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Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： LI Jie CHEN ya-feng GAO Lei LI Yi-jie FENG Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(ELISA),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the SAP+HON group had significantly fewer pathological *** with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the SAP+HON group did not show these abnormalities(P0.01).Studies of Caco-2 cells indicated that LPS increased the levels of occludin and claudin-1 as well as tight junction permeability,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

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Advances in memristor based artificial neuron fabrication-materials,models,and applications

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International Journal of Extreme Manufacturing 2024年第1期6卷 27-50页

作者： Jingyao Bian Zhiyong Liu Ye Tao Zhongqiang Wang Xiaoning Zhao ya Lin Haiyang Xu Yichun Liu Key Laboratory for UV Light-Emitting Materials and Technology(Northeast Normal University) Ministry of Education5268 Renmin StreetChangchunPeople’s Republic of China

Spiking neural network(SNN),widely known as the third-generation neural network,has been frequently investigated due to its excellent spatiotemporal information processing capability,high biological plausibility,and low energy consumption *** to the working mechanism of human brain,the SNN system transmits information through the spiking action of ***,artificial neurons are critical building blocks for constructing SNN in *** are drawing growing attention due to low consumption,high speed,and nonlinearity characteristics,which are recently introduced to mimic the functions of biological *** have proposed multifarious memristive materials including organic materials,inorganic materials,or even two-dimensional *** advantage of the unique electrical behavior of these materials,several neuron models are successfully implemented,such as Hodgkin–Huxley model,leaky integrate-and-fire model and integrate-and-fire *** this review,the recent reports of artificial neurons based on memristive devices are *** addition,we highlight the models and applications through combining artificial neuronal devices with sensors or other electronic ***,the future challenges and outlooks of memristor-based artificial neurons are discussed,and the development of hardware implementation of brain-like intelligence system based on SNN is also prospected.

关键词： artificial neuron memristor memristive materials neuron model micro-nano manufacturing spiking neural network

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Application of Fusobacterium nucleatum as a biomarker in gastrointestinal malignancies

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2271-2283页

作者： Long-Chen Yu ya-Ping Li Yue-Ming Xin Mai Mao ya-Xin Pan Yi-Xuan Qu Zheng-Dong Luo Yi Zhang Xin Zhang Department of Clinical Laboratory Qilu Hospital of Shandong UniversityShandong Engineering Research Center of Biomarker and Artificial Intelligence ApplicationJinan 250012Shandong ProvinceChina

The morbidity and mortality of gastrointestinal(GI)malignancies are among the highest in the world,posing a serious threat to human *** of the insidious onset of the cancer,it is difficult for patients to be diagnosed at an early stage,and it rapidly progresses to an advanced stage,resulting in poor treatment and *** nucleatum(***)is a gram-negative,sporefree anaerobic bacterium that primarily colonizes the oral cavity and is implicated in the development of colorectal,esophageal,gastric,and pancreatic cancers via various intricate *** development in novel research suggests that *** may function as a biomarker in GI *** the abundance of *** in stool,saliva,and serum samples of patients may aid in the diagnosis,risk assessment,and prognosis monitoring of GI *** editorial systematically describes the biological roles and mechanisms of *** in GI malignancies focusing on the application of *** as a biomarker in the diagnosis and prognosis of GI malignancies to promote the clinical translation of *** and GI tumors-related research.

关键词： Gastrointestinal malignancies Fusobacterium nucleatum Biomarker Diagnosis Prognosis

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Engineering FeOOH/Ni(OH)_(2) heterostructures on Ni_(3)S_(2)surface to enhance seawater splitting

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Rare Metals 2024年第5期43卷 1989-1998页

作者： Chen yang ya-Dong Li Li-Juan Cao Xi-Long Wang Han-Pu Liang Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 100049China

The construction of highly stable and efficient electrocatalysts is desirable for seawater splitting but remains challenging due to the high concentration of Cl-in ***,FeOOH/Ni(OH)_(2)heterostructure supported on Ni_(3)S_(2)-covered nickel foam(Fe–Ni/Ni_(3)S_(2)/NF)was fabricated by hydrothermal and etching methods,as well as anodic oxidation *** electronic structure of FeOOH and Ni(OH)_(2)could be modulated after depositing FeOOH nanoparticles on Ni(OH)_(2)nanosheet,which greatly boosted the catalytic *** the catalyst used as an electrode for oxygen evolution reaction(OER),it needed low overpotentials of 266 and 368 m V to achieve current densities of 100 and 800 m A·cm^(-2),respectively,in 1 mol·L^(-1)KOH+seawater *** can operate continuously at 100 m A·cm^(-2)for 400 h without obvious ***,in situ generated SO_(4)^(2-)from inner Ni_(3)S_(2)during electrolysis process would accumulate on the surface of active sites to form passivation layers to repel Cl^(-),which seemed to be responsible for superior *** study not only synthesizes an OER catalyst for highly selective and stable seawater splitting,but also gives a novel approach for industrial hydrogen production.

