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Stem Cells and Exosomes-associated Therapeutic Applications

Journal of Clinical and Nursing Research 2024年第6期8卷 232-246页

作者： Usama ahmed Muhammad Abubakar Rooma Ayyoub Baqaur Rehman Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Department of Biosciences COMSATS University IslamabadPark RdIslamabad Capital Territory 45550Pakistan

Exosomes are extracellular vesicles with sizes from 30 to 150 nm in diameter and modulate the transport of multiple intracellular biological molecules including proteins,nucleic acids,lipids,and *** regulate a large number of cells and are involved in different pathological and physiological activities including carcinogenesis,viral infection,cell-cell communication and immune responses as *** cell-derived exosomes carry many benefits over simple stem cells in the form of easy access,freedom from tumourigenic capabilities,non-infusion toxicity,effortless preservation,and *** have almost the same properties and perform functions effectively in the same way as their parental cells do like adult stem cells and embryonic stem *** to their pluripotent or multipotent abilities,stem cells(SCs)transform into several types of *** addition to other secretions,SC also give exosomes,which in turn shows therapeutic significance for many disorders,including cancer,diabetes mellitus,skin allergies and regenerative *** originating from mesenchymal stem cells(MSCs)have miRNAs,lipids,and proteins that trigger diabetes and cancer situations in *** from SCs(sc-exos)are preferred to SC as there are fewer side effects and other challenges,including effectiveness,drug delivery,lower immunogenicity and *** the current review,we summarize the data from the last 5 years'articles about exosomes and stem cell-derived microvesicles for the therapeutic potential of various diseases such as cancer,Alzheimer's disease,diabetes,and Parkinson's disease with clinical challenges and future aspects.

关键词： Stem cells Exosomes Therapeutic Cancer Parkinson Diabetes

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A Family of GCK-MODY, About 02 Cases and Review of the Literature

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Open Journal of Endocrine and Metabolic Diseases 2024年第7期14卷 135-142页

作者： Malad Mohamed Tadlaoui Abderrahman Riznat Malak Guerboub ahmed Anas Department of Endocrinology Mohamed V Military Instruction Hospital Rabat Morocco

Positive diagnosis of diabetes is currently easy, but typing diagnosis of diabetes still remains a challenge for every clinician. It is currently accepted that types of diabetes apart from T1D and T2D can expand and include several forms of diabetes mellitus;From gestational diabetes, to all forms of secondary diabetes mellitus due to medications, intercurrent disease but also infections, and finally monogenic diabetes, whose diagnosis is not always easy to establish. The aim is to reveal the difficulties that clinicians may face in the process of etiological diagnosis regarding the suspicion of this type of monogenic diabetes, through the study of 2 cases, in which MODY type diabetes was suspected. Today we recognize 17 different genetic mutations that can all lead to MODY diabetes, the most common mutation of which is GCK coding for the glucokinase, the real sensor of pancreatic Beta-cell. The truly stable glycemic profile, with an A1C ranging between 7% and 7.5%, confirmed with a TIR always above 70% and a good MAGE, but also the rarity of degenerative complications and pharmacological therapeutic abstention which can last for years, these would be the most striking clinical characteristics of a GCK MODY.

关键词： Maturity Onset Diabetes of the Young Diabetes Typing Glucokinase GCK Mutation

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Antibody Pattern: Correlation of Age and Gender in ANA and Anti-ds-DNA Prevalence

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Journal of Clinical and Nursing Research 2024年第6期8卷 373-381页

作者： Usama ahmed Hijazi Mallick Amber Khan Muhammad Zubair Department of Medicine School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Dow International Medical College Karachi Pakistan Department of Biosciences Shaheed Zulfikar Ali Bhutto Institute of Science and Technology(SZABIST)KarachiPakistan Institute of Biological Sciences Khwaja Fareed University of Engineering and Information TechnologyRahim Yar KhanPakistan

