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Corpus callosum in schizophrenia with deficit and non-deficit syndrome:a statistical shape analysis

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General Psychiatry 2021年第6期34卷 42-48页

作者： Yaşar Türk Ilker Ercan Ibrahim Sahin Basak Erdemli Gursel Arda Uzunoglu CemÖge Elmas Beyazyüz yakup albayrak Department of Radiology Medical Faculty of Bülent Ecevit UniversityKozluZonguldakTurkey Department of Biostatistics Bursa Uludag University Faculty of MedicineBursaTurkey Department of Radiology Bursa Uludag University Faculty of MedicineBursaTurkey Department of Psychiatry Çorlu State HospitalÇorluTurkey Department of Psychiatry Medical Faculty of Tekirdag Namık Kemal UniversityTekirdagTurkey

Background The corpus callosum(CC)is the most targeted region in the cerebrum that integrates cognitive data between homologous areas in the right and left *** Our study used statistical analysis to determine whether there was a correlation between shape changes in the CC in patients with schizophrenia(SZ)(deficit syndrome(DS)and non-deficit syndrome(NDS))and healthy control(HC)*** This study consisted of 27 HC subjects and 50 schizophrenic patients(20 with DS and 30 with NDS).3 patients with DS and 4 patients with NDS were ***-dimensional,sagittal,T1-spoiled,gradient-echo imaging was *** anatomical landmarks were selected and marked on each image using specific *** As to comparing the Procrustes mean shapes of the CC,statistically significant differences were observed between HC and SZ(DS+NDS)(p=0.017,James’s Fj=73.732),HC and DS(p<0.001,James’s Fj=140.843),HC and NDS(p=0.006,James’s Fj=89.178)and also DS and NDS(p<0.001,James’s Fj=152.967).Shape variability in the form of CC was 0.131,0.085,0.082 and 0.086 in the HC,SZ(DS+NDS),DS and NDS groups,*** This study reveals callosal shape variations in patients with SZ and their DS and NDS subgroups that take into account the CC’s topographic distribution.

关键词： schizophrenia shape analysis

Is sarcopenia effective on survival in patients with metastatic gastric cancer?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1861-1868页

作者： Ozlem Dogan Hayriye Sahinli yakup Duzkopru Tuba Akdag Abdulkadir Kocanoglu Department of Medical Oncology Adıyaman University Training and Research HospitalAdiyaman 02100Turkey Department of Medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey Department of Radiology University of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06000Turkey Department of Medical Oncology Ankara Ataturk Sanatoryum Training and Research HospitalAnkara 06170Turkey

BACKGROUND Sarcopenia is a progressively diminishing state characterized by the reduction of muscle mass and density,which is frequently observed in malignancies of solid *** To assess how sarcopenia affects the overall survival of individuals who have been diagnosed with metastatic gastric *** The study retrospectively included individuals who had been diagnosed with metastatic gastric cancer between January 2008 and December *** was identified through the calculation of the average Hounsfield units(HUAC)using computed tomography(CT)images taken at the time of diagnosis in *** A total of 118 patients with metastatic gastric cancer were *** was detected in 29 patients(24.6%).The median survival of all patients was 8(1-43)*** median survival of patients with sarcopenia was 2 mo,while it was 10 mo for those without sarcopenia(P<0.001).A significant relationship was found between sarcopenia and *** Sarcopenia has been observed to impact survival outcomes in various types of solid tumor *** patients can be identified in a short time,easily and inexpensively,by HUAC measurements from CT images used for diagnosis,and survival could be promoted with nutritional support.

