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Advances in the research on the biological effects of heavy-ion radiation

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中华放射医学与防护杂志 2015年第1期35卷 35-39,72页

作者： DongJuancong zuoyahui 030006 Taiyuan China Institute for Radiation Protection

Heavy iron radiation offer significant advantages for the treatment of deep-seated local tumors in comparison to conventional megavolt photon *** a plethora of malignancies,current radiotherapy using photons or protons yields marginal benefits in local control and *** the last decade,heavy- ion radiotherapy facilities have slowly been constructed in Europe and Asia,demonstrating favorable results for many of the malignancies for which conventional radiotherapy yields poor ***,for a radiobiological perspective,the mechanism whereby heavy ion works in overcoming radio-resistance and the mechanismwherebyradiotherapycombinedwith systemic therapies extends local control and survival are not yet fully *** radiation,comprised of energetic protons and heavy nuclei,has been shown to cause distinct biological damage compared with radiation on earth,leading to large uncertainties in the projection of cancer and other healthrisks,andobscuringevaluationofthe effectiveness of possible *** in the field of biological effects of heavy charged particles is needed for both heavy-ion therapy and protection from the exposure to galactic cosmic radiation in long- term manned space *** article reviews the progress in the research of the biological effects of heavy-ionradiationinspaceexplorationand radiotherapy,and the open questions that remain to be addressed.

关键词：临床医学诊断放射医学

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肿瘤患儿疲乏管理的最佳证据总结

中华现代护理杂志 2024年第27期30卷 3685-3693页

作者：曹金金王媛媛戴谦李萌何梦雪沈南平左雅慧李梅南京医科大学附属明基医院护理部南京210019 浙江省中医院/浙江中医药大学第一附属医院ICU 杭州川310000 南京医科大学附属儿童医院血液科南京210008 南京医科大学附属儿童医院护理部南京210008 上海交通大学医学院附属上海儿童医学中心血液肿瘤科上海200127 上海交通大学医学院附属上海儿童医学中心护理部上海200127 南京医科大学护理学院南京211166 南京医科大学附属明基医院国际医疗中心南京210019

目的为评价、总结国内外关于肿瘤患儿疲乏管理的最佳证据,为医护人员改善患儿的疲乏症状提供参考。方法系统检索国内外临床决策支持系统、指南网站、相关专业协会网站、数据库中关于肿瘤患儿疲乏管理的证据,包括最佳实践、推荐实践、指... 详细信息

目的为评价、总结国内外关于肿瘤患儿疲乏管理的最佳证据,为医护人员改善患儿的疲乏症状提供参考。方法系统检索国内外临床决策支持系统、指南网站、相关专业协会网站、数据库中关于肿瘤患儿疲乏管理的证据,包括最佳实践、推荐实践、指南、系统评价、证据总结、专家共识。检索时限为建库至2023年4月。由2名研究者独立进行文献质量评价及证据提取。结果共纳人17篇文献,其中指南4篇,系统评价13篇。最终从肿瘤患儿疲乏的评估与筛查、危险因素的识别、健康教育、运动干预、药物干预及其他干预6个方面提取32条最佳证据。结论总结的肿瘤患儿疲乏管理的最佳证据可为医护人员改善其疲乏症状提供依据。建议医护人员结合临床情境、专业意见和患者意愿,筛选最佳证据,制订个性化的疲乏管理方案。

关键词：月肿瘤儿童疲乏循证护理儿科护理

Study on serum proteoics in rats irradiated by 137Cs γ-ray

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Study on serum proteoics in rats irradiated by 137Cs γ-ray

Regulatory effects of CDT1、RAN genes in human hepatocytesthat were genomic instability induced by radiation

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： yahui zuo Xuhong Dang Huifang Zhang Zhikai Duan China Institute for Radiation Protection

Objective To investigate the changes of proteomics in serum of Sprague-Dawley(SD)rats after accumulated irradiation by 137 Cs γ ray. Methods Thirty matureSD rats were randomly divided into three groups:0.2Gy group, 2Gy group and healthy controlgroup. Rats were irradiated at dose rate of 0.336mGy/min for 10 days and 20 dayscontinuously. Isobaric tags for relative and absolute quantitation(iTRAQ) was used to analyzethe different protein expression in serum of irradiated rats. Gene Ontology, KEGGpathway and protein-protein interaction network analysis was conducted using *** In total, 363 protein spots were identified. 29 proteins were differentially expressedboth in two groups compared with control, of which 10 were up-regulated and 19down-regulated. Based on softwares about classtification of biological process categories,classtification of cellular component and classtification of molecular function, differentiallyexpressed proteins may play important role in metabolic process, regulation of biologicalprocess, protein binding, catalytic activity. Analysis with the PAJEK software demonstratedthat those 16 differentially expressed proteins could form a complicated interaction networkwhere Glutathione S-transferase P1(GSTP1), Phosphoglycerate kinase 1(PGK1) andProtein disulfide-isomerase(PDI) might be key *** Accumulated irradiationcan induce differentially expressed proteins in serum of irradiated rats. Analysis on functional roles of the screened proteins GSTP1, PGK1 and PDI may provide insight intofurther mechanistic investigations and underlying molecular biomarkers induced by accumulated irradiation.