The study was designed to find the prevalence of ANA antibodies and anti-dsDNA antibodies in samples tested at AFIP Rawalpindi and their correlation with age and gender and to find positive and negative predictive values of ANA *** this purpose,twelve thousand nine hundred sixty-seven(12,967)patients were analyzed for ANA with four hundred sixty-eight(468)healthy samples tested as control and four thousand seven hundred three(4,703)patients tested for ds-DNA *** data of all samples tested by indirect immunofluorescence(IF)for ANA antibodies and dsDNA antibodies was *** address positive and negative predictive values another control group(autoimmunity not suspected)of serum samples was taken from the healthy *** the first group,age,gender,ANA antibodies and ds-DNA antibodies results(both tests performed by IIF)data was collected from a computer record cell;for the second control group,ANA antibodies were performed by IIF.12,967 and 4,703 samples(Group 1)were tested for ANA antibodies and dsDNA antibodies,respectively,during this period.1,119(9%)and 99(2%)were found positive for ANA antibodies and ds DNA *** these positive samples,850(76%)and 73(74%)were females *** predisposition towards autoimmunity(ANA)was found significant with a P value of(P=0.001).Relation of age was also found significant with anti-ANA antibodies with a P value of(P=0.001).This study shows a negative correlation between age(P=0.025)and gender(P=0.001)with anti-dsDNA which is also *** prevalence was found below the mean age of 38 years(SD±16.635)for ANA antibodies and the mean age of 35 years(SD±15.066)for ds-DNA *** age of ANA antibodies and dsDNA antibodies positive patients ranged from 1 year old to 98 years old and 2 years old to 95 years old *** the second(autoimmunity-free)control group,a total of 468 samples were tested for ANA antibodies and 9(2%)were found ***

关键词： ANA Anti ds-DNA Autoimmunity SLE Immune fluorescence

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Decoding Retinoblastoma: Differential Gene Expression

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International Journal of Clinical Medicine 2024年第4期15卷 177-196页

作者： ahmed Jasim Mahmood Al-Mashhadani Franko Shehaj Lianhong Zhou Department of Ophthalmology Renmin Hospital of Wuhan University Wuhan China

Background: Retinoblastoma, the most common intraocular pediatric cancer, presents complexities in its genetic landscape that necessitate a deeper understanding for improved therapeutic interventions. This study leverages computational tools to dissect the differential gene expression profiles in retinoblastoma. Methods: Employing an in silico approach, we analyzed gene expression data from public repositories by applying rigorous statistical models, including limma and de seq 2, for identifying differentially expressed genes DEGs. Our findings were validated through cross-referencing with independent datasets and existing literature. We further employed functional annotation and pathway analysis to elucidate the biological significance of these DEGs. Results: Our computational analysis confirmed the dysregulation of key retinoblastoma-associated genes. In comparison to normal retinal tissue, RB1 exhibited a 2.5-fold increase in expression (adjusted p Conclusions: Our analysis reinforces the critical genetic alterations known in retinoblastoma and unveils new avenues for research into the disease’s molecular basis. The discovery of chemoresistance markers and immune-related genes opens potential pathways for personalized treatment strategies. The study’s outcomes emphasize the power of in silico analyses in unraveling complex cancer genomics.

关键词： Retinoblastoma Gene Expression In Silico Study Differentially Expressed Genes Chemoresistance Immune Response Computational Biology

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Thermo-Physical Potential of Recycled Banana Fibers for Improving the Thermal and Mechanical Properties of Biosourced Gypsum-Based Materials

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Journal of Renewable Materials 2024年第4期12卷 843-867页

作者： Youssef Maaloufa Soumia Mounir Sara Ibnelhaj Fatima Zohra El Wardi Asma Souidi Yakubu Aminu Dodo Malika Atigui Mina Amazal Abelhamid Khabbazi Hassan Demrati ahmed Aharoune National School of Architecture Agadir New ComplexIbn Zohr UniversityAgadirMorocco Energy Materials and Sustainable Development(EMDD)Center for WaterNatural ResourcesEnvironment and Sustainable Development(CERNE2D)Mohammed V UniversityRabatMorocco Thermodynamics and Energetics Laboratory Faculty of ScienceIbn Zohr UniversityAgadirMorocco Architectural Engineering Department Najran UniversityNajranSaudi Arabia The Centre of Scientific and Engineering Research Najran UniversityNajranSaudi Arabia Physics Department LPMAT LaboratoryFaculty of Sciences Ain ChockHassan II UniversityCasablancaMorocco

