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Matrix metalloproteinase 2 contributes to adult eclosion and immune response in the small hive beetle,Aethina tumida

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Insect Science 2024年第3期31卷 733-747页

作者： Lixian Wu yajing xu Liangbin Li Dainan Cao Fang Liu Hongxia Zhao Guangdong Key Laboratssory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouChina

During the pupal-adult eclosion process of holometabolous insects,the old cuticle is shed and replaced by a completely different new cuticle that requires tanning and expansion,along with extensive extracellular matrix(ECM)remodeling.In vertebrates,matrix metalloproteinases(MMPs),a class of zinc-dependent endopeptidases,play key roles in regulating the ECM that surrounds cells.However,little is known about these extracellular proteinases available in insects.The small hive beetle(SHB),Aethina tumida,is a widespread invasive parasite of honey bees.In this study,6 MMP homologs were identified in the SHB genome.RNA interference experiments showed that all 6 AtMmps are not required for the larval-pupal transition,only AtMmp2 was essential for pupal-adult eclosion in SHB.Knockdown of AtMmp2 resulted in eclosion defects and wing expansion failure,as well as mortality within 3 d of adult eclosion.Transcriptomic analysis revealed that knockdown of AtMmp2 significantly increased expression of the Toll and Imd pathways,chitin metabolism,and cross-linking(such as the pro-phenoloxidase activating cascade pathway and the tyrosine-mediated cuticle sclerotization and pigmentation pathway).These data revealed evolutionarily conserved functions of Mmp2 in controlling adult eclosion and wing expansion,also provided a preliminary exploration of the novel function of regulating Toll and Imd pathways,as well as new insights into how MMPs regulate insect development and defense barriers.

关键词： Aethina tumida adult eclosion immune response matrix metalloproteinase RNAinterference

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Applying RNA sequencing technology to explore repair mechanism of Tuina on gastrocnemius muscle in sciatic nerve injury rats

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Chinese Medical Journal 2022年第19期135卷 2378-2379页

作者： Taotao Lyu Zhifeng Liu Tianyuan Yu Mengqian Lu Yingqi Zhang Yi Jiao Hourong Wang yajing xu Qian Guan School of Acupuncture Moxibustion and TuinaBejing University of Chinese MedicineBeijing 100029China Tuina Research Center of Beijing University of Chinese Medicine Bejing 100029China

To the Editor:Peripheral nerve injury(PNI)refers to the injury of the peripheral nerve plexus,nerve trunk,or its branches undertheaction of externalforces.Skeletal muscle-derived cells servea strong secretory,function while they can differentiate into Schwann cell-like cells or other ceil types,so that it can,effectively promote regeneration'of peripheral nerves.llUsing some specific acupuncture points with mild mechanical stimulation on the surface can have a positive effect on nerve repair.2i Tuina helps relieve symptoms such as muscle spasms and pain caused by nerve damage.There are three points belonging to the Bladder meridian of foot Taiyang(BL)and the Gallbladder meridian of foot Shaoyang(GB),which usually are selected to carry out Tuina.According to the anatomical nerve position,Yinmen(BL37)is on the sciatic nerve trunk,Chengshan(BL57)is on the tibial nerve,and Yanglingquan(GB34)is on the common peroneal nerve;meanwhile,the three points are on the sciatic nerve or its branches.The three points are on the biceps femoris,gastrocnemius,and tibial anterior muscles.

关键词： meridian gastro acupuncture

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An investigation of the influence of intestinal flora in external traditional Chinese medicine therapy

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 10-18页

作者： Hourong Wang Zhifeng Liu Tianyuan Yu Yingqi Zhang Yi Jiao Di Liu yajing xu Qian Guan Mengqian Lu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102488China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Dongfang Hospital Beijing University of Chinese MedicineBeijing 100078China

External therapy,which has been used for millennia to treat disease,has now become the newest member of complementary and alternative therapies.A growing number of clinical studies and animal experiments have shown that external therapy exerts a positive effect on the intestinal flora.In this paper,we review the research related to external therapy on various systemic diseases and focus on changes in the intestinal flora.We found that studies on external therapy are dominated by acupuncture and tuina,primarily aimed at the treatment of digestive and neurological diseases.However,the deeper mechanism of regulation of the intestinal flora by external therapy has not yet been experimentally confirmed.

