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Electroacupuncture activates AMPKa1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer's disease by regulating hippocampal mitochondrial dynamics

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Journal of Integrative Medicine 2024年第5期22卷 588-599页

作者： Wei-wei Jia Hua-wei Lin Min-guang yang ya-ling dai yan-yi Ding Wen-shan Xu Si-nuo Wang ya-jun Cao Sheng-xiang Liang Zhi-fu Wang Cong Chen Wei-lin Liu College of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine The Institute of Rehabilitation Industry Fujian University of Traditional Chinese Medicine National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese Medicine Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine Fujian University of Traditional Chinese Medicine

Objective: Studies have shown that electroacupuncture(EA) can alleviate cognitive impairments from Alzheimer's disease(AD) by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK), but the specific mechanism involved remains to be elucidated. Therefore, this study explores the potential mechanism by which EA improves cognitive function from the perspective of mitochondrial ***: The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKa1-subunit conditional knockout(AMPKa1-cKO) were used for experiments. To evaluate the effects of EA treatment on cognitive function, the T-maze and Morris water maze were used. In addition,chemical exchange saturation transfer, thioflavin staining, transmission electron microscopy, mitochondrial membrane potential, and Western blotting were used to examine the potential mechanisms underlying the effects of EA on APP/PS1 ***: Both APP/PS1 mice and AMPKa1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory impairment. Inactivation of the AMPK/peroxisome proliferatoractivated receptor-γ coactivator-1a(PGC-1a) pathway increased pathological amyloid-β(Aβ) deposition and aggravated the dysfunction in mitochondrial dynamics. In addition, EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1a pathway, specifically by reducing pathological Aβ deposition, normalizing energy metabolism, protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins, and downregulating the expression of fission proteins. However, the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by ***: The regulation of hippocampal mitochondrial dynamics and reduction in Aβ deposition via the AMPK/PGC-1a pathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.

关键词： Adenosine monophosphate-activated protein kinase Alzheimer’s disease Cognitive impairment Electroacupuncture Hippocampus Mitochondrial dynamics

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Gene expression profiles of peripheral blood mononuclear cells from patients with atopic dermatitis stimulated with Malassezia globosa

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Chinese Medical Journal 2021年第22期134卷 2759-2761页

作者： Mao Lu ya-ling dai Xin Ran Sushmita Pradhan Hai-Rong Liu Mei Ou Hong-Mei Wu Yu-Ping Ran Department of Dermatovenereology Sichuan University West China HospitalChengduSichuan 610041China Department of Dermatovenereology The First Affiliated Hospital of Chengdu Medical CollegeChengduSichuan 610500China Department of Laboratory Medicine The First Affiliated Hospital of Chengdu Medical CollegeChengduSichuan 610500China.

To the Editor:Malassezia located in the skin of patients with atopic dermatitis(AD)might be related to its pathogenesis,consisting of Malassezia globosa and Malassezia restricta as the dominant species.[1]However,the specific molecular mechanisms of Malassezia on host immune cells from AD patients are still *** our study,the Affymetrix Human Prime View array was used to detect the effect of *** on the gene expression of peripheral blood mononuclear cells(PBMCs)from AD patients,which was favorable to further understand the role of Malassezia colonization in the pathogenesis of AD.

关键词： patients dermatitis pathogenesis

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Trotter–Kato Approximations of Impulsive Neutral SPDEs in Hilbert Spaces

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1229-1243页

作者： Ming LIU Xia ZHANG ling Fei dai School of Mathematical Sciences Tiangong UniversityTianjin 300387P.R.China

This paper studies a class of impulsive neutral stochastic partial differential equations in real Hilbert *** main goal here is to consider the Trotter-Kato approximations of mild solutions of such equations in the pth-mean(p≥2).As an application,a classical limit theorem on the dependence of such equations on a parameter is *** novelty of this paper is that the combination of this approximating system and such equations has not been considered before.

