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Genes & Diseases 2024年第3期11卷 15-17页

作者： Mutaz Amin Rongling Wu teodor t.Postolache Claudia Gragnoli iNSERM US14-OrphanetParis 75014France University of Paris Paris 75013France Department of Biochemistryand Molecular Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Department of Public Health Sciences Penn State College of MedicineHersheyPA 17033USA Department of Statistics Penn State College of MedicineHersheyPA 17033USA Mood and Anxiety Program Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA Rocky Mount.i. Mental illness Research Education and Clinical Center(MiRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO80246USA Mental illness Research Education and Clinical Center(MiRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Molecular Biology Laboratory Bios Biotech Multi-Diagnostic Health CenterRome 00197Italy

Major depressive disorder(MDD)and type 2 diabetes(t2D)are two common complex multifactorial disorders that share several genetic and environmental risk factors such as hypercortisolism and related genes'riskvariants wit.i. the stress response and the neuroendocrine hypothalamicpit.i.ary *** stress,the pit.i.ary gland releases prolactin(PRL),whose effects are pleiotropic and include mood control and insulin secretion from the beta cells.1 Variations in the prolactin receptor(PRLR)gene are associated in rodent models with stress level,depressionlike behavior,2 and hepatic insulin sensitivity3 and in humans with maternal glucose homeostasis and gestational diabetes.

关键词： diabetes prolactin pit.i.ary

Muscle amino acid profiles of eleven species of aquacultured animals and their potential value in feed formulation

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Aquaculture and Fisheries 2024年第4期9卷 642-652页

作者： Ewen McLean Kelly B.Alfrey Delbert M.Gat.i. iii t.Gibson Gaylord Frederick t.Barrows Aqua Cognoscenti LLC 479 Henslowe LaneWest ColumbiaSC29170USA Anthropocene institute 855 El Camino RealSte 13A N399Palo AltoCA94301USA texas A&M University Department of Ecology and Conservation BiologyCollege StationTX77843USA US Fish and Wildlife Service Bozeman Fish Technology Center4050 Bridger Canyon RoadBozemanMT59715USA Aquatic Feed technologies LLC 48 West Plaza del LagoIslamoradaFL33036USA

the complete quantitative essential amino acid(EAA)requirements of aquacultured animals are largely unknown except for a handful of *** is problematic because formulation of least-cost diets for target animals demands precise knowledge of EAA *** way of approximating EAA requirements is to use correlations between whole-body and/or muscle EAA profiles using essential to total EAA ratios(A/E ratios).t.i. method requires a reference,quantified EAA requirement,usually lysine(Lys).to systematically evaluate the A/E ratio method,muscle AA profiles were measured in 10 species of teleost and whiteleg *** fish,Lys represented the dominant muscle EAA measured,ranging between 7.06 and 9.58 g/100 g prot.i.,whereas,in shrimp,arginine(Arg)was quantified as the principal *** non-EAA,glutamate(Glu)and glutamine were consistently the NEAA recorded at highest levels whereas,in shrimp,Glu+Gln was highest followed by aspartate(Asp)plus asparagine(Asn).Except for Arg,which was t.i.e that of fish(Piteleg shrimp expressed similar muscle A/E *** of relationship between muscle EAA levels and known requirements were all strongly and positively correlated for non-salmonid *** using Lys as the reference EAA there were few semblances between measured and estimated EAA requirements.

关键词： Aquafeed A/E ratio EAA requirement ideal prot.i. Muscle Fishmeal replacement

the role of melatonin receptor 1B gene(MtNR1B)in the susceptibility to depression and type 2 diabetes comorbidity

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Genes & Diseases 2024年第3期11卷 113-115页

作者： Mutaz Amin Benjamin Rafla Rongling Wu teodor t.Postolache Cclaudia Gragnoli iNSERM US14-OrphanetParis 75014France Department of Biochemistry and Molecular Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Department of Public Health Sciences Penn State College of MedicineHersheyPA 17033USA Department of Statistics Penn State College of MedicineHersheyPA 17033USA Mood and Anxiety Program Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA Rocky Mount.i. Mental llness Research Education and Clinical Center(MiRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO 80246USA Mental ilness Research Education and Clinical Center(MiRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Molecular Biology Laboratory Bios Biotech Multi-Diagnostic Health CenterRome00197Italy

Melatonin is an endogenous monoamine hormone secreted by the pineal *** signaling has been shown to play a role in circadian rhythm regulation,lipid and glucose metabolism,and obesity,and it has anti-inflammatory and antioxidant *** melatonin receptor 1B gene(MtNR1B)is expressed in,among other tissues,the brain and pancreatic beta cells,and risk variants for t2D have been reported as impairing early insulin secretion and increasing fasting glucose levels.^(1) Variants in the MtNR1B gene also have been reported in patients with depression(MDD).

