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Risk of cardiovascular death in patients with hepatocellular carcinoma based on the Fine-Gray model

World Journal of Gastrointestinal Oncology 2024年第3期16卷 844-856页

作者： Yu-Liang zhang Zi-Rong Liu Zhi Liu Yi Bai Hao Chi Da-Peng Chen ya-min zhang Zi-Lin Cui First Central Clinical College Tianjin Medical UniversityTianjin 300070China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of cancers worldwide,ranking fifth among men and seventh among women,resulting in more than 7 million deaths *** the development of medical tech-nology,the 5-year survival rate of HCC patients can be increased to 70%.How-ever,HCC patients are often at increased risk of cardiovascular disease(CVD)death due to exposure to potentially cardiotoxic treatments compared with non-HCC ***,CVD and cancer have become major disease burdens ***,further research is needed to lessen the risk of CVD death in HCC patient *** This study was conducted on the basis of the Surveillance,Epidemiology,and End Results database and included HCC patients with a diagnosis period from 2010 to *** independent risk factors were identified using the Fine-Gray model.A nomograph was constructed to predict the CVM in HCC *** nomograph performance was measured using Harrell’s concordance index(C-index),calibration curve,receiver operating characteristic(ROC)curve,and area under the ROC curve(AUC)***,the net benefit was estimated via decision curve analysis(DCA).RESULTS The study included 21545 HCC patients,of whom 619 died of ***(5 cm:2.090(1.543-2.830),Pmination and calibration of the nomograph were *** C-index values for the training and validation sets were 0.736 and 0.665,*** AUC values of the ROC curves at 2,4,and 6 years were 0.702,0.725,0.740 in the training set and 0.697,0.710,0.744 in the validation set,*** calibration curves showed that the

关键词： Hepatocellular carcinoma Cardiovascular disease deaths Fine-Gray model Risk factor Nomograph Predict

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HIF-1α facilitates glioma proliferation and invasion by activating pyroptosis signaling axis

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中华神经外科杂志(英文) 2024年第02期10卷 115-123页

作者： Wang Xin-Wei Fu Hao zhang ya-min The First Central Clinical School Tianjin Medical University Tianjin China Department of General Medicine Characteristic Medical Center of PAP Tianjin China

Background HIF-1α is thought to be a novel regulator which contributes to carcinogenesis. However, the mechanism underlying the effect of HIF-1α in gliomas remains largely *** In the research, we demonstrate that HIF-lα mRNA and protein levels are elevated in glioma cells. The colony formation assays, transwell assays, and wound-healing assays showed that overexpression of HIF-1α promoted proliferation and invasion of glioma *** Overexpression of HIF-lα also increased the expression of inflammatory factors related to pyrolysis (TNF-α, IL-10, and IL-1β) and protein related to pyrolysis signal pathway (NLRP3, ASC, caspase-1, GSDMD, and GSDME).Conclusions Therefore, we speculate that HIF-1α promotes the proliferation and invasion of glial cells by regulating pyrolysis pathway. These results might provide a novel strategy and target for treatment of glioma.

关键词： Glial cells Hypoxia-inducing factor 1α SHG44 cells Pyroptosis

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Intratumoural microorganism can affect the progression of hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4232-4243页

作者： Bao-Qun Liu Yi Bai Da-Peng Chen ya-min zhang Tian-Ze Wang Jing-Rui Chen Xiang-Yu Liu Bin Zheng Zi-Lin Cui First Central Clinical College Tianjin Medical UniversityTianjin 300070China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China Tianjin First Central Hospital Clinic Institute School of MedicineNankai UniversityTianjin 300192China School of Medicine Tianjin UniversityTianjin 300072China

