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Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynow.ka Bartosz Karaszew.ki Grzegorz w.grzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow.and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and ow.ng to their prevalence,severity.

关键词： organs Alzheimer death

Recent Advances in High Pressure and Temperature Rheological Studies

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Journal of Earth Science 2010年第5期21卷 495-516页

作者： Nadege Hilairet Przemyslaw.dera Center for Advanced Radiation Sources The University of Chicago 5640 South Ellis Avenue Chicago Illinois 60637 USA

Rheological studies at high pressure and temperature using in-situ X-ray diffraction and imaging have made significant progresses in recent years, thanks to a combination of recent developments in several areas：（1） advances in synchrotron X-ray techniques, （2） advances in deformation devices and the abilities to control pressure, temperature, stress, strain and strain rates, （3） theoretical and computational advances in stress determination based on pow.er and single crystal diffraction, （4） theoretical and computational advances in modeling of grain-level micromcchanics based on elasto-plastic and visco-plastic self-consistent formulations. In this article, w. briefly introduce the experimental techniques and theoretical background for in-situ high pressure, high temperature rheological studies, and then review.recent studies of rheological properties of major mantle materials. Some currently encountered issues have prompted developments in single-crystal quasi-Laue diffraction for complete stress tensor determination and textural evolution of poly-phased composites based on X-ray microtomography. Future prospects are discussed.

关键词： rheology deformation composite synchrotron radiation high pressure and high temperature diffraction tomography.

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last tw. decades,the dogma that cell fate is immutable has been increasingly challenged,w.th important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is pow.rful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates w.thout first passing through a stem cell state.

关键词： programming passing proof

Viscosity behavior of magnetic suspensions in fluid-assisted finishing

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Progress in Natural Science:Materials International 2008年第1期18卷 91-96页

作者： yam Yeung China Department of Mechanical and Automation Engineering The Chinese University of Hong Kong New.Territories Shatin

Magnetic fluid-assisted finishing has been verified both theoretically and experimentally as an effective fabrication technology for opti- cal mirrors and *** purpose of this paper is to introduce a novel design of polishing tool and demonstrate the possible applica- tions of this *** w.rk includes studying the viscosity of the magnetic suspensions of micrometer-sized Carbonyl iron particles under the influence of a magnetic *** the cases of magnetizable suspension w.th and w.thout abrasive cerium oxide par- ticles are studied for their ensuing polishing *** of material removal function is conducted using a w.ko Nat1100 *** to reduce surface roughness w.th the proposed tool are also performed using a K9 mirror as the *** show.that the surface accuracy is improved over three times to less than 0.5 nm after tw. cycles of polishing.

关键词： Surface roughness Micro-structure Super-smooth Fluid-assisted finishing Material removal rate

Linear-scaling computation of excited states in time-domain

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Science China Chemistry 2014年第1期57卷 70-77页

作者： yam ChiYung CHEN GuanHua Department of Chemistry The University of Hong Kong Beijing Computational Science Research Center

The applicability of quantum mechanical methods is severely limited by their poor *** circumvent the problem,linearscaling methods for quantum mechanical calculations had been *** physical basis of linear-scaling methods is the locality in quantum mechanics w.ere the properties or observables of a system are w.akly influenced by factors spatially far *** the substantial efforts spent on devising linear-scaling methods for ground state,there is also a grow.ng interest in the development of linear-scaling methods for excited *** review.gives an overview.of linear-scaling approaches for excited states solved in real time-domain.

关键词： linear-scaling methods,quantum chemistry,time-domain,density matrix

Optimal Selling Time in Stock Market over a Finite Time Horizon

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Acta Mathematicae Applicatae Sinica 2012年第3期28卷 557-570页

作者： S.C.P.yam S.P.YUNG w.ZHOU The Chinese University of Hong Kong China The University of Hong Kong China

In this paper, w. examine the best time to sell a stock at a price being as close as possible to its highest price over a finite time horizon [0, T], w.ere the stock price is modelled by a geometric Brow.ian motion and the ＇closeness＇ is measured by the relative error of the stock price to its highest price over [0, T]. More precisely, w. w.nt to optimize the expression：V^＊=sup 0≤τ≤T E[Vτ/MT],w.ere （Vt）t≥0 is a geometric Drow.ian motion w.th constant drift α and constant volatility σ 〉 0, Mt = max Vs 0≤a〈t is the running maximum of the stock price, and the supremum is taken over all possible stopping times 0 ≤ τ≤T adapted to the natural filtration （Ft）t≥0 of the stock price. The above problem has been considered by Shiryacv, Xu and Zhou （2008） and Du Toit and Peskir （2009）. In this paper w. provide an independent proof that w.en α=1/ 2 σ^2 , a selling strategy is optimal if and only if it sells the stock either at the terminal time T or at the 1 2 moment w.en the stock price hits its maximum price so far. Besides, w.en α 〉1/2σ^2 , selling the stock at the terminal time T is the unique optimal selling strategy. Our approach to the problem is purely probabilistic and has been inspired by relating the notion of dominant stopping pr of a stopping time τ to the optimal stopping strategy arisen in the classical ＂Secretary Problem＂.

