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Function a.d dysfunction of GEMIN5:understa.ding a.novel neurodevelopmenta. disorder

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Neura. Regenera.ion Resea.ch 2024年第11期19卷 2377-2386页

作者： Ch.rles h.Nelson Uda. b.Pa.dey Depa.tment of Pedia.rics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Ch.ldren’s Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

Th. recent identifica.ion of a.neurodevelopmenta. disorder with.cerebella. a.roph. a.d motor dysfunction(NEDCa.)h.s resulted in a. increa.ed interest in GEMIN5,a.multifunction RNa.binding *** th. la.gest member of th. surviva. motor neuron complex,GEMIN5 pla.s a.key role in th. biogenesis of sma.l nuclea. ribonucleoproteins wh.le a.so exh.biting tra.sla.iona. regula.ory functions a. a. independent *** ma.y questions rema.n rega.ding both.th. pa.h.genesis a.d pa.h.ph.siology of th.s new disorder,considera.le progress h.s been ma.e in th. brief time since its *** th.s review,we exa.ine GEMIN5 with.n th. context of NEDCa.,focusing on th. structure,function,a.d expression of th. protein specifica.ly in rega.d to th. disorder ***,we explore th. current a.ima. models of NEDCa.,a. well a. potentia. molecula. pa.h.a.s for trea.ment a.d future directions of *** review provides a.compreh.nsive overview of recent a.va.ces in our understa.ding of th.s unique member of th. surviva. motor neuron complex.

关键词： cerebella. a.roph. GEMIN5 neurodevelopmenta. disorder neurologica. disea.e SMN complex

Recent a.va.ces in FeCl_(3)-ph.toca.a.yzed orga.ic rea.tions via.h.drogen-a.om tra.sfer

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Ch.nese Ch.mica. Letters 2024年第9期35卷 32-40页

作者： Xia.-ya Yua. Cong-Cong Wa.g bing Yu Green Ca.a.ysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001China Na.iona. Engineering Resea.ch.Center of Low-Ca.bon Processing a.d Utiliza.ion of Forest bioma.s Nanjing Forestry UniversityNanjing 210037China

In recent yea.s,FeCl_(3)-ph.toca.a.yzed direct C–h.Si–h.bond functiona.iza.ion rea.tions h.ve a.tra.ted h.ge *** th.se tra.sforma.ions,ch.orine ra.ica.(Cl·)could be genera.ed from FeCl_(3)via.a.liga.dto-meta. ch.rge tra.sfer(LMCT)/h.molysis process under ligh. *** resulting ch.orine ra.ica. subsequently a.ts a. a.h.drogen a.om tra.sfer(h.T)a.ent to a.stra.t th. h.drogen a.om of a.iph.tic C–h.O–h.or Si–h.bonds to give th. corresponding C/Si/O-centered ra.ica.s for va.ious orga.ic *** th.s review,we summa.ized th. recent a.va.ces in th. a.plica.ion of FeCl_(3)a. a.h.T ph.toca.a.yst for th. C/Si–h.functiona.iza.ion to construct C–C,C–N,C–Si,C–S,C–b,a.d C-P bonds.

关键词： FeCl_(3) Ph.toca.a.ysis Liga.d-to-meta. ch.rge tra.sfer h.drogen a.om tra.sfer Ch.orine ra.ica.

blocka.e of Rh.-a.socia.ed kina.e prevents inh.bition of a.on regenera.ion of periph.ra. nerves induced by a.ti-ga.glioside a.tibodies

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Neura. Regenera.ion Resea.ch 2024年第4期19卷 895-899页

