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TuBg1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 195-209页

作者： yan Zhang Zhen-Zhen Wang An-Qi Han Ming-ya yang Li-Xin Zhu fa-Ming Pan Yong Wang Department of general Surgery The Second Hospital of Anhui Medical UniversityHefei 230601China Department of general Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China The Key Laboratory of Major Autoimmune Diseases Anhui Medical UniversityHefei 230032China

Background:As reported,γ-tubulin(TuBg1)is related to the occurrence and development of various types of malignant ***,its role in hepatocellular cancer(HCC)is not *** present study was to investigate the relationship between TuBg1 and clinical parameters and survival in HCC ***:The correlation between TuBg1 and clinical parameters and survival in HCC patients was ex-plored by bioinformatics *** was used for the *** molecular function of TuBg1 was measured using colony formation,scratch assay,trans-well assay and flow *** set enrichment analysis(gSEA)was used to pick up the enriched pathways,followed by investigating the target pathways using Western *** tumor-immune system interactions and drug bank database(TISIDB)was used to evaluate TuBg1 and *** on the TuBg1-related immune genes,a prognostic model was constructed and was further validated internally and ***:The bioinformatic analysis found high expressed TuBg1 in HCC tissue,which was confirmed us-ing immunohistochemistry and Western *** silencing the TuBg1 in HCC cell lines,more g1 arrested cells were found,cell proliferation and invasion were inhibited,and apoptosis was ***,the silence of TuBg1 increased the expressions of Ataxia-Telangiectasia and Rad-3(ATR),phospho-P38 mitogen-activated protein kinase(P-P38MAPK),phospho-P53(P-P53),B-cell lymphoma-2 associated X protein(Bax),cleaved caspase 3 and P21;decreased the expressions of B-cell lymphoma-2(Bcl-2),cyclin D1,cyclin E2,cyclin-dependent kinase 2(CDK2)and *** correlation analysis of immunohistochemistry and clinical parameters and survival data revealed that TuBg1 was negatively corre-lated with the overall *** constructed immune prognosis model could effectively evaluate the ***:The increased expression of TuBg1 in HCC is associated with poor prognosis,which might be involved in the oc

关键词： TuBg1 Hepatocellular carcinoma Apoptosis Cell cycling Immunomodulators

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Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological Research 2024年第3期45卷 551-566页

作者： Chen Ling Su-Su Liu Yu-ya Wang gui-Tao Huo yan-Wei yang Nan Xu Hong Wang Yong Wu Yu-fa Miao Rui Fu Yu-Wei Zhao Chang-fa fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China National Center for Safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China Division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China Division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

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Imprints of ultralight axions on the gravitational wave and pulsar timing measurement

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 23-29页

作者： Ning Xie fa Peng Huang MOE Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinGravitational Wave Research Center of CNSASun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

The axion or axion-like particle motivated from a natural solution of strong CP problem or string theory is a promising dark matter *** study the new observational effects of ultralight axion-like particles by the space-borne gravitational wave detector and the radio *** the neutron star-black hole binary as an example,we demonstrate that the gravitational waveform could be obviously modified by the slow depletion of the axion cloud around the black hole formed through the superradiance *** compare these new effects on the binary with the well-studied effects from dynamical friction with dark matter and dipole radiation in model-independent ***,we discuss the constraints from LIgO/Virgo and study the detectability of the ultralight axion particles at LISA and TianQin.

关键词： gravitational wave axion dark matter

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Indian monsoon drove the dispersal of the thoracica group of Scytodes spitting spiders

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Zoological Research 2024年第1期45卷 152-159页

作者： Yu-fa Luo Shu-Qiang Li School of Life and Environmental Sciences Shaoxing UniversityShaoxingZhejiang 312000China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

We examined the global biogeography of the Scytodes thoracica group of spitting spiders based on 23 years of sampling at the species level(61 species in the thoracica group and 84 species of Scytodes)using DNA data from six *** results indicated that the thoracica group initially dispersed from Southeast Asia to East Africa between 46.5 and 33.0 million years ago,and dispersal events intensified between Southeast/South Asia and East/South Africa from the early to late *** timing of these events indicates that Asian-African faunal exchange of the thoracica group was driven by the Indian monsoon,and the pattern of dispersal suggests that colonialization took root when the Indian monsoon shifted from a North-South direction to an East-West direction from the middle Eocene.