关键词： optimal Stopping stock selling buy and hold local time

The Strategy of Escalation and Negotiation: The Iran Nuclear Dispute

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Journal of Systems Science and Systems Engineering 2019年第4期28卷 434-448页

作者： Tobias w. Langenegger Keith w. Hipel Department of Management Technology and Economics ETH Zurich Zurich Switzerland Department of Systems Design Engineering University of Waterloo Waterloo Ontario Canada

The strategic decisions and resulting consequences surrounding the conflict betw.en the United States of America (US) and Iran regarding the Iranian nuclear program are formally investigated using a flexible decision methodology called the Graph Model for Conflict Resolution (GMCR). This highly controversial dispute caught the w.rld's attention as concerns w.re grow.ng that Iran w.uld reach a position w.ere it w.uld be able to build nuclear w.apons, thereby posing a risk to w.rld security. w.ile Iran insisted on its rights for the peaceful use of nuclear technology;the international community;led by the US, tried to discourage the nuclear activities of Iran to ensure its obligations to the non-proliferation of nuclear w.apons. This led to an escalation of tension on both sides, w.th an extension of the nuclear program by Iran and an increase in sanctions by the US, before it w.s possible to arrive at a negotiated agreement. As demonstrated in this paper, a systematic GMCR investigation provides valuable strategic insights into this important conflict. Further, it illustrates w.ys in w.ich the conflict could have evolved, as w.ll as mechanisms for stopping an escalation like this in the future.

关键词： Negotiation Graph Model for Conflict Resolution Iran US nuclear security economic sanctions

Tow.rd understanding Cretaceous climate An updated review

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Science China Earth Sciences 2017年第1期60卷 5-19页

作者： w.lliam w. HAY Department of Geological Sciences and University Museum University of Colorado at Boulder 2045 Windcliff Dr. Estes Park CO 80517 USA

New.data and ideas are changing our view.of conditions during the *** of the continents w.s low.r than originally thought,eliminating the'cold continental interior paradox'of fossils of plants that could not tolerate freezing occurring in regions indicated by climate models to be w.ll below.freezing in *** controversy over the height of Cretaceous sea levels has been resolved by know.edge of the effects of passage of the subducted slab of the Farallon Plate beneath the North American *** cause of shorter term sea level changes of the order of 30 to 50 meters is not because of grow.h and decay of ice sheets,but more likely the filling and release of w.ter from groundw.ter reservoirs and lakes although there may have been some ice in the Early and latest *** dioxide w.s not the only significant greenhouse gas;methane contributed significantly to the w.rmer *** of very w.rm tropical ocean temperatures(>40℃)have implications for the nature of plant life on land limited by Rubisco *** land surfaces w.re much w.tter than has been thought,w.th meandering rivers and many oxbow.lakes providing habitat for large dinosaurs.A major rethinking of the nature of conditions on a w.rmer Earth is underw.y,and a new.suite of paleoclimate simulations for the Cretaceous is needed.

关键词： Cretaceous Paleogeography Paleotopography Sea level Greenhouse Paleohydrology Paleoclimate

DEM prediction of industrial and geophysical particle flow.

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Particuology 2010年第2期8卷 106-118页

作者： Paul w. Cleary CSIRO Mathematical and Information Sciences Private Bag 33 Clayton South 3169 Australia

Simulation of industrial particle flow. using DEM （Discrete Element Method） offers the opportunity for better understanding of the flow.dynamics by the inclusion of particle scale physics that often determine the nature of these flow.. Increased understanding from the models can lead to improvements in equip- ment design and operation, potentially leading to large increases in equipment and process efficiency, throughput and]or product quality. Industrial applications are typically large and involve complex par- ticulate behaviour in complex geometries. This paper explores the critical influence of particle shape on granular system behaviour and then discusses examples of DEM applied to several large industrial problems. 2009 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. All rights reserved.

关键词： DEMGranular flow.andslideMillScreenMixing