关键词： Traditional Chinese medicine External therapy Intestinal flora Digestive diseases Neurological diseases Acupoint Mechanism

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Comparison of the clinical outcomes of hematologic malignancies after myeloablative haploidentical transplantation with G-CSF/ATG and posttransplant cyclophosphamide:results from the Chinese Bone Marrow Transplantation Registry Group(CBMTRG)

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Science China(Life Sciences) 2020年第4期63卷 571-581页

作者： Feifei Tang yajing xu Huiren Chen Lanping xu Xiaohui Zhang Yu Wang Qifa Liu Depei Wu Xiaojun Huang Peking University People’s Hospital Peking University Institute of HematologyBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Xiangya Hospital Central South UniversityChangsha 410008China PLA Army General Hospital Beijing 100700China Nanfang Hospital Southern Medical UniversityGuangzhou 510515China The First Affiliated Hospital of Soochow University Suzhou 215006China Peking-Tsinghua Center for Life Sciences Beijing 100871China

This study compared G-CSF/ATG and PTCy in myeloablative haploidentical hematopoietic stem cell transplantation(haploHSCT)for hematologic malignancies between January 2013 and March 2018 reporting to the Chinese Bone Marrow Transplantation Registry Group(CBMTRG).For each PTCy,G-CSF/ATG subjects(1:4)were selected using the nested case-pair method.In total,220 patients including 176 in G-CSF/ATG group and 44 in PTCy group were analyzed.The incidences of 30-day neutrophil engraftment(88.6%vs.96.6%,P=0.001),90-day platelet engraftment(84.1%vs.94.2%,P=0.04),the median time to neutrophil engraftment(17 days vs.12 days,P=0.000)and platelet engraftment(22 days vs.17 days,P=0.001)were significantly inferior in PTCy group.The incidences of grades 2–4 and 3–4 acute graft-versus-host disease(GVHD),chronic GVHD and severe chronic GVHD were comparable.Among G-CSF/ATG and PTCy groups,the 3-year progression-free survival,overall survival,cumulative incidences of nonrelapse mortality and relapse was 74.3%vs.61%(P=0.045),78.3%vs.65.2%(P=0.039),12%vs.27.3%(P=0.008),and 14.9%vs.11.7%(P=0.61),respectively.G-CSF/ATG can achieve better engraftment,PFS and OS,and lower incidence of NRM compared to PTCy in myeloablative haplo-HSCT for hematologic malignancies.

关键词： myeloablative haploidentical transplantation granulocyte colony-stimulating factor antithymocyte globulin posttransplantation cyclophosphamide

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Effect of pediatric tuina on hypothalamic metabolites in young rabbits using liquid chromatography-mass spectrometry

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 188-196页

作者： Zhifeng Liu Yi Jiao Tianyuan Yu Yingqi Zhang Di Liu Hourong Wang yajing xu Qian Guan Taotao Lv Jian Shu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing102488China Department of Acupuncture Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Shu Acupuncture Clinic FayettevilleNY13066USA

Objective: To investigate the changes in the hypothalamic metabolites of lipopolysaccharide(LPS) febrile young rabbits after the treatment with pediatric tuina.Methods: A total of 30 young rabbits were randomly assigned into three groups: the normal group, the model group, and the tuina group. Both the model group and the tuina group were injected intravenously with LPS. “Six antipyretic manipulations”(pushing Tianmen, pushing Kangong, kneading Taiyang,kneading Erhougaogu, clearing Tianheshui, and pushing Jizhu) were administered 1 h after the LPS injection in the tuina group. The rectal temperatures of the young rabbits were monitored during the experiment to explore the antipyretic effect. Three hours after the injection, the content of interleukin-1β(IL-1β), tumor necrosis factor(TNF)-a, and prostaglandin E;(PGE;) in the serum was detected. In addition, liquid chromatography-mass spectrometry(LC-MS) was used for the hypothalamus metabolomics.Results: Compared with the model group, the rectal temperature of the tuina group was decreased at 2 h and 3 h after the LPS injection(P =.04, P =.03, respectively), and the content of IL-1β, TNF-a, and PGE2was decreased(P =.03, P =.003, and P =.008, respectively). The metabolomics results showed that there were 23 potential biomarkers after the tuina intervention, enriching 27 pathways. Lipid metabolites,especially glycerophospholipids, were a majority of the altered metabolites. The primary metabolic pathways affected by tuina included the arachidonic acid metabolism, the GABAergic synapse, D-glutamine and D-glutamate metabolism, and the glutamatergic synapse.Conclusion: Pediatric tuina reduced the temperature of the febrile rabbits and downregulated the expression of IL-1β, TNF-a, and PGE2, and the antipyretic mechanism may be related to changes in metabolites and metabolic pathways in the hypothalamus.