关键词： Hounsfield units Sarcopenia Gastric cancer Survival Psoas muscle mass Muscle density

Evaluation of Interferon-Gamma Release Assay Testing and Tuberculin Skin Test for Early Diagnosis of Tuberculosis in Children and Adolescents

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Open Journal of Pediatrics 2024年第3期14卷 558-567页

作者： Yelda Sorguç Miray Çelebi Yılmaz Yüce Ayhan yakup Yaman Şener Tulumoğlu Aybüke Akaslan Kara İlker Devrim University of Health Sciences Dr. Beh&#231et Uz Child Disease and Pediatric Surgery Training and Research Hospital Medical Microbiology &#304zmir T&#252rkiye Department of Pediatric Infectious Diseases University of Health Sciences Dr. Beh&#231et Uz Child Disease and Pediatric Surgery Training and Research Hospital &#304zmir T&#252rkiye

Background: This study aimed to evaluate the diagnostic value of interferon-γ release assay (IGRA), a sensitive microbiological diagnostic method, in children and adolescents with suspected tuberculosis in a country with a high burden of tuberculosis. Method: This study included 581 children and adolescents aged 4 - 19 years who were suspected of having tuberculosis, were latently infected with Mycobacterium tuberculosis, and had received at least one dose of BCG vaccine between April 17, 2019, and February 24, 2021. The study evaluated the TST results of 106 patients who had a positive Quantiferon test and were suspected of having tuberculosis. Results: The study included 581 patients aged between 4 and 19 years. Of these, 106 patients tested positive for the Quantiferon test, while 19 were indeterminate and 456 were negative. The Quantiferon test positivity rate was 18.24%. Among the 106 QFT-Plus-positive cases, 23 patients also tested positive for TST. The difference in distribution was found to be statistically significant. Conclusion: The QFT-Plus test is considered an alternative to TST and other microbiological diagnostic methods for early tuberculosis diagnosis, particularly in children and adolescents.

关键词： Interferon Gamma Release Assay Children Tuberculin Test Children Latent Tuberculosis

中古中外文化交流的新探索--读《波斯锦与锁子甲:中古中国与萨珊文明》

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西域研究 2024年第1期 181-185页

作者：王平吾斯曼江·亚库甫陕西师范大学中国西部边疆研究院

人类历史文化的发展建立在交流互动和文明互鉴的基础上,人类文明史实际上是一部交流互鉴史,古代各大文明古国之间的互动关系是国际重大学术问题,其中,中古波斯与中国文化交流研究一直是学界关注的主要课题之一。“中国同古代西方诸文明... 详细信息

人类历史文化的发展建立在交流互动和文明互鉴的基础上,人类文明史实际上是一部交流互鉴史,古代各大文明古国之间的互动关系是国际重大学术问题,其中,中古波斯与中国文化交流研究一直是学界关注的主要课题之一。“中国同古代西方诸文明之间的交通与交流,源远流长,甚至可追溯到远古混沌时期。”((1))因此,“探讨中国与波斯的关系就具有重要的学术意义。”

关键词：中外文化交流交流互动人类历史文化中古中国古代西方锁子甲古波斯交流互鉴

Topographic tear film trend and new parameters for noninvasive break up time test

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1932-1939页

作者： yakup Acet Department of Ophthalmology Mardin Training and Research HospitalMardin 47100Turkey

AIM:To evaluate the quantitative and qualitative results of the noninvasive tear film break-up time(NI-BUT)test and investigate the predictive ability of the new NIBUT parameter in discriminating between normal Ocular Surface Disease Index(OSDI;scores≤12)and abnormal OSDI(scores≥13).METHODS:A total of 341 eyes of 341 volunteers who applied for routine eye outpatient control were included in the prospective *** participants'noninvasive first tear film break-up time(NIF-BUT),noninvasive average tear film break-up time(NIAvg-BUT)and average value of the first three break-up time(A3F-BUT)were analyzed.A3F-BUT,the new NI-BUT parameter,is calculated by adding the NIF-BUT value to the 2^(nd )break-up time value that has a difference of at most 1 second from the NIF-BUT value and to the 3^(rd) break-up time and then dividing the respective sum by *** operating characteristic(ROC)curve and forward logistic regression analyses were performed to determine the parameter that had the best predictive ability between the OSDI ***:The NI-BUT values of 255 eyes of 255 volunteers included in the study were analyzed *** mean NIF-BUT,NIAvg-BUT,and A3F-BUT values were calculated as 5.3±3.0,8±3.1,and 5.8±3.0 seconds,*** three parameters were found to be significantly lower in the abnormal OSDI group(P=0.014,0.034,and 0.011,respectively).The area under the curve(AUC)of the A3F-BUT to predict abnormal OSDI was AUC=0.625(0.529-0.720),P=0.011 and NIF-BUT was AUC=0.599(0.502-0.696),P=*** A3F-BUT parameter and NIF-BUT parameters were found to be significantly efficient in discriminating abnormal ***:The new parameter for the NI-BUT test has more predictive ability in the discrimination of OSDI groups.

