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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang Li Li‑Jiao Wang jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan wei Xu Tao Li su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong Zhang Xiao‑Yang sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑wei Hu Han‑xiong Huang wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Gong Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Kang sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng Wang Peng‑Cheng Wang Zhao‑hui Wang Zhong‑wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑hui Zhang Hang‑Chang Zhang Lin‑Hao Zhang Qi‑wei Zhang Xian‑Peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao Dong Li Shao-Lin xiong Yan-Qiu Zhang Yang su wei Chen Yi Zhao Xiao-Bo Li Jia-Cong Liu Wen-Xi Peng Rui Qiao Xin-Qiao Li Xiang-Yang Wen Li-Ming Song Shi-Jie Zheng Xin-Ying Song Xiao-Yun Zhao Yue Huang Shuang-Nan Zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen wei Chen Yan-Qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-wei Guo Jian-Jian He Bin Li Chao Li Chao-Yang Li Gang Li Jian-hui Li Lu Li Qing-Xin Li Yan-Guo Li jing Liang Xiao-Hua Liang Jin-Yuan Liao Xiao-jing Liu Ya-Qing Liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-Li Shi jing-Yan Shi Gong-Xing sun Xi-Lei sun You-Li Tuo Chen-wei Wang hui Wang Jin Wang Jin-Zhou Wang Ping Wang Wen-Shuai Wang Hong Wu Sheng-Lun Xie Yan-Bing Xu Yu-Peng Xu Wang-Chen Xue Sheng Yang Min Yao Jian-Ying Ye Qi-Bin Yi Chao-Yue Zhang Da-Li Zhang Fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

乙型肝炎病毒C蛋白对NK细胞功能影响的体外研究

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中华实验和临床病毒学杂志 2008年第4期22卷 275-277页

作者：刘映霞位兴辉李兵罗志雄谢婧靖谭艳龙素军周伯平广东医学院附属深圳市第三人民医院深圳518020 南华大学附属第一医院

目的研究乙型肝炎病毒C蛋白在NK细胞中的表达及其对NK细胞功能的影响。方法用脂质体转染法将HBVC基因真核表达载体pHBI-CMV-HBC转入NK-92细胞，通过Western Blot检测C基因在NK-92细胞中表达．用ELISA法检测NK细胞分泌IFN-γ水平，MTT法... 详细信息

目的研究乙型肝炎病毒C蛋白在NK细胞中的表达及其对NK细胞功能的影响。方法用脂质体转染法将HBVC基因真核表达载体pHBI-CMV-HBC转入NK-92细胞，通过Western Blot检测C基因在NK-92细胞中表达．用ELISA法检测NK细胞分泌IFN-γ水平，MTT法检测NK细胞对HepG2细胞的细胞毒作用。结果Western Blot证实转染有pHBI-CMV-HBC的NK-92细胞能表达HBVC蛋白。转染了重组真核表达质粒的NK-92细胞IFN-γ水平均高于空质粒对照组和空白对照组（P〈0．01）。与两对照组相比，重组真核表达质粒转染组NK-92细胞对于HepG2细胞的细胞毒活性明显提高，差异具有统计学意义（P〈0．01）。结论HBc基因瞬时高表达可影响NK-92细胞分泌IFN-γ和细胞毒功能。

关键词：肝炎病毒乙型肝炎核心抗原乙型杀伤细胞天然干扰素Ⅱ型

双源256排CT联合食管超声对心房颤动患者左心房/左心耳血栓的检测价值

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内科急危重症杂志 2018年第6期24卷 472-474页

作者：程光辉陈艳张劲林韩宏伟李振苏晞武汉亚洲心脏病医院武汉430000

目的:比较双源256排CT(MDCT)和食管超声(TEE)对左心房/左心耳血栓检出的准确性。方法:拟行导管消融术的房颤患者1 178例,术前48 h内同1天行MDCT和TEE检查,必要时复查TEE,并再次MDCT阅片。评价MDCT和TEE的准确性。结果:经TEE检测出有血栓... 详细信息

目的:比较双源256排CT(MDCT)和食管超声(TEE)对左心房/左心耳血栓检出的准确性。方法:拟行导管消融术的房颤患者1 178例,术前48 h内同1天行MDCT和TEE检查,必要时复查TEE,并再次MDCT阅片。评价MDCT和TEE的准确性。结果:经TEE检测出有血栓者186例,其中假阳性2例。经MDCT检测出有血栓者176例,无假阳性,假阴性8例(4. 3%),MDCT的敏感性95. 7%,特异性100%,阳性预测值100%,阴性预测值99%。2种检测方法的Kappa值为0. 974(P <0. 05)。结论:MDCT不能完全取代食管超声作为检测左心房/左心耳血栓的手段。术前常规同时行MDCT和TEE,能提高左心房/左心耳血栓诊断的准确性。

