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虚拟仿真技术在病原生物学实验教学中的探索

中国病原生物学杂志 2024年第2期19卷 248-250页

作者：张永鹏韩亚飞吴越刘艳俊王莹河北北方学院中医学院河北张家口075000

虚拟仿真技术作为新的计算机技术,为学生学习病原生物学打开新天地,在开拓新型病原生物学实验课程教学中具有独特优势。本文通过分析虚拟仿真技术的优势、建设虚拟仿真实验室的必要性、虚拟仿真实验教学项目的现状与问题,以痰液中结核... 详细信息

虚拟仿真技术作为新的计算机技术,为学生学习病原生物学打开新天地,在开拓新型病原生物学实验课程教学中具有独特优势。本文通过分析虚拟仿真技术的优势、建设虚拟仿真实验室的必要性、虚拟仿真实验教学项目的现状与问题,以痰液中结核分枝杆菌检测为例探索虚拟仿真技术在病原生物实验教学中的应用。

关键词：虚拟仿真实验病原生物学实验教学

F框/WD-40域蛋白11对三阴性乳腺癌细胞增殖、迁移的影响

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中华内分泌外科杂志（中英文） 2024年第2期18卷 184-189页

作者：赵娴刘相萍宫明凯王硕隋爱华韩亚斐王海波青岛大学附属医院乳腺病诊疗中心青岛266003 青岛大学附属医院医学研究中心青岛266003 潍坊市中医医院乳腺外科潍坊261000

视频导读乳腺癌是女性最常见的恶性肿瘤,迄今为止,探索三阴性乳腺癌(TNBC)的靶向治疗始终是医学研究的热点。TNBC是一种特殊分子亚型的乳腺癌类型,因其侵袭性强、转移复发风险高且缺乏有效治疗靶点,导致患者预后差,严重威胁女性健康,是... 详细信息

视频导读乳腺癌是女性最常见的恶性肿瘤,迄今为止,探索三阴性乳腺癌(TNBC)的靶向治疗始终是医学研究的热点。TNBC是一种特殊分子亚型的乳腺癌类型,因其侵袭性强、转移复发风险高且缺乏有效治疗靶点,导致患者预后差,严重威胁女性健康,是临床亟待解决的治疗难题。本文研究FBXW11对TNBC生物学功能活性的影响,将进一步探讨FBXW11影响TNBC功能潜在作用机制,以便为TNBC的靶向治疗提供新的理论依据。

关键词：乳腺癌三阴性乳腺癌 F框/WD-40域蛋白11 增殖迁移

Assessing non-point source pollution in an apple-dominant basin and associated best fertilizer management based on SWAT modeling

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International Soil and Water Conservation Research 2023年第2期11卷 353-364页

作者： Yiwen han Zhong liu yafei Chen Yingxuan Li Haipeng liu Lianghong Song Yong Chen College of Land Science and Technology China Agricultural UniversityBejing100193China Key Laboratory of Arable Land Conservation in North China Ministry of Agriculture and Rural AfairsBejing100193China Technology Innovation Center of Land Engineering Ministry of Natural ResourcesBeijing100037China Yantai Hydrology Bureau Yantai264009China

Investigating the impact of apple-dominated areas on nitrogen(N)and phosphorus(P)losses at a basin scale was essential for the sustainable development of apple industry in *** study conducted a survey on fertilizer application and built a Soil and Water Assessment Tool(SWAT)model to quantita-tively analyze the N and P losses in the Qixia apple-dominated ***,the decreases in N and P losses through adjusting the fertilizer application modes were *** showed that average N and P losses in the Wulong River Basin(WRB)were 44.4 and 0.365 kg ha^(-1)in 2011-2017,respectively,and apple orchards accounted for 733%and 51.4%of the total N and P losses in the *** nine fertilizer scheduling scenarios,three fertilizer schedule scenarios,automatic fertilizer application(S-AUTO),"one shot"mode(S1),and regulated fertilizer application(S-BSD),had the lowest N and P losses in apple *** decreases in N loss ranged from 20.6%to 26.1%at the subbasin scale and 14.8%-30.7%at the basin outlet when applying the S-AUTO,S1,and S-BSD fertilizer application modes in Qixia apple orchards and all apple orchards in the *** reductions in P loss varied from 22.0%to 46.1%at the subbasin scale and 14.6%-25.6%at the basin *** orchard-dominated basin,N and P losses can be effectively reduced by optimizing the orchard fertilizer scheduling strategies.

