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Automated robot and artificial intelligence-powered wastewater surveillance for proactive mpox outbreak prediction

生物安全与健康(英文) 2024年第4期06卷 225-234页

作者： Ou Guanyong Tang Yuxuan Liu Jiexiang hao yabin Chen Zhi Huang Ting Li Shaxi Niu Shiyu Peng Yun Feng Jiaqi Tu Hongwei Yang Yang Zhang Han Liu Yingxia Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious Disease State Key Discipline of Infectious Disease the Third People’s Hospital of Shenzhen Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China International Collaborative Laboratory ofD Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale Optoelectronics College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen China Shenzhen Clinical Medical College Guangzhou University of Chinese Medicine Shenzhen China Shenzhen Metasensing Tech Limited Company Shenzhen China Guangdong Provincial Centre for Diseases Control and Prevention Guangzhou China

In the wake of the largest-ever recorded outbreak of mpox in terms of magnitude and geographical spread in human history since May 2022, we innovatively developed an automated online sewage virus enrichment and concentration robot for disease tracking. Coupled with an artificial intelligence (AI) model, our research aims to estimate mpox cases based on the concentration of the monkeypox virus (MPXV) in wastewater. Our research has revealed a compelling link between the levels of MPXV in wastewater and the number of clinically confirmed mpox infections, a finding that is reinforced by the ability of our AI prediction model to forecast cases with remarkable precision, capturing 87 % of the data’s variability. However, it is worth noting that this high precision in predictions may be related to the relatively high frequency of data acquisition and the relatively non-mobile isolated environment of the hospital itself. In conclusion, this study represents a significant step forward in our ability to track and respond to mpox outbreaks. It has the potential to revolutionize public health surveillance by utilizing innovative technologies for disease surveillance and prediction.

关键词： Automated online sewage virus enrichment robot Artificial intelligence (AI) model Early warning system Mpox Monkeypox virus (MPXV)

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自动化病历质控系统应用效果评价

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中国卫生信息管理杂志 2024年第3期21卷 464-470页

作者：徐芳郝雅斌牛宇翔首都医科大学附属北京友谊医院北京市100050

目的在病历信息化建设基础上,建立并优化自动化病历质控系统,对运行病历进行持续、动态、有效的监测,以提高病案质量。方法在北京某三级甲等医院中,以电子病历系统为基础,建立运行病历的质量控制和管理方案,对运行中的病历进行自动检测... 详细信息

目的在病历信息化建设基础上,建立并优化自动化病历质控系统,对运行病历进行持续、动态、有效的监测,以提高病案质量。方法在北京某三级甲等医院中,以电子病历系统为基础,建立运行病历的质量控制和管理方案,对运行中的病历进行自动检测、分析和评价,并通过多种渠道反馈给医院及科室管理者,以便随时掌握运行病历的质量并及时应对。结果利用临床数据中心和移动互联网建立的自动化病历质控系统对运行病历的评分与人工抽检病历的评分结果基本一致,尚不能说明两种质控方式的评分结果有差异。2022年9月运行病历月合格率同比增长33.81%。研究期间,运行病历合格率的季度环比增长率为0.15%~18.12%。结论自动化病历质控系统可以有效提高病历质控的覆盖率和时效性,有助于规范病历书写,提高医疗质量,改善医疗服务和保障医疗安全。

关键词：自动化病历质控系统运行病历

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The nature of electron density enhancement over a wide altitude range during ionosphere heating experiments at EISCAT

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Earth and Planetary Physics 2024年第2期8卷 408-414页

作者： Jun Wu Jian Wu Jie Feng QingLiang Li ShuJi hao ZhengWen Xu HaiSheng Zhao yabin Zhang National Key Laboratory of Electromagnetic Environment China Research Institute of Radio Wave PropagationBeijing 102206China School of Physics Xidian UniversityXi’an 710071China

During the course of ionospheric heating experiments, researchers at the European Incoherent Scatter Scientific Association (EISCAT) observed an apparent electron density enhancement. The enhancement extended over a wide range of altitudes, above the reflection altitude of the high-frequency pump wave. However, whether this enhancement actually corresponds to a true enhancement in electron density remains an open question. When the dispersion relation of ion acoustic waves is followed, the frequency ratio of the enhanced ion line to the background ion line suggests that the profile of the effective ion mass may have remained unchanged. Furthermore, the solar radio flux and ion drift velocity indicate no significant changes in the ion species and their densities. In conclusion, the electron density enhancement observed at EISCAT should not, in fact, be considered a true enhancement.

