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First-episode psychiatric disorder risk from SARS-Co V-2 infection:A clinical analysis with Chinese psychiatric inpatients

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Journal of Biomedical Research 2025年第1期39卷 50-60页

作者： ya Xie Zifeng xu Yumin Zhang Yisheng Li Pengyu Du Chun Wang Clinical Mental Health Center the Affiliated Brain Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Medical School of Nanjing University NanjingJiangsu 210008China

The extensive spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)throughout China in late 2022 has underscored the correlation between this virus and severe psychiatric ***,there remains a lack of reported clinical and pathological ***,we retrospectively reviewed the electronic medical records of psychiatric inpatients for seven days from early January ***-one inpatients who developed first-episode psychiatric disorders within two weeks after SARS-CoV-2 infection were recruited,while 24 uninfected first-episode psychiatric inpatients were selected as *** analyses of clinical manifestations,routine laboratory tests,and imaging examinations were *** investigation demonstrated a 330%increase in the incidence of first-episode psychiatric inpatients after SARS-CoV-2 infection in 2023,compared with the preceding year without SARS-CoV-2 *** cases exhibited psychiatric symptoms within one week of SARS-CoV-2 infection,which resolved after approximately two weeks,with no residual symptoms after three ***-way ANOVA demonstrated a significant difference in the highest fever temperature between inpatients with and without psychotic *** inpatients displayed elevated levels of interleukin-4,interleukin-8,and interferon-α,but decreased levels of eosinophils and *** findings suggest that SARS-CoV-2 may contribute to the development of psychiatric disorders,likely mediated by the virus-induced inflammatory response and neuronal dysfunction in the context of psychological distress.

关键词： COVID-19 SARS-CoV-2 psychiatric disorders inflammation interleukins

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神华胜利煤矿工资制度改革的指导思想与操作方式

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内蒙古煤炭经济 2009年第6期 95-96,99页

作者：魏亚旭神华北电胜利能源有限公司露天煤矿内蒙古锡林郭勒026015

本文以神华胜利煤矿工资制度改革前期工作为论述重点,以促进企业迅速做大做强,持续发展。

关键词：煤炭企业工资制度改革指导思想

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Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression

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World Journal of Psychiatry 2025年第1期15卷 32-36页

作者： Min xu Hai-Ying Jin Feng-Li Sun wei-Dong Jin Department of Psychiatry Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Psychiatry Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Psychiatry Zhejiang Provincial Mental Health CenterHangzhou 311122Zhejiang ProvinceChina

Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent ***,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake *** studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent *** the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side *** review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

关键词： Child depression Adolescent depression Antidepressant Switch Suicide Non-suicidal self injury

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Efficiency improvement for post-sulfurized CIGS solar cells enabled by in situ Na doping

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Journal of Energy Chemistry 2025年第2期101卷 324-332页

作者： Zeran Gao Yuchen Xiong Jiawen Wang Shanshan Tian Wanlei Dai Haoyu xu Xinzhan Wang Chao Gao yali Sun wei Yu National-Local Joint Engineering Laboratory of New Energy Photovoltaic Devices Key Laboratory of Brain-like Neuromorphic Devices and Systems of Hebei Province Hebei University

Despite sulfurization offers the advantage of improving the photovoltaic performance in preparing Cu（In,Ga）Se2（CIGS） absorbers,deep level defects in the absorber and poor energy level alignment on the front surface are still main obstacles limiting the improvement of power co nversion efficiency（PCE） in sulfided CIGS solar ***,an in-situ Na doping strategy is proposed,in which the tailing effect of crystal growth is used to promote the sulfurization of CIGS *** is found that the grain growth is supported by Na incorporating due to the enrichment of NaSexnear the upper *** high soluble Na during grain growth can not only suppress intrinsic InCudonor defects in the absorber,but also tailor S distribution in bulk and the band alignment at the heterojunction,which are both beneficial for the effective electron ***,the Na aggregation near the bottom of the absorber also contributes to the crystalline quality increasing and favorable ultra-thin MoSe2formation at back contact,resulting in a reduced barrier height conducive to hole *** of the champion device is as high as 16.76% with a 28% *** research offers new insights into synthesizing CIGS solar cells and other chalcogenide solar cells with superior cell performance when using an intense sulfurization process.

