scale comparative transcriptome research between these two species has not yet been fully explored. Here, we conducted systematic comparisons utilizing newly sequenced RNA-seq data from84 samples(41 MFA samples and 43 MMU samples)encompassing 14 common tissues. Our findings revealed a small fraction of genes(3.7%) with differential expression between the two species, as well as 36.5% of genes with tissue-specific expression in both macaques. Comparison of gene expression between macaques and humans indicated that 22.6% of orthologous genes displayed differential expression in at least two tissues. Moreover,19.41% of genes that overlapped with macaque-specific structural variants showed differential expression between humans and macaques. Of these, the FAM220A gene exhibited elevated expression in humans compared to macaques due to lineage-specific duplication. In summary,this study presents a large-scale transcriptomic comparison between MMU and MFA and between macaques and humans. The discovery of gene expression variations not only enhances the biomedical utility of macaque models but also contributes to the wider field of primate genomics.

关键词： Crab-eating macaques Rhesus macaques Comparative transcriptomics Biomedical models Nonhuman primates RNA-seq Duplicated genes

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Source and level of dietary iron influence semen quality by affecting inflammation, oxidative stress and iron utilization levels in boars

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2044-2058页

作者： Yinghui Wu yamei li Yueyue Miao Hongkui Wei Hefeng Luo Chunxiao Ren Yawei Zhang Juan Chen Tanghong Wei Jiyan Deng Jian Peng Department of Animal Nutrition and Feed Science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China The Cooperative Innovation Center for Sustainable Pig Production Wuhan 400700China Frontiers Science Center for Animal Breeding and Sustainable Production Wuhan 430070China Dekon Food and Agriculture Group Chengdu 610000China Xingjia Bio-Engineering Co.Ltd Changsha 410011China

Background Boars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia,which suggested that the current level and form of iron supplementation in boar diets may be ***,56 healthy Topeka E line boars aged 15–21 months were randomly divided into 5 groups:basal diet supplemented with 96 mg/kg ferrous sulfate(FeSO_(4))and 54 mg/kg glycine chelated iron(Gly-Fe,control);80 mg/kg or 115 mg/kg Gly-Fe;80 mg/kg or 115 mg/kg methionine hydroxyl analogue chelated iron(MHA-Fe,from CalimetFe)for 16 *** effects of dietary iron supplementation with different sources and levels on semen quality in boars were *** 1)Serum Fe and hemoglobin concentrations were not affected by reduced dietary iron levels in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups compared with the control group(P>0.05).2)Serum interleukin-6(IL-6)and sperm malondialdehyde(MDA)levels in the 80 mg/kg or 115 mg/kg MHA-Fe groups were lower than those in the control group(Plity in boars was not evident.5)Serum IL-6 level was positively correlated with hepcidin concentration(Plity ***

关键词： Adult boars Iron level Iron source Iron status Semen quality

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Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae

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Science China(life Sciences) 2024年第2期67卷 421-423页

作者： Chi Zhang Lulu Zhang Feng Wang Yaling Zeng liying Sun Di Wang yamei li liqin Wang Junping Peng NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100176China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical SciencesBeijing 100730China Shenzhen Center for Chronic Disease Control Shenzhen 518020China

Dear Editor,Bacterial antimicrobial resistance(AMR)poses a serious threat to global human health(Antimicrobial Resistance Collaborators,2022).Comprehensive profiling of AMR and accurate molecular typing are important for tracking and controlling the emergence and dissemination of antibiotic-resistant bacteria(Yahara et al.,2021).We previously developed a multiplex amplicon sequencing-based method for directly sequencing AMR-related loci in *** from clinical samples(Zhang et al.,2021).

关键词： gonorrhoeae resistance

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不同拉伸方式对健康人膝关节肌肉力量及垂直纵跳表现的即刻影响

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中国组织工程研究 2025年第18期29卷 3784-3790页

作者：赵禹涵李亚梅闫士芳姜华北河北体育学院河北省石家庄市050000 河北中医药大学河北省石家庄市050299

背景:静态拉伸可有效改善关节运动幅度,而动态拉伸通过肌肉的激活后增强效应,有效提高肌肉力量及运动表现。目的:探讨不同类型的拉伸方式对膝关节肌肉力量及垂直纵跳表现产生的即刻影响,为寻求最佳拉伸方案、提高运动表现、预防训练损... 详细信息

背景:静态拉伸可有效改善关节运动幅度,而动态拉伸通过肌肉的激活后增强效应,有效提高肌肉力量及运动表现。目的:探讨不同类型的拉伸方式对膝关节肌肉力量及垂直纵跳表现产生的即刻影响,为寻求最佳拉伸方案、提高运动表现、预防训练损伤提供理论支撑。方法:随机招募30名健康大学生,采用Biodex等速肌力测试仪、Qualisys红外动作捕捉系统及AMTI三维测力台分别采集股四头肌/腘绳肌静态拉伸、股四头肌/腘绳肌动态拉伸、股四头肌动态/腘绳肌静态拉伸、股四头肌静态/腘绳肌动态拉伸后的膝关节肌肉力量及垂直纵跳数据,利用膝关节峰值力矩、平均功率、纵跳高度、垂直地面反作用力峰值及关节运动幅度评估膝关节肌肉力量及垂直纵跳表现。结果与结论:(1)与股四头肌/腘绳肌静态拉伸相比,股四头肌/腘绳肌动态拉伸可显著提高膝关节峰值力矩、平均功率及纵跳高度(P<0.05),股四头肌动态/腘绳肌静态拉伸和股四头肌静态/腘绳肌动态拉伸分别提高伸膝和屈膝峰值力矩和平均功率(P<0.05);(2)与股四头肌/腘绳肌静态拉伸相比,股四头肌静态/腘绳肌动态拉伸后的第二垂直地面反作用力峰值显著下降(P<0.05);股四头肌/腘绳肌动态拉伸后的下肢关节运动幅度显著增加(P<0.05);(3)提示即刻的原动肌/拮抗肌动态拉伸和原动肌动态/拮抗肌静态拉伸可显著提高膝关节肌肉力量、垂直纵跳表现及关节运动幅度;较大的运动幅度有利于提高运动表现,并在着地时更好地吸收地面冲击力;同时,原动肌动态/拮抗肌静态拉伸对膝关节肌肉力量的提升效果优于原动肌/拮抗肌动态拉伸,原动肌静态拉伸/拮抗肌动态拉伸有利于提高垂直纵跳落地时的能量吸收能力,降低落地时损伤的风险。

关键词：动态拉伸静态拉伸原动肌拮抗肌膝关节等速肌力垂直纵跳组织化工程构建

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lipid Metabolism Coordinates UPRmt Induced by Decreased TCA Cycle Function In ***

Lipid Metabolism Coordinates UPRmt Induced by Decreased TCA ...

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第三届中国生物物理学会代谢生物学分会学术研讨会

作者：杨仁丹 yamei li Weizhen li Bin liang 昆明动物研究所 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences ＆ Yunnan Province Kunming Institute of ZoologyCAS College of Animal Medicine Yunnan Agricultural University

＜正＞The mitochondrial unfloded protein response （UPRmt） is a defensive means of mitochondrial self *** the misfolded protein in the mitochondria accumulates,mitochondrial will induce UPRmt to degradate the misfolded *** then transfer the signal to the nucleus to upregulate of protective *** this study,we find that mitochondrial perturbation caused by

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