关键词： incoherent scatter radar(ISR) ionospheric heating electron density ion acoustic wave

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CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant

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Nano-Micro Letters 2022年第10期14卷 83-94页

作者： Chenshuo Wu Zhi Chen Chaozhou Li yabin hao Yuxuan Tang Yuxuan Yuan Luxiao Chai Taojian Fan Jiangtian Yu Xiaopeng Ma Omar AAl-Hartomy SWageh Abdullah GAl-Sehemi Zhiguang Luo Yaqing He Jingfeng Li Zhongjian Xie Han Zhang International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Shenzhen International Institute for Biomedical Research Shenzhen 518116People’s Republic of China Department of Respiratory Shenzhen Children’s HospitalShenzhen 518038People’s Republic of China Institute of Pediatrics Shenzhen Children’s HospitalShenzhen 518038People’s Republic of China Shenzhen Han’s Tech Limited Company Shenzhen 518000People’s Republic of China Hospital of Guangzhou Medical University Qingyuan city People’s HospitalQingyuan 511518People’s Republic of China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityP.O.Box 9004Abha 61413Saudi Arabia Zhongmin(Shenzhen)Intelligent Ecology Co. LtdShenzhen 518055People’s Republic of China Shenzhen Center for Disease Control and Prevention Shenzhen 518055People’s Republic of China

Coronavirus disease 2019(COVID-19)is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The gold standard method for the diagnosis of SARS-CoV-2 depends on quantitative reverse transcription-polymerase chain reaction till now,which is time-consuming and requires expensive instrumentation,and the confirmation of variants relies on further sequencing ***,we first proposed a robust technique-methodology of electrochemical CRISPR sensing with the advantages of rapid,highly sensitivity and specificity for the detection of SARS-CoV-2 *** enhance the sensing capability,gold electrodes are uniformly decorated with electro-deposited gold *** DNA template identical to SARS-CoV-2 Delta spike gene sequence as model,our biosensor exhibits excellent analytical detection limit(50 fM)and high linearity(R2=0.987)over six orders of magnitude dynamic range from 100 fM to 10 nM without any nucleic-acid-amplification *** detection can be completed within 1 h with high stability and specificity which benefits from the CRISPR-Cas ***,based on the wireless micro-electrochemical platform,the proposed biosensor reveals promising application ability in point-of-care testing.

关键词： SARS-COV-2 variant Methodology of electrochemical CRISPR sensing(MOECS) Gold nanoparticles(AuNPs) Point-of-care testing(POCT)

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Preparation of highly conductive graphene-coated glass fibers by sol-gel and dip-coating method

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Journal of Materials Science & Technology 2019年第9期35卷 1989-1995页

作者： Minghe Fang Xuhai Xiong yabin hao Tengxin Zhang Han Wang Hui-Ming Cheng You Zeng Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy o f SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Liaoning Key Laboratory of Advanced Polymer Matrix Composites Shenyang Aerospace UniversityShenyang 110136China Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China

In order to fabricate highly-conductive glass fibers using graphene as multi-functional coatings, we reported the preparation of graphene-coated glass fibers with high electrical conductivity through solgel and dip-coating technique in a simple way. Graphene oxide (GO) was partially reduced to graphene hydrosol, and then glass fibers were dipped and coated with the reduced GO (rGO). After repeated solgel and dip-coating treatment, the glass fibers were fully covered with rGO coatings, and consequently exhibited increased hydrophobicity and high electrical conductivity. The graphene-coated fibers exhibited good electrical conductivity of 24.9 S/cm, being higher than that of other nanocarbon-coated fibers and commercial carbon fibers, which is mainly attributed to the high intrinsic electrical conductivity of rGO and full coverage of fiber surfaces. The wettability and electrical conductivity of the coated fibers strongly depended on the dip-coating times and coating thickness, which is closely associated with coverage degree and compact structure of the graphene coatings. By virtue of high conductivity and easy operation, the graphene-coated glass fibers have great potential to be used as flexible conductive wires, highly-sensitive sensors, and multi-functional fibers in many fields.