关键词： CBO CIGS Defect In situ doping Sulfurization

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Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus

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Journal of Environmental Sciences 2025年第2期148卷 13-26页

作者： Kun Wang xu Shi Hongjin Lin Tong xu Shiwen xu College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Harbin 150030China

Bisphenol A(BPA)is an industrial pollutant that can cause immune *** acts as an antioxidant,as selenium deficiency often accompanies oxidative stress,resulting in organ *** study is the first to demonstrate that BPA and/or selenium deficiency induce pyroptosis and ferroptosis-mediated thymic injury in chicken and chicken lymphoma cell(MDCC-MSB-1)via oxidative stress-induced endoplasmic reticulum(ER)*** established a broiler chicken model of BPA and/or selenium deficiency exposure and collected thymus samples as research subjects after 42 *** results demonstrated that BPA or selenium deficiency led to a decrease in antioxidant enzyme activities(T-AOC,CAT,and GSH-Px),accumulation of peroxides(H2O2 and MDA),significant upregulation of ER stress-relatedmarkers(GRP78,IER 1,PERK,EIF-2α,ATF4,and CHOP),a significant increase in iron ion levels,significant upregulation of pyroptosis-related gene(NLRP3,ASC,Caspase1,GSDMD,IL-18 and IL-1β),significantly increase ferroptosis-related genes(TFRC,COX2)and downregulate GPX4,HO-1,FTH,*** vitro experiments conducted in MDCC-MSB-1 cells confirmed the results,demonstrating that the addition of antioxidant(NAC),ER stress inhibitor(TUDCA)and pyroptosis inhibitor(Vx765)alleviated oxidative stress,endoplasmic reticulum stress,pyroptosis,and ***,this study concludes that the combined effects of oxidative stress and ER stress mediate pyroptosis and ferroptosis in chicken thymus induced by BPA exposure and selenium deficiency.

关键词： Bisphenol A Selenium deficiency ROS/ER stress Pyroptosis Ferroptosis Thymic injury

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Sini decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism

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Chinese Herbal Medicines 2025年第1期17卷 148-155页

作者： Cuiping Long Qian Zhou Min xu Xin Ding Xingxing Zhang ya Zhang Yuping Tang Guangguo Tan School of Pharmacy Shaanxi University of Chinese Medicine Department of Pharmacy Air Force Medical University Department of Traditional Chinese Medicine Xijing Hospital Air Force Medical University The Third Stationed Outpatient Department General Hospital of Central Theater Command of PLA

Objective:Myocardial inflammation during myocardial infarction(MI) could be inhibited by regulating arachidonic acid(AA) *** studies demonstrated that Sini Decoction(SND) was identified to be an effective prescription for treating heart failure(HF) caused by *** the anti-inflammatory mechanism of SND remained *** work was designed to investigate the anti-inflammato ry mechanism of SND through the AA metabolism pathway in vitro and in vivo ***:An inflammatory injury model of H9c2 cells was established by lipopolysaccharide(LPS)-stimulated macrophage-conditioned medium(CM).The MI model was built by the ligation of left anterior descending(LAD) branch of coronary artery in ***,the rats were divided into five groups:sham group,MI group,MI+Celecoxib group,MI+low-dose SND group(SND-L) and MI+high-dose SND group(SND-H).Cardiac function,histopathological changes and serum cytokines were examined four weeks *** blot analysis was conducted to verify the key enzymes levels in the AA metabolic pathway,including phospholipase A2(PLA2),cyclooxygenases(COXs) and lipoxygenases(LOXs).Results:These in vivo results demonstrated that SND could improve the cardiac function and pathological changes of rats with MI,and regulate the key inflammatory molecules in the AA metabolism pathway,including sPLA2,COX-1,COX-2,5-LOX and *** vitro,SND could decrease the release of proinflammatory cytokines including TNF-α and IL-6 and inhibit cell apoptosis in CM-induced H9c2 ***,SND could protect H9c2 cells from the damage of CM by regulating nuclear factor kappa-B(NF-κB) signal pathway and the expression of ***: SND may be a drug candidate for anti-inflammatory treatment during MI by regulating the multiple targets in the AA metabolism pathway.

