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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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Defects‑Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 528-547页

作者： Jiaolong Liu Siyu Zhang Dan Qu Xuejiao Zhou Moxuan Yin Chenxuan Wang Xuelin Zhang Sichen Li Peijun Zhang Yuqi Zhou Kai Tao Mengyang Li Bing wei Hongjing Wu Mengyang Li Bing wei Hongjing Wu School of Physics Xidian UniversityXi’an 710071People’s Republic of China School of Advanced Materials and Nanotechnology State Key Discipline Laboratory of Wide Band Gap Semiconductor TechnologyXidian UniversityXi’an 710071People’s Republic of China School of Microelectronics Xidian UniversityXi’an 710071People’s Republic of China School of Telecommunication Engineering Xidian UniversityXi’an 710071People’s Republic of China MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary School of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China The Ministry of Education Key Laboratory of Micro and Nano Systems forAerospace School of Mechanical EngineeringNorthwestern PolytechnicalUniversityXi’an 710072People’s Republic of China

Defects-rich heterointerfaces integrated with adjustable crystalline phases and atom vacancies,as well as veiled dielectric-responsive character,are instrumental in electromagnetic *** methods,however,constrain their delicate ***,an innovative alternative is proposed:carrageenan-assistant cations-regulated(CACR)strategy,which induces a series of sulfides nanoparticles rooted in situ on the surface of carbon *** unique configuration originates from strategic vacancy formation energy of sulfides and strong sulfides-carbon support interaction,benefiting the delicate construction of defects-rich heterostructures in M_(x)S_(y)/carbon composites(M-CAs).Impressively,these generated sulfur vacancies are firstly found to strengthen electron accumulation/consumption ability at heterointerfaces and,simultaneously,induct local asymmetry of electronic structure to evoke large dipole moment,ultimately leading to polarization coupling,i.e.,defect-type interfacial ***“Janus effect”(Janus effect means versatility,as in the Greek two-headed Janus)of interfacial sulfur vacancies is intuitively confirmed by both theoretical and experimental investigations for the first ***,the sulfur vacancies-rich heterostructured Co/Ni-CAs displays broad absorption bandwidth of 6.76 GHz at only 1.8 mm,compared to sulfur vacancies-free CAs without any dielectric *** defects-rich heterostructures,this one-pot CACR strategy may steer the design and development of advanced nanomaterials,boosting functionality across diverse application domains beyond electromagnetic response.

关键词： Defects-rich heterointerfaces Sulfides Polarization coupling Electromagnetic wave absorption

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Shear stress-induced delamination method for the mass production of Ti_(3)C_(2)Tx MXene nanosheets

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Journal of Materiomics 2023年第6期9卷 1151-1159页

作者： Zehang Zhou Lingfei wei ya Yi Shiyi Feng Zeying Zhan dong Tian Canhui Lu State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China Institute of Ecological and Environmental Sciences Sichuan Agricultural UniversityChengdu611130China

MXene nanosheets are considered advantageous for functional materials,but current delamination methods to prepare MXene nanosheets have many limitations including high cost,small production scale,low efficiency,and deteriorated structure integrity of obtained ***,we propose a simple,efficient,and scalable shear stress-induced delamination(SSID)strategy to boost the production of single-/few-layered Ti_(3)C_(2)T_(x) MXene *** dynamics simulation indicates that the pan mill-type grinding discs create a strong hydrodynamic flow field,which exerts gigantic shear stress to substantially delaminate the multilayered MXene stacks into homogeneously dispersed MXene ***,shear stress generated from vigorous water flow has limited fragmentation effect,ensuring large lateral size and good structure integrity to the obtained MXene nanosheets as evidenced by the morphological and structural *** to conventional delamination methods,this novel SSID strategy exhibits great advantages in terms of efficiency,scalability and the properties of resultant MXene nanosheets,which opens up great opportunity for the scalable production and commercialization of high-performance MXene-based materials.

关键词： MXene nanosheets Hydrodynamic flow field Shear stress-induced delamination Structural evolution Structure integrity

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Comparative phosphoproteomics reveal new candidates in the regulation of spermatogenesis of Drosophila melanogaster

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Insect Science 2022年第6期29卷 1703-1720页

作者： Bin Mao wei Zhang ya Zheng dong Li Meng-yan Chen Yu-Feng Wang School of Life Sciences Hubei Key Laboratory of Genetic Regulation and Integrative BiologyCentral China Normal UniversityWuhanChina