The development of bio-sourced materials is essential to ensuring sustainable construction;it is considered a locomotive of the green ***,it is an abundant material in our country,to which very little attention is being *** work aims to valorize the waste of the trunks of banana trees to be used in ***,the physicochemical properties of the fiber,such as the percentage of crystallization and its morphology,have been determined by X-ray diffraction tests and scanning electron microscopy to confirm the potential and the impact of the mode of drying on the quality of the banana fibers,with the purpose to promote the use of this material in ***,the results obtained with the gypsum matrix allowed us to note a preponderant improvement in the composite’s thermal properties thanks to the variation of the banana fiber ***,the impact of the nature of the banana fiber distribution(either fiber mixed in matrix or fiber series model)on the flexural and compressive strengths of the composites was *** results obtained indicate that the insulation gain reaches up to 40%.It depends on the volume fraction and type of distribution of the banana ***,the thermal inertia of the composites developed,represented by thermal diffusivity and thermal effusivity,was *** indicate a gain of 40%and 25%,respectively,in terms of thermal diffusivity and thermal effusivity of the developed composites compared to plaster *** the mechanical properties,the flexural strength depends on the percentage of the volume fraction of banana fibers used,and it can reach 20%more than the flexural strength of plaster;nevertheless,there is a significant loss in terms of the compressive strength of the studied *** results obtained are confirmed by the microstructure of the fiber *** fact,the morphology of the banana fibers was improved by the drying *** reduces the amorphous area an

关键词： Biosourced materials fiber banana flexural strength mechanical properties open-air drying plaster thermal properties waste management

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Relationship between Seed Priming Mediated Seedling Vigor and Yield Performance of Spring Wheat

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1159-1177页

作者： Md.Parvez Anwar Masuma Akhter Sharmin Aktar Sinthia Afsana Kheya A.K.M.Mominul Islam Sabina Yeasmin ahmed Khairul Hasan Md.Harun Or Rashid Department of Agronomy Bangladesh Agricultural UniversityMymensingh2202Bangladesh

Seed priming is a pre-germinated technique that can enhance seed germination percentage,faster and synchro-nized germination,better seedling growth,and yield under stress *** ascertain the most effective seed priming method that would ensure the potential yield of wheat in Bangladesh,two experiments were carried out from December 2021 to March 2022 at the Department of Agronomy,Bangladesh Agricultural *** wheat varieties namely BARI Gom-28 and BWMRI Gom-1 were subjected to a range of priming chemicals in both lab and pot *** compounds included the following:control(no priming),hydropriming(distilled water),10000 ppm KNO_(3),15000 ppm KNO_(3),40000 ppm Mannitol,60000 ppm Mannitol,10000 ppm NaCl,20000 ppm NaCl,100 ppm PEG,150 ppm PEG,500 ppm NaOCl,1000 ppm NaOCl,10000 ppm CaCl_(2),20000 ppm CaCl_(2),10000 ppm KCl and 20000 ppm KCl.A complete randomized design(CRD)with three repli-cations was used to set up the *** results showed that BARI Gom-28 and BWMRI Gom-1 responded best to KCl priming in terms of rapid seed germination and strong seedling *** the other hand,the best priming agents for plant growth and productivity turned out to be CaCl_(2) and *** results of this study support the possibility of using seed priming as a technique to improve wheat plant development and output by raising seed emergence and survival rates.

关键词： Priming seedling percentage germination growth yield wheat

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Enhancing cotton resilience to challenging climates through genetic modifications

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Journal of Cotton Research 2024年第2期7卷 196-206页

作者： ahmed Ali Ijaz KHAN Azeem Iqbal NEGM Mohamed A.M. IQBAL Rida AZHAR Muhammad Tehseen KHAN Sultan Habibullah RANA Iqrar Ahmad Department of Plant Breeding and Genetics University of AgricultureFaisalabadFaisalabad 38000Pakistan Cotton Research Institute-Giza GizaEgypt Centre for Advanced Studies in Agriculture and Food Security University of AgricultureFaisalabadFaisalabad 38000Pakistan Centre of Agricultural Biochemistry and Biotechnology University of AgricultureFaisalabadFaisalabad 38000Pakistan School of Agriculture Sciences Zhengzhou UniversityZhengzhou 450000China

