检索结果-南通市图书馆

维甲酸下调结缔组织生长因子表达减轻新生大鼠高氧肺损伤的研究

在线全文

学校读者我要写书评

暂无评论

中国当代儿科杂志 2011年第3期13卷 248-251页

作者：徐雅丽陈贻骥张亚维重庆医科大学附属儿童医院新生儿诊治中心重庆400014

目的探讨维甲酸(ra)对高氧肺损伤保护作用的机制。方法 90只Sprague-Dawley新生鼠随机平分为空气组、高氧组和高氧+ra组。高氧组、高氧+ra组置于85%氧浓度的氧箱中,高氧+ra组每日腹腔注射ra 500μg/kg。分别于实验第4天、7天、14天行开... 详细信息

目的探讨维甲酸(ra)对高氧肺损伤保护作用的机制。方法 90只Sprague-Dawley新生鼠随机平分为空气组、高氧组和高氧+ra组。高氧组、高氧+ra组置于85%氧浓度的氧箱中,高氧+ra组每日腹腔注射ra 500μg/kg。分别于实验第4天、7天、14天行开胸术取新生鼠肺组织,苏木精-伊红染色光镜下行辐射状肺泡计数,逆转录聚合酶链反应(RT-PCR)、免疫组化检测肺组织结缔组织生长因子(CTGF)表达。结果与空气组相比,高氧组和高氧+ra组肺组织随氧暴露时间延长,出现炎性细胞浸润,肺泡结构紊乱,肺泡数量减少,肺间隔增厚,其中高氧+ra组病理改变明显轻于高氧组;在第7天和第14天,高氧组和高氧+ra组肺组织CTGF的mRNA和蛋白表达比空气组增加(Pra组中CTGF的mRNA和蛋白表达在第14 d比高氧组减少(Pra保护高氧肺损伤可能是通过下调CTGF表达。

关键词：维甲酸高氧肺损伤结缔组织生长因子新生大鼠

Adverse effects of maternal rheumatoid arthritis during pregnancy on children

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第9期134卷 1113-1115页

作者： Rong Li Dan Ma ya-Zhen Su Gai-Lian Zhang Ke Xu Li-Yun Zhang Department of Rheumatology Bethune Hospital Affiliated to Shanxi Medical UniversityTaiyuanShanxi 030032China Department of Rheumatology Shanxi Bethune HospitalTaiyuanShanxi 030032China

To the Editor:Rheumatoid arthritis(ra)is an autoimmune disease characterized by invasive arthritis,affecting approximately 1%of the global *** and middle-aged women are prone to ra and can experience one or more pregnancies during the course of the *** developmental origins of health and disease describes how health hazards occurring at a young age could affect one’s health in later life.[1]ra exposure during pregnancy can consequently influence the health of the *** paper discusses the pregnancy status of women with ra and the possible influence of ra on the health of the offspring.

关键词： pregnancy autoimmune offspring

在线全文

学校读者我要写书评

暂无评论

随机变量的量子分解和增长图的渐近谱分布

数学学报（中文版） 2022年第4期65卷 657-664页

作者：韩琦寇亚欣韩娅楠陆自强西北师范大学数学与统计学院兰州730070

本文给出了一般Bernoulli随机变量X的量子分解,三点路图m步返回路线条数的积分表示以及两类增长图-圈与完全二分图的渐近谱分布.这使得在量子概率框架下研究经典随机变量或经典概率分布成为可能,也在一定程度上展示了图的谱分析中的量... 详细信息

本文给出了一般Bernoulli随机变量X的量子分解,三点路图m步返回路线条数的积分表示以及两类增长图-圈与完全二分图的渐近谱分布.这使得在量子概率框架下研究经典随机变量或经典概率分布成为可能,也在一定程度上展示了图的谱分析中的量子概率技巧.

