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Integrative Zoology 2024年第2期19卷 339-342页

作者： yalin cheng Fumin LEI College of Life Science/Hebei Basic Science Center for Biotic Interactions Institute of Life Science and Green DevelopmentHebei UniversityBaodingChina Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingChina

The beak is a key evolutionary innovation in the avian tree of *** diversity in morphology shows birds’successful colonization of various ecological niches on the Earth(Pigot et al.2020),and its morphological plasticity can also enable birds to rapidly respond to changes in environments(Grant&Grant 2006).These natures helped birds survive multiple extinction events(Larson et al.2016).Therefore,investigating the morphological evolution of avian beaks and the underlying developmental and molecular mechanisms will help to decipher the evolution of birds and boost the development of the theory of evolutionary biology.

关键词： coordinate extinction enable

Metabolic and microbial changes in light-vented bulbul during recent northward range expansion

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Current Zoology 2024年第1期70卷 24-33页

作者： Yun Wu Ying Xiong Yanzhu Ji yalin cheng Qianghui Zhu Xiaolu Jiao Yongbin Chang Na Zhao Jing Yang Fumin Lei Gang Song Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China College of Life Science University of Chinese Academy of SciencesBeijing 100049China Department of Zoology College of Life scienceSichuan Agricultural UniversityYa'an 625099SichuanChina Henan Engineering Research Center of Bird-Related Outage Zhengzhou Normal UniversityZhengzhou 450044China School of Ecology and Environment Anhui Normal UniversityWuhu 241002AnhuiChina School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXian 710021China Centerfor Excellence inAnimal Evolutionand Genetics Chinese Academy of SciencesKunming 650223China

Endotherms recently expanding to cold environments generally exhibit strong physiological acclimation to sustain high body *** this process,gut microbes likely play a considerable role in host physiological functions,including digestion and *** light-vented bulbul Pycnonotus sinensis represents one such *** used to be restricted to the Oriental realm but expanded its distribution range north to the Palearctic areas during the past few ***,we explored the seasonal dynamics of the resting metabolic rate(RMR)and microbiota for local and newly colonized populations of the *** results showed that the mass-adjusted RMR and body mass were pos-itively correlated with latitude variations in both ***,the gut microbiota showed a corresponding variation to the northern cold *** the two northern populations,the alpha diversity decreased compared with those of the two southern *** differences were detected in dominant phyla,such as Firmicutes,Bacteroidetes,Proteobacteria,and Desulfobacterota in both *** core microbiota showed geographic differences in the winter,including the elevated relative abundance of 5 species in northern ***,to explore the link between microbial communities and host metabolic thermogenesis,we conducted a correlation analysis between microbiota and mass-adjusted *** found that more genera were significantly correlated with mass-adjusted RMR in the wintering season compared to the breeding season(71 vs.23).These results suggest that microbiota of the lighted-vented bulbul linked with thermogenesis in diversity and abundance under northward expansion.

关键词： bird body mass gutmicrobiota RMR season

经济支持对我国老年人医疗卫生服务利用的影响:基于健康状况的中介效应

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中国卫生事业管理 2024年第4期41卷 405-409,414页

作者：程亚林代涛郑英李力北京协和医学院北京100020 中国医学科学院医学信息研究所中国医学科学院卫生政策与管理研究中心

目的:基于健康状况的中介作用,分析经济支持、健康状况对我国老年人医疗卫生服务利用的影响机制。方法:将社会支持理论和安德森模型相结合,构建经济支持、健康状况对我国老年人医疗卫生服务利用影响机制的分析框架,并形成研究假设;利用2... 详细信息

