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Mental health disorders in child and adolescent survivors of post-war landmine explosions

Military Medical Research 2015年第4期3卷 201-206页

作者： mohammad Ali Hemmati Hamid Shokoohi Mehdi Masoumi Shahriar Khateri mohammadreza Soroush Ehsan Modirian Mahtab Poor Zamany Nejat Kermany Maryam Hosseini Batool Mousavi Janbazan Medical and Engineering Research Center (JMERC) Department of Emergency Medicine George Washington University Emergency Department Medical FacultyQazvin University of Medical Sciences Anesthesiology and Critical Care Labbafinejad Hospital Medical University of Shahid Beheshti Community and Preventive Medicine Janbazan Medical and Engineering Research Center(JMERC)

Background: To describe the mental health status of 78 child and adolescent survivors of post-war landmine ***: Child and adolescent survivors of landmine explosions who were younger than 18 years old at the time of the study were identified and enrolled in this study. The mental health status of the participants was assessed by general health assessment and psychiatric examinations. Psychiatric assessment and diagnosis were undertaken using the Diagnostic and Statistical Manual for mental disorders(DSM-IV) criteria. A psychiatrist visited and interviewed each survivor and identified psychiatric ***: Seventy-eight child and adolescent survivors with a mean age of 16.11±2 years old were identified and agreed to participate in the study. The mean age of the victims at the time of injury was 8.2±3.12 years old(range 2–15). Thirty-seven(47.4%) of the adolescent survivors suffered from at least one psychiatric disorder. Twenty-nine survivors(37.1%) were newly diagnosed and needed to start medication and psychiatric treatment. The most common findings were anxiety disorders(34.6%), including posttraumatic stress disorder(PTSD) in 20(25.6%), and generalized anxiety disorder(GAD) in 7(9%) subjects. Mild-Moderate depression was found in 5(6.4%) subjects. No personality disorders were observed, and two patients suffered from mental retardation. The study results revealed a significant association between age of casualty, duration of injury and limb amputation, and types of psychological ***: Child and adolescent survivors of landmine explosions had a high prevalence of psychiatric disorders.

关键词： Landmine Child survivors Depression Anxiety Iran

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Effect of hydro-alcoholic extract of Olea europaea on apoptosis-related genes and oxidative stress in a rat model of torsion/detorsion-induced ovarian damage

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Asian pacific Journal of Reproduction 2019年第4期8卷 148-156页

作者： Majid Shokoohi Malihe Soltani Seyed-Hosein Abtahi-Eivary Vahid Niazi mohammad Javad Rafeei Poor Hooman Ravaei Ramin Salimnejad Maryam Moghimian Hamed Shoorei Student in Nursing Student Research CommitteeGonabad University of Medical SciencesGonabadIran Women’s Reproductive Health Research Center Tabriz University of Medical SciencesTabrizIran Department of Basic Sciences Faculty of MedicineGonabad University of Medical SciencesGonabadIran Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehranIran Department of Biology Hakim Sabzevari UniversityRazavi KhorasanSabzevarIran Physiology Research Center Faculty of MedicineIran University of Medical SciencesTehranIran Research Laboratory for Embryology and Stem Cells Department of Anatomical Sciences and PathologySchool of MedicineArdabil University of Medical SciencesArdabilIran Department of Anatomical Sciences Faculty of MedicineBirjand University of Medical SciencesBirjandIran