The most common phenotype induced by the endosymbiont Wolbachia in in-sects is cytoplasmic incompatibility,where none or fewer progenies can be produced when Wolbachia-infected males mate with uninfected *** suggests that some modi-fications are induced in host sperms during spermatogenesis by *** identify the proteins whose phosphorylation states play essential roles in male reproduction in Drosophila melanogaster,we applied isobaric tags for relative and absolute quantitation(iTRAQ)-based proteomic strategy combined with titanium dioxide(TiO2)enrichment to compare the phosphoproteome of Wolbachia-infected with that of uninfected male re-productive systems in *** identified 182 phosphopeptides,defining 140 phosphoproteins,that have at least a 1.2 fold change in abundance with a P-value of<*** of the differentially abundant phosphoproteins(DAPPs)were associated with micro-tubule cytoskeleton organization and spermatid *** DAPPs included pro-teins already known to be associated with spermatogenesis,as well as many not previously studied during this *** genes coding for DAPPs were knocked down,respectively,in Wolbachia-free fly *** them,Slmap knockdown caused the most severe dam-age in spermatogenesis,with no mature sperm observed in seminal ***-orescence staining showed that the formation of individualization complex composed of actin cones was completely *** results suggest that Wolbachia may induce wide changes in the abundance of phosphorylated proteins which are closely related to male *** identifying phospho-modulated proteins we also provide a signifi-cant candidate set for future studies on their roles in spermatogenesis.

关键词： Drosophila melanogaster individualization complex phosphoproteome Slmap spermatogenesis

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Design and construction of super-long span bridges in China: Review and future perspectives

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Frontiers of Structural and Civil Engineering 2020年第4期14卷 803-838页

作者： wei HUANG Minshan PET Xiaodong LIU ya wei Intelligent Transportation System Research Center Southeast UniversityNanjing 211189China China Communications Construction Company Ltd. Beijing 100088China Department of Civil Engineering Tsinghua UniversiyBeijing 100084China

Super-long span bridges demand high design requirements and involve many difficulties when constructed,which is an important indicator to reflect the bridge technical level of a *** the past three decades,a large percentage of the new long-span bridges around the world were built in China,and thus,abundant technological innovations and experience have been accumulated during the design and *** paper aims to review and summarize the design and construction practices of the superstructure,the substructure,and the steel deck paving of the long-span bridges during the past decades as well as the current operation status of the existing long-span bridges in China.A future perspective was given on the developing trend of high-speed railway bridge,bridge over deep-sea,health monitoring and maintenance,intellectualization,standard system,and information technology,which is expected to guide the development direction for the construction of future super long-span bridges and promote China to become a strong bridge construction country.

关键词： long-span bridges steel box girder design technology construction technology,review and future perspectives

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Magnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder

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World Journal of Clinical Cases 2025年第2期13卷 5-9页

作者： wei Zhu Shanghai XiRong Information Science and Technology Co. LtdNational Science and Technology ParkSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 ***/hyperactivity disorder(ADHD)is considered a neurodevelopment and psychiatric disorder in *** characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and *** resonance imaging(MRI)has been used to assess medical images in Sotos syndrome and *** images process is considered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more complete information in single image in this *** the future,genetic mechanisms and artificial intelligence related to medical images could be used in the clinical diagnosis of Sotos syndrome and ADHD.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Genetic mutation Magnetic resonance imaging Wavelet fusion

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Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG Jian NIE wei HUANG Jin ZHU Ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN Qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

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Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第01期 26-34页

作者： Yutao Zhang Juan Li wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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Reduction in Microsegregation in Al-Cu Alloy by Alternating Magnetic Field

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Acta Metallurgica Sinica(English Letters) 2020年第2期33卷 267-274页

作者： Sheng-ya He Chuan-Jun Li Tong-Jun Zhan wei-dong Xuan Jiang Wang Zhong-Ming Ren State Key Laboratory of Advanced Special Steel and School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Helmholtz-Zentrum Dresden-Rossendorf(HZDR) 01328 DresdenGermany

The microsegregation behavior of the Al-4.5 wt%Cu alloy solidified at different cooling rates under the alternating magnetic field(AMF) was *** experimental results showed that the amount of non-equilibrium eutectics in the interdendritic region decreased upon applying the AMF at the same cooling *** change in microsegregation could be explained quantificationally by the modifications of dendritic coarsening,solid-state back diffusion and convection in the *** enhanced diffusivity in the solid owing to the AMF was beneficial for the improvement in microsegregation compared to the cases without an *** contrast,the enhanced dendritic coarsening and forced convection in the AMF were found to aggravate the microsegregation *** the contributions of the changes in above factors,an increase in solid diffusivity was found to be primarily responsible for the reduced microsegregation in the *** addition,the microsegregation in the AMF was modeled using the analytical model developed by *** calculated and experimental results were in reasonable agreement.

关键词： Microsegregation Solidification Alternating magnetic field Diffusion Coarsening Convection

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