关键词： noninvasive break-up time Ocular Surface Disease Index tear film topographic break-up time test

Case of takotsubo cardiomyopathy after surgical treatment of liver hydatid cyst: A case report

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World Journal of Clinical Cases 2023年第29期11卷 7187-7192页

作者： yakup Altaş Ülfet Abdullayeva Department of Cardiology Private Melikgazi HospitalKayseri 38030Turkey Department of General Surgery Private Melikgazi HospitalKayseri 38030Turkey

BACKGROUND Takotsubo cardiomyopathy,also called apical ballooning syndrome,is a disease that is often triggered by stress factors in postmenopausal women and mimics acute coronary *** aim of this article is to draw attention to takotsubo cardiomyopathy after surgical treatment of liver hydatid *** SUMMARY A 50-year-old diabetic and hypertensive female patient was evaluated preoperatively before general surgery for liver hydatid cyst,and no cardiac problems were *** patient was discharged on the 3rd postoperative day without any postoperative *** postoperative day 5,the patient presented to the emergency department with fever,shortness of breath,chills,and shivering and was hospitalized with the diagnosis of *** troponin levels remained high during *** was performed on postoperative day 7,after which the patient was referred to a tertiary center with the diagnosis of non-ST-elevation myocardial infarction due to akinesia in the apical *** angiography performed at the tertiary center showed normal coronary anatomy,and the patient was diagnosed with takotsubo *** Takotsubo cardiomyopathy mimicking myocardial infarction without ST segment elevation may develop after surgical treatment of liver hydatid cyst.

关键词： Takotsubo cardiomyopathy Liver hydatid cyst Noncardiac surgery Coronary angiography Echocardiography Case report

Effect of early atopic sensitization in children aged 0–2 years on the development of asthma symptoms at 9–11 years of age

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World Journal of Pediatrics 2022年第11期18卷 753-760页

作者： Himmet Haluk Akar Ebru Nadir Burçin Beken yakup Yeşil Division of Pediatric Immunology and Allergy University of Istanbul Health SciencesKanuni Sultan Suleyman Training and Research HospitalIstanbulTurkey Division of Pediatrics University of Istanbul Health SciencesKanuni Sultan Suleyman Training and Research HospitalIstanbulTurkey Department of Pediatric Immunology and Allergy School of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulTurkey

Background Personal genetic predisposition and early life environmental factors are important for the development of childhood *** aimed to search whether egg,milk and mite sensitizations at 0–2 years old are risk factors for asthma symptoms at 9–11 years *** A total of 210 wheezer children who had specific immunoglobulin(Ig)E in 2010–2012 were included in the study(followed by pediatric allergy).Patients were divided into non-atopic(group 1,n=157)and atopic patients[groups 2–7,n=53(5 patients were in both group 4 and group 5)]based on *** the International Study of Asthma and Allergy in Childhood questionnaire,current wheeze(CW,2nd question),exercise wheezing(EW,7th question),and dry cough(DC,8th question)were ***,parental allergies,eczema at 0–2 years,current eosinophil percentage and total IgE were *** Eczema was observed as an important risk factor[CW:odds ratio(OR)=2.83,95%confidence interval(CI)=1.54–5.23,P≤0.001;EW:OR=2.71,95%CI=1.33–5.54,P=0.006;DC:OR=3.03,95%CI=1.47–6.25,P=0.003],whereas having no atopic sensitization at 0–2-year-old(group 1)was found as a significant protective factor for asthma at 9–11 years old(CW:OR=0.32,95%CI=0.15–0.70,P=0.004;EW:OR=0.21,95%CI 0.10–0.44,P≤0.001;DC:OR=0.25,95%CI=0.10–0.59,P=0.002).Conclusion Early personal eczema is a significant risk factor for the development of asthma symptoms at 9–11 years old,whereas not having an allergic sensitization at 0–2 years old(group 1)is an important protective factor.