Objective: To evaluate the impact of Olea (O.) europaea extract on markers of oxidative stress and apoptosis of ovarian tissues in a rat model of torsion/detorsion-induced ovarian damage. Methods: A total of 28 Wistar female rats were randomly assigned into 4 groups, with 7 rats in each group. The sham group received a 2.5 cm longitudinal incision in the midline part of the abdomen which was then sutured with 5-0 nylon thread;the torsion/detorsion group underwent torsion induction for 3 h followed by reperfusion for 10 days;the torsion/detorsion+O. europaea group received 300 mg/kg hydro-alcoholic extract of O. europaea 30 min before detorsion, followed by reperfusion for 10 days;and the O. europaea group only received 300 mg/kg hydro-alcoholic extract of O. europaea for 10 days. After the treatment period, blood samples were taken;the levels of estrogen, glutathione peroxidase, superoxide dismutase, and malondialdehyde were assayed. The histological changes, as well as the rate of apoptosis in ovarian tissues, were also carried out by histomorphometric analysis at day 10 post-procedure. Results: Histological comparisons demonstrated a significant detrimental change in the torsion/detorsion group as compared with other groups. The number of pre-antral and antral follicles and corpus luteum was significantly decreased in the torsion/detorsion group compared with the sham group, while treatment with O. europaea could enhance their numbers (P<0.05). The index of apoptosis and the number of atretic body in the ovarian tissue were significantly higher in the torsion/detorsion group compared with the sham group (P<0.05). The concentrations of glutathione peroxidase, estrogen, and superoxide dismutase as well as the mRNA expression of Bcl-2 were considerably diminished in the torsion/detorsion group while they were elevated in the torsion/detorsion+O. europaea group (P<0.05) compared with the torsion/detorsion group. The serum malondialdehyde level and the mRNA expression

关键词： Ischemia/reperfusion Oxidative stress Olea europaea Ovarian torsion Apoptotic gene expression

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Hepatitis E: Discovery, global impact, control and cure

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World Journal of Gastroenterology 2016年第31期22卷 7030-7045页

作者： mohammad S Khuroo Mehnaaz S Khuroo Naira S Khuroo Digestive Diseases Centre Dr. Khuroo's medical Clinic Srinagar Kashmir 190010 India Sher-I-Kashmir Institute of Medical Sciences Srinagar Kashmir 190010 India Department of Pathology Govt. Medical College Srinagar Kashmir 190001 India

Hepatitis E was identified as an epidemic of non-A, non-B hepatitis from Kashmir, India in 1978. Hepatitis E virus(HEV), the etiological agent is the sole member of family Hepeviridae. The virus has marked heterogeneity and infects many animals like bats, camel, chicken, deer, boar, mongoose, pigs, rats, rabbit and cutthroat trout. Hepatitis E is a disease with a major global impact and has two distinct epidemiological patterns. Hepatitis E is an imperative health issue in developing nations, transmitted through sullied water and happens most every now in young adults. The disease is particularly severe during pregnancy and in people with underlying liver cirrhosis. Autochthonous hepatitis E is increasingly recognized in developed countries. The virus infects domestic pigs, wild boar and Sika deer in these countries. HEV infections in humans occur by eating the undercooked game flesh, raw liver from supermarkets and Figatelli sausages. Blood transfusion-associated HEV infections occur in many countries and screening of donors for HEV RNA is under consideration. Hepatitis E causes a number of extrahepatic diseases, including a wide spectrum of neurological syndromes. HEV genotype 3 causes prolonged viremia, chronic hepatitis, liver fibrosis and cirrhosis in organ transplant patients. The virus is amenable to ribavirin monotherapy and most patients clear the virus in a few weeks. Hepatitis E vaccine-239, marketed in China, has shown high efficacy with sustained protection for over four years.

关键词： Communicable diseases Discovery Hepatitis E Hepatitis E virus Vaccine Zoonosis

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内镜超声引导下细针穿刺活检用于实质病变的标本获取:一项前瞻性队列研究

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Gastroenterology Report 2020年第5期8卷 349-354,I0001页

作者： Lindsey M.Temnykh Mahmoud A.Rahal Zahra Zia mohammad A.Al-Haddad Department of Internal Medicine Indiana University School of MedicineIndianapolisINUSA Division of Gastroenterology and Hepatology Department of Internal MedicineIndiana University School of MedicineIndianapolisINUSA

背景:内镜超声引导下细针穿刺活检(EUS-FNB)的应用日渐增多以提高实质病变的细胞学检出率,但其相较于目前的细针穿刺抽吸(FNA)的优越性并未获明确证实。本研究旨在比较在EUS引导下采用新型Franseen-tip穿刺针的FNB与传统FNA的诊断准确... 详细信息