关键词： MtNR1B metabolism properties.

Decision and Coordination of an E-commerce Supply Chain Considering Returns and Network Externalities

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Journal of Systems Science and Systems Engineering 2024年第5期33卷 552-575页

作者： Liang Shen Fei Lin Yuyan Wang Luping Ding t.C.E.Cheng Dexia Wang School of Public Finance and taxation Shandong University of Finance and Economicsjinan 250014China bschool of Management Science and Engineering Shandong University of Finance and EconomicsJinan 250014China PolyU Business School The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China

Considering the large number of returns in online sales and the network externalities of e-platforms,we develop a decentralized model and a centralized model to explore the impacts of returns and network externalities on e-commerce supply chain(ECSC)*** show that.i. the decentralized model,the service level,price,market demand,and ECSC members’profits increase with the network externality ***,the service level and price increase,while the market demand and ECSC members’profits decrease with the product return *** centralized model is the optimal operating mode when it.i. properly *** design the“commission and return cost-sharing”contract to optimize ECSC,in which the proportion of the e-platform’s sharing of the return handling cost.i. exactly equal to the proportion of the system profit after *** on the decentralized model,we develop two extended models in which we endogenize the impacts of the service level and return rate on the network externality *** comparisons between the extended and decentralized models,we show that high-quality service can improve ECSC’s profitability,while a high return rate hurts its economic performance.

关键词： E-commerce supply chain coordination mechanism network externalities return products

Multi-scale habitat.i.fluences sprainting and group size of a freshwater-obligate smooth-coated otter(Lutrogale perspicillata) in tungabhadra Otter Conservation Reserve, india

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Ecological Processes 2024年第1期13卷 159-175页

作者： Ankit Moun P.Ramesh Kumar M.Malat.i.Priya t.Ramesh Riddhika Kalle Sálim Ali Centre for Ornithology and Natural History Deputy Conservator of Forests Bellary Territorial Forest Division Deputy Conservator of Forests Working Plan and Survey and Research WingBellary Territorial Forest Division Centre for Functional Biodiversity University of Kwa Zulu-Natal

Background the impact of changing land-use patterns and associated anthropogenic threats on scale-dependent habitat use of semi-aquatic mustelids in scent-marking and social behaviour can provide important.i.sights into the habitat ecology of smooth-coated otters(Lutrogale perspicillata).Methods We sampled 180 stream segments(100–400 m) as spatial replicates of 60 1-km2 sites to record indirect evidence(i.e. spraints and mass lat.i.e sites) and group sizes of smooth-coated otters along the tungabhadra Otter Conservation Reserve(tOCR) during the dry season. to quantify habitat, we recorded stream characteristics, riparian vegetation, and anthropogenic disturbances at the local scale, and hydro-environmental characteristics and land uses at the landscape scale. Using Markovian-chain detection and occupancy models, we assessed the multi-scale habitat use of otters in their selection of suitable areas for scent-marking based on repeated presence-absence data on spraint/lat.i.e locations along the tOCR. We further used linear regression techniques to explore relationships between the number of individuals in smooth-coated otter group and hydro-environmental characteristics, spraint/lat.i.e encounter rate, anthropogenic pressure, land cover, topography, and *** At the local scale, the probability of spraint deposition and group size decreased with anthropogenic disturbance while the probability of spraint detections decreased with grass cover. At the landscape scale, the probability of otter site use for spraint deposition and group sizes increased in southeast flowing streams. Spraint deposition increased with the proportion of sugarcane fields, whereas in contrast, group size decreased with proportion of sugarcane *** Our findings highlight the first empirical evidence on multi-scale habitat use of a southern indian population of smooth-coated otters in an inland freshwater ecosystem surrounded by the scrub jungle–agriculture mat.i.. We sug

关键词： Presence-absence modelling inland river Freshwater ecosystem Semi-aquatic mammal Smooth-coated otter

Comparative analyses of mitogenomes in the social bees with insights into evolution of long inverted repeats in the Meliponini

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Zoological Research 2024年第1期45卷 160-175页