关键词：心房颤动双源256排CT 食管超声左心房/左心耳血栓

阿德福韦酯片在中国健康受试者中的药代动力学和生物等效性研究

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中国临床药理学杂志 2023年第8期39卷 1167-1171页

作者：徐佐恒王明静苏健芬付喜花刘伟雄姚建堤李小川李玉杰杨辉广州市番禺区中心医院药学部广东广州511400 广东工业大学生物医药学院广东广州510006 福建广生堂药业股份有限公司福建福州350002 桂林医学院药学院广西壮族自治区桂林541000 苏州旭辉检测有限公司江苏苏州215000

目的研究阿德福韦酯片受试制剂(10mg)和参比制剂(10 mg)在健康人空腹及餐后状态下的药代动力学特征,并对两种制剂的生物等效性进行评价。方法空腹试验24例健康受试者,餐后试验26例健康受试者,按双周期、自身交叉设计、单剂量口服阿德福... 详细信息

目的研究阿德福韦酯片受试制剂(10mg)和参比制剂(10 mg)在健康人空腹及餐后状态下的药代动力学特征,并对两种制剂的生物等效性进行评价。方法空腹试验24例健康受试者,餐后试验26例健康受试者,按双周期、自身交叉设计、单剂量口服阿德福韦酯片受试制剂或参比制剂10 mg,使用高效液相色谱-串联质谱(HPLC-MS/MS)法测定给药后不同时间点的血药浓度,采用Phoenix WinNonlin软件(7.0版本)进行非房室模型药代动力学参数的估算分析,评价两种制剂的生物等效性。结果单次空腹口服药物后,参比制剂和受试制剂的C_(max)分别为(24.92±6.01)和(24.04±3.58)ng·mL^(-1),AUC_(0-t)为(284.85±45.04)和(299.69±49.31)ng·h·mL^(-1),AUC_(0-∞)为(304.44±47.58)和(317.27±50.04)ng·h·mL^(-1),t_(max)为0.75和1 h,t1/2为(9.02±1.06)和(9.60±1.81)h。在餐后试验中,参比制剂和受试制剂的C_(max)分别为(22.88±4.09)和(22.88±4.19)ng·mL^(-1),AUC_(0-t)为(287.42±52.07)和(291.11±53.68)ng·h·mL^(-1),AUC_(0-∞)为(302.74±52.95)和(308.05±53.88)ng·h·mL^(-1),t_(max)为3.5和3.5 h,t1/2为(9.54±2.47)和(9.17±2.03)h。受试制剂与参比制剂几何均值比的90%置信区间均完全落在80.00%~125.00%。结论2种阿德福韦酯片在中国健康受试者体内具有生物等效性。

关键词：阿德福韦酯药代动力学高效液相色谱-质谱联用生物等效性

呕吐毒素时间分辨荧光免疫层析法的建立与评价

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食品工业科技 2018年第20期39卷 233-239页

作者：张东升严艺琳熊晓辉董曼佳游京晶张一平江苏省苏微微生物研究有限公司江苏无锡214063 南京工业大学食品与轻工学院江苏南京211800

构建并评价了呕吐毒素(Deoxynivalenol,DON)时间分辨荧光免疫层析法(TRFIA)。以Eu^(3+)螯合物的纳米微球为荧光探针标记抗DON单抗,采用竞争抑制建立免疫层析定量方法,优化了微球与抗体标记量,检测的环境温度、反应时间、加样体积及缓冲... 详细信息

构建并评价了呕吐毒素(Deoxynivalenol,DON)时间分辨荧光免疫层析法(TRFIA)。以Eu^(3+)螯合物的纳米微球为荧光探针标记抗DON单抗,采用竞争抑制建立免疫层析定量方法,优化了微球与抗体标记量,检测的环境温度、反应时间、加样体积及缓冲体系;研究了方法的灵敏度、精密度及准确度。结果表明,每100μL荧光微球结合纯单抗50μg,最佳划膜浓度为1.0 mg/m L,最佳测定条件为室温(25±2)℃,10 min,加样体积100μL,PBS (0.01 mol/L,pH7.2)的缓冲体系,方法的灵敏度为0.25 ng/m L,线性范围为0.5~25.0 ng/m L,玉米、小麦阴性样本(加标浓度200、500、1000、2000μg/kg)平均加标回收率为91.4%~109.3%,6种典型样本经TRFIA与免疫亲和净化-高效液相色谱法(IAC-HPLC)同时测定DON含量,相关系数r达0.9754。TRFIA具有灵敏度高、速度快、定量准等技术特点,适用于谷物及制品中DON的快速定量。

关键词：呕吐毒素时间分辨荧光微球免疫层析法评价检测

氨磷汀对人巨核细胞白血病Dami细胞增殖及分化的影响

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中国药理学与毒理学杂志 2016年第7期30卷 723-727页