背景:内镜超声引导下细针穿刺活检(EUS-FNB)的应用日渐增多以提高实质病变的细胞学检出率,但其相较于目前的细针穿刺抽吸(FNA)的优越性并未获明确证实。本研究旨在比较在EUS引导下采用新型Franseen-tip穿刺针的FNB与传统FNA的诊断准确性及操作相关指标。方法:入组接受EUS-FNB检查的连续实质病变患者,前瞻性记录其操作相关指标,包括患者人口统计资料、穿刺次数、诊断样本的充分性、不良反应和恢复时间。研究组采用Acquire针抽取样本。同时纳入行EUSFNA检查的实质病变患者作为对照组,对照组采用Expect针抽取样本。结果:180例行EUS-FNB和183例行EUS-FNA进行实质病变样本采集的患者纳入研究。FNB组较FNA组平均操作时间显著缩短(37.4 min vs 44.9 min,P<0.001),平均穿刺次数明显减少(2.9次vs 3.8次,P<0.001),细胞学检出率明显提高(98.3%vs 90.2%,P=0.003)。两组不良事件发生率的差异无统计学意义(1.1%vs 0.5%,P=0.564)。结论:EUS-FNB用于实质病变的病理活检是安全可行的,可减少穿刺次数,缩短操作时间,提高病变检出率。FNB或可替代FNA作为所有实质病变的首选标本获取方法。

关键词： endoscopic ultrasound fine-needle biopsy fine-needle aspiration pancreatic tumors

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Sinus Bradycardia Rare but Expected Complications of Chemo Regimen Involving Dexamethasone: Case Report

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Open Journal of Blood Diseases 2017年第1期7卷 47-50页

作者： Jinqiong Li mohammad Arphan Azaad Yongping Li Qiurong Zhang Department of Clinical Medical College Dali University Dali China Department of Hematology Affiliated Hospital Dali University Dali China

Weight gain, Osteoporosis, Glucose intolerance, Hypertension, and Cataract are the common complications associated with Dexamethasone. However, here we report a case of Multiple Myeloma who received chemotherapy involving Dexamethasone. Although this patient has no previous comorbid cardiac condition, he developed Sinus Bradycardia during the latter part of chemo regimen. Ironically Sinus Bradycardia was asymptomatic in these cases. The exact mechanism of how Dexamethasone causes Sinus Bradycardia is yet not properly understood, and some of the possible mechanisms of Dexamethasone causing Sinus Bradycardia have been postulated below.

关键词： Dexamethasone Sinus Bradycardia Multiple Myeloma

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Co-encapsulation of curcumin and doxorubicin in albumin nanoparticles blocks the adaptive treatment tolerance of cancer cells

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Biophysics Reports 2019年第1期5卷 19-30页

作者： Seyed mohammad Motevalli Ahmed Shaker Eltahan Lu Liu Andrea Magrini Nicola Rosato Weisheng Guo Massimo Bottini Xing-Jie Liang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China University of Chinese Academy of Sciences Department of Experimental Medicine University of Rome Tor Vergata Department of Biomedicine and Prevention University of Rome Tor Vergata Nanoscience & Nanotechnology & Innovative Instrumentation (NAST) Centre University of Rome Tor Vergata Inflammatory and Infectious Disease Center Sanford-Burnham Medical Research Institute

The adaptive treatment tolerance(ATT) of cancer cells is the main encumbrance to cancer chemotherapy.A potential solution to this problem is to treat cancer cells with multiple drugs using nanoparticles(NPs).In this study, we tested the co-administration of curcumin(Cur) and doxorubicin(Dox) to MCF-7 resistant breast cancer cells to block the ATT and elicit efficient cell killing. Drugs were co-administered to cells both sequentially and simultaneously. Sequential drug co-administration was carried out by pre-treating the cells with albumin nanoparticles(ANPs) loaded with Cur(Cur@ANPs) followed by treatment with Dox-loaded ANPs(Dox@ANPs). Simultaneous drug co-administration was carried out by treating the cells with ANPs loaded with both the drugs(Cur/Dox@ANPs). We found that the simultaneous drug co-administration led to a greater intra-cellular accumulation of Dox and cell killing with respect to the sequential drug co-administration. However, the simultaneous drug co-administration led to a lower intracellular accumulation of Cur with respect to the sequential drug co-administration. We showed that this result was due to the aggregation and entrapment of Cur in the lysosomes as soon as it was released from Cur@ANPs, a phenomenon called lysosomotropism. In contrast, the simultaneous release of Dox and Cur from Cur/Dox@ANPs into the lysosomes led to lysosomal p H elevation, which, in turn, avoided Cur aggregation, led to lysosome swelling and drug release in the cytosol, and finally provoked efficient cell killing. Our study shed the light on the molecular processes driving the therapeutic effects of anti-cancer drugs co-administered to cancer cells in different manners.