关键词： Fever Pediatric tuina Metabolomics Liquid chromatography coupled with mass spectrometry Hypothalamus Interleukin-1b Tumor necrosis factor-a Prostaglandin E_(2)

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知识共创视角下协同要素异质性、知识场活性对社区创新绩效的影响

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科技进步与对策 2024年第14期41卷 102-110页

作者：王松徐雅静刘新民山东科技大学经济管理学院山东青岛266590 青岛农业大学经济管理学院山东青岛266109

以资源基础理论和团队异质性理论为依托,从知识共创视角提炼出社区知识协同中多维要素异质性的计量方法和共创情境的表征变量,利用Python程序爬取魅族社区数据,考察不同要素对创新绩效的差异化影响,以及知识场活性在其中发挥的中介传递... 详细信息

以资源基础理论和团队异质性理论为依托,从知识共创视角提炼出社区知识协同中多维要素异质性的计量方法和共创情境的表征变量,利用Python程序爬取魅族社区数据,考察不同要素对创新绩效的差异化影响,以及知识场活性在其中发挥的中介传递作用。研究结果显示:知识共创过程中用户异质性、内容异质性和表达形式异质性对社区知识场活性具有正向影响,情感异质性对知识场活性具有倒U型影响;知识场活性对创新绩效具有正向影响,且在用户异质性、内容异质性、表达形式异质性与创新绩效关系中发挥部分中介作用。

关键词：知识共创协同要素异质性知识场活性创新绩效

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Multi-objective optimization of methane production system from biomass through anaerobic digestion

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Chinese Journal of Chemical Engineering 2018年第10期26卷 2084-2092页

作者： Weijun Li Jakob Kj?bsted Huusom Zhimao Zhou Yi Nie yajing xu Xiangping Zhang Beijing Key Laboratory of Ionic Liquids Clean Process State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Sino-Danish Center for Education and Research University of Chinese Academy of Sciences Department of Chemical & Biochemical Engineering Technical University of Denmark

This work addressed the multi-objective optimization of a biogas production system considering both environmental and economic criteria. A mixed integer non-linear programming(MINLP) model was established and solved with non-dominated sorting genetic algorithm Ⅱ, from which the Pareto fronts, the optimal technology combinations and operation conditions were obtained and analyzed. It's found that the system is feasible in both environmental and economic considerations after optimization. The most expensive processing section is decarbonization; the most expensive equipment is anaerobic digester; the most power-consuming processing section is digestion, followed by decarbonization and waste management. The positive green degree value on the process is attributed to processing section of digestion and waste management. 3:1 chicken feces and corn straw, solar energy, pressure swing adsorption and 3:1 chicken feces and rice straw, solar energy, pressure swing adsorption are turned out to be two robust technology combinations under different prices of methane and electricity by sensitivity analysis. The optimization results provide support for optimal design and operation of biogas production system considering environmental and economic objectives.

关键词：生产系统优化生物资源消化甲烷厌氧 Pareto 操作条件

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Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4903-4913页

作者： Ruoyang Shao Yu Zhang Jinping He Fen Huang Zhiping Fan Kaibo Yang yajing xu Na xu Yi Luo Lan Deng Xi Zhang Jia Chen Mingzhe Han xudong Li Sijian Yu Hui Liu Xinquan Liang Xiaodan Luo Pengcheng Shi Zhixiang Wang Ling Jiang xuan Zhou Ren Lin Yan Chen Sanfang Tu Jing Sun Yu Wang Qifa Liu Li xuan Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China clinical Medical Research Center of Hematology Diseases of Guangdong Province Guangzhou 510515China Department of Hematology Xiangya HospitalCentral South UniversityChangsha 410008China Bone Marrow Transplantation Center the First Affliated HospitalZhejang University School of MedicineHangzhou 310oo9China Department of Hematology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Department of Hematology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Department of Hematology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China The First Affliated Hospital of Soochow University Suzhou 215006China Hematopoietic Stem Cell Transplantation Center Institute of Hematology and Blood Diseases HospitalPeking Union Medical College and Chinese Academy of Medical SciencesTianjin 300020China Department of Hematology the Third Afliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630China Department of Hematology the First People's Hospitalf ChenzhouChenzhou 423099China Deparment of Hematlogy the First Affiliated Hospitalof GuangzhouMedical UniversityGuangzhou 510120China Department of Hematology the Fifth Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510799China Department of Hematlogy Peking University People's HospitalBeijing 100044China Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics NationalKey Discipline of Human AnatomySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Sorafenib therapy improves overall survival(OS)in patients with FLT3 internal tandem duplication(ITD)acute myeloid leukemia(AML)undergoing allogeneic hematopoietic stem cell transplantation.We explored the efficacy of sorafenib therapy in this population with different concomitant genetic patterns.In this multi-center,cohort study,we enrolled patients with FLT3-ITD AML undergoing allogenic hematopoietic cell transplantation.Patients with sorafenib maintenance post-transplantation for at least four weeks were allocated to the sorafenib group,and otherwise to the control group.