关键词： Anodic oxidation Heterostructure Oxygen evolution reaction Seawater splitting

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Low-molecular-weight heparin and preeclampsia—does the sword cut both ways?Three case reports and review of literature

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World Journal of Clinical Cases 2024年第9期12卷 1634-1643页

作者： Dan Shan Tao Li Xi Tan ya-Yi Hu Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan UniversityMinistry of EducationChengdu 610000SichuanChina

BACKGROUND Low-molecular-weight heparins(LMWH)are the most commonly used anticoagulants during *** is considered to be the drug of choice due to its safety in not crossing *** the beneficial effect in the improvement of microcirculation,prophylactic application of LMWH in patients with preeclampsia became a ***,the bleeding risk related with LMWH in preeclampsia patients has seldomly been *** current study aimed to identify the potential risks regarding LMWH application in patients with *** SUMMARY Herein we present a case series of three pregnant women diagnosed with preeclampsia on LMWH therapy during *** the cases experienced catastrophic hemorrhagic *** reviewing the twenty-one meta-analyses,the bleeding risk related with LMWH seems *** one study analyzed the bleeding risk of LMWH and found a significantly higher risk of developing PPH in women receiving *** studies reported minor bleeding risks,none of these were serious enough to stop LMWH *** of bleeding either from uterus or from intrabdominal organs in preeclampsia patients on LMWH therapy should not be *** management of blood pressure even after delivery and homeostasis suture in surgery are *** Consideration should be given to the balance between benefits and risks of LMWH in patients with preeclampsia.

关键词： Pregnancy Preeclampsia Low-molecular-weight heparin Hemorrhage Case report

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Clinical value of precise rehabilitation nursing in management of cerebral infarction

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World Journal of Clinical Cases 2024年第1期12卷 24-31页

作者： ya-Na Xu Xiu-Zhen Wang Xiao-Rong Zhang Department of Neurology Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina Department of Neurosurgery The First People's Hospital of Jiangxia DistrictWuhan City(Union Jiangnan Hospital of Huazhong University of Science and Technology)Wuhan 430200Hubei ProvinceChina

BACKGROUND Cerebral infarction,previously referred to as cerebral infarction or ischemic stroke,refers to the localized brain tissue experiencing ischemic necrosis or softening due to disorders in brain blood supply,ischemia,and *** precision rehabilitation nursing model for chronic disease management is a continuous,fixed,orderly,and efficient nursing model aimed at standardizing the clinical nursing process,reducing the wastage of medical resources,and improving the quality of medical *** To analyze the value of a precise rehabilitation nursing model for chronic disease management in patients with cerebral *** Patients(n=124)admitted to our hospital with cerebral infarction between November 2019 and November 2021 were enrolled as the study *** random number table method was used to divide them into a conventional nursing intervention group(n=61)and a model nursing intervention group(n=63).Changes in the nursing index for the two groups were compared after conventional nursing intervention and precise rehabilitation intervention nursing for chronic disease *** Compared with the conventional intervention group,the model intervention group had a shorter time to clinical symptom relief(P0.05),lower Hamilton Anxiety Scale and Hamilton Depression Scale scores,a lower incidence of total complications(P0.05),a higher disease knowledge mastery rate,higher safety and quality,and a higher overall nursing satisfaction rate(P0.05).CONCLUSION The precision rehabilitation nursing model for chronic disease management improves the clinical symptoms of patients with cerebral infarction,reducing the incidence of total complications and improving the clinical outcome of patients,and is worthy of application in clinical practice.

关键词： Precise rehabilitation nursing model for chronic disease management Cerebral infarction Knowledge of disease Safety and quality

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Trade-off analyses between food provision and soil conservation service of Grain for Green Program in Mountainous Area

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International Soil and Water Conservation Research 2024年第1期12卷 43-53页

作者： yawen Li Yuxiang Li Xingwu Duan Zhongyin Cai ya Li Baiyun He Long Yin Institute of International River and Eco-security Yunnan UniversityKunming650091PR China Yunnan Key Laboratory of International Rivers and Trans-boundary Eco-security Kunming650091PR China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085PR China University of Chinese Academy of Sciences Beijing100049PR China

The Grain for Green Program and soil and water conservation engineering initiatives are crucial for controlling erosion in steep-slope ***,it is still unclear how these two management methods should be carried out in respect to the situation in mountainous ***,taking a typical mountainous area in southwest China as an example,we simulated six scenarios in order to compare the food provisioning service(FPS)and soil conservation service of the Grain for Green Program(converting to grassland)and Construction Measures(converting to sloping terrace)under different *** showed that when farmland with a>25°slope was converted into grassland,the amount of soil erosion(M)decreased by 21.0%,while FPS decreased by only 0.7%.However,when farmland with a>25°slope was converted into sloping terrace,M decreased by 31.3%while FPS increased by 18.7%.With the increases of farmland slope ranges in the Construction Measures scenario,M gradually decreased and FPS gradually *** when farmland>15°was converted into sloping terrace,M decreased by 63.9%and FPS increased by 52.7%.Furthermore,the trade-offs of Construction Measures are lower than that of Grain for Green on different slope ***,we conclude that Construction Measures are a more suitable method in mountainous areas than the Grain for Green,and we suggest that further research be conducted to consider the ecological risks of construction engineering measures.