关键词：邻接矩阵谱相互作用Fock空间代数概率空间量子分解

Involvement of P2X7 receptor signaling on regulating the differentiation of Th17 cells and type Ⅱ collagen-induced experimental arthritis in mice

在线全文

学校读者我要写书评

暂无评论

Involvement of P2X7 receptor signaling on regulating the dif...

HPLC-ELSD在肝微粒体中银杏萜内酯的测定及其代谢研究中的应用

第十三届江浙沪儿科学术会议暨2016年浙江省医学会儿科学学术年会

作者： Fan Zhi-Dan Zhang ya-Yuan Yu Hai-Guo 南京市儿童医院

Interleukin(IL)-17 producing T helper(Th17)cells have been established as major effector cells in the pathogenesis of rheumatoid arthritis(ra).The P2X7 receptor(P2X7R)has emerged as a potential site in the regulation of inflammation in ra but little is known of its functional role on the differentiation of Th17 cells.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国药学杂志 2005年第22期40卷 1745-1748页

作者：裘雅渔姚彤炜浙江大学药学院药物分析与药物代谢研究室

目的为研究银杏萜内酯的代谢作用机制和进一步开发利用,建立其体外代谢的HPLC-ELSD测定法。方法以Dia-monsilTMODS-C18为色谱柱;甲醇-水(37:63)为流动相,流速1.0mL·min-1;蒸发光散射检测器(ELSD)检测:漂移管温度60℃,雾化气(N2)压力0.2... 详细信息

目的为研究银杏萜内酯的代谢作用机制和进一步开发利用,建立其体外代谢的HPLC-ELSD测定法。方法以Dia-monsilTMODS-C18为色谱柱;甲醇-水(37:63)为流动相,流速1.0mL·min-1;蒸发光散射检测器(ELSD)检测:漂移管温度60℃,雾化气(N2)压力0.25MPa。鼠肝微粒体孵育液中银杏萜内酯用乙醚提取,空气流下挥干乙醚,残渣用适量流动相溶解,取40μL进样,测定剩余银杏内酯A,B,C和白果内酯的含量。对鼠肝微粒体孵育液中银杏萜内酯的HPLC-ELSD进行方法学研究,并应用于银杏萜内酯的体外代谢研究。结果白果内酯、银杏内酯A、银杏内酯B和银杏内酯C分别在3.30-133.60,6.8-136.0,5.40-109.0和3.6-72.0mg·L-1内呈现良好的线性关系,相关系数r分别为0.9936,0.9964,0.9959和0.9930(n=5)。测得定量限分别为3.30,6.80,5.40和3.60mg·L-1(RSD<15%,n=3);检测限分别为12,32,20和16ng(S/N=3);方法回收率分别为85.9%-102.9%,85.9%-98.3%,88.6%-98.9%和85.4%-101.8%(n=5),日内、日间精密度小于10.5%。孵育液中其他成分不干扰银杏萜内酯的测定。结论本法简便、准确,可用于银杏萜内酯的体外代谢研究。

关键词：银杏内酯微粒体药物代谢高效液相色谱法蒸发光散射检测器

湖北竹山黄绿色-绿色绿松石伴生矿的谱学研究

在线全文

学校读者我要写书评

暂无评论

光谱学与光谱分析 2020年第6期40卷 1815-1820页

作者：库雅伦杨明星李妍中国地质大学(武汉)珠宝学院湖北武汉430074 中国地质大学(武汉)珠宝检测中心湖北武汉430074

近年来绿松石市场上出现了俗称"绿松石伴生矿"的天然矿物,颜色丰富,有紫色、白色、褐黄色、黄绿色、绿色等,其中黄绿色-绿色系绿松石伴生矿相对其他颜色绿松石伴生矿与绿松石外观较为相似,鉴别难度较大。为探究其鉴别特征,选取两块来自... 详细信息

