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A mathematical model of cortical bone remodeling at cellular level under mechanical stimulus

Acta Mechanica Sinica 2012年第6期28卷 1678-1692页

作者： Qing-Hua Qin ya-nan wang Research School of Engineering The Australian National University

A bone cell population dynamics model for cor- tical bone remodeling under mechanical stimulus is devel- oped in this paper. The external experiments extracted from the literature which have not been used in the creation of the model are used to test the validity of the model. Not only can the model compare reasonably well with these ex- perimental results such as the increase percentage of final values of bone mineral content （BMC） and bone fracture en- ergy （BFE） among different loading schemes （which proves the validity of the model）, but also predict the realtime devel- opment pattern of BMC and BFE, as well as the dynamics of osteoblasts （OBA）, osteoclasts （OCA）, nitric oxide （NO） and prostaglandin E2 （PGE2） for each loading scheme, which can hardly be monitored through experiment. In conclusion, the model is the first of its kind that is able to provide an in- sight into the quantitative mechanism of bone remodeling at cellular level by which bone cells are activated by mechan- ical stimulus in order to start resorption/formation of bone mass. More importantly, this model has laid a solid foun- dation based on which future work such as systemic control theory analysis of bone remodeling under mechanical stimu- lus can be investigated. The to-be identified control mecha- nism will help to develop effective drugs and combined non- pharmacological therapies to combat bone loss pathologies. Also this deeper understanding of how mechanical forces quantitatively interact with skeletal tissue is essential for the generation of bone tissue for tissue replacement purposes in tissue engineering.

关键词： Cortical bone remodeling Cell population dy-namics Mechanotransduction Mechanosensitivity Bonefracture energy - Bone mineral content

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Convergence of the viscosity solution of non-autonomous Hamilton-Jacobi equations

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Science China Mathematics 2021年第8期64卷 1789-1800页

作者： Cui Chen ya-nan wang Jun yan The Faculty of Science Jiangsu UniversityZhenjiang 212013China School of Mathematical Sciences Nanjing Normal UniversityNanjing 210097China School of Mathematical Sciences Fudan UniversityShanghai 200433China Shanghai Key Laboratory for Contemporary Applied Mathematics Shanghai 200433China

In this paper,we investigate the non-autonomous Hamilton-Jacobi equation{ə_(t)u+H(t,x,ə_(x)=0,u(x,t)_(0))=φ(x),x∈M where H is 1-periodic with respect to t and M is a compact Riemannian manifold without *** obtain the viscosity solution denoted by T_(t_(0))^(t)φ(x)and show T_(t_(0))^(t)φ(x)converges uniformly to a time-periodic viscosity solution u^(*)(x,t)ofə_(t)u+H(t,x,ə_(x)u,u)=0.

关键词： Hamilton-Jacobi equation viscosity solution large-time behavior

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Analytical formula for the cross section of hadron production from e^(+)e^(−) collisions around the narrow charmouinum resonances

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Chinese Physics C 2024年第11期48卷 43-51页

作者： ya-nan wang ya-Di wang Ping wang North China Electric Power Unversity Beijing 102206China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

The paper reports an analytical formula for the production cross section of e^(+)e^(−)annihilation to hadrons in the vicinity of a narrow resonance,particularly in theτ-charm region,while considering initial state *** some approximations in its derivation,comparison between the analytical formula and direct integration of ISR shows good accuracy,indicating that the analytical formula meets current experimental ***,this paper presents a comparison of the cross section between the analytical formula and calculations using the ConExc Monte Carlo *** efficiency of the analytical formula in significantly reducing computing time makes it a favorable choice for the regression procedure to extract the parameters of narrow charmonium resonances in experiments.