关键词： Apple orchards Questionnaire survey N and P losses Optimized fertilizer management Basin management

一种VUHF频段1500 W超宽带大功率功放设计实现

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计算机与网络 2024年第3期50卷 216-222页

作者：魏利郝韩邦杰敦书波王亚飞王志刚柳占伟杨尚张旭中国电子科技集团公司第五十四研究所空装驻天津地区第一军事代表室

介绍了一种VUHF频段1 500 W超宽带功放的设计与实现，频率覆盖30～520 MHz全频带。采用ADS软件大信号模型仿真的方法对功率管进行阻抗匹配，设计了VUHF频段150 W末级模块；采用大功率传输线变压器和移相网络进行大功率分合路，同时完成9... 详细信息

介绍了一种VUHF频段1 500 W超宽带功放的设计与实现，频率覆盖30～520 MHz全频带。采用ADS软件大信号模型仿真的方法对功率管进行阻抗匹配，设计了VUHF频段150 W末级模块；采用大功率传输线变压器和移相网络进行大功率分合路，同时完成90°移相，提高功放整机的偶次/奇次谐波抑制，实现了VUHF频段16路大功率合成；采用数字仿真和结构优化相结合的方式进行液冷机箱设计，并使用Icepak软件设计了高效散热器，对机箱内模块的布局进行优化仿真；采用全面的控制保护电路，提高功放的稳定性和可靠性。

关键词： VUHF频段传输线变压器 90°移相高效散热器

Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle

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生物活性材料(英文) 2023年第2期20卷 166-178页

作者： Shuming Sun han liu Yan Hu Yanpeng Wang Mingri Zhao Yijun Yuan yafei han Yingying Jing Jin Cui Xiaoxiang Ren Xiao Chen Jiacan Su Molecular Biology Research Center Center for Medical GeneticsHunan Province Key Laboratory of Basic and Applied HematologySchool of Life SciencesCentral South UniversityChangsha410078China Institute of Translational Medicine Shanghai UniversityShanghai200444China Center for Medical Genetics&Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsh1Hunan410013China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of BiologyCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan410082China Department of Orthopedics Traum1 Shanghai Changhai HospitalNaval Medical UniversityShanghai200433China

Skeletal muscle disorders have posed great threats to *** delivery of drugs and oligonucleotides to skeletal muscle is *** can improve targeting *** this study,for the first time,the human skeletal muscle-specific ssDNA aptamers(HSM01,etc.)were selected and identified with Systematic Evolution of Ligands by Exponential Enrichment(SELEX).The HSM01 ssDNA aptamer preferentially interacted with human skeletal muscle cells in *** in vivo study using tree shrews showed that the HSM01 ssDNA aptamer specifically targeted human skeletal muscle ***,the ability of HSM01 ssDNA aptamer to target skeletal muscle cells was not affected by the formation of a disulfide bond with nanoliposomes in vitro or in vivo,suggesting a potential new approach for targeted drug delivery to skeletal muscles via ***,this newly identified ssDNA aptamer and nanoliposome modification could be used for the treatment of human skeletal muscle diseases.

关键词： Aptamer SELEX Human skeletal muscle Target delivery Nanoliposomes

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刻槽采样法在油页岩露天矿的应用实践

露天采矿技术 2024年第4期39卷 101-104页

作者：韩岗胡红倩周亚菲刘建锋何疆生吕荣刚新疆宝明矿业有限公司新疆吉木萨尔831700 新疆大学地质与矿业工程学院新疆乌鲁木齐830000 库尔勒金川矿业有限公司新疆库尔勒841000

为了更加准确可靠地反映油页岩矿体、岩体赋存状况,更加有效地应用于矿山地质管理、选矿管理、提高矿石质量与产量;基于新疆天山北麓油页岩赋存状态及油页岩露天矿采矿工作特点,介绍了刻槽采样法在油页岩开采中的应用场景,如测线的选择... 详细信息

为了更加准确可靠地反映油页岩矿体、岩体赋存状况,更加有效地应用于矿山地质管理、选矿管理、提高矿石质量与产量;基于新疆天山北麓油页岩赋存状态及油页岩露天矿采矿工作特点,介绍了刻槽采样法在油页岩开采中的应用场景,如测线的选择、工具准备,化验方法、取样费用分析、取样质量保障与安全措施;并结合取样化验成果,进行了矿体圈定方法、测线柱状图及平面图绘制、刻槽结果应用示例论述。

关键词：油页岩矿体刻槽采样法矿体圈定选矿

地黄饮子调节海马神经突触可塑性作用机制研究

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山东中医药大学学报 2024年第3期48卷 337-347页

作者：李少创韩诚张正赵雅飞秦亚莉刘昕贺文彬张俊龙山西中医药大学分子中医药学国家级国际联合研究中心山西太原030024 山西中医药大学中医脑病学山西省重点实验室山西太原030024

目的:观察地黄饮子改善阿尔茨海默病(AD)模型小鼠学习记忆能力及对海马突触可塑性的影响,探讨AD治疗机制。方法:选用50只6月龄SAMP8小鼠构建AD动物模型,采用RANDBETWEEN随机函数将其分为模型组、盐酸美金刚组及地黄饮子低、中、高剂量组... 详细信息