关键词： Albumin nanoparticles Doxorubicin Curcumin P-glycoprotein Lysosomal pH

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Processed Radio Frequency towards Pancreas Enhancing the Deadly Diabetes Worldwide

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Journal of Endocrinology Research 2021年第1期3卷 1-20页

作者： Md.Rahimullah Miah mohammad Abdul Hannan AAM Shazzadur Rahman Md.Shahariar Khan Md Mokbul Hossain Ishrat Tasnim Rahman Md.Sabbir Hossain Chowdhury Shadman Shahriar mohammad Basir Uddin mohammad Taimur Hossain Talukdar mohammad Shamsul Alam S.A.M.Imran Hossain Alamgir Adil Samdany Shahriar Hussain Chowdhury Alexander Kiew Sayok Department of Health Information Technology Northeast Medical Pvt.LimitedSylhetBangladesh. Department of Endocrinology North East Medical College&HospitalSylhetBangladesh. Department of Medicine North East Medical CollegeSylhetBangladesh. Department of Paediatrics North East Medical College&HospitalSylhetBangladesh. Department of Pharmacology North East Medical College and HospitalSylhetBangladesh. Ananda Niketan SylhetBangladesh. Department of Pathology North East Medical College and HospitalSylhetBangladesh. USA and Ex-student of North East Medical College SylhetBangladesh. Department of Paediatrics North East Medical College and HospitalSylhetBangladesh Department of Clinical Oncology North East Medical College and HospitalSylhetBangladesh. Department of Forensic Medicine North East Medical College and HospitalSylhetBangladesh. Department of Oral and Maxillofacial Surgery North East Medical CollegeSylhetBangladesh. Department of Orthopedics North East Medical CollegeSylhetBangladesh. Department of Dermatology North East Medical CollegeSylhetBangladesh. IBEC University Malaysia SarawakKota SamarahanSarawakMalaysia.

Diabetes is a chronic and debilitating disease,which is associated with a range of complications putting tremendous burden on medical,economic and socio-technological infrastructure *** the higher authorities of health services are facing the excruciating cumulative reasons of diabetes as a very imperative worldwide issue in the 21st *** study aims to relook at the misapplication of the processed radio frequency that frailties in the pancreas within and around the personal body boundary *** administered sensor data were obtained at laboratory experiments from the selected specimens on dogs and cats in light and dark *** study shows the frequent urine flow speed varies with sudden infection due to treated wireless sensor networks in active open *** overweight and obese persons are increasingly affected in diabetes with comprehensive urinary pressure due to continuous staying at dark *** findings replicate the increasing tide of diabetes *** study also represents the difficulties of physicians to provide adequate diabetic management according to their expectancy due to insecure personal area network control *** sensor network is indispensable for healthcare but such network is at risk to health security due to digitalized poisoning within GPS *** study recommends the anti-radiation integrated system policy with user’s security alternative approach to inspire dealing with National Health Policy and Sustainable Development Goals 2030.

关键词： Diabetes Radio frequency Pancreas Active open eyes Body boundary Network security

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特殊医学状态的伊朗患者肌肉注射纯化Vero细胞狂犬病疫苗（PVRV）后的中和抗体反应

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中华实验和临床病毒学杂志 2018年第5期32卷 532-532页

作者： Pooneh Rahimi RouhAllah Vahabpour mohammad reza Aghasadeghi 吕新军(编译)

使用WHO批准的的疫苗之一进行暴露后预防处置是预防狂犬病可以选择的方法。某些特殊医学状态（诸如怀孕、慢性乙型肝炎病毒感染、淋巴瘤等不同类型的癌症、Ⅰ型和Ⅱ型糖尿病、类风湿性关节炎和红斑狼疮患者使用皮质类固醇激素）患者不... 详细信息

使用WHO批准的的疫苗之一进行暴露后预防处置是预防狂犬病可以选择的方法。某些特殊医学状态（诸如怀孕、慢性乙型肝炎病毒感染、淋巴瘤等不同类型的癌症、Ⅰ型和Ⅱ型糖尿病、类风湿性关节炎和红斑狼疮患者使用皮质类固醇激素）患者不正常的免疫学功能会损害各种疫苗的免疫应答。处于上述医学状态的患者接种狂犬病疫苗后的免疫学反应从未被检测过。