作者： Yu-Ran Li Zheng-Wei Wang Richard t.Corlett Wen-Bin Yu Yunnan Key Laboratory for the Conservation of tropical Rainforests and Asian Elephants&Center for integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China CAS Key Laboratory of tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China Southeast Asia Biodiversity Research institute Chinese Academy of SciencesMenglaYunnan 666303China University of Chinese Academy of Sciences Shijingshan DistrictBeijing 100049China

the insect mitogenome is typically a compact circular molecule with highly conserved gene ***,mitogenome structural variations have been reported in specific taxa,and gene rearrangements,usually the tRNAs,occur in different *** synapomorphies of mitogenome organizations can provide information for phylogenetic inferences,comparative analyses of mitogenomes have been given increasing ***,most studies use a very few species to represent the whole genus,t.i.e,family,or even order,overlooking potential variations at lower taxonomic levels,which might lead to some incorrect *** provide new insights into mitogenome organizations and their implications for phylogenetic inference,t.i. study conducted comparative analyses for mitogenomes of three social bee t.i.es(Meliponini,Bombini,and Apini)based on the phylogenetic framework with denser taxonomic sampling at the species and population *** analyses revealed that mitogenomes of Apini and Bombini are the typical type,while those of Meliponini show diverse variations in mitogenome sizes and *** inverted repeats(iRs)cause significant gene rearrangements of prot.i. coding genes(PCGs)and rRNAs in indo-Malay/Australian stingless bee *** evolution analyses showed that the lineage with iRs have lower dN/dS ratios for PCGs than lineages without.i.s,indicating potential effects of iRs on the evolution of mitochondrial *** finding of iRs and different patterns of gene rearrangements suggested that Meliponini is a hotspot.i. mitogenome *** conserved PCGs and rRNAs whose rearrangements were found only in the mentioned lineages wit.i. Meliponini,tRNA rearrangements are common across all three t.i.es of social bees,and are significant even at the species level,indicating that comprehensive sampling is needed to fully understand the patterns of tRNA rearrangements,and their implications for phylogenetic inference.

关键词： Social bees Phylogeny Mitogenome structure Gene rearrangement inverted repeats

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Clinical features of gastroesophageal reflux disease and erosive esophagitis:insights from patients undergoing esophagogastroduodenoscopy in resource-limited Et.i.pia

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World Journal of Gastroenterology 2024年第34期30卷 3883-3893页

作者： Firehiwot A Mengistie Abate B Shewaye Abel t tasamma Zekarias S Ayalew Department of internal Medicine Addis Ababa UniversityAddis Ababa 1176Addis AbabaEthiopia Department of internal Medicine Rheum Rheumatology and Internal Medicine Specialty ClinicAddis Ababa 1000Addis AbabaEthiopia Division of Gastroenterology and Hepatology Department of Internal MedicineAdera Medical and Surgical CenterAddis Ababa 1000Addis AbabaEthiopia

BACKGROUND Gastroesophageal reflux disease(GERD)is a common disease worldwide with varying clinical presentations and risk *** data for Africa is lacking,but an increasing trend is expected due to demographic and epidemiological *** endoscopic studies for general gastrointestinal disorders have shown some patients with erosive esophagitis(EE),no studies in Et.i.pia have investigated the clinical characteristics,risk factors,and severity of GERD using esophagogastroduodenoscopy(EGD).AiM to assess the clinical features of GERD in Et.i.pian patients who underwent EGD and determine the severity and risk factors of *** We conducted a multicenter,retrospective cross-sectional study of 221 patients diagnosed with GERD and endoscopic findings of EE at trauma Associated Severe Hemorrhage and Amniotic Membrane Stem Cell between January 2019 and August *** were collected from electronic medical records and phone call *** used descriptive statistics and binary logistic regression analysis with SPSS version 26 to identify the association between variables with a statistical significance set at P valuethe mean±SD age of the patients was 44.8(±15.9)years,with a male-to-female ratio of 1.6:*** most commonly reported symptom was epigast.i. pain(80.5%),followed by heartburn(43%).Los Angeles(LA)-A EE was diagnosed in 71.1%of patients,followed by LA-B(14.9%),LA-C(7.7%),and LA-D(5.9%).Multivariate analysis showed that age 50 or above,presence of bleeding,and endoscopic findings of duodenitis/duodenopathy were significantly associated with severe EE(Pt.i.ture and Barrett’s esophagus were observed in 4.5%and 1.36%of patients with EE,*** Most of the patients had milder EE with fewer ***,severe EE was more prevalent.i. older patients and those with duodenitis/duodenopathy.