作者： a.drés bera.do Cristia. R.ba.a.lio bárba.a.b.báez Rubén Sa.buelli Ka.im a.Sh.ikh.Pa.lo h.h.Lopez La.ora.orio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Depa.ta.ento de Química.biológica.Centro de Investiga.iones en Química.biológica.de Córdoba.CIQUIbIC)-Consejo Na.iona. de Investiga.iones Cientifica. y Técnica.(CONICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de a.a.omía.Pa.ológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Depa.tment of Neurology University of Texas Medical School at Houston

a.ti-ga.glioside a.tibodies a.e a.socia.ed with.dela.ed/poor clinica. recovery in Guilla.n-ba.rèsyndrome,mostly rela.ed to h.lted a.on ***-linking of cell surfa.e ga.gliosides by a.ti-ga.glioside a.tibodies triggers inh.bition of nerve repa.r in in vitro a.d in vivo pa.a.igms of a.on *** effects involve th. a.tiva.ion of th. sma.l GTPa.e Rh. a.ROCK signa.ing pa.h.a.s,wh.ch.nega.ively modula.e growth.cone cytoskeleton,simila.ly to well sta.lish.d inh.bitors of a.on regenera.ion described so *** a.m of th.s work wa. to perform a.proof of concept study to demonstra.e th. effectiveness of Y-27632,a.selective ph.rma.ologica. inh.bitor of ROCK,in a.mouse model of a.on regenera.ion of periph.ra. nerves,wh.re th. pa.sive immuniza.ion with.a.monoclona. a.tibody ta.geting ga.gliosides GD1a.a.d GT1b wa. previously reported to exert a.potent inh.bitory effect on regenera.ion of both.myelina.ed a.d unmyelina.ed *** results demonstra.e a.differentia. sensitivity of myelina.ed a.d unmyelina.ed a.ons to th. pro-regenera.ive effect of *** with.a.tota. dosa.e of 9 mg/kg of Y-27632 resulted in a.complete prevention of a.ti-GD1a.GT1b monoclona. a.tibody-media.ed inh.bition of a.on regenera.ion of unmyelina.ed fibers to skin a.d th. functiona. recovery of mech.nica. cuta.eous *** contra.t,th. sa.e dose sh.wed toxic effects on th. regenera.ion of myelina.ed ***,sca.e down of th. dosa.e of Y-27632 to 5 mg/kg resulted in a.significa.t a.th.ugh.not complete recovery of regenera.ed myelina.ed a.ons exposed to a.ti-GD1a.GT1b monoclona. a.tibody in th. a.sence of toxicity in a.ima.s exposed to only ***,th.se findings confirm th. in vivo pa.ticipa.ion of Rh. a.ROCK signa.ing pa.h.a.s in th. molecula. mech.nisms a.socia.ed with.th. inh.bition of a.on regenera.ion induced by a.ti-GD1a.GT1b monoclona. *** findings open th. possibility of th.ra.eutic ph.rma.ologica. intervention ta.geting Rh. a.R

关键词： a.ti-ga.glioside a.tibodies a.ti-glyca. a.tibodies a.on regenera.ion ga.glioside Guilla.n-ba.résyndrome nerve repa.r ROCK Y-27632

ph.Induced Self-a.sembly of a.E Fluorescent Probe for Tumor Ima.ing

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Ch.nese Journa. of Polymer Science 2024年第1期42卷 7-13,I0005页

作者： Jing-Yua. Xia.g Wen-Long Zh.ng h.-Ting Li ya-Ning h. Depa.tment of Ch.mica. Engineering Key Laboratory of Advanced Materials(MOE)Tsinghua UniversityBejing 100084China

Th.s work reported a. a.E fluorescent probe for tumor ima.ing ba.ed on th. p h.induced self-a.sembly stra.egy. Th. fluorescent probe wa. composed of a. a.id-responsive soluble copolymer PEG-b-Pa.a.DMMa.with.a.ma.eic a.id a.ide group a.d a. a.ionic soluble a.grega.ion-induced emission fluorogen(a.Egen) TPE-2SO_(3)^(-). Th. polymer could be tra.sformed into a.protona.ed a.ine-conta.ning polymer a.ter th. h.drolysis of ma.eic a.id a.ide in a.idic tumor microenvironment, wh.ch.would be furth.r self-a.sembled with.TPE-2SO_(3)^(-)to form a.grega.ed na.opa.ticles. Th. tra.sition of TPE-2SO_(3)^(-)from dispersed sta.e to a.grega.ed sta.e led to a. obvious increa.e in fluorescence intensity due to its a.E ch.ra.teristics.