关键词： initial state radiation production cross section observed cross section analytic form

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Multi-factor high-order intuitionistic fuzzy timeseries forecasting model

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Journal of Systems Engineering and Electronics 2016年第5期27卷 1054-1062页

作者： ya'nan wang Yingjie Lei yang Lei Xiaoshi Fan Air and Missile Defense College Air Force Engineering UniversityXi'an 710051China Department of Electronics Technology Engineering University of Armed Police ForceXi'an 710051China

Fuzzy sets theory cannot describe the neutrality degreeof data, which has largely limited the objectivity of fuzzy time seriesin uncertain data forecasting. With this regard, a multi-factor highorderintuitionistic fuzzy time series forecasting model is built. Inthe new model, a fuzzy clustering algorithm is used to get unequalintervals, and a more objective technique for ascertaining membershipand non-membership functions of the intuitionistic fuzzy setis proposed. On these bases, forecast rules based on multidimensionalintuitionistic fuzzy modus ponens inference are ***, contrast experiments on the daily mean temperature ofBeijing are carried out, which show that the novel model has aclear advantage of improving the forecast accuracy.

关键词： multi-factor high-order intuitionistic fuzzy time series,forecasting model intuitionistic fuzzy inference.

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Modeling electric field of power metal-oxide-semiconductor field-effect transistor with dielectric trench based on Schwarz–Christoffel transformation

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Chinese Physics B 2019年第5期28卷 366-373页

作者： Zhi-Gang wang Tao Liao ya-nan wang School of Information Science and Technology Southwest Jiao Tong University

A power metal-oxide-semiconductor field-effect transistor(MOSFET) with dielectric trench is investigated to enhance the reversed blocking capability. The dielectric trench with a low permittivity to reduce the electric field at reversed blocking state has been studied. To analyze the electric field, the drift region is segmented into four regions, where the conformal mapping method based on Schwarz–Christoffel transformation has been applied. According to the analysis, the improvement in the electric field for using the low permittivity trench is mainly due to the two electric field peaks generated in the drift region around this dielectric trench. The analytical results of the electric field and the potential models are in good agreement with the simulation results.

关键词： conformal mapping Schwarz–Christoffel transformation electric field trench metal-oxidesemiconductor field-effect transistor (MOSFET) breakdown voltage

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Carbene-enabled ether activation through the formation of oxonium: a theoretical view

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Organic Chemistry Frontiers 2022年第5期9卷 1247-1253页

作者： ya-nan wang Xinghua wang Shi-Jun Li Yu Lan College of Chemistry and Institute of Green CatalysisZhengzhou University100 Science AvenueZhengzhou 450001HenanP.R.China School of Chemistry and Chemical Engineering and Chongqing Key Laboratory of Theoretical and Computational ChemistryChongqing UniversityChongqing 400030P.R.China

Here,we report a theoretical investigation of the reactivity and chemoselectivity of carbene-enabled ether *** mechanism obtained from DFT calculations revealed that the final products were dependent on the stability of the oxonium intermediate,which was afforded by nucleophilic attack of the corresponding ether onto a carbene ***,we found that the nucleophilicity of ethers was crucial but not their *** decomposition analysis based on absolutely localized molecular orbitals showed that the nucleophilicity of ethers was critical for polarization and charge transfer,leading to the chemoselectivity.

关键词： activation absolutely carbene

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Accidental discovery of appendiceal carcinoma during gynecological surgery:A case report

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World Journal of Clinical Cases 2022年第22期10卷 8040-8044页

作者： Lin wang yan Dong ya-Hui Chen ya-nan wang Lin Sun Department of Clinical Medicine Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Obstetrics and Gynecology The Affiliated Hospital of Jining Medical UniversityJining 272000Shandong ProvinceChina

BACKGROUND Malignant tumors of the appendix are extremely rare,constituting about 1%of all gastrointestinal ***,pathology identifies these tumors during or after appendectomy because they are difficult to detect at the preoperative *** case report aims to introduce the definitive diagnosis and treatment of mucinous adenocarcinoma of the *** SUMMARY A 49-year-old female patient came to our hospital with right lower abdominal pain,nausea,and vomiting for three *** was no change in the menstrual *** ultrasound showed a cystic,solid mass in the right *** enhanced computed tomography showed a thick *** was found on exploration of the appendix during gynecological *** right colon was *** surgery,the patient received chemotherapy and is recovering *** Appendiceal carcinoma is frequently found during or after surgery,and both preoperative examination and early evaluation of clinical manifestations are extremely important.

