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Metabonomic studies of pancreatic cancer response to radiotherapy in a mouse xenograft model using magnetic resonance spectroscopy and principal components analysis

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World Journal of Gastroenterology 2013年第26期19卷 4200-4208页

作者： Xin-Hong He Wen-Tao Li ya-jia gu Bao-Feng yang Hui-Wen Deng Yi-Hua Yu Wei-Jun Peng Department of Radiology Fudan University Shanghai Cancer Center Shanghai Key Laboratory of Functional Magnetic Resonance Imaging Physics Department East China Normal University

AIM: To investigate the metabolic profiles of xenograft pancreatic cancer before and after radiotherapy by high-resolution magic angle spinning proton magnetic resonance spectroscopy (HRMAS 1H NMR) combined with principal components analysis (PCA) and evaluate the radiotherapeutic effect. METHODS: The nude mouse xenograft model of human pancreatic cancer was established by injecting human pancreatic cancer cell SW1990 subcutaneously into the nude mice. When the tumors volume reached 800 mm3 , the mice received various radiation doses. Two weeks later, tumor tissue sections were prepared for running the NMR measurements. 1H NMR and PCA were used to determine the changes in the metabolic profiles of tumor tissues after radiotherapy. Metabolic profiles of normal pancreas, pancreatic tumor tissues, and radiationtreated pancreatic tumor tissues were compared. RESULTS: Compared with 1H NMR spectra of the normal nude mouse pancreas, the levels of choline, taurine, alanine, isoleucine, leucine, valine, lactate, and glutamic acid of the pancreatic cancer group were increased, whereas an opposite trend for phosphocholine, glycerophosphocholine, and betaine was observed. The ratio of phosphocholine to creatine, and glycerophosphocholine to creatine showed noticeable decrease in the pancreatic cancer group. After further evaluation of the tissue metabolic profile after treatment with three different radiation doses, no significant change in metabolites was observed in the 1H NMR spectra, while the inhibition of tumor growth was in proportion to the radiation doses. However, PCA results showed that the levels of choline and betaine were decreased with the increased radiation dose, and conversely, the level of acetic acid was dramatically increased. CONCLUSION: The combined methods were demonstrated to have the potential for allowing early diagnosis and assessment of pancreatic cancer response to radiotherapy.

关键词： High-resolution magic angle spinning proton magnetic resonance spectroscopy Principal components analysis Pancreatic cancer Radiotherapy

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Bidirectional crosstalk between therapeutic cancer vaccines and the tumor microenvironment:Beyond tumor antigens

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Fundamental Research 2023年第6期3卷 1005-1024页

作者： Si-Wei Zhang Han Wang Xiao-Hong Ding Yu-Ling Xiao Zhi-Ming Shao Chao You ya-jia gu Yi-Zhou jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Department of Radiology Fudan University Shanghai Cancer Center270 Dong’an RoadShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China

Immunotherapy has rejuvenated cancer therapy,especially after anti-PD-(L)1 came onto the *** the many therapeutic options,therapeutic cancer vaccines are one of the most essential *** great progress has been made in research on tumor antigen vaccines,few phase III trials have shown clinical *** of the reasons lies in obstruction from the tumor microenvironment(TME).Meanwhile,the therapeutic cancer vaccine reshapes the TME in an ambivalent way,leading to immune stimulation or immune *** this review,we summarize recent progress on the interaction between therapeutic cancer vaccines and the *** respect to vaccine resistance,innate immunosuppressive TME components and acquired resistance caused by vaccination are both *** the underlying mechanism of this crosstalk provides insight into the treatment of cancer by directly targeting the TME or synergizing with other therapeutics.

关键词： Therapeutic cancer vaccine Tumor microenvironment Acquired resistance Immunosupportive Immunosuppressive

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IN VIVO ~1 H MAGNETIC RESONANCE SPECTROSCOPY IN EVALUATION OF HEPATOCELLULAR CARCINOMA AND ITS EARLY RESPONSE TO TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION

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Chinese Medical Sciences Journal 2006年第4期21卷 258-264页

作者： Bin Wu Wei-jun Peng Pei-jun Wang ya-jia gu Wen-tao Li Liang-pin Zhou Feng Tang guo-ming Zhong Department of Diagnostic Radiology Cancer Hospital Fudan University Shanghai 200032 Department of Radiology Tongji Hospital Tongji University Shanghai 200065

