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Enhancement of T cell infiltration via tumor-targeted Th9 cell delivery improves the efficacy of antitumor immunotherapy of solid tumors

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Bioactive Materials 2023年第5期23卷 508-523页

作者： Tao Chen Yucheng Xue Shengdong Wang Jinwei Lu Hao Zhou Wenkan Zhang Zhiyi Zhou Binghao Li Yong Li Zenan Wang Changwei Li Yinwang Eloy Hangxiang Sun Yihang Shen mohamed Diaty Diarra Chang Ge Xupeng Chai Haochen Mou Peng Lin Xiaohua Yu Zhaoming ye Orthopaedic Oncology Services Department of OrthopaedicsThe Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310009China Orthopaedic Research Institute Zhejiang UniversityHangzhou310009China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou310009China The Second Clinical Medical College of Zhejiang Chinese Medical University Hangzhou310009China Qingtian People’s Hospital Department of OrthopedicsLishui323900China Department of Orthopedics Shanghai Key Laboratory for the Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai20025China Department of Radiology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China

Insufficient infiltration of T cells severely compromises the antitumor efficacy of adoptive cell therapy(ACT)against solid ***,we present a facile immune cell surface engineering strategy aiming to substantially enhance the anti-tumor efficacy of Th9-mediated ACT by rapidly identifying tumor-specific binding ligands and improving the infiltration of infused cells into solid ***-genetic decoration of Th9 cells with tumor-targeting peptide screened from phage display not only allowed precise targeted ACT against highly heterogeneous solid tumors but also substantially enhanced infiltration of CD8+T cells,which led to improved antitumor ***,infusion of Th9 cells modified with tumor-specific binding ligands facilitated the enhanced distribution of tumor-killing cells and remodeled the immunosuppressive microenvironment of solid tumors via IL-9 mediated ***,we presented a simple,cost-effective,and cell-friendly strategy to enhance the efficacy of ACT against solid tumors with the potential to complement the current ACT.

关键词： Adoptive cell therapy(ACT) Phage display Cell surface engineering Th9 cell Solid tumor

Sclerosing Cholangitis after Transcatheter Arterial Chemoembolization:a Case Report

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Chinese Medical Sciences Journal 2011年第3期26卷 190-193页

作者： Kai Qu Chang Liu Qi-fei Wu Bo Wang Aasef mohamed Ali Mansoor Hao Qin Qiang Ma ya-min Liu Department of Hepatobiliary Surgery the First Affiliated HospitalMedical School of Xi＇an Jiaotong UniversityXi＇an 710061China Department of Cardiovascular Intervention the First Affiliated HospitalMedical School of Xi＇an Jiaotong UniversityXi＇an 710061China

SCLEROSING cholangitis represents progressing jaundice or/and paroxysmal symptom of cholangitis, finally developing to end-stage of liver *** compared with primary sclerosing cholangitis (PSC), there are no apparent differences in pathology and clinical manifestation in secondary sclerosing cholangitis (SSC).But unlike PSC, SSC always has underlying causes, the most common being biliary obstruction, surgical trauma and ischemic injury of bile duct during liver transplantation .1,2 Repeated transcatheter arterial chemoembolization (TACE) leading to progressive SSC was rarely *** of its rapid and irreversible progression, once SSC begins, it is difficult to deal ***, clinicians need to pay more attention to it.

关键词：二次硬化胆管病例报告肝动脉化疗栓塞肝脏疾病临床表现

Integrability of det▽u and Evolutionary Wente's Problem Associated to Heat Operator

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Chinese Annals of Mathematics,Series B 2007年第5期28卷 527-532页

作者： Sami BARAKET Makkia DAMMAK mohamed JLELI Dong ye Departement de mathematiques Faculte des Sciences de Tunis Campus Universitaire2092 TunisTunisie. Departement de mathematiques Ecole Superieure des Sciences et Techniques de Tunis5 Avenue Taha-HusseinTunis BP 56Bab Menara 1008Tunisie. Departement de mathematiques UMR8088Universite de Cergy-Pontoise site Saint-Martin BP22295302 Cergy-Pontoise cedexFrance.

