Low-molecular-weight heparin and preeclampsia—does the sword cut both ways?Three case reports and review of literature

作     者：Dan Shan Tao Li Xi Tan Ya-Yi Hu 

作者机构：Department of Obstetrics and GynecologyWest China Second University HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina Key Laboratory of Birth Defects and Related Diseases of Women and ChildrenSichuan UniversityMinistry of EducationChengdu 610000SichuanChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2024年第12卷第9期

页      面：1634-1643页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China No.82301924 

主　　题：Pregnancy Preeclampsia Low-molecular-weight heparin Hemorrhage Case report 

摘      要：BACKGROUND Low-molecular-weight heparins(LMWH)are the most commonly used anticoagulants during *** is considered to be the drug of choice due to its safety in not crossing *** the beneficial effect in the improvement of microcirculation,prophylactic application of LMWH in patients with preeclampsia became a ***,the bleeding risk related with LMWH in preeclampsia patients has seldomly been *** current study aimed to identify the potential risks regarding LMWH application in patients with *** SUMMARY Herein we present a case series of three pregnant women diagnosed with preeclampsia on LMWH therapy during *** the cases experienced catastrophic hemorrhagic *** reviewing the twenty-one meta-analyses,the bleeding risk related with LMWH seems *** one study analyzed the bleeding risk of LMWH and found a significantly higher risk of developing PPH in women receiving *** studies reported minor bleeding risks,none of these were serious enough to stop LMWH *** of bleeding either from uterus or from intrabdominal organs in preeclampsia patients on LMWH therapy should not be *** management of blood pressure even after delivery and homeostasis suture in surgery are *** Consideration should be given to the balance between benefits and risks of LMWH in patients with preeclampsia.