关键词： anti-inflammation arachidonic acid metabolism pathway conditioned medium myocardial infarction Sini Decoction

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming xu wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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Influence of trains meeting on the ventilation performance of equipment compartment with independent air duct in high-speed train:numerical and experimental study

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Railway Engineering Science 2025年第1期33卷 127-150页

作者： Yitong Wu wei Zhou Xifeng Liang Xinchao Su Kewei xu Yutao Xia Zhixin Wang Sinisa Krajnović Key Laboratory of Traffic Safety On Track Ministry of EducationSchool of Traffic and Transportation EngineeringCentral South UniversityChangsha 410075China Joint International Research Laboratory of Key Technology for Rail Traffic Safety Central South UniversityChangsha 410075China Division of Fluid Dynamics Department of Mechanics and Maritime SciencesChalmers University of TechnologySE‑41296 GothenburgSweden

During the train meeting events,train equipment compartments are exposed to the worst pressure changes,potentially affecting the ventilation performance of equipment,particularly for electrical facilities equipped with independent air *** this paper,a two-step method is used for numerical computation:(1)obtaining the temporal and spatial transient node data of the flow field sections during the train-passing simulation and(2)using the data as the input data for the equipment compartment *** addition,this paper also compares the difference in equipment ventilation between the single-train and trainpassing scenarios in real vehicle *** results indicate that the primary factors influencing ventilation effectiveness are the aerodynamic compression and deceleration of airflow induced by the other train's nose,as well as the instability of the external flow field in the wake of the other *** train crossing,the air is forced into the air duct,with a maximum ratio of the airflow in-duct to the airflow out-duct reaching *** average mass flow falls below the rated mass flow for the *** to the rated air volume of converter,the maximum suppression rates obtained from testing and simulation are-24.5%and-16.8%,*** to the single-train operation,the maximum suppression rates obtained from testing and simulation are-15%and-18%,*** findings provide valuable insights into the design and operation of high-speed trains.

关键词： Train-passing event Electrical facilities Independent air duct Ventilation performance

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li yang wei Kang Zhou Xin Huang Xing Zhou Jie xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New EnergyCollaborative Innovation Center of Chemistry for Energy Materials(iChEM)Fudan UniversityShanghai 200433China Department of Chemistry Boston CollegeChestnut HillMA 02467USA School of Materials Science and Engineering Anhui University of TechnologyMa’anshan 243002AnhuiChina

Sodium-ion batteries (SIBs) with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials(>1 V).Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material (tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na_(4)TDC) has been developed with low redox potential (<0.7 V) and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na_(4)TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg cm^(-2).By pairing with a thick Na_(3)V_(2)(PO_(4))_(3)cathode (20.6 mg cm^(-2)),the as-fabricated full cell exhibited high operating voltage (2.8 V),excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na_(4)TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China(Life Sciences) 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli wei Guanghan Fan Zhengxing Lian xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang wei Xiao xu Department of Hepatobiliary and Pancreatic Surgery People’s Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui UniversityLishui 323000China NHFPC Key Laboratory of Combined Multi-Organ Transplantation Hangzhou 310003China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People’s HospitalHangzhou 310006China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Urology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalHangzhou 310011China Hangzhou Medical College Hangzhou 310059China Zhejiang University School of Medicine Hangzhou 310058China

Dear Editor,Liver transplantation(LT)is the only curative therapy for patients with endstage liver disease(He et al.,2023;Ling et al.,2022).Post-transplant hypertriglyceridemia(PTHT),which has an incidence of up to 32.8%in 6 months after LT,is one of the major post-transplant complications(Toshima et al.,2020).With the prolongation of the recipient’s survival time,the incidence of PTHT is increasing,becoming an important factor that affects the recipient’s quality of life and survival *** with various metabolic complications,including PTHT,have a 1.78 times higher risk of atherosclerotic cardiovascular disease(ASCVD)development and death than recipients without these complications(Jiménez Pérez et al.,2016).Studies have shown that PTHT,accompanied by other posttransplant metabolic complications and immunosuppressants,are important risk factors for post-transplant ASCVD and mediate 19%–42% of nongraft-related deaths(Davis and Shadab Siddiqui,2017;Jiménez-Pérez et al.,2016).However,early prediction of PTHT remains a major challenge.

关键词： liver graft

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