Objective To investigate the value of in vivo proton magnetic resonance spectroscopy （MRS） in the assessment of hepatocelhilar carcinoma （HCC） and monitor its metabolic change shortly after transcatheter arterial chemoembolization （TACE）. Mothoda In this prospective study, 28 consecutive patients with large HCC （ ≥3 cm in diameter） confirmed by fine needle aspiration biopsy were recruited. The ^1H MRS of all hepatic lesions and some uninvolved liver parenchyma were performed with 1.5T whole body MR scanner. Among them, 15 cases were evaluated again about one week after TACE. The main metabolites such as choline and lipid before and after interventional therapy were measured to assess the early response of the tumor. The technical success rate of IH MRS in liver was high （33/41, 80% ）, closely related to breath motion, location of lesion, and size of voxeL In spectra, the choline compound peak of HCC elevated compared with uninvolved liver parenchyma. After TACE, both the amplitude and the area of choline resonance peak significantly descended （ choline-to-lipid ratios from 0.352±0. 080 to 0. 167±0. 030, P = 0. 026; from 0. 205±0. 060 to 0. 070±0. 020, P = 0. 042, respectively ） ; yet lipid resonance peak ascended. Conclusions In vivo tH MRS is technically feasible for the evaluation of large focal hepatic lesions, however, the reproducibility and stability are not as good as routine MR scan. IH MRS can monitor the early stage metabolic changes of HCC after TACE but limitation like quantification still exists.

关键词： hepatocellular carcinoma magnetic resonance imaging proton magnetic resonance spectroscopy transcatheter arterial chemoembolization

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Sclerosing Adenosis:Ultrasonographic and Mammographic Findings and Correlation with Histopathology

Sclerosing Adenosis:Ultrasonographic and Mammographic Findin...

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中国超声医学工程学会第十一届全国腹部超声医学学术会议

作者： ya-Ling Chen jia-jian Chen Cai Chang Yi Gao Jiong Wu Wen-Tao yang ya-jia gu Department of Ultrasound Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer Center Department of Pathology Fudan University Shanghai Cancer Center Department of Diagnostic Radiology Fudan University Shanghai Cancer Center

Objective To evaluate radiological findings especially ultrasonographic features of sclerosing adenosis(SA),and to correlate with histopathological *** and methods A retrospective review identified 191 patients(200 lesions)confirmed as SA histopathologically through breast surgery between July 2009 and December2012,among whom 145 patients(151 lesions) with SA as the major component were included for ultrasonographic(US) and mammographic(MG) *** All the 145 patients analyzed were female,with the mean age 46.8±7.8 years(range,25-71 years).All the 145 patients(151 lesions) underwent US,and imaging findings were:heterogeneously echogenic areas in 9.3%(14/151),masses in 51.7%(78/151),masses with calcifications in 13.9%(21/151),focal acoustic shadowing in 4.0%(6/151),and negative in 21.2%(32/151).Among the 119 lesions of visible abnormalities,87.4%(104/119)were hypoechoic,58.0%(69/119) were irregular in shape,52.1%(62/119) had an ill-defined margin,calcifications were found in 17.6%(21/119),and 7.6%(9/119) were hypervascular,while none of the characteristics above showed significant correlation with histopathology.A total of 136 patients underwent MG in our center,and imaging findings were:microcalcifications in 31.6%(43/136),masses in 23.5%(32/136),asymmetric focal density in 14.7%(20/136),focal architectural distortion in 22.8%(31/136),and negative in 7.4%(10/136).Mass lesions were fewer in MG than in US(23.5% vs 65.6%).The AUC of US deciding benign or malignant ones was significantly higher than MG(0.547 vs 0.497,P=0.036).In the 60 lesions which were overestimated by BI-RADS US Category,one or more features of malignant signs were found in US *** The most common finding of SA was masses with or without calcifications on US,while microcalcifications on *** accuracy of US was limited,but higher than MG,and mimicry of malignancy might contribute to misdiagnosis of US.

关键词： breast sclerosing adenosis ultrasonography mammography histopathology

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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li yakun gu Wei Ma Yuying guan Mengyuan guo Qianqian Shao Xunming Ji jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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婴儿配方奶粉氧诱导氧化的分析

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食品工业科技 2017年第6期38卷 116-118,123页

作者：蒋雯瑶苏米亚贾宏信顾建明上海大学生命科学学院上海200444 乳业生物技术国家重点实验室光明乳业股份有限公司技术中心上海乳业生物工程技术研究中心上海200436

通过氧诱导氧化的方式对婴儿配方奶粉的氧化诱导稳定性进行考察,以过氧化值(PV)、硫代巴比妥酸值(TBA)和色度值的变化来评估奶粉的氧化程度,分析奶粉氧化过程中各个指标的变化趋势。结果表明:婴儿配方奶粉氧化诱导期内,随着诱导时间的延... 详细信息