关键词： Gastroesophageal reflux disease Erosive esophagitis Hiatal hernia Esophagogastroduodenoscopy Heart burn

Finite barrier bound state

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Light(Science & Applications) 2024年第4期13卷 664-671页

作者： tao Liu Kai Bai Yicheng Zhang Duanduan Wan Yun Lai C.t.Chan Meng Xiao Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education and School of Physics and technology Wuhan University430072 WuhanChina. National Laboratory of Solid State Microstructures School of Physicsand Collaborative Innovation Center of Advanced MicrostructuresNanjing University210093 NanjingChina. Department of Physics The Hong Kong University of Science and TechnologyClear Water BayKowloon999077Hong KongChina. Wuhan institute of Quantum technology 430206 WuhanChina

A boundary mode localized on one side of a finite-size lat.i.e can tunnel to the opposite side which results in unwanted *** wisdom tells that the tunneling probability decays exponentially with the size of the system which thus requires many lat.i.e sites before eventually becoming negligibly *** we show that the tunneling probability for some boundary modes can apparently vanish at specific ***,similar to bound states in the continuum,a boundary mode can be completely trapped wit.i. very few lat.i.e sites where the bulk bandgap is not even *** int.i.uingly,the number of trapped states equals the number of lat.i.e sites along the normal direction of the *** provide two configurations and validate the existence of t.i. peculiar finite barrier-bound state experimentally in a dielect.i. photonic crystal at microwave *** work offers extreme flexibility in tuning the coupling between localized states and channels as well as a new mechanism that facilitates unprecedented manipulation of light.

关键词： boundary state eventually

the CCD instrument background of the SMiLE SXi

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Earth and Planetary Physics 2024年第1期8卷 15-24页

作者： M.W.J.Hubbard O.Hetherington D.J.Hall t.W.Buggey S.Parsons t.Arnold A.Holland C.Pagani S.Sembay Centre for Electronic imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observational Astronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

the ESA and CAS SMiLE mission orbit.i. highly elliptical and will pass through multiple radiation *** Soft X-ray imager(SXi)instrument aboard has a radiation shutter door designed to close when the surrounding radiation flux is *** shutter door will close when passing below an altitude threshold to protect against trapped particles in the Earth’s Van Allen ***,two radiation environments can be approximated based on the shutter door position:open and *** instrument background for the CCDs(Charge-Coupled Devices)that form the focal plane array of the SXi were evaluated for the two *** to the correlation of the space environment with the solar cycle,the solar minima and maxima,the background was also evaluated at these two *** results demonstrated that the highest.i.strument background will occur during solar minima due to the main cont.i.uting source being Galactic Cosmic Rays(GCRs).it was also found that the open background was highest for solar minima and that the closed background was highest during solar *** is due to the radiation shutter door acting as a scattering centre and the changes in the energy flux dist.i.ution of the GCRs between the two solar extremes.

关键词： instrument background X-ray astronomy space radiation

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Strong coupling and catenary field enhancement.i. the hybrid plasmonic metamaterial cavity and tMDC monolayers

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Opto-Electronic Advances 2024年第5期7卷 20-32页

作者： Andergachew Mekonnen Berhe Khalil As’ham ibrahim Al-Ani Haroldo t.Hattori Andrey E.Miroshnichenko School of Engineering and technology University of New South Wales at CanberraNorthcott DriveCanberra ACT 2610Australia

Strong coupling between resonantly matched surface plasmons of metals and excitons of quantum emitters results in the formation of new plasmon-exciton hybridized energy *** plasmon-exciton strong coupling,plasmonic nanocavities play a significant role due to their ability to confine light.i. an ultrasmall ***,two-dimensional transition metal dichalcogenides(tMDCs) have a significant exciton binding energy and remain stable at ambient conditions,making them an excellent alternative for investigating light-matter *** a result,strong plasmon-exciton coupling has been reported by introducing a single metallic ***,single nanoparticles have lower spatial confinement of electromagnetic fields and limited tunability to match the excitonic ***,we introduce the concept of catenary-shaped optical fields induced by plasmonic metamaterial cavities to scale the strength of plasmon-exciton *** demonstrated plasmon modes of metallic metamaterial cavities offer high confinement and tunability and can match with the excitons of tMDCs to exhibit a strong coupling regime by tuning either the size of the cavity gap or *** calculated Rabi split.i.g of Au-MoSe_2 and Au-WSe_2 heterostructures strongly depends on the catenary-like field enhancement.i.duced by the Au cavity,resulting in room-temperature Rabi split.i.g ranging between 77.86 and 320 me *** plasmonic metamaterial cavities can pave the way for manipulating excitons in tMDCs and operating active nanophotonic devices at ambient temperature.

关键词： catenary-shaped field enhancement strong coupling plasmon exciton Rabi split.i.g

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