关键词： Graphene Glassfiber Sol-gel Dip-coating Coating Electrical conductivity

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Wastewater surveillance and an automated robot:effectively tracking SARS-CoV-2 transmission in the post-epidemic era

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National Science Review 2023年第6期10卷 86-95页

作者： Guanyong Ou Yuxuan Tang Shiyu Niu Liwen Wu Shaxi Li Yang Yang Jun Wang Yun Peng Chuanfu Huang Wei Hu Qinghua Hu Yinghui Li Yang Ping Chao Lin Boping Yu Qi Han yabin hao Zhiguang Luo Wende Tian Han Zhang Yingxia Liu National Clinical Research Center for Infectious Disease State Key Discipline of Infectious Disease The Third People's Hospital of Shenzhen Second Hospital Affiliated to Southern University of Science and Technology School of Medicine Southern University of Science and Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale Optoelectronics College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen Longhua Drainage Co. Ltd. Shenzhen Center for Disease Control and Prevention Microbiology Laboratory Shenzhen Center for Disease Control and Prevention Power China Eco-Environmental Group Co. Ltd. Shenzhen Water Planning & Design Institute Co. Ltd. Shenzhen Academy of Environmental Sciences School of Civil and Environmental Engineering Harbin Institute of Technology (Shenzhen) 1Institute of Solid Wastes and Physical Environment Research Shenzhen Academy of Environmental Sciences Shenzhen Metasensing Technology Co. Ltd. 13. Zhongmin (Shenzhen) intelligent ecology Co. Ltd. Research Centre for Eco-Environmental Sciences Chinese Academy of Sciences

Wastewater-based epidemiology(WBE) has exhibited great utility in the early and rapid identification of SARS-C ***,the efficacy of wastewater surveillance under China’ s previous strict epidemic prevention policy remains to be *** collected the WBE data of wastewater treatment plants(WWTPs) in the Third People’s Hospital of Shenzhen and several communities to determine the significant effectiveness of routine wastewater surveillance in monitoring the local spread of SARS-C oV-2under tight containment of the *** results of 1 month of continuous wastewater surveillance showed that positive signals for SARS-C oV-2 RNA were detected in the wastewater samples,and a significant positive correlation was observed between the virus concentration and the number of daily *** addition,the community’ s domestic wastewater surveillance results were confirmed even 3 days before,or simultaneously with,the infected patient being confirmed as having the ***,an automated sewage virus detection robot,ShenNong No.l robot,was developed,showing a high degree of agreement with experimental data,offering the possibility of large-scale multi-point ***,our results illustrated the clear indicative role of wastewater surveillance in combating COVID-19 and provided a practical basis for rapidly expanding the feasibility and value of routine wastewater surveillance for future emerging infectious diseases.

关键词： SARS-CoV-2 wastewater surveillance wastewater-based epidemiology WWTP automated robot

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A graphene-laminated electrode with high glucose oxidase loading for highly-sensitive glucose detection

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Journal of Materials Science & Technology 2021年第7期66卷 57-63页

作者： yabin hao Minghe Fang Chuan Xu Zhe Ying Han Wang Rui Zhang Hui-Ming Cheng You Zeng Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Liaoning Cancer Hospital and Institute Shenyang 110042China Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China

Graphene oxide(GO) has received considerable attention for glucose detection because of high surface area, abundant functional groups, and good biocompatibility. Defects and functional groups of the GO are beneficial to immobilization of glucose oxidase(GOD), but sacrificing electron-transfer capability for highly-sensitive detection. In order to obtain high GOD loading and highly-sensitive detection of biosensors, we first designed and fabricated a graphene-laminated electrode by combining GO and edgefunctionalized graphene(FG) layers together onto glassy-carbon electrode. The graphene-laminated electrodes exhibited faster electron transfer rate, higher GOD loading of 3.80 × 10^(-9) mol·cm^(-2), and higher detection sensitivity of 46.71 μA·mM^(-1)·cm^(-2) than other graphene-based biosensors reported in literature. Such high performance is mainly attributed to the abundant functional groups of GO, high electrical conductivity of FG, and strong interactions between components in the graphene-laminated *** virtue of their high enzyme loading and highly-sensitive detection, the graphene-laminated electrodes show great potential to be widely used as high-performance biosensors in the field of medical diagnosis.

关键词： Graphene Laminated structure Electrode Glucose detection Biosensor

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Transfer-free CVD graphene for highly sensitive glucose sensors

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Journal of Materials Science & Technology 2020年第2期37卷 71-76页

作者： Shijing Wei yabin hao Zhe Ying Chuan Xu Qinwei Wei Sen Xue Hui-Ming Cheng Wencai Ren Lai-Peng Ma You Zeng Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Physical Science and Technology ShanghaiTech UniversityShanghai200031China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai200050China University of Chinese Academy of Sciences Beijing100049China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China School of Materials Science and Engineering Northeastern UniversityShenyang110819China Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen Institute(TBSI)Tsinghua UniversityShenzhen518055China

Chemical vapor deposition(CVD)graphene film is a promising electrode-modifying material for fabricating high-performance glucose sensor due to its high electrical conductivity and two-dimensional structure over large ***,the use of typical metal-based CVD graphene suffers from the residue contamination of polymer transfer-support and heavy metal *** this work,we directly grew fewlayer graphene on the SiO2/Si substrate without transfer process and then fabricated graphene-based glucose sensors by sequentially immobilizing glucose oxidase and depositing Nafion layer on its surface that was functionalized by oxygen-plasma *** transfer-and metal-free process shows distinct advantage over the common metal-CVD method in improving the electrochemical performance by eliminating the contamination of ***-obtained glucose sensor shows a high sensitivity(16.16μA mM-1cm-2)with a detection limit of 124.19μ*** method is simple and promising for the development of highly sensitive glucose sensors.