关键词： Soil erosion Grain for green Construction measures Mountainous areas

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Drivers of spatial structure in thinned forests

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Forest Ecosystems 2024年第2期11卷 202-213页

作者： Zichun Wang yaoxiang Li Guangyu Wang Zheyu Zhang ya Chen Xiaoli Liu Rundong Peng College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin150040China Department of Forest Resources Management University of British ColumbiaVancouverCanada

Background:As is widely known,an increasing number of forest areas were managed to preserve and enhance the health of forest ***,previous research on forest management has often overlooked the importance of ***:Our objectives were to define the direction of structure-based forest ***,we investigated the relationships between forest structure and the regeneration,growth,and mortality of trees under different thinning ***,the drivers of forest structural change were ***:On the basis of 92 sites selected from northeastern China,with different recovery time (from 1 to 15years) and different thinning intensities (0–59.9%) since the last *** component analysis (PCA)identified relationships among factors determining forest spatial *** structural equation model (SEM)was used to analyze the driving factors behind the changes in forest spatial structure after ***:Light thinning (0–20%trees removed) promoted forest regeneration,and heavy thinning (over 35% of trees removed) facilitated forest ***,only moderate thinning (20%–35%trees removed) created a reasonable spatial *** dead trees were clustered,and they were hardly affected by thinning ***,thinning intensity,recovery time,and altitude indirectly improve the spatial structure of the forest by influencing diameter at breast height (DBH) and canopy ***:Creating larger DBH and canopy area through thinning will promote the formation of complex forest structures,which cultivates healthy and stable forests.

关键词： Thinning Natural secondary forest Spatial structure Dynamic changes Growth factors Structural equation modeling

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Rim^(18)F-fluorodeoxyglucose uptake of hepatic cavernous hemangioma on positron emission tomography/computed tomography:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2243-2247页

作者： Yong-An Hu ya-Xin Guo Qi-Feng Huang Department of Nuclear Medicine Jinhua Hospital of Zhejiang UniversityJinhua Municipal Central HospitalJinhua 321000Zhejiang ProvinceChina

BACKGROUND Peripheral FDG accumulation in a hepatic hemangioma presenting in a patient with prolonged fever is ***,clinicians should pay close attention to patients with hepatic *** SUMMARY A 54-year-old woman with a 4-wk history of daily fevers was admitted to our hospital.A whole body^(18)-Fluordesoxyglucose(PET-FDG)positron emission tomography/computed tomography(PET/CT)was performed to elucidate the source of the ***,whole body^(18)-FDG PET/CT raised the suspicion of a malignant lesion because of peripheral FDG accumulation(SUVmax 3.5 g/mL)higher than that of the normal liver parenchyma(SUVmax 1.6 g/mL)surrounding a hypoactive area,and no other abnormalities were ***,the patient underwent liver mass *** showed a hepatic cavernous hemangioma with fatty infiltration around the *** fever disappeared four days after surgery and the patient did not present any complications during *** Fatty infiltration in the peripheral parts of hepatic cavernous hemangioma may lead to subacute inflammation which further activate the Kupffer *** may cause prolonged fever and peripheral rim FDG accumulation on PET/CT.

关键词： ^(18)-Fluordesoxyglucose positron emission tomography/computed tomography Hepatocellular carcinoma Fever Fatty infiltration Case report

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Spatial Structure of Peer Networks and Academic Achievement Based on a Random Control Trial Experiment

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China & World Economy 2024年第3期32卷 67-97页

作者： Shilan Feng ya Tan Zhi Wang Qinghua Zhang School of Marxism Peking UniversityChina School of International Trade and Economics University of International Business and EconomicsChina China Center for Economic Studies Fudan Universityand Shanghai Institute of International Finance and EconomicsChina Guanghua School of Management Peking UniversityChina

This paper investigates whether changing the seating arrangement in a classroom can facilitate positive spillovers from top-performing students to others,using a field experiment conducted in a Chinese high *** study groups with balanced abilities,the treatment altered the spatial distribution by assigning the two top students to seats in the spatial center of each *** the reference groups where students were allowed to choose their own seating arrangements,the lowest performing were significantly less likely to sit next to a top student than they would be under a random *** results suggest that,in the treated groups,there could be enhanced academic spillovers from the top *** treatment especially benefited the two lowest performing students in science *** contrast,the treatment exerted negative effects on the test scores of the two middle-performing students,due to a disruption *** results suggest that the spatial layout of a peer network can have a significant impact on learning outcomes.

关键词： field experiment peer effects social interactions spatial structure test scores

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