In this note,the authors resolve an evolutionary Wente's problem associated to heat equation,where the special integrability of det▽u for u∈H^1(R^2,R^2)is used.

关键词：雅可比行列式函数行列式热平衡积分

Virological profile of hepatitis B infection in Black African HBsAg chronic carriers

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Open Journal of gastroenterology 2013年第2期3卷 113-118页

作者： Koffi Alain Attia Stanislas Doffou ya Henriette Kissi Demba Bangoura Seka Mondesir Pianiza Kouame Alassan Mahassadi Fulgence yao Bathaix mohamed Sayegh Thérèse N’dri-Yoman Clinique Médicale Danga Cocody Abidjan Cote d’Ivoire Service de Médecine et d’Hépato-gastroentérologie CHU Yopougon Abidjan Cote d’Ivoire

Aims: 1) Describe virological profile of patients followed-up for chronic Hepatitis B virus (HBV);2) Search for a correlation between cirrhosis and virological profile of patients. Patients and Methods: Retrospective study about 75 HBsAg positive patients followed-up for at least one year in two medical structures of Abidjan. Studied parameters: clinical signs, biological check-up (serum transaminases every 3 months for at least one year, platelets count and prothrombin rate), abdominal echography, virological check-up (HBsAg, HBeAg, anti-HBe, total anti-HBc, anti-VHC and anti- HIV Ab, HBV DNA biannual quantification during at least one year). Histological or biochemical evaluation of hepatic activity and fibrosis were realized in case of transaminases elevation or HBV DNA > 2000 IU/ml. Results: The mean age of our 75 patients (54 men) was 42.1 ± 11.54 years. HBV was fortuitously discovered in most of our patients (74.7% of the cases). The HBV inactive chronic carriage was 50.7%;HBeAg-positive and HBeAg-negative chronic hepatitis represented respectively 9.3% and 40% of the cases. Mean B viral load was 327.5 IU/ml in HBV inactive chronic carriers, 44,047,663 IU/ml in HBeAg-positive chronic HBV and 20,231,822 IU/ml in HBeAg-negative chronic HBV. Cirrhosis prevalence was significantly high- er in positive or negative HBeAg chronic HBV than in HBV inactive chronic carriers (32.4% vs. 5.3%, p = 0.008;OR = 8.6). Conclusion: Our patients’ virological profile was dominated by HBeAg-negative chronic HBV and HBV inactive chronic carriage. The risk of having cirrhosis was multiplied by 8.6 in case of active chronic hepatitis compared with HBV inactive chronic carriage.

关键词： Hepatitis B Virus Virological Profile Cirrhosis

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裂隙岩体精细化数值模型构建与爆破模拟

爆破 2023年第4期40卷 44-51页

作者：叶海旺韦文蓬周汉红余梦豪李兴旺雷涛温颖王其洲石斌宏于燕张生钟传山高玉文 HASSAN Abdou mohamed Abdelkader 武汉理工大学资源与环境工程学院武汉430070 武汉市公安局治安管理局武汉430077 华新水泥股份有限公司武汉430200 五矿勘查开发有限公司北京100044

裂隙岩体爆破数值模拟过程中,裂隙分布模型的真实性,是影响数值模拟结果的关键因素之一,现有节理裂隙构建方法难以实现三维分布上的复杂表征或是实现操作过于繁杂。为探索在LS-DYNA软件中构建三维分布上真实、复杂表征的节理裂隙模型简... 详细信息

裂隙岩体爆破数值模拟过程中,裂隙分布模型的真实性,是影响数值模拟结果的关键因素之一,现有节理裂隙构建方法难以实现三维分布上的复杂表征或是实现操作过于繁杂。为探索在LS-DYNA软件中构建三维分布上真实、复杂表征的节理裂隙模型简单可行的操作方法,通过MATLAB软件对爆破数值模型K文件进行解析重组,按照节理裂隙三维分布规律进行勾勒并赋予节理裂隙材料本构,构建出符合节理裂隙分布规律的节理岩体三维精细化数值模型。以某露天石灰石矿山为实例,开展节理裂隙三维分布规律统计分析并在台阶爆破数值模型中进行还原,基于裂隙岩体精细化数值模型,开展露天台阶爆破数值模拟试验和现场爆破试验对比研究。结果表明:采用解析重组方法构建的数值节理模型与实际节理裂隙的误差小于13%;节理裂隙面使岩体内的损伤分布规律发生了变化,与完整岩体相比,损伤范围增加了12.04%,粒径处于0~100 mm的占比降低了8.11%;爆破模拟得到的损伤结果与现场破碎效果接近,统计粒径在0~100 mm之间的碎块的占比,误差为4.16%。解析重组法构建三维节理裂隙,可行、操作简便,数值模拟结果接近实际。