通过氧诱导氧化的方式对婴儿配方奶粉的氧化诱导稳定性进行考察,以过氧化值(PV)、硫代巴比妥酸值(TBA)和色度值的变化来评估奶粉的氧化程度,分析奶粉氧化过程中各个指标的变化趋势。结果表明:婴儿配方奶粉氧化诱导期内,随着诱导时间的延长,PV值和TBA值都呈现先上升后下降的趋势,奶粉亮度值(L*)逐渐降低,红度值(a*)和黄度值(b*)逐渐增高,奶粉颜色不断变黄,变暗,失去光泽。结论:婴儿配方奶粉诱导氧化的分析可以快速了解奶粉的氧化趋势,对于预测婴儿配方奶粉的货架期具有一定的指导意义。

关键词：婴儿配方奶粉诱导氧化过氧化值硫代巴比妥酸值色度值

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Identification of nonlinear process described by neural fuzzy Hammerstein-Wiener model using multi-signal processing

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Advances in Manufacturing 2023年第4期11卷 694-707页

作者： Feng Li Li jia ya gu College of Electrical and Information Engineering Jiangsu University of TechnologyChangzhou213001JiangsuPeople’s Republic of China School of Mechatronics Engineering and Automation Shanghai UniversityShanghai200444People’s Republic of China School of Electrical Engineering and Automation Changshu Institute of TechnologyChangshu215500JiangsuPeople’s Republic of China

In this study,a novel approach for nonlinear process identification via neural fuzzy-based Hammerstein-Wiener model with process disturbance by means of multi-signal processing is *** Hammerstein-Wiener model consists of three blocks where a dynamic linear block is sandwiched between two static nonlinear ***-signal sources are designed for achieving identification separation of the Hammerstein-Wiener *** correlation analysis theory is utilized for estimating unknown parameters of output nonlinearity and linear block using separable signals,thus the interference of process disturbance is ***,the immeasurable intermediate variable and immeasurable noise term in identification model is taken over by auxiliary model output and estimate residuals,and then auxiliary model-based recursive extended least squares parameter estimation algorithm is derived to calculate parameters of the input nonlinearity and noise ***,convergence analysis of the suggested identification scheme is derived using stochastic process *** simulation results indicate that proposed identification approach yields high identification accuracy and has good robustness.

关键词： Nonlinear process Parameter identification Hammerstein-Wiener model Neural fuzzy model Multiple signal processing

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Effect of confinement on the three-phase equilibrium of water-oil-CO_(2)mixtures in nanopores

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Petroleum Science 2022年第1期19卷 203-210页

作者： Yi-Lei Song Shao-Hua gu Zhao-Jie Song Zhuo-ya Zhang Xu-ya Chang jia guo State Key Laboratory of Petroleum Resources and Prospecting and Unconventional Petroleum Research Institute China University of Petroleum-BeijingBeijing102249China Sinopec Petroleum Exploration and Production Research Institute Beijing100083China

Accurate characterization of fluid phase behavior is an important aspect of CO_(2) enhanced shale oil *** far,however,there has been little discussion about the nanopore confinement effect,including adsorption and capillarity on the phase equilibrium of water-oil-CO_(2) *** this study,an improved three-phase flash algorithm is proposed for calculating the phase behavior of water-oil-gas mixture on the basis of an extended Young-Laplace equation and a newly developed fugacity calculation *** fugacity model can consider the effect of water-oil-gas adsorption on phase equilibrium.A water-Bakken oil-CO_(2) mixture is utilized to verify the accuracy of the flash algorithm and investigate the confinement *** show that the confinement effect promotes the transfer of all components in the vapor phase to other phases,while the transfer of water,CO_(2),and lighter hydrocarbons is more *** leads to a large decrease,a large increase,and a small increase in the mole fraction of the vapor,oleic,and aqueous phases,*** the confinement effect is considered,the density difference of vaporoleic phases decreases,and the interfacial tension of vapor-oleic phases decreases;however,the density difference of vapor-aqueous phases increases,the interfacial tension of vapor-aqueous phases still decreases.

关键词： Three-phase behavior Water-oil-CO_(2)mixtures Nanopore confinement CO_(2)enhanced oil recovery Shale reservoirs

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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-jia Hao Xu-ya Chai Pei-Sai Li yang Liu Li-Xia Liu Ying Xu Pan-Pan yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： ya-Xin Xu Xiao-Xuan Niu Wen-Chang jia Jing Wen Xue-Lin Cheng yan Han Ming-Hui Peng Jing Zhou yao Liu Sun-Fang jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

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