关键词： p h.responsive Self-a.sembly Fluorescent probe a.E Tumor ima.ing

Multiple sca.es meth.d for a.a.yzing a.forced da.ped rota.iona. pendulum oscilla.orwith.a.lows

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Communica.ions in Th.oretica. Ph.sics 2024年第5期76卷 58-67页

作者： h.ifa.a.a.yousef a.va.o h.Sa.a. b M a.ota.bi S a.El-Ta.ta.y Depa.tment of Ph.sics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Depa.tment of Ma.h.ma.ics a.d Sta.istics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Depa.tment of Ph.sics Faculty of SciencePort Said UniversityPort Said 42521Egypt Resea.ch.Center for Ph.sics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

Th.s study reports th. a.a.ytica. solution for a.genera.ized rota.iona. pendulum system with.ga.lows a.d periodic excited *** multiple sca.es meth.d(MSM)is a.plied to solve th. proposed *** types of rota.iona. pendulum oscilla.ors a.e studied a.d ta.ked a.out in *** include th. forced da.ped rota.ing pendulum oscilla.or with.ga.lows,th. da.ped sta.da.d simple pendulum oscilla.or,a.d th. da.ped rota.ing pendulum oscilla.or with.ut *** MSM first-order a.proxima.ions for a.l th. ca.es mentioned a.e derived in *** obta.ned results a.e illustra.ed with.concrete numerica. *** first-order MSM a.proxima.ions a.e compa.ed to th. fourth.order Runge-Kutta.RK4)numerica. ***,th. ma.imum error is estima.ed for th. first-order a.proxima.ions obta.ned th.ough.th. MSM,compa.ed to th. numerica. a.proxima.ions obta.ned by th. RK4 ***,we conducted a.compa.a.ive a.a.ysis of th. outcomes obta.ned by th. used meth.d(MSM)a.d h.-MSM to a.certa.n th.ir respective levels of *** proposed meth.d ca. be a.plied to a.a.yze ma.y strong nonlinea. oscilla.ory equa.ions.

关键词： rota.iona. pendulum system multiple sca.es meth.d a.proxima.e solution da.ped oscilla.ions forced pendulum with.ga.lows h.-multiple sca.es meth.d

Dyna.ic lith.um-compensa.ion mech.nism for densifica.ion of ga.net-type Li_(7)La.(3)Zr_(2)O_(12)electrolyte by Li_(2)O a.mosph.re buffer pa.r

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Na.o Resea.ch 2024年第7期17卷 6184-6191页

作者： Ch.jun Zh.ng ya Ch.n h.oxin Dong yan Lu Jun Jin Zh.oyin Wen Ca. Key La.ora.ory of Ma.eria.s for Energy Conversion Shanghai Institute of CeramicsChinese Academy of ScienceShanghai 200050China Sta.e Key La. h.gh.Performa.ce Cera. a.d Superfine Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Ma.eria.s Science a.d Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Solid-sta.e lith.um meta. ba.teries a.e one of th. most promising options for next-genera.ion ba.teries pursuing h.gh.energy density a.d ***,th. inevita.le vola.iliza.ion of lith.um compounds during sintering lea.s to low rela.ive density a.d low ionic conductivity of solid-sta.e ***,th. dyna.ic lith.um-compensa.ion mech.nism is proposed to fa.ilita.e th. densifica.ion of Ta.substituted ga.net-type electrolyte(Li_(6.5)La.(3)Zr_(1.5)Ta.(0.5)O_(12)(LLZT))th.ough.th. reversible ma.ipula.ing of Li_(2)O ***_(2)ZrO_(3)is used a. moth.r powder a.ditive,wh.ch.rea.ts with.Li_(2)O in sintering a.mosph.re a.d forms Li_(6)Zr_(2)O_(7).Li_(2)ZrO_(3)/Li_(6)Zr_(2)O_(7)buffer pa.r ma.ipula.es th. sintering Li_(2)O a.mosph.re,wh.ch.is vita. for LLZT,with.n th. Li_(2)O pa.tia. pressure ra.ge corresponding to Li_(2)ZrO_(3)a.d Li_(6)Zr_(2)O_(7).Furth.rmore,th. reversibility mech.nism of buffer pa.r for Li_(2)O a.sorption a.d relea.e is *** obta.ned LLZT exh.bits a.rela.ive density of over 96%a.d a. ionic conductivity exceeding 7×10^(−4)S·cm^(−1)with.no a.norma. gra.n *** symmetric cell demonstra.es a. excellent lith.um dendrite suppressing a.ility(sta.le cycling a. a.current density of 0.3 ma.cm^(−2)for over 1000 h..Such.dyna.ic lith.um-compensa.ion stra.egy h.s been successfully a.plied in a.mosph.re ma.ipula.ion of LLZT sintering process,wh.ch.reduces th. dependence of LLZT on th. Li_(2)O a.mosph.re,ma.ing it conducive to la.ge-sca.e prepa.a.ion of electrolyte cera.ics.

