Bidirectional crosstalk between therapeutic cancer vaccines and the tumor microenvironment:Beyond tumor antigens
作者机构：Key Laboratory of Breast Cancer in ShanghaiDepartment of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Department of RadiologyFudan University Shanghai Cancer Center270 Dong’an RoadShanghai 200032China Department of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China
出 版 物：《Fundamental Research》 (自然科学基础研究（英文版）)
年 卷 期：2023年第3卷第6期
页 面：1005-1024页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the National Natural Science Foundation of China(81922048 and 81874112)
主 题：Therapeutic cancer vaccine Tumor microenvironment Acquired resistance Immunosupportive Immunosuppressive
摘 要：Immunotherapy has rejuvenated cancer therapy,especially after anti-PD-(L)1 came onto the *** the many therapeutic options,therapeutic cancer vaccines are one of the most essential *** great progress has been made in research on tumor antigen vaccines,few phase III trials have shown clinical *** of the reasons lies in obstruction from the tumor microenvironment(TME).Meanwhile,the therapeutic cancer vaccine reshapes the TME in an ambivalent way,leading to immune stimulation or immune *** this review,we summarize recent progress on the interaction between therapeutic cancer vaccines and the *** respect to vaccine resistance,innate immunosuppressive TME components and acquired resistance caused by vaccination are both *** the underlying mechanism of this crosstalk provides insight into the treatment of cancer by directly targeting the TME or synergizing with other therapeutics.
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