目的:基于健康状况的中介作用,分析经济支持、健康状况对我国老年人医疗卫生服务利用的影响机制。方法:将社会支持理论和安德森模型相结合,构建经济支持、健康状况对我国老年人医疗卫生服务利用影响机制的分析框架,并形成研究假设;利用2021中国综合社会调查数据与结构方程模型,对假设进行验证。结果:(1)家庭经济支持对我国老年人健康状况、医疗卫生服务利用均具有显著直接正向影响(P均<0.001);(2)家庭经济支持对我国老年人医疗卫生服务利用的影响效应,受老年人健康状况的“遮掩”,直接效应为0.140(P<0.001),间接效应为-0.152(P<0.001),总效应为-0.012,总效应不显著;(3)社会经济支持对我国老年人健康状况和医疗卫生服务利用均无显著直接影响;(4)社会经济支持通过中介变量(家庭经济支持),对我国老年人健康状况产生间接影响(P<0.001);(5)健康状况对我国老年人医疗卫生服务利用具有显著负向影响(P<0.001)。结论:现阶段家庭经济支持对我国老年人医疗卫生服务需求释放、健康状况提升发挥着更加直接与重要的作用,而社会经济支持是家庭经济支持的有效补充。建议发挥政府主导作用,不断完善多层次、多来源的经济支持保障体系,推进居家社区医养结合服务体系建设,有效满足老年人医疗卫生服务需求,保障老年人群健康权益。

关键词：人口老龄化经济支持医疗卫生服务利用

微卫星不稳定性在头颈部鳞状细胞癌中的研究进展

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中华病理学杂志 2024年第6期53卷 647-650页

作者：郭颖程亚林杨鑫鑫孟宏学哈尔滨医科大学附属肿瘤医院病理科哈尔滨150081 哈尔滨医科大学附属肿瘤医院精准医学中心哈尔滨150081

头颈部鳞状细胞癌患者可从抗程序性死亡受体1及其配体(PD-1/PD-L1)的免疫治疗中获益,但是相对较低的反应率阻碍了这种治疗方法在头颈部鳞状细胞癌治疗中的临床应用。而高度微卫星不稳定型肿瘤抗PD-1/PD-L1治疗的客观反应率较高。目前,... 详细信息

头颈部鳞状细胞癌患者可从抗程序性死亡受体1及其配体(PD-1/PD-L1)的免疫治疗中获益,但是相对较低的反应率阻碍了这种治疗方法在头颈部鳞状细胞癌治疗中的临床应用。而高度微卫星不稳定型肿瘤抗PD-1/PD-L1治疗的客观反应率较高。目前,国内关于头颈部鳞状细胞癌中微卫星不稳定性患病率、发病机制和临床疗效的数据有限。本文介绍微卫星不稳定性的发生机制及检测方法,总结微卫星不稳定性在头颈部鳞状细胞癌中的研究现状。

关键词：头颈部鳞状细胞癌微卫星不稳定临床疗效免疫治疗发病机制临床应用客观反应率患病率

Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds

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Integrative Zoology 2022年第6期17卷 1162-1178页

作者： Ying XIONG Yan HAO yalin cheng Liqing FAN Gang SONG Dongming LI Yanhua QU Fumin LEI Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Key Laboratory of Forest Ecology in Tibet Plateau of Ministry of Education Institute of Tibet Plateau EcologyTibet Agriculture&Animal Husbandry UniversityNyingchiChina Key Laboratory of Animal Physiology Biochemistry and Molecular Biology of Hebei ProvinceCollege of Life SciencesHebei Normal UniversityShijiazhuangChina Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingChina

Pectoralis phenotypic variation plays a fundamental role in locomotion and thermogenesis in highland ***-ever,its regulatory and metabolic mechanisms remain enigmatic to ***,we integrated phenomic,tran-scriptomic,and metabolomic approaches to determine muscle variation and its underpinning mechanisms across altitudinal *** conﬁrmed that all highland birds had considerable increases in muscle oxidative capacity,capillarity,and mitochondrial abundance in our ***,transcriptomic analyses found that differentially expressed genes in phenotype-associated modules enriched for blood vessel,muscle structure development,and mitochondrial *** similar traits and functional enrichments across highland birds,different mechanisms drove their occurrence in high-altitude tree sparrow and 2 snowﬁ***,a metabolic feature shared by all the 3 highland birds is the improvement in insulin sensitivity and glucose utilization through activating insulin signaling pathway,which is vital to increase muscle oxidative capacity and maintain metabolic ***,fatty acid biosynthesis and oxidation are enhanced in only 2 snowﬁnches which had a long evolutionary history on the high plateau,also differing from ketone body metabolism in recently introduced colonizer of the tree sparrow of the high *** study represents a vital contribution to reveal the regulatory and metabolic basis of pectoralis variation across altitudinal songbirds.