关键词： solid-sta.e ba.teries ga.net-type electrolyte h.gh.density electrolyte dyna.ic lith.um-compensa.ion buffer pa.r

Exploring Va.ia.ility in Sea.Level a. a.Tide Ga.ge Sta.ion th.ough.Control Ch.rts

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Journa. of Environmenta. & Ea.th.Sciences 2024年第1期6卷 11-18页

作者： h.bâkiİz Independent Sch.la. Boca Raton Florida33496USA

Monitoring tempora. ch.nges in sea.level is importa.t in a.sessing coa.ta. *** level a.oma.ies a. a.tide ga.ge sta.ion,if kinema.ica.ly conceived,include systema.ic va.ia.ions such.a. trend,a.celera.ion,periodic oscilla.ions,a.d ra.dom *** th.m,th. non-sta.iona.y na.ure of th. ra.dom sea.level va.ia.ions of known or unknown origin a. coa.ta. regions h.s been long recognized by th. sea.level *** study proposes th. a.a.yses of subgroups of ra.dom residua. sta.istics of a.rigorously formula.ed kinema.ic model solution of tide ga.ge va.ia.ions using X-ba. a.d S control *** a.proa.h.is demonstra.ed using Key West,Florida.tide ga.ge *** mea. a.d sta.da.d errors of 5-yea.-long subgroups of th. residua.s revea.ed th.t sea.level ch.nges a. th.s loca.ion h.ve been progressively intensifying from 1913 to th. *** oscilla.ions in sea.level a. th.s loca.ity ma. be a.tributed pa.tly to th. th.rma. expa.sion of sea.a.er with.increa.ing tempera.ures ca.sing la.ger buoyancy-rela.ed sea.level fluctua.ions a. well a. th. intensifica.ion of a.mosph.ric events including wind pa.terns a.d th. impa.t of ch.nges in inverted ba.ometer effects th.t will a.ter coa.ta. risk a.sessments for th. future.

关键词： Clima.e ch.nge Sea.level va.ia.ce X-ba. S control ch.rts

Exploring one ma.eria. for dua. a.plica.ions:a.red-emitting Mg2GeO4:Eu3+ na.oph.sph.r for future genera.ion energy efficient WLEDs a.d dosimetric a.plica.ions

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Journa. of Ra.e Ea.th. 2024年第10期42卷 1835-1845页

作者： a.sh.y a.jun G.P.Da.sh.n S.C.Sh.rma.h.Na.a.h.sh.na.D.V.Sunith. h.b.Premkuma. Depa.tment of Ph.sics Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied Sciences Ja.n University C.N.R.Ra. Centre for a.va.ced Ma.eria.s Tumkur University Sch.ol of a.plied Sciences (Ph.sics) REVA University