BACKGROUND Several recent studies have confirmed that intratumoural microorganisms can affect the occurrence and development of hepatocellular carcinoma(HCC);however,their role in tumor progression remains ***,there is a need for further research on the role of intratumoural microorganisms in *** To investigate the changes in intratumoural microorganisms in HCC and the effect of Propionibacterium on HCC *** HCC and normal liver tissue specimens were subjected to fluorescence in situ hybridization(FISH).After performing 16S rRNA sequencing on HCC and peritumoral tissues to analyze the differences between the two *** was cocultured with HCC cells in *** in cell proliferation and migration capacity were *** expression of NF-κB pathway related proteins in tumor cells was *** orthotopic liver implantation model and the subcutaneous xenograft model were *** tissues and subcutaneous tumors were collected 2 weeks *** FISH demonstrated the presence of microorganisms in HCC and normal liver tissues.16S rRNA sequencing revealed an abundance of Lysobacter,Lachnospiraceae,Pseudomonas,and Lactobacillus in HCC *** distribution and abundance of Propionibacterium showed differences between HCC and peritumoral tissues(P<0.05).In vitro studies demonstrated that Propionibacterium and its metabolite propionic acid(PA)inhibited the proliferation and migration of HCC cells(P<0.05).The expression of the proteins in NF-κB signaling pathway also decreased in HCC cells(P<0.05).CONCLUSION Microorganisms in HCC and normal liver tissues displayed significant *** PA-producing bacterium Propionibacterium in HCC exerts an effect on the NF-κB pathway,thereby affecting the biological behavior of HCC.

关键词： Hepatocellular carcinoma Intratumoural microbiome 16S rRNA sequencing Propionibacterium

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Knowledge,attitudes and experiences of genetic testing for autism spectrum disorders among caregivers,patients,and health providers:A systematic review

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World Journal of Psychiatry 2023年第5期13卷 247-261页

作者： Meng Zhou ya-min zhang Tao Li Department of Neurobiology Affiliated Mental Health Center&Hangzhou Seventh People’s HospitalZhejiang University School of MedicineHangzhou 310013Zhejiang ProvinceChina Liangzhu Laboratory MOE Frontier Science Center for Brain Science and Brain-machine IntegrationState Key Laboratory of Brain-machine IntelligenceZhejiang UniversityHangzhou 310013Zhejiang ProvinceChina NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang UniversityHangzhou 310013Zhejiang ProvinceChina

BACKGROUND Several genetic testing techniques have been recommended as a first-tier diagnostic tool in clinical practice for diagnosing autism spectrum disorder(ASD).However,the actual usage rate varies *** is due to various reasons,including knowledge and attitudes of caregivers,patients,and health providers toward genetic *** studies have therefore been conducted worldwide to investigate the knowledge,experiences,and attitudes toward genetic testing among caregivers of children with ASD,adolescent and adult ASD patients,and health providers who provide medical services for ***,no systematic review has been *** To systematically review research on knowledge,experiences,and attitudes towards genetic testing among caregivers of children with ASD,adolescent and adult ASD patients,and health *** We followed the Preferred Reporting Items for Systematic Reviews and Metaanalyses guidelines and searched the literature in three English language databases(PubMed,Web of Science,and PsychInfo)and two Chinese databases(CNKI and Wanfang).Searched literature was screened independently by two reviewers and discussed when inconsistency *** on characteristics of the study,characteristics of participants,and main findings regarding knowledge,experience,and attitudes of caregivers of children with ASD,adolescent and adult ASD patients,and health providers concerning ASD genetic testing were extracted from included papers into a charting form for *** We included 30 studies published between 2012 and 2022 and conducted in 9 *** of the studies(n=29)investigated caregivers of children with ASD,one study also included adolescent and adult patients,and two covered health ***(51.0%-100%)of the caregivers/patients knew there was a genetic cause for ASD and 17.0%to 78.1%were aware of ASD genetic ***,they lacked full understanding of genetic *** acquired relevant and nec

关键词： patients testing spectrum

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Sex-biased adaptation shapes uniparental gene pools in Tibetans

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Science China(Life Sciences) 2024年第3期67卷 611-613页

作者： min-Sheng Peng ya-Ping zhang State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan School of Life SciencesYunnan UniversityKunming 650091China

During the past two decades, a series of archaeological and genetic investigations substantially improve our perception of the hominin settlement of the Tibetan Plateau(zhang et al., 2022). In addition to the identifi... 详细信息

关键词： Tibetan Plateau altitude

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Porous carbon nanofibers derived from low-softening-point coal pitch towards all-carbon potassium ion hybrid capacitors