关键词：裂隙岩体裂隙分布规律地质模型 LS-DYNA 爆破数值模拟爆破试验

Prevalence of hepatitis B infection and factors associated in children of Ivorian HBsAg carrier subjects

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Open Journal of gastroenterology 2013年第4期3卷 237-240页

作者： Koffi Alain Attia ya Henriette Kissi Stanislas Doffou Demba Bangoura Roseline Flora Wilson Georges Bougha Fulgence yao Bathaix Kouame Alassan Mahassadi mohamed Sayegh Therese N’dri-Yoman Department of General Medicine and Hepato-gastroenterology Teaching Hospital of Yopougon Abidjan Cote d’Ivoire Medical Private hospital of Danga Cocody Abidjan Cote d’Ivoire

Aims of the Study: 1) Determine the Prevalence of Hepatitis B virus (HBV) infection in children (contact subjects) of chronic Hepatitis B surface antigen (HBsAg) carrier subjects (index subjects);2) Search for factors associated with HBV infection in these children. Patients and Methods: Retrospective-crosssectional study (January 5th, 2006 through December 31st, 2012). Studied parameters: biological and clinical characteristics of index subjects;Prevalence of HBsAg and Hepatitis B core antibody (HBcAb) in their children. Search for the HBV infection associated factors in the children (univariate analyses through Chi-square or Fisher’s exact test;multivariate analysis through a backward logistic regression). Results: Our 44 subjects’ median age was 43.1 ± 7.49 years and 88.6% of them lived with a spouse. Average number of children per index subjects was 2.3 ± 1.1. Our 92 children’s median age was 9.3 ± 4.55 (ranging from 1 to 15 years), and 43 (44.8%) were vaccinated against HBV. HBV infection prevalence was 24% (23/96 of which, 4 were HBsAg positive and 19 HBcAb positive subjects without HBsAg). Independent factors associated with HBV infection in children of index subjects were HBV DNA for index subjects >2000 IU/ml (OR = 11.5;p = 0.001), existence of HBV in two parents (OR = 7.9;p = 0.03) and absence of HBV vaccination in the children (OR = 30.9;p = 0.003). Conclusion: Immunization coverage for children of index subjects was insufficient, especially before the introduction of HBV vaccine into the enlarged vaccination program. Outside vertical transmission, those children were more exposed to HBV intrafamilial transmission risk when they were not immunized against HBV, when both parents were infected and when HBV viremia in index subjects was higher than 2000 IU/ml.

关键词： Hepatitis B Infection Intrafamilial Transmission Screening

鲁米诺/氨基磺酸电化学发光及其多巴胺检测应用

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电化学 2021年第2期27卷 168-176页

作者： Tesfaye Hailemariam Barkae mohamed Ibrahim Halawa Tadesse Haile Fereja Shimeles Addisu Kitte 马显贵陈业权徐国宝中国科学院长春应用化学研究所电分析化学国家重点实验室吉林长春130022 中国科学技术大学应用化学与工程学院安徽合肥230026 Wolkite university College of natural&computational scienceDepartment of chemistryP.O Box 07WolkiteEthiopia Department of Pharmaceutical Analytical Chemistry Faculty of PharmacyMansoura University35516MansouraEgypt 深圳大学化学与环境工程学院及物理与光电工程学院深圳广东518000 Ambo University College of Medicine and Health SciencesDepartment of PharmacyP.O.Box 19AmboEthiopia Jimma University College of Natural SciencesDepartment of ChemistryP.O.Box 378JimmaEthiopia

