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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Single-cell transcriptomics of murine mural cells reveals cellular heterogeneity

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Science China(Life Sciences) 2021年第7期64卷 1077-1086页

作者： ya-Na Guan yue Li Moom Roosan qing Jing Shanghai Jiao Tong University School of Medicine(SJTUSM)&CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of Sciences(CAS)Shanghai 200031China Chapman University IrvineCA 92618USA

Mural cells(MCs)wrap around the endothelium,and participate in the development and homeostasis of *** have been reported as heterogeneous population morphologically and ***,the transcriptional heterogeneity of MCs was rarely *** this study,we illustrated the transcriptional heterogeneity of MCs with different perspectives by using publicly available single-cell dataset ***,MCs are transcriptionally different from other cell types,and ligand-receptor interactions of different cells with MCs ***-clustering of MCs identified five distinct *** heterogeneity of MCs in tissues was reflected by MC coverage,various distribution of MC subclusters,and ligand-receptor interactions of MCs and parenchymal *** transcriptomic diversity of MCs revealed in this article will help facilitate further research into MCs.

关键词： mural cells single-cell analysis heterogeneity

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： yang Zhou Yuan-yan Huang Ding-yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-Chun yan Han-qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

ORDER SCHEDULING WITH CONTROLLABLE PROCESSING TIMES, COMMON DUE DATE AND THE PROCESSING DEADLINE

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Journal of Systems Science and Systems Engineering 2017年第2期26卷 199-218页

作者： qing yue Guohua Wan Antai College of Economics and Management Shanghai Jiao Tong University Shanghai 200030 China

Due date quotation and scheduling are important tools to match demand with production capacity in the MTO （make-to-order） environment. We consider an order scheduling problem faced by a manufacturing f＇trm operating in an MTO environment, where the firm needs to quote a common due date for the customers, and simultaneously control the processing times of customer orders （by allocating extra resources to process the orders） so as to complete the orders before a given deadline. The objective is to minimize the total costs of earliness, tardiness, due date assignment and extra resource consumption. We show the problem is NP-hard, even if the cost weights for controlling the order processing times are identical. We identify several polynomially solvable cases of the problem, and develop a branch and bound algorithm and three Tabu search algorithms to solve the general problem. We then conduct computational experiments to evaluate the performance of the three Tabu-search algorithms and show that they are generally effective in terms of solution quality.

关键词： Order scheduling due date assignment controllable processing times deadline

综合微阵列数据分析与动脉粥样硬化程序性细胞死亡相关的lncRNA-miRNA-mRNA竞争内源性网络

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中国药理学通报 2025年第1期41卷 156-163页

作者：杨琼宋月月贾雨涵盖秩舶杨雯晴张丹山东中医药大学中医药创新研究院山东济南250355

目的基于生物信息学挖掘与程序性细胞死亡相关的ceRNA网络在AS病理生理过程中的作用,以期为AS的诊断和治疗提供新的靶点。方法从GEO数据库筛选GSE97210和GSE28858数据集,筛选差异表达的lncRNA、mRNA和miRNA,而后基于ceRNA理论在Cytoscap... 详细信息

目的基于生物信息学挖掘与程序性细胞死亡相关的ceRNA网络在AS病理生理过程中的作用,以期为AS的诊断和治疗提供新的靶点。方法从GEO数据库筛选GSE97210和GSE28858数据集,筛选差异表达的lncRNA、mRNA和miRNA,而后基于ceRNA理论在Cytoscape3.7.2软件中构建lncRNA-miRNA-mRNA调控网络。其次对ceRNA网络中的mRNA进行GO和KEGG富集分析。再将ceRNA网络中的mRNA与自噬、焦亡和铁死亡相关的基因取交集,构建与程序性细胞死亡相关的ceRNA网络。结果共获得1208个DElncRNA、4723个DEmRNA和139个DEmiRNA。构建了一个由64个lncRNA、8个miRNA和167个mRNA组成的ceRNA网络。ceRNA网络中的mRNA主要在转录和迁移的正调控以及蛋白结合等生物功能和PI3K-Akt信号通路、mTOR信号通路等信号通路中显著富集。最终,构建了7种lncRNA介导的ceRNA对焦亡的调控途径和23种lncRNA介导的对铁死亡与自噬的调控途径。结论该研究构建了与程序性细胞死亡相关的ceRNA网络,有助于我们了解程序性细胞死亡导致AS的作用机制。

关键词：动脉粥样硬化 GEO数据库铁死亡自噬焦亡 CeRNA网络

Prediction of vertical PM2.5 concentrations alongside an elevated expressway by using the neural network hybrid model and generalized additive model

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Frontiers of Earth Science 2017年第2期11卷 347-360页

作者： ya GAO Zhanyong WANG qing-Chang LU Chao LIU Zhong-Ren PENG yue YU Center for ITS and UAV Applications Research State Key Laboratory of Ocean Engineering School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Urban and Regional Planning University of Florida FL 32611-5706 USA Department of Electrical and Systems Engineering University of Pennsylvania PA 19104-6314 USA