关键词： Asthma Children Risk factors

N_(2)and Ar dilution on the premixed biogas jet flame under external acoustic enforcement

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Propulsion and Power Research 2023年第4期12卷 486-504页

作者： Bugrahan Alabas Ilker Yılmaz yakupÇam Department of Aeronautical Engineering Faculty of Aeronautics and AstronauticsErciyes UniversityKayseri 38039Turkey Department of Energy Systems Engineering Faculty of TechnologyGazi UniversityAnkara 06560Turkey Department of Aircraft Maintenance and Repair Faculty of Aeronautics and AstronauticsErciyes UniversityKayseri 38039Turkey

In this study,combustion instabilities and flue gas emission changes under different dilutions of N_(2)(nitrogen)and Ar(argon)of a promising biogas mixture(70%CH4-30%CO_(2))in the fight against greenhouse gas emissions were *** the experiments,additions were made from 0%to 50%at intervals of 10%for both *** order to detect the instability of the flame,external acoustic enforcements at different frequencies was applied through the speakers placed in the combustion chamber *** dynamic pressure fluctuation values were *** results showed that low dilution ratios were effective in reducing flame instability for both inert ***,as the dilution ratio increased,the fuel/air mixture became leaner and blowoff *** the case of comparing two different gases,it has been observed that the effect of argon gas on reducing dynamic pressure fluctuation is *** outlet temperature and brightness values of the flame decreased in both Ar and N_(2)*** and NOx emissions increased with increasing diluent volume for all dilution *** the emissions of the two diluent gases are compared,the CO emission,which was 3134 ppm in the undiluted condition,increased up to 4949 ppm in 50%Ar dilution,while it increased to 4521 ppm in 50%N_(2)dilution.

关键词： Biogas Combustion instabilities Pollutant emissions Gas turbine combustor Dilution

Hemoglobin, albumin, lymphocyte, and platelet score as a predictor of prognosis in metastatic gastric cancer

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World Journal of Gastrointestinal Oncology 2023年第9期15卷 1626-1635页

作者： yakup Duzkopru Abdulkadir Kocanoglu Ozlem Dogan Hayriye Sahinli Ebru Cilbir Mustafa Altinbas Department of Medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey

BACKGROUND The hemoglobin,albumin,lymphocyte,and platelet(HALP)score,derived from a composite evaluation of markers reflecting the tumor-inflammation relationship and nutritional status,has been substantiated as a noteworthy prognostic determinant for diverse *** To investigate how the HALP score relates to prognosis in patients with metastatic gastric *** The cutoff values for the HALP score,neutrophil/lymphocyte ratio,and platelet/lymphocyte ratio were determined using receiver operating characteristic *** HALP scores were defined as those less than 24.79 and high HALP scores as those greater than *** The study cohort comprised 147 patients and 110 of them(74.8%)were *** patients'median age was 63(22-89)*** median overall survival was significantly superior in the patients with high HALP scores than in those with low HALP scores(10.4 mo vs 7.5 mo,respectively;P<0.001)CONCLUSION The HALP score was found to be a prognostic factor in patients with metastatic gastric cancer.

关键词： Biomarker Hemoglobin,albumin,lymphocyte,and platelet score Gastric cancer Nutritional index Prognosis Survival