关键词： altitude gas chromatography–mass spectrometry hypoxia pectoralis RNA–seq

Phosphorylation of ZmAL14 by ZmSnRK2.2 regulates drought resistance through derepressing ZmROP8 expression

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Journal of Integrative Plant Biology 2024年第7期66卷 1334-1350页

作者： yalin Wang Jinkui cheng Yazhen Guo Zhen Li Shuhua Yang Yu Wang Zhizhong Gong State Key Laboratory of Plant Environmental Resilience Frontiers Science Center for Molecular Design BreedingCollege of Biological SciencesChina Agricultural UniversityBeijing 100193China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China College of Life Sciences Institute of Life Science and Green DevelopmentHebei UniversityBaoding 071002China

Drought stress has negative effects on crop growth and *** of transcription factors that regulate the expression of drought-responsive genes is critical for understanding the transcriptional regulatory networks in response to drought,which facilitates the improvement of crop drought ***,we identified an Alfin-like(AL)family gene ZmAL14 that negatively regulates drought *** of ZmAL14 exhibits susceptibility to drought while mutation of ZmAL14 enhances drought *** abscisic acid(ABA)-activated protein kinase ZmSnRK2.2 interacts and phosphorylates ZmAL14 at T38 *** of ZmSnRK2.2 gene decreases drought resistance of maize.A dehydration-induced Rho-like small guanosine triphosphatase gene ZmROP8 is directly targeted and repressed by *** of ZmAL14 by ZmSnRK2.2 prevents its binding to the ZmROP8 promoter,thereby releasing the repression of ZmROP8 *** of ZmROP8 stimulates peroxidase activity and reduces hydrogen peroxide accumulation after drought ***,our study indicates that ZmAL14 is a negative regulator of drought resistance,which can be phosphorylated by ZmSnRK2.2 through the ABA signaling pathway,thus preventing its suppression on ZmROP8 transcription during drought stress response.

关键词： ZmAL14 drought tolerance transcription factor maize

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实事求是地比较中西文论

文艺理论研究 2005年第4期 40-47页

作者：程亚林武汉大学文学院湖北武汉430072

实事求是是从事中西文论比较研究必须遵循的原则。本文以香港学者黄维梁先生在中西文论比较背景中研究刘勰文论的个案为例,证明遵循这一原则,就会取得令人满意的比较成果;反之,比较结论就不能令人信服。

关键词：中西文论实事求是香港学者黄维梁遵循刘勰

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陶渊明与“嗟来之食”——《有会而作》新解

武汉大学学报（人文科学版） 2006年第2期59卷 181-186页

作者：程亚林武汉大学文学院湖北武汉430072

与王瑶、逯钦立、袁行霈先生的理解不同,陶渊明《有会而作》一诗最值得注意的地方是提出了反传统的新观念:在生死关头,不包含改变社会政治文化根本立场这种无理要求的“嗟来之食”可食,体现了诗人尊重人的生命、鄙视并捐弃虚礼的思想。... 详细信息

与王瑶、逯钦立、袁行霈先生的理解不同,陶渊明《有会而作》一诗最值得注意的地方是提出了反传统的新观念:在生死关头,不包含改变社会政治文化根本立场这种无理要求的“嗟来之食”可食,体现了诗人尊重人的生命、鄙视并捐弃虚礼的思想。这是陶渊明思想中至今尚未被人发掘、重视的一个亮点。