关键词： Impulsive neutral stochastic partial diferential equation Trotter-Kato approximations classical limit theorem

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Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer's disease:a meta-analysis and systematic review

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Neural Regeneration Research 2022年第11期17卷 2381-2390页

作者： Wei-Lin Liu Hua-Wei Lin Miao-Ran Lin yan Yu Huan-Huan Liu ya-ling dai Le-Wen Chen Wei-Wei Jia Xiao-Jun He Xiao-ling Li Jing-Fang Zhu Xie-Hua Xue Jing Tao Li-Dian Chen Academy of Rehabilitation Industry Fujian University of Traditional Chinese MedicineFuzhouFujian ProvinceChina Department of Biochemistry and Molecular Biology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese MedicineFuzhouFujian ProvinceChina Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine FuzhouFujian ProvinceChina

Blood exosomes,which are extracellular vesicles secreted by living cells into the circulating blood,are regarded as a relatively noninvasive novel tool for monitoring brain physiology and disease *** increasing number of blood cargo-loaded exosomes are emerging as potential biomarkers for preclinical and clinical Alzheimer's *** re,we conducted a meta-analysis and systematic review of molecular biomarkers derived from blood exosomes to comprehensively analyze their diagnostic performance in preclinical Alzheimer's disease,mild cognitive impairment,and Alzheimer's *** performed a literature search in PubMed,Web of Science,Embase,and Cochrane Library from their inception to August 15,*** research subjects mainly included Alzheimer's disease,mild cognitive impairment,and preclinical Alzheimer's *** identified 34 observational studies,of which 15 were included in the quantitative analysis(Newcastle-Ottawa Scale score 5.87 points)and 19 were used in the qualitative *** meta-analysis results showed that core biomarkers including Aβ_(1-42),P-T181-tau,P-S396-tau,and T-tau were increased in blood neuro nderived exosomes of preclinical Alzheimer's disease,mild cognitive impairment,and Alzheimer's disease patients.M olecules related to additional risk facto rs that are involved in neuroinflammation(C1q),metabolism disorder(P-S312-IRS-1),neurotrophic deficiency(HGF),vascular injury(VEGF-D),and autophagy-lysosomal system dysfunction(cathepsin D)were also *** the gene level,the differential expression of transc ription-related factors(REST)and microRNAs(miR-132)also affects RNA splicing,transport,and *** pathological changes contribute to neural loss and synaptic *** data confirm that the above-mentioned core molecules and additional ris k-related factors in blood exosomes can serve as candidate biomarkers for preclinical and clinical Alzheimer's *** findings support further development of

关键词： Alzheimer's disease amyloid-β biomarkers blood exosomes extracellular vesicles meta-analysis mild cognitive impairment systematic review tau protein

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A Denoiser for Correlated Noise Channel Decoding: Gated-Neural Network

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China Communications 2024年第2期21卷 122-128页

作者： Xiao Li ling Zhao Zhen dai Yonggang Lei School of Electronic and Information Engineering Beihang UniversityBeijing 100191China Beijing Institute of Tracking and Telecommunications Technology BITTT

This letter proposes a sliced-gated-convolutional neural network with belief propagation(SGCNN-BP) architecture for decoding long codes under correlated noise. The basic idea of SGCNNBP is using Neural Networks(NN) to transform the correlated noise into white noise, setting up the optimal condition for a standard BP decoder that takes the output from the NN. A gate-controlled neuron is used to regulate information flow and an optional operation—slicing is adopted to reduce parameters and lower training complexity. Simulation results show that SGCNN-BP has much better performance(with the largest gap being 5dB improvement) than a single BP decoder and achieves a nearly 1dB improvement compared to Fully Convolutional Networks(FCN).