在本文中,我们首次观察到氨基磺酸可以显著增强鲁米诺电化学发光,而且鲁米诺电化学发光的强度随着氨基磺酸浓度在0.1μmol·L^(-1)至500μmol·L^(-1)范围增加而线性增加。同时,我们观察到多巴胺可以显著猝灭鲁米诺-氨基磺酸电化学发光... 详细信息

在本文中,我们首次观察到氨基磺酸可以显著增强鲁米诺电化学发光,而且鲁米诺电化学发光的强度随着氨基磺酸浓度在0.1μmol·L^(-1)至500μmol·L^(-1)范围增加而线性增加。同时,我们观察到多巴胺可以显著猝灭鲁米诺-氨基磺酸电化学发光。基于该猝灭现象,我们建立了多巴胺的电化学发光分析方法,该方法的线性范围为0.5至20μmol·L^(-1),检出限为30 nmol·L^(-1)。该方法具有较好的选择性,尿酸、抗坏血酸、糖和一些氨基酸对电化学发光影响较小。采用标准加入法,成功地将鲁米诺-氨基磺酸体系用于尿液中多巴胺的电化学发光测定,回收率为103%~105%。另外,我们还考察了多巴胺的猝灭机理,并用Stern-Volmer方程计算了的动态猝灭常数。

关键词：电化学发光氨基磺酸鲁米诺多巴胺

Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun Kai yang Yu Liang Ke Xu Xue Feng Zhang Yun Kang Yu Qin Jin Jun Wei Hou Jing Zhang Tian yang Salah Hussein mohamed Saif ElDein Ze Hua Lei Hao Zhang Shuai Shao Zhao Ming Liu Ning Liu Xiang Zheng Ji Guo Su Sen Sen yang Xiangfeng Cong yao Tan Wenwen Lei Xue Jun gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie yang Islam Eltantawy Peng Xiao Fu Jie Shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi Chen Zhi Jing Ma Fan Zheng ya Nan Hou Xin Yu Li Xin Li Zhao Nian Wang Jin Liang Yin Xiao yan Mao Jin Zhang Liang Qu Yun Tao Zhang Xiao Ming yang Guizhen Wu Qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

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分层装药爆破间隔填塞长度优化研究

爆破 2017年第2期34卷 26-33页

作者：叶海旺汪柳俊冉成宁卫星雷涛房泽法 TAWUM Juvert Mabh SIDI mohamed Mahmoud 龙梅武汉理工大学资源与环境工程学院武汉430070 矿物资源加工与环境湖北省重点实验室武汉430070 武汉山友爆破科技工程有限公司武汉430070 武汉理工大学图书馆武汉430070

分层装药爆破在工程中应用广泛,其具有良好的爆破减振和提高孔口堵塞段破碎等效果。但是在实践中,合理的中间填塞长度选择一直缺乏依据。通过有限元软件LSDYNA对90 mm孔径6 m深的炮孔分别建立中间填塞段长度为25~105 cm的五个模型,上、... 详细信息

分层装药爆破在工程中应用广泛,其具有良好的爆破减振和提高孔口堵塞段破碎等效果。但是在实践中,合理的中间填塞长度选择一直缺乏依据。通过有限元软件LSDYNA对90 mm孔径6 m深的炮孔分别建立中间填塞段长度为25~105 cm的五个模型,上、下药包装药量固定,耦合装药,以爆破损伤以及单元所受最大拉应力两个指标来分析填塞段长度对分层爆破效果的影响。结果表明:中间填塞长度过短,能量集中作用于中间段,会导致岩石过于粉碎;中间填塞长度的增加,孔口堵塞段岩体破碎效果也随之改善,填塞长度105 cm和25 cm相比,地表处单元所受最大拉应力增加了约1倍,但中间段破碎效果弱化;当中间填塞段长度为85 cm时,中间填塞段岩体和上部岩体均有较好的破碎效果;通过振动分析,中间填塞长度变化对离炮孔较远区域爆破振动的影响较小。基于数值模拟结果的工程试验表明,最佳中间填塞段长度为85~95 cm,较数值模拟结果稍大。

关键词：控制爆破中间填塞长度损伤最大拉应力