作者：汪海涛杨波卢学春胡博杨红旗罗龙龙林洁李素霞范辉乔春霞王巍郎晓玲耿晶黎燕吴晓雄吕明朱宏丽中国人民解放军总医院老年血液科北京100853 军事医学科学院基础医学研究所免疫学研究室北京100850 中国人民解放军总医院第一附属医院血液科北京100048 北京大学肿瘤医院胸外科北京100142

目的探讨氨磷汀(依硫磷酸,Amf)对人巨核细胞白血病Dami细胞分化的影响。方法 Amf0.01~5.0 mmol·L^(-1)分别处理Dami细胞12 d,每天光镜下观察细胞形态,计数Dami细胞数量,绘制增殖曲线;第12天,计数直径>20μm细胞数量,透射电镜观察Dami... 详细信息

目的探讨氨磷汀(依硫磷酸,Amf)对人巨核细胞白血病Dami细胞分化的影响。方法 Amf0.01~5.0 mmol·L^(-1)分别处理Dami细胞12 d,每天光镜下观察细胞形态,计数Dami细胞数量,绘制增殖曲线;第12天,计数直径>20μm细胞数量,透射电镜观察Dami细胞血小板分界膜系统的形成,流式细胞仪检测细胞DNA倍体化及细胞表面抗原CD33,CD34和CD41a的变化。结果 Amf 0.1~1.0 mmol·L^(-1)促进Dami细胞分化;Amf>1.0 mmol·L^(-1)时抑制Dami细胞增殖,Amf 1.0 mmol·L^(-1)作用12 d后光镜下观察到细胞体积增大,直径>20μm细胞比例增加24.6%(P1.0 mmol·L^(-1)时抑制Dami细胞增殖,0.1~1.0 mmol·L^(-1)时诱导Dami细胞向成熟巨核细胞分化。

关键词：氨磷汀 Dami细胞细胞分化 CD41a DNA倍体化

恶性肿瘤患者住院期间营养风险变化的动态调查

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中华医学杂志 2018年第14期98卷 1093-1098页

作者：朱明炜韦军民陈伟杨鑫崔红元朱赛楠张片红熊剑郑堵奋宋洪江梁晓宇张丽许武英王鸿波苏国强冯丽君陈婷吴咏冬李卉孙建琴石燕童本德周苏明王新颖黄乙欢张博淼徐键张红雨常桂林贾震易陈胜芳胡景张晓伟王慧李占东高艳艳桂冰北京医院普外科 100730 北京协和医院肠外肠内营养科北京大学第一医院统计教研室浙江大学医学院附属第二医院沈阳军区总医院浙江医院哈尔滨医科大学附属肿瘤医院天津医科大学总医院南京脑科医院新疆医科大学附属第一医院第四军医大学西京医院厦门大学附属第一医院浙江大学医学院附属邵逸夫医院河南省人民医院首都医科大学附属北京友谊医院武警总医院复旦大学附属华东医院解放军总医院第二军医大学长征医院江苏省人民医院南京军区南京总医院重庆医科大学附属第一医院哈尔滨医科大学附属第二医院大连医科大学附属中山医院山东大学齐鲁医院复旦大学附属中山医院上海市第六人民医院同济大学附属同济医院首都医科大学附属复兴医院河北省人民医院四川大学华西医院北京大学肿瘤医院广州市第一人民医院大连市中心医院

目的应用营养风险筛查（NRS2002）工具，前瞻性动态调查恶性肿瘤住院患者住院期间营养状态变化，分析与临床结局的相关性。方法在2014年6—9月期间，对国内30家大医院进行前瞻、平行和多中心的调查研究；在消化内科、呼吸内科、肿瘤内... 详细信息

