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坚持问题导向、学理支撑,提高干部在线培训的针对性和实效性

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科教文汇 2014年第33期 5-7页

作者：张敏江亚玲孙文豪于海滨王哲赵志宏中共大连市委党校辽宁大连116013

几年来大连市干部在线学习坚持问题导向,学理支撑,增强网络培训的针对性和实效性。在组织管理运行机制、网络远程教学教务管理、在线培训方式、课程资源规划建设、在线培训学科建设等方面不断探索,创新实践。

关键词：在线培训课程资源建设教学教务管理

便秘贴联合莫沙必利治疗慢传输型便秘临床观察

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中国中医药现代远程教育 2019年第15期17卷 57-59页

作者：杨伟兴曾俊向未王天刚冯雯蒋亚玲李兵西南医科大学附属中医医院脾胃科四川泸州646000 大邑县中医院脾胃科四川大邑611300

目的探讨便秘贴治疗慢传输型便秘的临床疗效。方法选取我科2017年6月—2018年10月慢传输型便秘的患者60例,随机分成观察组和对照组,各30例。观察组采取便秘贴与莫沙必利联合治疗,对照组用莫沙必利治疗,比较2组患者的总体疗效。结果观察... 详细信息

目的探讨便秘贴治疗慢传输型便秘的临床疗效。方法选取我科2017年6月—2018年10月慢传输型便秘的患者60例,随机分成观察组和对照组,各30例。观察组采取便秘贴与莫沙必利联合治疗,对照组用莫沙必利治疗,比较2组患者的总体疗效。结果观察组患者总体疗效优于对照组,观察组治愈率26.7%,显效率50.0%,有效率23.3%,无效率0.0%;而对照组治愈率0.0%,显效率23.3%,有效率53.3%,无效率23.3%,差异显著(P<0.01)。结论便秘贴能有效提高临床疗效,缓解慢传输型便秘患者相关症状。

关键词：便秘贴莫沙必利慢传输型便秘外治法

Berberine improves central memory formation of CD8^(+)T cells:Implications for design of natural product-based vaccines

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2259-2268页

作者： Mingyan Li yaling Wang Lingzhi Zhang Changxing Gao Jing JLi Jiandong jiang Qing Zhu State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation StudyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization Yunnan University of Chinese MedicineYunnan 650500China

Berberine(BBR)as one of the most effective natural products has been increasingly used to treat various chronic diseases due to its immunosuppressive/tolerogenic ***,it is unknown if BBR can be applied without abrogating the efforts of *** we show that priming of CD8^(+)T cells in the presence of BBR lead to improved central memory formation(Tcm)with substantially reduced effector proliferation,primarily orchestrated through activation of AMPK and *** derived from vaccinated mice fed with BBR were able to adoptively transfer protective immunity to naIve *** of BBR-fed mice conferred better memory protection against infection without losing immediate effector efficacy,suggesting appreciable benefits from using BBR in ***,our study may help to lay the groundwork for mechanistic understanding of the immunomodulatory effects of natural products and their potential use as adjuvant that allows the design of novel vaccines with more desirable properties.

关键词： Berberine CD8^(+)T cell T cell priming Central memory AMPK Stat5 Vaccine design Naturally occurring compound

参苓白术散加减配合针灸治疗脾胃虚寒型胃脘痛的临床疗效研究

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反射疗法与康复医学 2020年第16期1卷 25-27页

作者：李丽冯雯蒋亚玲陈辉赵龙杨伟兴王天刚肖国辉西南医科大学附属中医医院脾胃风湿免疫病科四川泸州646000

目的探究参苓白术散加减配合针灸治疗脾胃虚寒型胃脘痛的临床疗效.方法选取2019年3月—2020年3月在西南医科大学附属中医医院进行治疗的脾胃虚寒型胃脘痛患者72例为研究对象,按照随机数字表法分为观察组及对照组,每组36例.应用参苓白术... 详细信息

目的探究参苓白术散加减配合针灸治疗脾胃虚寒型胃脘痛的临床疗效.方法选取2019年3月—2020年3月在西南医科大学附属中医医院进行治疗的脾胃虚寒型胃脘痛患者72例为研究对象,按照随机数字表法分为观察组及对照组,每组36例.应用参苓白术散加减配合针灸治疗的为观察组,单纯应用针灸治疗的为对照组.对比两组临床疗效、胃脘痛程度评分、生活质量、心理状态评分情况.结果观察组的临床治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后观察组的胃脘痛程度评分明显低于对照组,差异有统计学意义(P<0.05);观察组的社会、躯体、环境、心理、综合的生活质量评分均显著高于对照组,差异有统计学意义(P<0.05).结论针对脾胃虚寒型胃脘痛患者采用参苓白术散加减配合针灸治疗,可帮助患者快速康复,改善其生活质量,降低胃脘痛程度,取得显著治疗效果,具有临床应用价值.