Cotton is one of the most important fiber crops that plays a vital role in the textile *** production has been unstable over the years due to climate change induced biotic stresses such as insects,diseases,and weeds,as well as abiotic stresses including drought,salinity,heat,and *** breeding methods have been used to breed climate resilient cotton,but it requires a considerable amount of time to enhance crop tolerance to insect pests and changing climatic conditions.A promising strategy for improving tolerance against these stresses is genetic *** review article discusses the role of genetic engineering in cotton *** essential concepts and techniques include genome editing via clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(CRISPR-Cas9),overexpression of target genes,downregulation using RNA interference(RNAi),and virus-induced gene silencing(VIGS).Notably,the Agrobacterium-mediated transformation has made significant contributions to using these techniques for obtaining stable transgenic plants.

关键词： Cotton Genome editing Drought Salinity Heat

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孵化后期热处理对肉雏鸡骨骼肌和肝脏温敏TRP离子通道及线粒体功能的影响

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南京农业大学学报 2024年第3期47卷 530-538页

作者：李晓庆李盛周晓铧 Mohamed ahmed Fathi 李春梅南京农业大学动物科技学院家畜环境控制与智慧生产研究中心江苏南京210095

[目的]孵化后期热处理能够在一定程度上提高肉鸡的耐热性,而骨骼肌和肝脏线粒体功能及温敏瞬时电位(transient receptor potential,TRP)离子通道与机体耐热性密切相关。因此,本试验旨在研究孵化后期热处理(thermal manipulation,TM)对... 详细信息

[目的]孵化后期热处理能够在一定程度上提高肉鸡的耐热性,而骨骼肌和肝脏线粒体功能及温敏瞬时电位(transient receptor potential,TRP)离子通道与机体耐热性密切相关。因此,本试验旨在研究孵化后期热处理(thermal manipulation,TM)对雏鸡骨骼肌和肝脏温敏TRP离子通道及线粒体功能的影响。[方法]选取240枚AA肉鸡种蛋随机分为3组(每组8个重复,每重复10枚种蛋):CON组,37.5℃孵化;TM1组,在孵化期第16~18天39.5℃热处理3 h·d^(-1);TM2组,在孵化期第16~18天41.5℃热处理3 h·d^(-1)。出雏后测定1日龄直肠温度,检测胸肌、腿肌和肝脏组织相关基因表达水平。[结果]与CON组相比,孵化后期热处理显著降低了1日龄雏鸡的直肠温度(P<0.01),TM1组雏鸡腿肌器官指数显著增加(P<0.05)。与CON组相比,TM2组雏鸡胸肌的avUCP基因表达水平显著降低(P<0.01),COXⅣ(P<0.05)、Tfam(P<0.01)、PGC1α(P<0.05)、ATP5B(P<0.01)和IDH3α(P<0.01)基因表达水平均显著增加,TRPV1、TRPV2和TRPV3基因表达水平均显著降低(P<0.05),SERCA1基因表达水平显著增加(P<0.01)。与CON组相比,TM2组雏鸡腿肌的avUCP基因表达水平显著降低(P<0.01),ATP5B基因表达水平显著增加(P<0.05);TM2组雏鸡肝脏组织的Tfam和SERCA1基因表达水平显著增加(P<0.05)。相关性分析结果显示,温敏TRP基因表达水平与线粒体经典产热基因avUCP和avANT表达呈正相关关系,与线粒体氧化磷酸化功能相关基因表达水平呈负相关关系。[结论]孵化后期热处理可通过降低1日龄雏鸡胸肌的温敏TRP基因和线粒体产热相关基因表达水平水平,增加线粒体生物发生及氧化磷酸化功能相关基因表达水平,引起线粒体热适应性变化。

关键词：肉鸡孵化期热处理温敏TRP离子通道线粒体功能

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Probing the Efficiency of PPMG-Based Composite Electrolytes for Applications of Proton Exchange Membrane Fuel Cell