关键词： hematopoietic sorafenib patients

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Intraday Volatility Spillover between the Shanghai and Hong Kong Stock Markets—Evidence from A+H Shares after the Launch of the Shanghai-Hong Kong Stock Connect

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Journal of Management Science and Engineering 2017年第4期2卷 290-317页

作者： yajing xu Saiping Li Xiong Xiong Fei Ren School of Business East China University of Science and TechnologyShanghai 200237China Institute of Physics Academia SinicaTaipei 115TaiwanChina The College of Management and Economics Tianjin UniversityTianjin 300072China China Center for Social Computing and Analytics Tianjin UniversityTianjin 300072China Research Center for Econophysics East China University of Science and TechnologyShanghai 200237China

Using minute data of eligible A+H stocks under the Shanghai-Hong Kong Stock Connect(SHHKSC),we investigate the volatility spillover between the Shanghai and Hong Kong stock markets based on a generalized autoregressive conditional heteroskedasticity-X(GARCH-X)model with four exogenous variables,namely,volatilities of the corresponding stocks on the other market,volatilities of the indexes of both stock markets,and volatilities of the correlated stocks,which are selected using the dynamic conditional correlation model and bootstrap approach.Results show that after the launch of the SHHKSC,volatility spillovers are significant in both directions almost all the time,and the volatility spillover between the two stock markets tends to be larger when bidirectional capital flows under the SHHKSC increase or when important financial events occur.We also analyze the influences of the volatilities of correlated stocks and industries on the volatility spillover and volatilities of A+H stocks.The bidirectional volatility spillovers between Shanghai and Hong Kong stock markets do not change qualitatively after incorporating the volatilities of correlated stocks and industries in the GARCH-X model.Moreover,the average volatilities of the correlated stocks are shown to have significant influences on the volatilities of individual A+H stocks,and the influences increase when the local stock market shows a sharp rise or fall.Compared with the market indexes,the correlated stocks could be regarded as a more important and indispensable factor for individual A+H stocks’volatilities modeling,which may carry more information than the industry.

关键词： Volatility spillover Shanghai-Hong Kong Stock Connect DCC model GARCH-X model High-frequency data

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面向复杂山区微地貌的手持LiDAR点云滤波方法比较

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测绘通报 2024年第5期 24-28页

作者：徐亚静袁希平甘淑李绕波叶俊民昆明理工大学国土资源工程学院云南昆明650093 云南省高校高原山地空间信息测绘技术应用工程研究中心云南昆明650093 滇西应用技术大学地球科学与工程学院云南大理671006 滇西应用技术大学云南省高校山地实景点云数据处理及应用重点实验室云南大理671006

本文以手持激光点云数据是否可用于进行复杂山地土壤侵蚀和地表剥蚀测量为典型实例,试验对比分析了渐进加密三角网滤波算法、坡度滤波算法及布料模拟滤波算法在地面激光雷达点云分类中的性能。具体分别采用了3种滤波对应的参数对试验数... 详细信息

本文以手持激光点云数据是否可用于进行复杂山地土壤侵蚀和地表剥蚀测量为典型实例,试验对比分析了渐进加密三角网滤波算法、坡度滤波算法及布料模拟滤波算法在地面激光雷达点云分类中的性能。具体分别采用了3种滤波对应的参数对试验数据集进行测试以获得最高性能,并对比分析而获得每种算法的最优滤波。试验结果表明:对于平缓裸露地貌的滤波处理,布料模拟滤波效果最好,渐进加密三角网滤波次之,坡度滤波算法效果最差;对于复杂山地地貌的滤波处理,渐进加密三角网滤波算法滤波效果最好,布料模拟滤波次之,坡度滤波算法效果最差。试验研究成果为优化滤波算法的参数以提高其检测微地形变化的性能提供了有价值的信息,并验证了渐进加密三角网滤波在复杂地区滤波效果的有效性。

关键词：手持三维激光点云渐进加密三角网滤波坡度滤波布料模拟滤波平缓裸露地貌复杂山地地貌

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