近年来绿松石市场上出现了俗称"绿松石伴生矿"的天然矿物,颜色丰富,有紫色、白色、褐黄色、黄绿色、绿色等,其中黄绿色-绿色系绿松石伴生矿相对其他颜色绿松石伴生矿与绿松石外观较为相似,鉴别难度较大。为探究其鉴别特征,选取两块来自湖北省竹山县市场的黄绿色-绿色系伴生矿原石(样品E和F),对其进行基础宝石学、电子探针、X射线粉晶衍射、显微激光拉曼光谱及紫外-可见分光光谱测试。测试结果显示该色系绿松石伴生矿的主要矿物成分为氟磷灰石(Ca5(PO4)3F)、白云母(KAl2(AlSi3O10)(OH)2)等。电子探针背散射照片显示样品为结晶颗粒细小的多物相混杂的混合物,化学成分定量测试结果表明深色物相为含铝的硅酸盐,而浅色物相为含钙的磷酸盐,此外两样品含有2.27~6.22 Wt%的CuO和2.43~4.99 Wt%的FeO;有损测试X射线粉晶衍射可准确测试样品主要矿物为氟磷灰石和白云母及少量绿松石;样品的氟磷灰石和白云母典型拉曼谱峰可作为有效鉴别依据,其中964 cm^-1附近氟磷灰石的典型拉曼谱峰以及203,432,709和3626 cm^-1附近白云母的典型拉曼谱峰可将其与绿松石有效鉴别。紫外-可见吸收光谱测试结果表明样品的颜色成因与绿松石相似,主要是由Cu2+和Fe3+的电子跃迁所致。通过对该色系样品相对较系统的谱学测试,笔者认为拉曼光谱是鉴别绿松石伴生矿中不同矿物相的无损、快速、有效的方法,氟磷灰石和白云母典型拉曼谱峰可将其与绿松石有效区分。

关键词：绿松石伴生矿拉曼光谱 X射线粉晶衍射

Characterization and Ectopic Expression of a Populus Hydroxyacid Hyd roxyci n nam oylt ra nsferase

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2013年第6期6卷 1889-1903页

作者： Ai-Xia Cheng Jin-Ying Gou Xiao-Hong Yu Huijun yang Xin Fang Xiao-ya Chen Chang-Jun Liu Biosciences Department Brookhaven National Laboratory Upton NY 11973 USA School of Pharmaceutical Sciences Shandong University :linan 250012 China Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Shanghai 200032 China

Cutinized and suberized cell walls in plants constitute physiologically important environment interfaces. They act as barriers limiting the loss of water and nutrients and protecting against radiation and invasion of pathogens. The roles of cutin- and suberin polyesters are often attributed to their dominant aliphatic components, but the contri- bution of aromatic composition to their physiological function remains unclear. By functionally screening a subset of Populus trichocarpa BAHD/HXXXD acyltransferases, we identified a hydroxycinnamoyltransferase that shows specific transacylation activity on ~0-hydroxyacids using both feruloyl- and p-coumaroyl- CoA as the acyl donors. We named this enzyme P. trichocarpa hydroxyacid/fatty alcohol hydroxycinnamoyltransferase 1 （PtFHT1）. The ectopic expression of the PtFHT1 gene in Arabidopsis increased the incorporation of ferulate in root and seed suberins and in leaf cutin, but not that of p-coumarate, while the aliphatic load in both suberin and cutin polyesters essentially remained unaffected. The overaccumulation of ferulate in lipophilic polyester significantly increased the tolerance of transgenic plants to salt stress treatment; under sub-lethal conditions of salt stress, the ratios of their seed germination and seedling establishment were 50% higher than those of wild-type plants. Our study suggests that, although aromatics are the minor component of polyesters, they play important role in the sealing function of lipidic polymers in planta.

关键词： cutin suberin ferulate BAHD acyltransferase Populus.