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Rare Metals 2022年第11期41卷 3706-3716页

作者： Guang-Yuan Wang Xiao-Hong Wang Jin-Feng Sun ya-min zhang Lin-Rui Hou Chang-Zhou Yuan School of Materials Science and Engineering University of JinanJinan250022China

Potassium ion hybrid capacitors(PIHC)have promising applications in medium and large-scale energy storage systems due to their high energy/power density,abundant potassium resource and low ***,the slow kinetics of battery-type anodes originating from the large-size K+results in a mismatch between the two electrodes,rendering the modest energy density of ***,we first develop an electrospinning strategy to successfully synthesize fibrous precursor by using the HNO_(3)pre-oxidized low-softening-point coal pitch as the low-cost raw *** further carbonization or KOH activation,the two types of carbon nanofibers(CNF)are fabricated as anode and cathode materials,respectively,towards the dual-carbon PIHC *** to its threedimensional interconnected porous conducting network and large layer spacing,the resulted CNF anode material is endowed with high reversible capacities,excellent rate and long cycle ***,the activated CNF cathode with a large surface area of 2169 m^(2)·g^(-1)exhibits excellent capacitive performance.A PIHC constructed with the two fibrous electrodes delivers an energy density of110.0 Wh·kg^(-1)at 200.0 W kg^(-1),along with a capacitance retention of 83.5%after 10,000 cycles at 1.0 A·g^(-1).The contribution here provides a cost-efficiency avenue and platform for advanced dual-carbon PIHC.

关键词： Potassium ion hybrid capacitors(PIHC) Low-softening-point coal pitch Carbon nanofibers(CNF) Dual-carbon devices Long durability

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Effects of thrombopoietin pre-treatment on peri-liver transplantation thrombocytopenia in a mouse model of cirrhosis with hypersplenism

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2115-2122页

作者： Zi-Rong Liu ya-min zhang Zi-Lin Cui Wen Tong Department of Hepatobiliary Surgery Tianjin First Central HospitalTianjin 300070China

BACKGROUND During cirrhosis,the liver is impaired and unable to synthesize and clear thrombopoietin *** the same time,the spleen assumes the function of hemofiltration and storage due to liver dysfunction,resulting in hypersplenism and excessive removal of platelets in the spleen,further reducing platelet *** liver function is decompensated in cirrhotic patients,the decrease of thrombopoietin(TPO)synthesis is the main reason for the decrease of new platelet *** change of TPO leads to thrombocytopenia and bleeding tendency in cirrhotic patients with *** To investigate the clinical efficacy of recombinant human TPO(rhTPO)in the treatment of perioperative thrombocytopenia during liver transplantation in cirrhotic mice with *** C57BL/6J mice and TPO receptor-deficient mice were used to establish models of cirrhosis with ***,these mice underwent orthotopic liver transplantation(OLT).The mice in the experimental group were given rhTPO treatment for 3 consecutive days before surgery and 5 consecutive days after surgery,while the mice in the control group received the same dose of saline at the same *** in liver function and platelet counts were determined between the experimental and control ***-linked immunosorbent assay was used to assess the expression of TPO and TPO receptor(c-Mpl)in the *** Preoperative administration of rhTPO significantly improved peri-OLT thrombocytopenia in mice with cirrhosis and *** the expression of TPO receptors exacerbated peri-OLT *** concentration of TPO decreased while the concentration of c-Mpl increased in compensation in the mouse model of cirrhosis with *** pre-treatment significantly increased the postoperative TPO concentration in mice,which in turn led to a decrease in the c-Mpl *** pre-treatment also significantly enhanced the Janus kinase(Jak)/signal

关键词： Thrombopoietin pre-treatment Cirrhosis Liver transplantation Perioperative period Platelet

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Overexpression of Csk-binding protein decreases growth,invasion,and migration of esophageal carcinoma cells by controlling Src activation

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World Journal of Gastroenterology 2015年第6期21卷 1814-1820页

作者： Dong Zhou Peng Dong Yu-min Li Fa-Cai Guo An-Ping zhang Run-Ze Song ya-min zhang Zhi-Yong Li Dong Yuan Chuan yang Gansu Provincial Key Laboratory of Digestive System Tumors Lanzhou University Second Hospital Department of Cardiology Aviation General Hospital Department of Vascular Surgery Lanzhou University Second Hospital