A study on vertical variation of PM2.5 concentrations was carried out in this paper. Field measurements were conducted at eight different floor heights outside a building alongside a typical elevated expressway in downtown Shanghai, China. Results show that PM2.5 concentration decreases significantly with the increase of height from the 3rd to 7th floor or the 8th to 15th floor, and increases suddenly from the 7th to 8th floor which is the same height as the elevated expressway. A non-parametric test indicates that the data of PM2.5 concentration is statistically different under the 7th floor and above the 8th floor at the 5% significance level. To investigate the relationships between PM2.5 concentration and influencing factors, the Pearson correlation analysis was performed and the results indicate that both traffic and meteorological factors have crucial impacts on the variation of PM2.5 concentration, but there is a rather large variation in correlation coefficients under the 7th floor and above the 8th floor. Furthermore, the back propagation neural network based on principal component analysis （PCA-BPNN）, as well as generalized additive model （GAM）, was applied to predict the vertical PM2.5 concentration and examined with the field measurement dataset. Experimental results indicated that both models can obtain accurate predictions, while PCA-BPNN model provides more reliable and accurate predictions as it can reduce the complexity and eliminate data co-linearity. These findings reveal the vertical distribution of PM2.5 concentration and the potential of the proposed model to be applicable to predict the vertical trends of air pollution in similar situations.

关键词： vertical variations principal component ana-lysis back propagation neural network generalized additivemodel urban elevated expressway

基于CNN和Transformer交叉教学的半监督医学图像分割

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陕西科技大学学报 2025年第1期43卷 185-192页

作者：杨云胡雯青杨虹吴亚男陕西科技大学电子信息与人工智能学院陕西西安710021 西安富德医疗电子有限公司陕西西安710075 西安计量技术研究院陕西西安710199

由于医学图像分割领域缺乏高质量的标注数据,半监督学习方法在医学图像语义分割任务中受到高度重视.为了充分利用卷积神经网络(Convolutional Neural Network,CNN)和Transformer在半监督学习中的优势,本文提出一种基于CNN与Transformer... 详细信息

由于医学图像分割领域缺乏高质量的标注数据,半监督学习方法在医学图像语义分割任务中受到高度重视.为了充分利用卷积神经网络(Convolutional Neural Network,CNN)和Transformer在半监督学习中的优势,本文提出一种基于CNN与Transformer交叉教学的半监督医学图像分割方法.该方法将经典的深度协同训练从一致性正则化简化为交叉教学,利用循环伪标签方案使两个网络的预测差异转换为无监督损失,以鼓励两个网络具有一致的低熵预测.所提方法在ISIC 2018数据集上进行实验,在采用20%的标注比例时,Dice系数和Jaccard系数分别达到87.25%和79.17%,相比于监督U-Net++的训练结果分别提升了2.89%和3.53%,并且优于目前主流的半监督学习方法,验证了所提方法在半监督医学图像分割上的有效性和泛化性.

关键词：半监督学习图像语义分割交叉教学循环伪标签

Adhesion Performances Between Two Orthotropic Solids Influenced by Temperature Increment

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Acta Mechanica Solida Sinica 2024年第3期37卷 430-443页

作者： qing-Hui Luo yue-Ting Zhou School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai200092China

The classical adhesive contact models belong to isothermal adhesion theories,where the effect of temperature on adhesion was ***,a number of experimental results indicated that the adhesion behaviors can be significantly affected by *** this paper,the two-dimensional non-slipping anisothermal adhesion behaviors between two orthotropic elastic cylinders are investigated within the framework of the Johnson-Kendall-Roberts *** stated problem is reduced to the coupled singular integral equations by virtue of the Fourier integral transform,which are solved analytically with the analytical function *** closed-form solutions for the stress fields in the presence of thermoelastic effect are *** stable equilibrium state of contact system is determined by virtue of the Griffith energy *** effect of temperature difference on adhesion behaviors between orthotropic solids is *** is found that the difference between the oscillatory and non-oscillatory solutions increases with increasing the degree of anisotropy of orthotropic *** oscillatory solution cannot be well approximated by the non-oscillatory solution for the orthotropic materials with relatively high anisotropy.

关键词： Adhesive contact Non-slipping JKR model Temperature Griffith energy balance

A mathematical model of cortical bone remodeling at cellular level under mechanical stimulus

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Acta Mechanica Sinica 2012年第6期28卷 1678-1692页

作者： qing-Hua Qin ya-Nan Wang Research School of Engineering The Australian National University

A bone cell population dynamics model for cor- tical bone remodeling under mechanical stimulus is devel- oped in this paper. The external experiments extracted from the literature which have not been used in the creation of the model are used to test the validity of the model. Not only can the model compare reasonably well with these ex- perimental results such as the increase percentage of final values of bone mineral content （BMC） and bone fracture en- ergy （BFE） among different loading schemes （which proves the validity of the model）, but also predict the realtime devel- opment pattern of BMC and BFE, as well as the dynamics of osteoblasts （OBA）, osteoclasts （OCA）, nitric oxide （NO） and prostaglandin E2 （PGE2） for each loading scheme, which can hardly be monitored through experiment. In conclusion, the model is the first of its kind that is able to provide an in- sight into the quantitative mechanism of bone remodeling at cellular level by which bone cells are activated by mechan- ical stimulus in order to start resorption/formation of bone mass. More importantly, this model has laid a solid foun- dation based on which future work such as systemic control theory analysis of bone remodeling under mechanical stimu- lus can be investigated. The to-be identified control mecha- nism will help to develop effective drugs and combined non- pharmacological therapies to combat bone loss pathologies. Also this deeper understanding of how mechanical forces quantitatively interact with skeletal tissue is essential for the generation of bone tissue for tissue replacement purposes in tissue engineering.

关键词： Cortical bone remodeling Cell population dy-namics Mechanotransduction Mechanosensitivity Bonefracture energy - Bone mineral content