Analysis of long noncoding RNA-associated competing endogenous RNA network in glucagon-like peptide-1 receptor agonist-mediated protection inβcells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2020年第9期11卷 374-390页

作者： Li-Juan Cui Tao Bai Lin-Ping Zhi Zhi-Hong Liu Tao Liu Huan Xue Huan-Huan yang Xiao-Hua yang Min Zhang ya-Ru Niu Yun-Feng Liu Yi Zhang Department of Pharmacology Basic Medical CollegeShanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Endocrinology The First Clinical Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Respiratory Medicine The First Clinical Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of General Surgery Shanxi Bethune HospitalTaiyuan 030006Shanxi ProvinceChina College of Pharmacy Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Second Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND Long noncoding RNAs(lncRNAs)and mRNAs are widely involved in various physiological and pathological *** use of glucagon-like peptide-1 receptor agonists(GLP-1ras)is a novel therapeutic strategy that could promote insulin secretion and decrease the rate ofβ-cell apoptosis in type 2 diabetes mellitus(T2DM)***,the specific lncRNAs and mRNAs and their functions in these processes have not been fully identified and *** To identify the lncRNAs and mRNAs that are involved in the protective effect of GLP-1ra inβcells,and their *** rat gene microarray was used to screen differentially expressed(DE)lncRNAs and mRNAs inβcells treated with geniposide,a *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed to assess the underlying functions of DE *** mRNAs were filtered using the STRING database and the Cytoscape plugin,*** order to reveal the regulatory relationship between lncRNAs and hub mRNAs,their co-expression network was constructed based on the Pearson coefficient of DE lncRNAs and mRNAs,and competing endogenous RNA(ceRNA)mechanism was explored through miranda and TargetScan *** We identified 308 DE lncRNAs and 128 DE mRNAs with a fold change filter of≥1.5 and P valueration,and ERK1 and ERK2 ***,Htr2a,and Agtr1a were screened as hub mRNAs using the STRING database and the Cytoscape plugin,*** result was further verified using SwissTargetPrediction *** the co-expression network and competing endogenous(ceRNA)mechanism,we identified seven lncRNAs(NONraTT027738,NONraTT027888,NONraTT030038,etc.)co-expressed with the three hub mRNAs(Pomc,Htr2a,and Agtr1a)based on the Pearson coefficient of

关键词： Type 2 diabetes βcell Long noncoding RNA Competing endogenous RNA Co-expression analysis Glucagon-like peptide-1 receptor agonist

Epigenetic regulatory differentiation of hematopoietic stem cells to the red lineage

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reproductive and Developmental Medicine 2024年第3期8卷 169-177页

作者： Hong-Xing Li Yi-Hong Chai Xiao-Hong Sun Xiao-Xia He ya-Ming Xi The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000China Key Laboratory for Reproductive Medicine and Embryo of Gansu Province Lanzhou 730000China Department of Hematology The First Hospital of Lanzhou UniversityLanzhou 730000China

The differentiation process from hematopoietic stem cells(HSCs)to mature red blood cells(RBCs)is characterized by remarkable precision and is tightly controlled from the initial lineage commitment to eventual terminal *** is the dynamic journey of HSCs through various functional and phenotypic *** physiological course of erythrogenesis is intricately linked to significant changes in chromatin accessibility,necessitating precise coordination of transcription factors and epigenetic *** review presents a comprehensive overview of recent investigations into the molecular-level epigenetic regulatory factors that influence the differentiation of the erythroid *** encompasses the exploration of transcriptional,post-transcriptional,and post-translational regulatory *** intricate interplay of epigenetic and transcriptional regulatory networks in erythroid differentiation not only enhances our understanding of this fundamental biological process but also provides valuable insights into the underlying mechanisms contributing to the pathogenesis of disorders associated with abnormal erythroid *** findings hold significant promise for the development of novel therapeutic strategies to address these diseases and improve patient outcomes.

关键词： Hematopoietic stem cells Differentiation Epigenetics Post-translational regulation