关键词：陶渊明《有会而作》 “嗟来之食”

Larger in-plane upper critical field and superconducting diode effect observed in topological superconductor candidate InNbS_(2)nanoribbons

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Nano Research 2024年第7期17卷 6686-6694页

作者： Bo Zheng Changlong Wang Xukun Feng Xiaozhen Sun Shasha Wang Dawei Qiu Xiang Ma Ruimin Li Guanglei cheng Lan Wang yalin Lu Peng Li Shengyuan A.Yang Bin Xiang Department of Materials Science and Engineering CAS Key Lab of Materials for Energy ConversionAnhui Laboratory of Advanced Photon Science and TechnologyUniversity of Science and Technology of ChinaHefei 230026China Research Laboratory for Quantum Materials Singapore University of Technology and DesignSingapore 487372Singapore School of Microelectronics University of Science and Technology of ChinaHefei 230052China CAS Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Lab of Low Dimensional Magnetism and Spintronic Devices School of PhysicsHefei University of TechnologyHefei 230009China Research Laboratory for Quantum Materials IAPMEUniversity of MacaoMacaoChina

Recently,the coexistence of topology and superconductivity has garnered considerable ***,the dimensionality of these materials is crucial for the realization of topological quantum ***,the naturally grown materials,especially with one-dimensional feature that exhibits the coexistence of topology and superconductivity,still face challenges in terms of experimental realization and scalability,which hinders the fundamental research development and the potential to revolutionize quantum ***,we report the first experimental synthesis of quasi-one-dimensional InNbS_(2)nanoribbons that exhibit the coexistence of topological order and superconductivity via a chemical vapor transport ***,the inplane upper critical field of InNbS_(2)nanoribbons exceeds the Pauli paramagnetic limit by more than 2.2 times,which can be attributed to the enhanced spin-orbit coupling and the weakened interlayer interaction between the NbS_(2)layers induced by the insertion of In atoms,making InNbS_(2)exhibit spin-momentum locking similar to that of monolayer NbS_(2).Moreover,for the first time,we report the superconducting diode effect in a quasi-one-dimensional superconductor system without any inherent geometric *** measured maximum efficiency is manifested as 14%,observed atμ0H≈±60 mT,and we propose that the superconducting diode effect can potentially be attributed to the presence of the nontrivial topological *** work provides a platform for studying exotic phenomena in condensed matter physics and potential applications in quantum computing and quantum information processing.

关键词： topological order superconductivity nanoribbon superconducting anisotropy superconducting diode

Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows

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National Science Review 2020年第1期7卷 113-127页

作者： Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang yalin cheng Shane Du Bay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences BGI Genomics BGI-Shenzhen University of Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Committee on Evolutionary Biology University of Chicago Life Sciences Section Integrative Research Center Field Museum of Natural History Key Laboratory of Animal Physiology Biochemistry and Molecular Biology of Hebei Province College of Life Sciences Hebei Normal University Department of Bioinformatics and Genetics Swedish Museum of Natural History College of Life Sciences Shaanxi Normal University China National Gene Bank BGI-Shenzhen Human Genetics Genome Institute of Singapore Agency for Science Technology and Research

Known as the ‘third polar region’, the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there. Previous studies of birds, animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence. The adaptive processes during the initial phase of highland adaptation remain poorly understood. We studied a human commensal, the Eurasian Tree Sparrow, which has followed human agriculture to the Qinghai-Tibet Plateau. Despite strong phenotypic differentiation at multiple levels, in particular in muscle-related phenotypes, highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years. In a one-month acclimation experiment investigating phenotypic plasticity, we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes. Through population genetic analyses, we identified a signature of polygenic adaptation, whereby shifts in allele frequencies are spread across multiple loci, many of which are associated with muscle-related processes. Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution, shedding light on early stages of adaptive evolution to a novel environment.

关键词： denovo genome early stage adaptation high elevation muscle phenotypes polygenic adaptation regulatory evolution