关键词： Accumulated irradiatin Serum proteomics Isobaric tags for relative and absoluteq uantitation(iTRAQ) Interaction network

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Regulatory effects of CDT1、RAN genes in human hepatocytesth...

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Xuhong Dang yahui zuo Yayi Yuan Jiangong Liu Hongyan Liu China Institute for Radiation Protection

It has been known that genome instability exists in many cancers, and it may be a potentialcause of tumorigenesis. Our studies demonstrated that genomic instability can be inducedby ionizing radiation in human hepatocytes, and CDT1、RAN、HAVCR2 genes were differentialexpressed in human hepatocytes that were genomic instability induced by ionizingradiation. To further investigate the regulatory effects of CDT1、RAN、HAVCR2 genes ongenomic instability induced by ionizing radiation, RNA interference was used to silence thegenes including CDT1、RAN respectively in human hepatocytes that were genomic ***, CDT1 and RAN were overexpressed respectively. The apoptosis wasdetected by Annexin Ⅴ-APC flow cytometry(FCM) and the cell cycle was determined byFCM with single PI staining. And the expression changes of CDT1、RAN、HAVCR2、p53genes were assayed by real time fluorescence quantitative PCR technology. The resultsshowed that CDT1 silencing downregulated RAN expression, upregulated HAVCR2、p53genes expression, and inhibited apoptosis;however, overexpression of CDT1 downregulatedRAN、p53 genes and promotes apoptosis. RAN silencing upregulated HAVCR2、p53genes expression and inhibited apoptosis, arrest the cells at G1 phase;however, over expression of RAN down regulated CDT1、 p53 genes and promotes apoptosis. In conclusion,CDT1、RAN、HAVCR2、p53 genes interacted each other, involving genomic instabilitythrough apoptosis regulation and cell cycle regulation.

关键词： Genomic instability Human hepatocytes RNA interference Ionizing radiation Overexpression

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非交换微分从属鞅

中国科学：数学 2023年第12期53卷 1853-1868页

作者：左雅慧吴恋焦勇中南大学数学与统计学院长沙410085

本文对非交换微分从属鞅及其相关理论的最新进展进行总结,具体包括:非交换微分从属鞅的一些基本不等式、均方函数估计和非交换弱控制鞅不等式及其应用等.

关键词：非交换微分从属鞅强弱型估计均方函数非交换弱控制鞅

国际生物剂量实验室网络建设与生物剂量估算技术研究现状

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辐射研究与辐射工艺学报 2020年第6期38卷 30-37页

作者：董娟聪左雅慧中国辐射防护研究院太原030006

围绕核与辐射事故应急中的剂量估算问题,结合中国辐射防护研究院实际情况,介绍了国际生物剂量实验室网络建设的基本情况、生物剂量估算技术的研究现状及未来的发展趋势。

关键词：核或辐射应急生物剂量计网络高通量筛选

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中子的相对生物学效应及复合效应研究现状

中国辐射卫生 2021年第6期30卷 788-793页

作者：柴栋静党旭红左雅慧中国辐射防护研究院山西太原030006

随着科学技术的发展,核与辐射广泛应用于工业、军事、医学等领域,随之而来的辐射暴露也越来越多。当前核反应堆和核潜艇的运行、肿瘤放射治疗、太空飞行、核装置爆炸以及核泄漏等均涉及到中子辐射的暴露。中子是一种高传能线密度(Linear... 详细信息

随着科学技术的发展,核与辐射广泛应用于工业、军事、医学等领域,随之而来的辐射暴露也越来越多。当前核反应堆和核潜艇的运行、肿瘤放射治疗、太空飞行、核装置爆炸以及核泄漏等均涉及到中子辐射的暴露。中子是一种高传能线密度(Linear Energy Transfer,LET)射线,电离密度大,能量沉积严重,会对生物体造成严重的损伤效应。因此在辐射暴露事件中,进行中子辐射损伤效应的评估至关重要。相对生物学效应(Relative Biological Effectiveness,RBE)就是常用的估算中子暴露风险的一种手段。特定辐射条件下的RBE值取决于自身暴露条件,如中子本身的能量、剂量和剂量率以及所涉及的组织或细胞类型等,本文将从这几方面展开对中子RBE值的讨论。此外,当前绝大部分辐射暴露场均为混合场,因此充分考虑混合场中的其他成分所产生的影响同样重要。

关键词：中子相对生物学效应复合效应