目的:观察地黄饮子改善阿尔茨海默病(AD)模型小鼠学习记忆能力及对海马突触可塑性的影响,探讨AD治疗机制。方法:选用50只6月龄SAMP8小鼠构建AD动物模型,采用RANDBETWEEN随机函数将其分为模型组、盐酸美金刚组及地黄饮子低、中、高剂量组各10只,选用同龄SAMR1小鼠10只作为正常组。地黄饮子各剂量组及盐酸美金刚组按照给药剂量给予相应药物灌胃,正常组和模型组给予等体积纯水灌胃,连续给药12周。新物体识别、Morris水迷宫、巴恩斯迷宫法分别检测小鼠的学习记忆能力,在体海马场电位实验记录小鼠海马长时程增强(LTP)效应,免疫组化实验检测突触后致密蛋白-95(PSD-95)、突触素(SYN)蛋白水平的变化,蛋白质印迹法检测海马神经元NMDAR1、NMDAR2B、Ca2+在细胞内所结合钙调蛋白依赖性蛋白激酶Ⅱ(CaMKⅡ)蛋白表达情况。结果:与模型组比较,地黄饮子各剂量组小鼠新物体识别系数增加,差异有统计学意义(P0.05),在逃生箱所在象限停留时间明显增加,差异有统计学意义(P<0.05)。在体海马场电位记录实验表明,高频刺激前各组小鼠fEPSPs斜率无明显差异,高频刺激后30 min、60 min地黄饮子各剂量组较模型组斜率增高,差异均有统计学意义(P<0.05)。与模型组比较,地黄饮子各剂量组CA1区海马神经元PSD-95蛋白、SYN蛋白表达水平上升;地黄饮子各剂量组CA3区海马神经元PSD-95蛋白、SYN蛋白表达水平上升。与模型组比较,地黄饮子各剂量组海马神经元CaMKⅡ、NMDAR1、NMDAR2B蛋白表达水平升高。结论:地黄饮子能改善AD模型小鼠的学习记忆能力,机制可能为通过调节海马神经元Ca2+维持神经突触可塑性,。

关键词：阿尔茨海默病地黄饮子海马突触可塑性长时程增强效应钙离子小鼠学习记忆能力

Characterization on the Microstructures of Brominated Natural Rubber from Latex

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Journal of Wuhan University of Technology(Materials Science) 2019年第1期34卷 201-206页

作者：薛行华 liu yafei han Xiuping LI Guang WANG Zhiyong College of Materials and Chemical Engineering Hainan University Department of Chemistry and Physics Troy University

To elucidate the mechanism of brominated natural rubber(BNR), eight BNR samples with different bromine content were prepared from latex in different bromination time, and the microstructures were characterized by Fourier transform infrared spectroscopy(FTIR) and ~1H-NMR spectroscopy, respectively. The hardness of BNR increased and its nature transformed from elastomer to resin with the increase of bromine content. Unlike chlorinated natural rubber(CNR), FTIR showed that there were no carbonyl groups on the molecular chains of BNR. ~1H-NMR spectroscopy revealed that the reaction activity of bromine and the secondary hydrogen atom of BNR were much higher than those of the primary one. The brominated substitution took place in the hydrogen atom of CH_3 and CH_2 groups firstly, then in the late period of bromination the bond of C=C was transferred to the saturated bond of C-C due to the Markovnikov addition of hydrogen bromide. Based on these findings, the mechanism of BNR from latex could be deduced as a free radical reaction and the detailed bromination process was presented.

关键词： natural rubber bromination microstructure mechanism radical reaction

High Potential Columnar Nanocrystalline AlN Films Deposited by RF Reactive Magnetron Sputtering

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Nano-Micro Letters 2012年第1期4卷 40-44页

作者： Chengzhang han Da Chen Yaozhong Zhang Dong Xu Yijian liu Eric Siu-Wai Kong yafei Zhang Key Laboratory for Thin Film and Microfabrication of the Ministry of Education Research Institute of Micro/Nano Science and Technology Shanghai Jiao Tong University Department of Applied Physics College of Science Shandong University of Science and Technology

Columnar nanocrystalline aluminum nitride(cnc-AlN) thin films with(002) orientation and uniform texture have been deposited successfully on large silicon wafers by RF reactive magnetron *** the optimum sputtering parameters, the deposited cnc-AlN thin films show a c-axis preferred orientation with a crystallite size of about 28 nm and surface roughness(RMS) of about 1.29 nm. The cnc-AlN thin films were well transparent with an optical band gap about 4.8 e V, and the residual compressive stress and the defect density in the film have been revealed by Ramon spectroscopy. Moreover, piezoelectric performances of the cnc-AlN thin films executed effectively in a film bulk acoustic resonator structure.

关键词： Columnar film Aluminum nitride Piezoelectric effect RF sputtering Optical property