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Transactions of Tianjin University 2024年第3期30卷 262-283页

作者： Shakeel ahmed Faizah Altaf Safyan Akram Khan Sumaira Manzoor Aziz Ahmad Muhammad Mansha Shahid Ali Ata-ur-Rehman Karl Jacob School of Material Science and Engineering Henan International Joint Laboratory of Nano-Photoelectric Magnetic MaterialsHenan University of TechnologyZhengzhou 450001China Interdisciplinary Research Center for Hydrogen Technologies and Carbon Management King Fahd University of Petroleum and Minerals31261 DhahranSaudi Arabia School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

PPMG-based composite electrolytes were fabricated via the solution method using the polyvinyl alcohol and polyvinylpyrrolidone blend reinforced with various contents of sulfonated inorganic *** acid was employed as the sulfonating agent to functionalize the external surface of the inorganic filler,i.e.,graphene *** proton conductivities of the newly prepared proton exchange membranes(PEMs)were increased by increasing the temperature and content of sulfonated graphene oxide(SGO),i.e.,ranging from 0.025 S/cm to 0.060 S/*** induction of the optimum level of SGO is determined to be an excellent route to enhance ionic *** single-cell performance test was conducted by sandwiching the newly prepared PEMs between an anode(0.2 mg/cm^(2) Pt/Ru)and a cathode(0.2 mg/cm^(2) Pt)to prepare membrane electrode assemblies,followed by hot pressing under a pressure of approximately 100 kg/cm^(2) at 60℃for 5–10 *** highest power densities achieved with PPMG PEMs were 14.9 and 35.60 mW/cm^(2) at 25℃and 70℃,respectively,at ambient pressure with 100%relative *** showed that the newly prepared PEMs exhibit good electrochemical *** results indicated that the prepared composite membrane with 6 wt%filler can be used as an alternative membrane for applications of high-performance proton exchange membrane fuel cell.

关键词： Proton exchange membrane fuel cell Sulfonated graphene oxide Polyvinylpyrrolidone Solution casting Membrane electrode assembly Fuel cell performance

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Advances in DNA methylation and its role in cytoplasmic male sterility in higher plants

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Journal of Integrative Agriculture 2024年第1期23卷 1-19页

作者： Atiqur Rahman Hasan Sofiur Rahman Shakil Uddin Naima Sultana Shirin Akhter Ujjal Kumar Nath Shamsun Nahar Begum Mazadul Islam Afroz Naznin Nurul Amin Sharif ahmed Akbar Hossain Department of Genetics and Plant Breeding Bangladesh Agricultural UniversityMymensingh 2202Bangladesh Plant Breeding Division Bangladesh Institute of Nuclear AgricultureMymensingh 2202Bangladesh Tuber Crop Research Centre Bangladesh Agricultural Research Institute(BARI)Joydebpur 1701Bangladesh Horticulture Research Centre Bangladesh Agricultural Research Institute(BARI)Joydebpur 1701Bangladesh Biotechnology Division Bangladesh Agricultural Research Institute(BARI)Joydebpur 1701Bangladesh International Rice Research Institute Bangladesh OfficeDhaka 1213Bangladesh Division of Soil Science Bangladesh Wheat and Maize Research InstituteDinajpur 5200Bangladesh

The impact of epigenetic modifications like DNA methylation on plant phenotypes has expanded the possibilities for crop *** methylation plays a part in the regulation of both the chromatin structure and gene expression,and the enzyme involved,DNA methyltransferase,executes the methylation process within the plant *** regulating crucial biological pathways,epigenetic changes actively contribute to the creation of the ***,epigenome editing may assist in overcoming some of the drawbacks of genome editing,which can have minor off-target consequences and merely facilitate the loss of a gene’s *** drawbacks include gene knockout,which can have such off-target *** review provides examples of several molecular characteristics of DNA methylation,as well as some plant physiological processes that are impacted by these epigenetic changes in the *** also discuss how DNA alterations might be used to improve crops and meet the demands of sustainable and environmentally-friendly farming.

关键词： DNA methylation epigenetics CMS male sterility chromatin architecture gene expression higher plants

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