关键词：脾胃虚寒胃脘痛参苓白术散加减

Mild hyperthermia-enhanced chemo-photothermal synergistic therapy using doxorubicin-loaded gold nanovesicles

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Chinese Chemical Letters 2021年第8期32卷 2411-2414页

作者： Zhuoting Deng Chao jiang Muhammad Rizwan Younis Shan Lei yaling He Haoxing Zheng Peng Huang Jing Lin Marshall Laboratory of Biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Health Science CenterShenzhen 518060China

Gold nanovesicles(GVs) with unique plasmonic property and large cavity hold great potential as a stimuli-responsive nanocarrier to deliver drugs for efficient tumor chemotherapy and other therapies ***,we developed doxorubicin-loaded gold nanovesicles(DGVs),offering infrared thermal(IRT) and photoacoustic(PA) dual-modal imaging guided mild hype rthermia-enhanced chemophotothermal cancer synergistic *** DGVs are self-assembled by gold nanoparticles modified with amphiphilic copolymer in a predetermined concentration of doxorubicin through film rehydration *** the influence of laser excitation,the as-prepared DGVs exhibited good photothermal effect,which triggered the structural disruption of GVs and thus,allowed the efficient release of encapsulated DOX to enhance cell uptake for fluorescence imaging and tumor chemotherapy,*** addition,DGVs also showed a strong PA and IRT signals in *** study demonstrated the potential of DGVs as stimuli-responsive drug delivery systems and cancer theranostics.

关键词： Mild hyperthermia Chemo-photothermal synergistic therapy Gold nanovesicles Doxorubicin Photoacoustic imaging

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集中供热热力站短期热负荷预测模型对比研究

区域供热 2024年第1期 146-158页

作者：果泽泉何波何强周继平蒋雅玲张凡陈超郭放鄢烈详京能东风(十堰)能源发展有限公司湖北十堰442000 汉谷云智(武汉)科技有限公司湖北武汉430000

以湖北省十堰市一个集中供热热力站为对象,基于实测运行数据和气象数据进行供热负荷预测研究。分别采用随机森林(Random Forest,RF)、极度梯度提升(eXtreme Gradient Boosting,XGBoost)、BP神经网络、支持向量回归(Support Vector Regre... 详细信息

以湖北省十堰市一个集中供热热力站为对象,基于实测运行数据和气象数据进行供热负荷预测研究。分别采用随机森林(Random Forest,RF)、极度梯度提升(eXtreme Gradient Boosting,XGBoost)、BP神经网络、支持向量回归(Support Vector Regression,SVR)、长短期记忆(Long Short Term Memory,LSTM)神经网络5种方法进行预测模型训练及测试,基于粒子群优化算法(Particle Swarm Optimization,PSO)优化各模型参数,获得最优模型,在此基础上针对不同模型在不同短期负荷预测情景下的表现进行对比研究。研究结果表明:在未来24h预测情景下,随机森林、XGBoost模型的预测精度最高,二者的平均绝对误差(MAE)分别为0.84 W/m^(2)及1.00 W/m^(2)。在未来1h预测情景下,SVR模型的预测精度最高,其MAE为0.18 W/m^(2)。

关键词：集中供热负荷预测随机森林极度梯度提升 BP神经网络支持向量回归长短期记忆神经网络

Independent and Combined Associations of Sleep Duration, Bedtime, and Polygenic Risk Score with the Risk of Hearing Loss among Middle-Aged and Old Chinese: The Dongfeng–Tongji Cohort Study

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Research 2024年第1期2023卷 721-733页

作者： Miao Liu Haiqing Zhang Zhichao Wang Tingting Mo Xuefeng Lai yaling He Minghui jiang Meian He Weijia Kong Tangchun Wu Xiaomin Zhang Department of Occupational and Environmental Health Ministry of Education Key Laboratory of Environment and Healthand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Evidence available on the independent and combined associations of sleep duration,bedtime,and genetic predisposition with hearing loss was *** present study included 15,827 participants from the Dongfeng–Tongji cohort *** risk was characterized by polygenic risk score(PRS)based on 37 genetic loci related to hearing *** conducted multivariate logistic regression models to assess the odds ratio(OR)for hearing loss with sleep duration and bedtime,as well as the joint association and interaction with *** showed that hearing loss was independently associated with sleeping≥9 h/night compared to the recommended 7 to9:00 *** 10:00 *** to those with bedtime>10:00 *** 11:00 p.m.,with estimated ORs of 1.25,1.27,and 1.16,respectively.