关键词： geological event Climate change Ballooning organism faunal exchange Species distribution

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Shuxuening Injection Inhibits Apoptosis and Reduces Myocardial Ischemia-Reperfusion Injury in Rats through PI3K/AKT Pathway

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Chinese Journal of Integrative Medicine 2024年第5期30卷 421-432页

作者： YUE Tong-tong CAO Ying-jie CAO ya-xuan LI Wei-xia WANg Xiao-yan SI Chun-ying XIA Han ZHU Ming-jun TANg Jin-fa WANg He The First Clinical Medical College of Henan University of Chinese Medicine Zhengzhou 450046China Department of Pharmacy the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China Department of Cardiovascular Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China

Objective: To investigate the main components and potential mechanism of Shuxuening Injection(SXNI) in the treatment of myocardial ischemia-reperfusion injury(MIRI) through network pharmacology and in vivo research. Methods: The Traditional Chinese Medicine Systems Pharmacology(TCMSP) and Pharm Mapper databases were used to extract and evaluate the effective components of ginkgo biloba leaves, the main component of SXNI. The Online Mendelian Inheritance in Man(OMIM) and gene Cards databases were searched for disease targets and obtain the drug target and disease target intersections. The active ingredient-target network was built using Cytoscape 3.9.1 software. The STRing database, Metascape online platform, and R language were used to obtain the key targets and signaling pathways of the anti-MIRI effects of SXNI. In order to verify the therapeutic effect of different concentrations of SXNI on MIRI in rats, 60 rats were first divided into 5 groups according to random number table method: the sham operation group, the model group, SXNI low-dose(3.68 mg/kg), medium-dose(7.35 mg/kg), and high-dose(14.7 mg/kg) groups, with 12 rats in each group. Then, another 60 rats were randomly divided into 5 groups: the sham operation group, the model group, SXNI group(14.7 mg/kg), SXNI+LY294002 group,and LY294002 group, with 12 rats in each group. The drug was then administered intraperitoneally at body weight for 14 days. The main biological processes were validated using in vivo testing. Evans blue/triphenyltetrazolium chloride(TTC) double staining, hematoxylin-eosin(HE) staining, terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay, enzyme-linked immunosorbent assay(ELISA), and Western blot analysis were used to investigate the efficacy and mechanism of SXNI in MIRI rats. Results: Eleven core targets and 30 Kyoto Encyclopedia of genes and genomes(KEgg) pathways were selected. Among these, the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) pathway was

关键词： myocardial ischemia reperfusion injury PI3K/AKT signaling pathway Shuxuening Injection apoptosis ginkgo biloba leaves

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Analytical Solution for the Reissner-Sagoci Problem of a Piezoelectric Half-Space

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Acta Mechanica Solida Sinica 2024年第3期37卷 363-370页

作者： Keqiang Hu Cun-fa.gao Zengtao Chen Zheng Zhong State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China Department of Mechanical Engineering University of AlbertaEdmontonABT6G 1H9Canada School of Science Harbin Institute of TechnologyShenzhen518055China

In this paper,a transversely isotropic piezoelectric half-space with the isotropy axis parallel to the z-axis is considered under rotation on a rigid circular disk bonded to the surface of the piezoelectric *** is a type of Reissner-Sagoci mixed boundary value *** utilizing the Hankel transform,the mixed boundary value problem is simplified into solving a pair of dual integral ***-field analytical expressions for displacement,stresses,and electric displacement inside the half-space are *** shear stresses and electric displacement on the surface are found to be singular at the edge of the rigid circular disk,and the stress intensity factors and electric displacement intensity factor are *** results show that material properties and geometric size have significant effects on displacement,shear stresses,and electric displacement.

关键词： Piezoelectric half-space Circular disk Reissner-Sagoci problem Stress intensity factor Electric displacement intensity factor

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Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study

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World Journal of gastroenterology 2024年第11期30卷 1572-1587页

作者： Shi-Ju Chen Da-ya Zhang Xia Wu fa-Ming Zhang Bo-Ta Cui Yi-Hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Microbiota Medicine&Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina

BACKgROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transplantation(WMT).Most existing studies have focused on observing the clinical ***,the mechanism of action of FMT for the effective management of CD-particularly in-depth multi-omics analysis involving the metagenome,metatranscriptome,and metabolome-has not yet been *** To assess the efficacy of WMT for CD and explore alterations in the microbiome and metabolome in response to *** We conducted a prospective,open-label,single-center clinical *** CD patients underwent *** clinical responses(defined as a decrease in their CD Activity Index score of>100 points)and their microbiome(metagenome,metatranscriptome)and metabolome profiles were evaluated three months after the *** Seven of the 11 patients(63.6%)showed an optimal clinical response three months *** microbiome diversity significantly increased after WMT,consistent with improved clinical *** of the metagenome and metatranscriptome analyses revealed consistent alterations in certain strains,such as faecalibac-terium prausnitzii,Roseburia intestinalis,and Escherichia *** addition,metabolomics analyses demonstrated that CD patients had elevated levels of various amino acids before treatment compared to the ***,levels of vital amino acids that may be associated with disease progression(e.g.,L-glutamic acid,gamma-glutamyl-leucine,and prolyl-glutamine)were reduced after *** WMT demonstrated therapeutic efficacy in CD treatment,likely due to the effective reconstruction of the patient’s ***-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.

关键词： Crohn’s disease Clinical trials Fecal microbiota transplant Metagenome Metatranscriptome Metabolome

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NUDT5 promotes the growth,metastasis,and Warburg effect of IDH wild-type glioblastoma multiforme cells by upregulating TRIM47

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 82-92页

作者： Zi-fa Zhang Shu-Ming Liu Neurosurgery Department Shanxi Bethune HospitalTaiyuanShanxi Province030022China Shanxi Academy of Medical Sciences TaiyuanShanxi province030022China Emergency Department Taiyuan People’s HospitalTaiyuanShanxi Province030021China

Objective:To explore the regulatory mechanism of NUDT5 in glioblastoma multiforme(gBM).Methods:gEPIA database was used to predict the expressions of NUDT5 and tripartite motif family proteins 47(TRIM47)in gBM ***-qPCR and Western blot analyses were performed to examine NUDT5 expression in gBM ***-229 cell proliferation,migration as well as invasion were estimated by CCK-8,colony formation,wound healing,and Transwell assays following interference with *** assay,L-lactic acid kit,glucose detection kit,and ATP detection kit were applied for the detection of glycolysis-related ***-immunoprecipitation experiment was carried out to verify the relationship between NUDT5 and ***:gEPIA database showed that NUDT5 expression was significantly increased in gBM *** the expression of NUDT5 in gBM cells significantly suppressed the viability,proliferation,invasion,migration,and glycolysis of gBM ***,TRIM47 was highly expressed in gBM cells and interacted with *** of TRIM47 partially reversed the inhibitory effect of NUDT5 downregulation on the proliferation,metastasis,and glycolysis of gBM ***:NUDT5 promotes the growth,metastasis,and Warburg effect of gBM cells by upregulating *** NUDT5 and TRIM47 can be used as targets for gMB treatment.

关键词： glioblastoma multiforme NUDT5 TRIM47 growth Metastasis Warburg effect

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Area Operators on Bergman Spaces

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1161-1176页

作者： Xiao Fen LV Jordi PAU Mao fa WANg Department of Mathematics Huzhou UniversityHuzhou 313000P.R.China Departament de Matemàtiques i Informàtica Universitat de Barcelona08007 BarcelonaCataloniaSpain School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

We completely characterize the boundedness of area operators from the Bergman spaces A_(α)^(p)(Bn)to the Lebesgue spaces L^(q)(S_(n))for all 0 详细信息

We completely characterize the boundedness of area operators from the Bergman spaces A_(α)^(p)(Bn)to the Lebesgue spaces L^(q)(S_(n))for all 0gral and Carleson measures,*** Math.,54,2487–2500(2011)].Especially,in the case q

关键词： Area operator Bergman space tent space area formula

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High-temperature wetting behavior between slag and refractory

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Journal of Iron and Steel Research International 2024年第6期31卷 1304-1319页

作者： Yong-xin Wang ya-ge Li ya-bo gao Zhong Huang Hai-jun Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Slag corrosion is one of the main factors of the damage of refractory,and its primary manifestations involve the melting of refractory in slag and the slag penetration into refractory,both of which are highly related to the wetting behavior between slag and *** high-temperature wettability could be characterized by parameters including the surface tension,adhesion work,and spreading coefficient of the slag on refractory surface,and it could be suppressed by altering the slag/refractory interface,thus resulting in an improved anti-corrosion *** this,the key knowledges of the slag corrosion,theory of wetting behavior and test of high-temperature contact angle were firstly ***,the major factors influencing the high-temperature slag wetting behavior were discussed based on the aspects of slag composition,refractory composition,and surface ***,the future research direction was proposed in this field.

关键词： High-temperature wetting Refractory Slag corrosion Surface tension

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