Th. envisa.ed design a.d developme nt of individua. ma.e ria.s to exca.a.e a.broa.er spectrum of desired properties a.d offer multiple a.plica.ions a.e h.gh.y *** th.s in mind,a.series of forsterite-structured Mg2GeO4:Eu3+（1 mol%-9 mol%） na.oph.sph.rs wa. synth.sized via.a.solution combustion meth.d using oxa.yl dih.dra.ide a. a.*** X-ra. diffra.tion pa.terns confirm th. orth.rh.mbic crysta. system with.a.Puma.spa.e *** results clea.ly sh.w irregula.ly sh.ped cluster-like structures with.a.grega.ion of th. *** diffuse reflecta.ce spectra.th. optica. energy ba.d ga. of th. Mg2GeO4:Eu3+（1 mol%-9 mol%） na.oph.sph.rs wa. estima.ed a.d obta.ned to be～4.12-4.32 *** ph.toluminescence emission spectra.exh.bit intense pea.s a. ～579,589,610,661,a.d 707 nm,wh.ch.a.e due to ch.ra.teristic5D0→7F0,5D0→7F1,5Do→7F2,5D0→7F3a.d5D0→7F4tra.sitions of Eu3+ions,*** Commission Interna.iona. de L'Ecla.ra.e color coordina.es a.e gra.ua.ly tuned from pa.e red（0.5980,0.4012） to a.pure red（0.6385,0.3611） *** glow pea.s sh.wca.e excellent super-linea. response a. low doses of γ-irra.ia.ions,indica.ing th.t th. prepa.ed ph.sph.r ca. be used in th.rmoluminescent persona. dosimetry wh.ch.is a.biologica. tissue *** a.orementioned results demonstra.e th.t th. prepa.ed Mg2GeO4:Eu3+（1 mol%-9 mol%） na.oph.sph.rs a.e considered a. excellent ca.dida.e for dua. a.plica.ions,i.e.,red component in future genera.ion wh.te-ligh.-emitting diodes（WLEDs） a.d persona. dosimetric a.plica.ions.

关键词： Dosimetry Na.oph.sph.rs Ph.toluminescence Ph.tometric properties Ra.e ea.th. Th.rmoluminescence

Pelleting a.d pa.ticle size reduction of corn increa.e net energy a.d digestibility of fiber,protein,a.d fa. in corn-soybea. mea. diets fed to group-h.used pigs

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Journa. of a.ima. Science a.d biotech.ology 2024年第4期15卷 1751-1760页

作者： Su a.Lee Diego a.Rodriguez Ch.d b.Pa.lk h.ns h.Stein Depa.tment of a.ima. Sciences University of IllinoisUrbanaIL 61801USA Depa.tment of Gra.n Sciences a.d Industry Kansas State UniversityManhattanKS 66506USA

ba.kground Reduction of th. pa.ticle size of corn increa.es energy digestibility a.d concentra.ions of digestible a.d meta.oliza.le *** ma. a.so reduce pa.ticle size of gra.n,but it is not known if th.re a.e intera.tions between pa.ticle size reduction a.d *** objective of th.s experiment wa. to test th. h.poth.sis th.t pa.ticle size reduction a.d pelleting,sepa.a.ely or in combina.ion,increa.e N ba.a.ce,a.pa.ent tota. tra.t digestibility(a.TD)of fiber a.d fa.,a.d net energy(NE)in corn-soybea. mea. diets fed to group-h.used *** Six corn-soybea. mea.-ba.ed diets were used in a.3×2 fa.toria. design with.3 pa.ticle sizes of corn(i.e.,700,500,or 300μm)a.d 2 diet forms(i.e.,mea. or pelleted).Pigs were a.lowed a. libitum a.cess to feed a.d ***-four ca.tra.ed ma.e pigs(initia. weigh.:29.52 kg;sta.da.d divia.ion:1.40)were a.lotted to th. 6 diets using a.6×6 La.in squa.e design with.6 ca.orimeter ch.mbers(i.e.,4 pigs/ch.mber)a.d 6 *** consumption a.d CO_(2)a.d Ch.(4)productions were mea.ured during fed a.d fa.ting sta.es a.d feca. a.d urine sa.ples were *** Rega.dless of pa.ticle size of corn,th. a.TD of gross energy(GE),N,a.d a.id-h.drolyzed eth.r extra.t(a.E),a.d th. concentra.ion of NE were grea.er(Ph.n in mea. *** of diet form,th. a.TD of GE,N,a.d a.E,a.d th. concentra.ion of NE were increa.ed(linea.;Pby reducing th. pa.ticle size of corn,but th. increa.e wa. grea.er in mea. diets th.n in pelleted diets(intera.tion;Pboth.pelleting a.d reduction of corn pa.ticle size increa.ed nutrient digestibility a.d NE,but increa.es were grea.er in mea. diets th.n in pelleted diets.

关键词： Corn Digestibility Feed tech.ology Net energy Pa.ticle size Pelleting