关键词： Vero细胞狂犬病疫苗红斑狼疮患者医学状态抗体反应肌肉注射慢性乙型肝炎病毒感染皮质类固醇激素类风湿性关节炎

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Green synthesis,antimicrobial and cytotoxic effects of silver nanoparticles using Eucalyptus chapmaniana leaves extract

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Asian Pacific Journal of Tropical Biomedicine 2013年第1期3卷 58-63页

作者： Ghassan mohammad Sulaiman Wasnaa Hatif Mohammed Thorria Radam Marzoog Ahmed Abdul Amir Al-Amiery Abdul Amir H.Kadhum Abu Bakar Mohamad Biotechnology Division Applied Science DepartmentUniversity of Technology Applied Chemistry Division Applied Science DepartmentUniversity of Technology Chemical and Process Engineering Department Universiti Kebangsaan Malaysia

Objective:To synthesize silver nanopaticles from leaves extract of Eucalyptus chapmaniana(***)and test the antimicrobial of the nanoparticles against different pathogenic bacteria,yeast and its toxicity against human acute promyelocytic leukemia(HL-60)cell ***:Ten milliliter of leaves extract was mixed with 90 mL of 0.01 mmol/mL or 0.02 mmol/mL aqueous AgNO_3 and exposed to sun light for 1 h.A change from yellowish to reddish brown color was *** using UV-vis spectrophotometery and X-ray diffraction analysis were *** activity against six microorganisms was tested using well diffusion method and cytoxicity test using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide,a yellow tetrazole was obtained on the human leukemia cell line(HL-60).Results:UV-vis spectral analysis showed silver surface plasmon resonance band at 413 nm.X-ray diffraction showed that the particles were crystalline in nature with face centered cubic structure of the bulk silver with broad beaks at 38.50°and 44.76°.The synthesized silver nanoparticles efficiently inhibited various pathogenic organisms and reduced viability of the HL-60 cells in a dose-dependent ***:It has been demonstrated that the extract of *** leaves are capable of producing silver nanoparticles extracellularly and the Ag nanoparticles are quite stable in *** studies are needed to fully characterize the toxicity and the mechanisms involved with the antimicrobial and anticancer activity of these particles.

关键词： Eucalyptus chapmaniana Silver nanoparticles Antimicrobial activity Cytotoxic effect

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Hydrothermal synthesis and characterization of carbon-doped TiO2 nanoparticles

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Chinese Physics B 2020年第11期29卷 516-521页

作者： Zafar Ali Javaid Ismail Rafaqat Hussain AShah Arshad Mahmood Arbab mohammad Toufiq Shams ur Rahman Department of Physics COMSATS University IslamabadPark RoadIslamabad 45550Pakistan Department of Chemistry COMSATS University IslamabadPark RoadIslamabad 45550Pakistan National Institute of Lasers and Optronics College Pakistan Institute of Engineering and Applied Sciences(NILOP-CPIEAS)Nilore 45650IslamabadPakistan Department of Physics Hazara University MansehraMansehra 21300Pakistan

We report the hydrothermal growth of pure and doped TiO2 nanoparticles with different concentrations of *** microstructure of the as-synthesized samples is characterized by x-ray diffraction(XRD),field emission scanning electron microscopy(FESEM),energy dispersive x-ray spectroscopy(EDX),and Raman spectroscopy to understand the structure and *** XRD patterns confirm the formation of anatase phase of TiO2 with the average crystallite size is calculated to be in the range of 13 nm to 14.7 *** functional groups of these nanostructures are characterized by Fourier transformed infrared(FT-IR)spectroscopy,which further confirms the single anatase phase of the synthesized ***-visible absorption spectroscopy is used to understand the absorption behavior,which shows modification in the optical bandgap from 3.13 eV(pure TiO2)to 3.74 eV(1.2 mol%C-doped TiO2).Furthermore,the Ti^3+centers associated with oxygen vacancies are identified using electron paramagnetic resonance spectroscopy(EPR).

关键词： titanium dioxide hydrothermal synthesis defect states bandgap

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