关键词： Abdominal pain Pelvic mass Appendix carcinoma Mucinous adenocarcinoma Case report

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Brain tumors:Cancer stem-like cells interact with tumor microenvironment

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World Journal of Stem Cells 2020年第12期12卷 1439-1454页

作者： Hai-Long Liu ya-nan wang Shi-Yu Feng Department of Neurosurgery Chinese PLA General HospitalBeijing 100853China Department of Pathology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Cancer stem-like cells(CSCs)with potential of self-renewal drive *** tumor microenvironment(TME)has been identified as a critical regulator of malignancy *** researchers are searching new ways to characterize tumors with the goal of predicting how they respond to ***,we describe the striking parallels between normal stem cells and *** review the microenvironmental aspects of brain tumors,in particular composition and vital roles of immune cells infiltrating glioma and *** highlighting that CSCs cooperate with TME via various cellular communication approaches,we discuss the recent advances in therapeutic strategies targeting the components of *** of the complex and interconnected factors can facilitate the development of promising treatments for these deadly malignancies.

关键词： Cancer stem-like cells Microenvironment Brain tumor Inflammation Clinical application Glioma

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Special epithelioid trophoblastic tumor:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9354-9360页

作者： ya-nan wang yan Dong Lin wang ya-Hui Chen Hai-yang Hu Jing Guo Lin Sun Departments of Clinical Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Gynecology Affiliated Hospital of Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Pathology Affiliated Hospital of Jining Medical UniversityJining 272000Shandong ProvinceChina

BACKGROUND Epithelioid trophoblastic tumor(ETT)is a special type of gestational trophoblastic ***,its pathogenesis has been incompletely *** rarely occurs in the ovaries and fallopian tubes,unlike placental site trophoblastic tumor,requiring a histopathological biopsy and immunohistochemistry for further *** SUMMARY A 29-year-old woman with irregular vaginal bleeding and elevated serum chorionic gonadotropin(β-hCG)levels presented similar symptoms to ectopic *** ultrasound revealed abnormal echoes of the left ***,the pathology of the left ovary and fallopian tube was reported as *** patient was followed up with regular hCG measurements and *** blood hCG values showed an upward trend 3 mo after the operation and then chemotherapy was *** current health status is *** For women of childbearing age with elevated serumβ-hCG levels,practitioners should consider ETT and be alert to the poor prognosis of the *** surgery,the patient’s condition should be closely observed to prevent recurrence and *** chemotherapy is only helpful for treating the disease to a certain extent.

关键词： Trophoblastic tumor Epithelioid trophoblastic tumor Serum chorionic gonadotropin Vaginal bleeding The partial hydatidiform mole Choriocarcinoma Case report

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Methylation of 2-methylnaphthalene with methanol to 2,6-dimethylnaphthalene over HZSM-5 modified by NH_4F and SrO

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Chinese Chemical Letters 2007年第10期18卷 1281-1284页

作者： Chen Zhang Xin Wen Guo ya nan wang Xiang Sheng wang Chun Shan Song State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 China Clean Fuels and Catalysis Program The Energy Institute and Department of Energy ＆ Geo-Environmental Engineering The Penmylvania State University 209 Academic Projects Building University Park PA 16802 USA

The methylation of 2-methylnaphthalene （2-MN） into 2,6-dimethylnaphthalene （2,6-DMN） was investigated over the solid acid catalysts. The results show that HZSM-5 modified by NH4F has better catalytic performance than parent HZSM-5 due to the decrease in the acidity. When NH4F/HZSM-5 is further modified by SrO, its catalytic activity decreases due to the decrease in the total acid amount and acidic strength. As a result, the comprehensive modification of NH4F and SrO leads to the inere, ase in the 2,6- DMN selectivity （2,6-DMN to DMN）, up to 64.8% when 2-MN conversion is 10%. We calculated the ESP charge by density functional theory and the results show that the 6-position in 2-MN has higher ESP charge value than 7-position. The formation of 2,6-DMN is favored energetically as compared to that for 2,7-DMN. This suggests during the alkylation of 2-MN inside the ZSM-5 channel, the formation of 2,6-DMN is favored electronically than that of 2,7-DMN. Hence, lowering the acidity of catalyst is a key factor to obtain high selectivity of 2,6-DMN.

关键词： 2,6-DMN, Modification Selectivity ESP charge

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