关键词： belief propagation channel decoding correlated noise neural network

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Numerical study on the effective thermal conductivity and thermal tortuosity of porous media with different morphologies

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Science China(Technological Sciences) 2024年第6期67卷 1685-1694页

作者： DU Shen LI Dong LI Meng-Jie HE ya-ling Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an710049China

Effective thermal conductivity and thermal tortuosity are crucial parameters for evaluating the effectiveness of heat conduction within porous *** direct pore-scale numerical simulation method is applied to investigate the heat conduction processes inside porous structures with different *** thermal conduction performances of idealized porous structures are directly compared with real foams across a wide range of *** foam structures are reconstructed using X-ray computed tomography and image processing techniques,while Kelvin and Weaire-Phelan structures are generated through periodic unit cell *** detailed temperature fields inside the porous structures are determined by solving the heat conduction equation at the pore *** results present that the equivalent thermal conductivity of Kelvin and Weaire-Phelan structures is similar to and greater than that of the real foam structure with the same strut *** thermal tortuosity of real foam structure is relatively larger and the heat conduction path becomes straighter by adopting the anisotropic *** thermal tortuosity of the fluid channels for Kelvin,Weaire-Phelan,and real foam structures is close to *** thermal conductivity of porous structures with heat transfer fluid increases as the thermal conductivity ratio of fluid to solid becomes larger.A small porosity of porous media leads to a larger equivalent thermal conductivity due to the dominant contribution of porous skeleton in the heat conduction *** derived from parallel and series models,as well as the Maxwell-Eucken models,provide decent predictions of effective thermal conductivity,with an average error of less than 8%in the entire range of thermal conductivity ratio.

关键词： volumetric solar receiver porous morphology direct pore-scale simulation equivalent thermal conductivity thermal tortuosity empirical correlation

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Effect of liquid surface depression size on discharge characteristics and chemical distribution in the plasma-liquid anode system

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Plasma Science and Technology 2024年第9期26卷 17-31页

作者： Yun ling Dong dai Jiaxin CHANG Buang WANG School of Electric Power South China University of TechnologyGuangzhou 510641People’s Republic of China University of Richmond Richmond 23173United States of America

Atmospheric pressure plasma-liquid interactions exist in a variety of applications,including wastewater treatment,wound sterilization,and *** practice,the phenomenon of liquid surface depression will inevitably *** applied gas will cause a depression on the liquid surface,which will undoubtedly affect the plasma generation and further affect the application ***,the effect of liquid surface deformation on the plasma is still *** this work,numerical models are developed to reveal the mechanism of liquid surface depressions affecting plasma discharge characteristics and the consequential distribution of plasma species,and further study the influence of liquid surface depressions of different sizes generated by different helium flow rates on the *** show that the liquid surface deformation changes the initial spatial electric field,resulting in the rearrangement of electrons on the liquid *** charges deposited on the liquid surface further increase the degree of distortion of the electric ***,the electric field and electron distribution affected by the liquid surface depression significantly influence the generation and distribution of active species,which determines the practical effectiveness of the relevant *** work explores the phenomenon of liquid surface depression,which has been neglected in previous related work,and contributes to further understanding of plasma-liquid interactions,providing better theoretical guidance for related applications and technologies.

关键词： plasma-liquid interaction deformation of the liquid surface liquid anode species fluxes

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Stabilizing zinc anode using zeolite imidazole framework functionalized separator for durable aqueous zinc-ion batteries

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Journal of Energy Chemistry 2024年第3期90卷 23-31,I0003页

作者： Weisong Zhang Xinyan Zhu ling Kang Ziyu Peng Jing Zhu Liang Pan Lei dai Shude Liu ling Wang Yongguang Liu Zhangxing He School of Chemical Engineering North China University of Science and TechnologyTangshan 063009HebeiChina Shanghai Key Laboratory of Multidimensional Information Processing East China Normal UniversityShanghai 201620China College of Textiles Donghua UniversityShanghai 201620China