AIM:To investigate the mechanisms by which Cskbinding protein(CBP)inhibits tumor progression in esophageal ***:A CBP overexpressing esophageal carcinoma cell line(TE-1)was *** growth,invasion,and migration of CBP-TE-1 cells,as well as the expression of Src were then determined and compared with those in normal TE-1 ***:The expression of Src was decreased by the overexpression of CBP in TE-1 *** growth,invasion,and migration of TE-1 cells were decreased by the overexpression of ***:This study indicates that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of *** may be a potential tumor suppressor and targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma.

关键词： Csk-binding protein Esophageal carcinoma Cell grow

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A retrospective study of the occurrence of ischemic-type biliary lesions post liver transplantation

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Science China(Life Sciences) 2016年第5期59卷 529-531页

作者： Rui Shi ya-min zhang Yong-Lin Deng Hong Zheng Cheng Pan Zhong-yang Shen Tianjin Key Laboratory of Organ Transplantation Department of Hepatobiliary Surgery First Center Hospital Clinic Institute Tianjin Medical University

Dear Editors, lschemic-type biliary lesions （ITBLs） significantly reduce patient and graft survival rates. Research data regarding the causes of ITBL are rare. ITBLs is an important cause of post liver transplantation graft loss and patient death. The exact cause of this type of biliary complication remains un- clear. To establish strategies for ITBL treatment or preven- tion, the risk factors of ITBL must be elucidated. The objective of this single-center retrospective study was to investigate the risk factors of ITBL in orthotopic liver transplanta- tion （OLT） patients.

关键词：肝移植胆道病变血型预防方法风险因素危险因素存活率

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Development and validation of novel nomograms to predict survival of patients with tongue squamous cell carcinoma

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World Journal of Clinical Cases 2022年第32期10卷 11726-11742页

作者： Xia-yan Luo ya-min zhang Run-Qiu Zhu Shan-Shan yang Lu-Fang Zhou Hui-Yong Zhu Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Stomatology Sanmen People’s HospitalTaizhou 317100Zhejiang ProvinceChina Department of Stomatology Jiangshan People's HospitalQuzhou 324199Zhejiang ProvinceChina

BACKGROUND There is no unified standard to predict postoperative survival in patients with tongue squamous cell carcinoma(TSCC),hence the urgency to develop a model to accurately predict the prognosis of these *** To develop and validate nomograms for predicting overall survival(OS)and cancer-specific survival(CSS)of patients with *** A cohort of 3454 patients with TSCC from the Surveillance,Epidemiology,and End Results(SEER)database was used to develop nomograms;another independent cohort of 203 patients with TSCC from the Department of Oral and Maxillofacial Surgery,First Affiliated Hospital of Zhejiang University School of Medicine,was used for external *** and multivariate analyses were performed to identify useful variables for the development of *** calibration curve,area under the receiver operating characteristic curve(AUC)analysis,concordance index(C-index),net reclassification index(NRI),and decision curve analysis(DCA)were used to assess the calibration,discrimination ability,and clinical utility of the *** Eight variables were selected and used to develop nomograms for patients with *** Cindex(0.741 and 0.757 for OS and CSS in the training cohort and 0.800 and 0.830 in the validation cohort,respectively)and AUC indicated that the discrimination abilities of these nomograms were *** calibration curves of OS and CSS indicated that the predicted and actual values were consistent in both the training and validation *** NRI values(training cohort:0.493 and 0.482 for 3-and 5-year OS and 0.424 and 0.402 for 3-and 5-year CSS;validation cohort:0.635 and 0.750 for 3-and 5-year OS and 0.354 and 0.608 for 3-and 5-year CSS,respectively)and DCA results indicated that the nomograms were significantly better than the tumor-node-metastasis staging system in predicting the prognosis of patients with *** Our nomograms can accurately predict patient prognoses and assist clinician

关键词： Tongue squamous cell carcinoma Overall survival Cancer-specific survival Nomogram Prognosis

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