关键词： Middle hearing fen

柴黄清胰活血颗粒对重症急性胰腺炎大鼠胰腺组织细胞自噬的影响

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重庆医学 2023年第24期52卷 3699-3706页

作者：蒋亚玲张雨森冯雯王天刚陈辉向未李翼王阳洋李丽西南医科大学附属中医医院脾胃科四川泸州646000

目的观察柴黄清胰活血颗粒对重症急性胰腺炎(SAP)大鼠胰腺组织细胞自噬的影响。方法将SD大鼠随机分为假手术组(SO组)、SAP组和柴黄清胰活血颗粒治疗组(CH组),应用3.5%牛磺胆酸钠建立SAP模型,CH组予以柴黄清胰活血颗粒灌胃,SO组和SAP... 详细信息

目的观察柴黄清胰活血颗粒对重症急性胰腺炎(SAP)大鼠胰腺组织细胞自噬的影响。方法将SD大鼠随机分为假手术组(SO组)、SAP组和柴黄清胰活血颗粒治疗组(CH组),应用3.5%牛磺胆酸钠建立SAP模型,CH组予以柴黄清胰活血颗粒灌胃,SO组和SAP组予以生理盐水灌胃,12、24 h分批处死大鼠。苏木素-伊红(HE)染色对胰腺组织进行病理学评价;Western blot检测自噬效应蛋白(Beclin-1)、微管相关蛋白1轻链3-Ⅰ(LC3-Ⅰ)、微管相关蛋白1轻链3-Ⅱ(LC3-Ⅱ)、可溶/不可溶自噬底物募集蛋白(Soluble/Insoluble p62)、溶酶体相关膜蛋白2(LAMP2)相对表达水平;免疫荧光双染色法检测LC3表达,并进行LC3和Insulin共定位分析。结果 12、24 h时,与SO组比较,SAP组和CH组病理学评分明显升高,LC3-Ⅱ/LC3-Ⅰ、Beclin-1、LAMP2、p62(Insoluble)相对表达水平明显升高,p62(Soluble)相对表达水平明显降低,LC3免疫荧光强度升高,差异有统计学意义(P0.05)。蛋白共定位分析结果显示,SAP组LC3和胰岛素(Insulin)在胰岛细胞的细胞质区域、分泌颗粒区域中均有分布,SO组及CH组未见明显共定位表现。结论柴黄清胰活血颗粒可抑制SAP大鼠胰腺组织Beclin-1、LC3-Ⅱ/LC3-Ⅰ、p62(Insoluble)、LAMP2相对表达水平,从而抑制SAP中异常活跃自噬,提高自噬通量,发挥对胰腺细胞的保护作用。

关键词：柴黄清胰活血颗粒自噬自噬通量重症急性胰腺炎

A botanical medicine dragon’s blood exhibited clinical antithrombosis efficacy similar to low molecular weight heparin

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Science China(Life Sciences) 2021年第10期64卷 1691-1701页

作者： jiangbin Liang Song Mei Xiangyu Qiao Wei Pan Yan Zhao Shaohui Shi yaling Zhai Haizhao Wen Guoping Wu Chengyu jiang Department of Orthopaedic Trauma Aviation General HospitalBeijing 100012China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical CollegeBeijing 100005China

Deep vein thrombosis(DVT)is a common complication following traumatic fracture with a 0.5%–1%annual *** molecular weight heparin(LMWH)is the most commonly used anticoagulation drug for DVT prevention,but treatment with LMWH is *** aim is to compare the antithrombotic effect of dragon’s blood,an oral botanical anticoagulant medicine approved by the Chinese FDA,with LMWH in patients undergoing hip fracture surgery and to explore the molecular mechanisms of anticoagulation *** study recruited patients and divided them into LMWH and dragon’s blood treatment *** index tests,Doppler ultrasound and mRNA sequencing were performed before and after anticoagulation *** was no significant difference in postoperative DVT incidence between the two groups(23.1%versus 15.4%,P=0.694).D-dimer(D-D)and fibrinogen degradation product(FDP)showed significant reductions in both groups after anticoagulation *** identified SLC4A1,PROS1,PRKAR2B and seven other genes as being differentially expressed during anticoagulation therapy in both *** correlated with coagulation indexes were also ***’s blood and LMWH showed similar effects on DVT and produced similar gene expression changes in patients undergoing hip fracture surgery,indicating that dragon’s blood is a more convenient antithrombosis medicine(oral)than LMWH(hypodermic injection).

关键词： dragon’s blood low molecular weight heparin deep vein thrombosis transcriptome