关键词： Graphene Chemical vapor deposition Transfer-free Oxygen-plasma treatment Glucose sensor

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A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2

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National Science Review 2022年第8期9卷 100-109页

作者： Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai yabin hao Yuxuan Tang Omar A.Al-Hartomy Swelm Wageh Abdullah G.Al-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education 3. Shenzhen Institute of Translational Medicine 4. Department of Otolaryngology Shenzhen Second People’s Hospital 5. the First Affiliated Hospital 6. Institute of Microscale Optoelectronics Shenzhen University 7. Shenzhen International Institute for Biomedical Research 8. Shenzhen Han’s Tech Limited Company 9. Shenzhen Metasensing Tech Limited Company Department of Physics Faculty of Science King Abdulaziz University Research Center for Advanced Materials Science (RCAMS) King Khalid University Department of Chemistry College of Science King Khalid University Zhongmin (Shenzhen) Intelligent Ecology Co.Ltd Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Department of Laboratory Medicine Shenzhen Children’s Hospital Optoelectronics Research Center School of Science Minzu University of China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Research Unit of Adaptive Evolution and Control of Emerging Viruses Chinese Academy of Medical Sciences Institute of Pathogenic Organism Shenzhen Center for Disease Control and Prevention Respiratory Department Shenzhen Children’s Hospital Institute of Pediatrics Shenzhen Children’s Hospital

The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus, and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed. On the other hand, several concerning SARS-Co V-2 variants,including Omicron, are required to be identified as soon as the samples are identified as ‘positive’.Unfortunately, a traditional PCR test does not allow their specific identification. Herein, for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing), which combines an optical sensing technology-surface plasmon resonance(SPR) with the ‘gene scissors’ clustered regularly interspaced short palindromic repeat(CRISPR) technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants. MOPCS is a low-cost, CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA, without the need for amplification,within 38 min from sample input to results output, and achieve a limit of detection of 15 fM. MOPCS achieves a highly sensitive analysis of SARS-Co V-2, and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron) and BA.1(a subtype of Omicron). This platform was also used to analyze some recently collected patient samples from a local outbreak in China, identified by the Centers for Disease Control and Prevention. This innovative CRISPR-empowered SPR platform will further contribute to the fast, sensitive and accurate detection of target nucleic acid sequences with single-base mutations.

关键词： surface plasmon resonance CRISPR SARS-CoV-2 Omicron variant

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基于界面氢键结构的石墨烯/聚合物复合材料的阻尼性能

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材料研究学报 2023年第6期37卷 401-407页

作者：张藤心王函郝亚斌张建岗孙新阳曾尤中国科学院金属研究所沈阳材料科学国家研究中心沈阳110016 中国科学技术大学材料科学与工程学院沈阳110016

提出在石墨烯/聚合物复合材料内构筑界面氢键结构,利用氢键的动态可逆性和断裂/再生过程中的能量耗散可显著提高复合材料的阻尼性能。对石墨烯和聚(苯乙烯-乙烯-丁二烯-苯乙烯)(SEBS)进行接枝改性,引入氢键单元从而在石墨烯/SEBS复合材... 详细信息

提出在石墨烯/聚合物复合材料内构筑界面氢键结构,利用氢键的动态可逆性和断裂/再生过程中的能量耗散可显著提高复合材料的阻尼性能。对石墨烯和聚(苯乙烯-乙烯-丁二烯-苯乙烯)(SEBS)进行接枝改性,引入氢键单元从而在石墨烯/SEBS复合材料的界面构筑了多重氢键结构。研究了这种复合材料的循环拉伸以及动态力学性能。结果表明,这种复合材料的弹性模量、滞后损耗、阻尼因子比SEBS分别提高165%、237%和42%。强度和阻尼性能的显著提高,主要归因于复合材料组元间界面氢键的相互作用、高效应力传递、以及氢键可逆断裂/再生过程中显著的能量耗散。

关键词：复合材料阻尼性能界面氢键石墨烯力学强度

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