目的应用营养风险筛查（NRS2002）工具，前瞻性动态调查恶性肿瘤住院患者住院期间营养状态变化，分析与临床结局的相关性。方法在2014年6—9月期间，对国内30家大医院进行前瞻、平行和多中心的调查研究；在消化内科、呼吸内科、肿瘤内科、普通外科、胸外科和老年科等多个临床科室，研究对象为各种恶性肿瘤住院患者，住院时间在7～30d，年龄≥18岁，于人院和出院24h内记录其临床资料、进行人体物理指标测量和实验室检查，应用营养风险筛查（NRS2002）工具；记录住院期间营养支持情况和临床结局指标，分析住院患者是否存在营养风险与临床结局的相关性。结果有2402例恶性肿瘤患者进人本研究，淘汰74例没有完成NRS2002的患者，最终纳入2328例；其主要疾病诊断病例数居前五位的包括结直肠肿瘤587例、肺肿瘤567例、胃肿瘤564例、食管肿瘤146例、肝肿瘤119例；与入院时的检查相比，患者在出院时的体质指数（BMI）、体重、握力和小腿围均显著降低（P〈0．05）；总蛋白、白蛋白、前白蛋白、血红蛋白均明显低于入院时水平（P〈0．05）；本组2328例患者入院时完成了营养风险筛查，其中入院时营养不足发生率为11．1％（BMI≤18．5，258／2328例）；出院时营养不足发生率为10．9％（BMI≤18．5，254／2328例），前后结果相似（X2=0．0197，P=0．888）。入院时NRS2002评分≥3分（存在营养风险）有1204例（51．7％）；出院时NRS2002评分≥3分有1352例（58．1％），前后比较x2值=49．9，P〈0．001；其中结直肠、胃、肺等肿瘤患者出院时的营养风险发生率显著高于入院时（P〈0．05）；入院时和出院时存在营养风险的恶性肿瘤住院患者，其感染并发症和其他并发症明显多于没有营养风险者；与没有营养风险者比较，入院时存在营养风险者，其ICU住院时问显著增加（P=0．042）相关；出院时存在营养风险者，其住院费用显著增多（P〈0．01）。结论恶性肿瘤患者入院时营养风险发生率较高，与不良临床结局相关；合理进行营养干预，预防体重丢失可提高生活质量。

关键词：恶性肿瘤动态营养调查出院患者营养状态营养风险筛查临床结局

Changed clinical aspects of primary liver cancer in China during the past 30 years

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 194-198页

作者： Bing-hui Yang, jing-Lin Xia, Li-Wen Huang, Zhao-You Tang, Ming-Shan Chen, Jin-Qing Li, An-Min Liang, Qin-Guo Mo, hui-Shan Lu, Chao-Liu Dai, Lu-Nan Yan, Zhi-Jian Yu, Rong-Sheng Rao, Le-Qun Li, Zhi-xiong su, Zhuang-wei Fang Shanghai, China Liver Cancer Institute & Zhongshan Hospital, Fudan University, Shanghai 200032, China Tumor Hospital, Zhongshan University, Guangzhou 510000, China Tumor Hospital, Guangxi Medical Universi- ty, Nanning 530000, China Xiehe Hospital, Fujian Medical University, Fuzhou 350000, China Second Hos- pital, Chinese Medical University, Shenyang 110000, China Huaxi Hospital, Sichuan University, Chengdu 610041, China Hospital Affiliated to Nantong Medical University, Nantong 226000 , China Second Hospital, Jiangxi Medical University, Nanchang 330000 , China First Hospital Affiliated to Guangxi Medical University, Nanning 530000 , China People’s Hospital of Hainan Province, Haikou 570000, China Liver Cancer Institute & Zhongshan Hospital Fudan University Shanghai 200032 China. bhyang@zshospital. net

BACKGROUND: Primary liver cancer (PLC) is one of the most frequently seen tumors in China. Thirty years ago, patients with PLC were often detected at relatively late stage, with a palpable mass or marked clinical symptoms and poor prognosis. In the past 30 years, the diagnosis and treatment of PLC have been greatly improved with better prognosis. METHODS: In order to study the changes of PLC during the 30 years, the clinical data of 3250 patients with PLC from 10 medical institutions of China were collected, ana- lyzed , and compared with those of 3254 PLC patients be- fore the 30 years. REsuLTS: In the 3250 patients aged 1-80 years, with an average age of 49.1 years, the male to female ratio (2.3:1) was lower than that before the 30 years. 73.5% of the 3250 patients sought medical advice within 3 months after the onset of the disease in contrast to 63.8% before the 30 years. Compared with those patients before the 30 years the symptoms and signs were alleviated generally. The HBsAg positive rate was 81.0%, but the HCV-Ab positive rate was 13.2%. The AFP level in 75% of patients was elevated, but in the remaining 25% was normal. 1912 patients (58.8%) were confirmed pathologically. Among them 1755 patients (91.8%) had hepatocellular carcinoma. The overall resec- tion rate was 46.3%. Those who had early, middle, late stage carcinoma accounted for 29.9%, 51.5%, and 18.6%respectively in contrast to 0.4%, 47.0%, and 52.6% repor- ted before the 30 years. The 1-, 3-, 5-year survival rates of the patients were 66.1%, 39.7%, and 32.5% respectively, whereas 93.5%, 70.1%, and 59.1% for the early stage pa- tients, and 65.3%, 30.5%, and 23.5% for the middle stage patients. The half and 1-year survival rates of the late stage patients were 52.5%, and 14.7%, respectively. CONCLUSION: Comparison with the clinical data before and after the 30 years show that PLC can be diagnosed ear- ly. More PLC patients tend to undergo resection while re- ceiving a better conservative treatment, w

关键词： primary liver cancer diagnosis therapy survival rate