Aqueous zinc-ion batteries(AZIBs) hold great promise as a viable alternative to lithium-ion batteries owing to their high energy density and environmental ***,AZIBs are consistently plagued by the formation of zinc dendrites and concurrent side reactions,which significantly diminish their overall service life,In this study,the glass fiber separator(GF) is modified using zeolite imidazole salt framework-8(ZIF-8),enabling the development of efficient ***-8,which is abundant in nitrogen content,efficiently regulates the desolvation of [Zn(H_(2)O)_(6)]^(2+) to inhibit hydrogen ***,it possesses abundant nanochannels that facilitate the uniform deposition of Zn~(2+) via a localized action,thereby hindering the formation of *** insulating properties of ZIF-8 help prevent Zn^(2+) and water from trapping electron reduction at the layer surface,which reduces corrosion of the zinc ***,ZIF-8-GF achieves the even transport of Zn^(2+) and regulates the homogeneous deposition along the Zn(002) crystal surface,thus significantly enhancing the electrochemical performance of the AZIBs,In particular,the Zn|Zn symmetric cell with the ZIF-8-GF separator delivers a stable cycle life at0.5 mA cm^(-2) of 2300 *** Zn|ZIF-8-GF|MnO_(2) cell exhibits reduced voltage polarization while maintaining a capacity retention rate(93.4%) after 1200 cycles at 1.2 A g^(-1) The unique design of the modified diaphragm provides a new approach to realizing high-performance AZIBs.

关键词： Aqueous zinc-ion batteries Separators modifications ZIF-8 Zn deposition Dendrite-free

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Covalently Bonded Ni Sites in Black Phosphorene with Electron Redistribution for Efficient Metal‑Lightweighted Water Electrolysis

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Nano-Micro Letters 2024年第6期16卷 233-245页

作者： Wenfang Zhai ya Chen yaoda Liu Yuanyuan Ma Paranthaman Vijayakumar Yuanbin Qin Yongquan Qu Zhengfei dai State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China SSN Research Centre SSN College of EngineeringChennaiTamil Nadu 603110India

The metal-lightweighted electrocatalysts for water splitting are highly desired for sustainable and economic hydrogen energy deployments,but *** this work,a low-content Ni-functionalized approach triggers the high capability of black phosphorene(BP)with hydrogen and oxygen evolution reaction(HER/OER)*** a facile in situ electro-exfoliation route,the ionized Ni sites are covalently functionalized in BP nanosheets with electron redistribution and controllable metal *** is found that the as-fabricated Ni-BP electrocatalysts can drive the water splitting with much enhanced HER and OER *** 1.0 M KOH electrolyte,the optimized 1.5 wt%Nifunctionalized BP nanosheets have readily achieved low overpotentials of 136 mV for HER and 230 mV for OER at 10 mA cm^(−2).Moreover,the covalently bonding between Ni and P has also strengthened the catalytic stability of the Ni-functionalized BP electrocatalyst,stably delivering the overall water splitting for 50 h at 20 mA cm^(−2).Theoretical calculations have revealed that Ni–P covalent binding can regulate the electronic structure and optimize the reaction energy barrier to improve the catalytic activity *** work confirms that Ni-functionalized BP is a suitable candidate for electrocatalytic overall water splitting,and provides effective strategies for constructing metal-lightweighted economic electrocatalysts.

关键词： Black phosphorus Water electrolysis Electrocatalyst Electron redistribution Covalent functionalization

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Recent advances and perspectives of zinc metal-free anodes for zinc ion batteries

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 33-47页

作者： Jiabing Miao Yingxiao Du Ruotong Li Zekun Zhang Ningning Zhao Lei dai ling Wang Zhangxing He Science and Technology Innovation Center of Circular Economy Ha’erwusu Open-Pit Coal MineChina Shenhua Energy Co.Ltd.Ordos 010300China Research Center of Comprehensive Utilization of Coal Associated Resources National Energy GroupOrdos 010300China School of Chemical Engineering North China University of Science and TechnologyTangshan 063009China

Zinc-ion batteries(ZIBs) are recognized as potential energy storage devices due to their advantages of low cost, high energy density, and environmental friendliness. However, zinc anodes are subject to unavoidable zinc dendrites, passivation, corrosion, and hydrogen evolution reactions during the charging and discharging of batteries, becoming obstacles to the practical application of ZIBs. Appropriate zinc metal-free anodes provide a higher working potential than metallic zinc anodes, effectively solving the problems of zinc dendrites, hydrogen evolution, and side reactions during the operation of metallic zinc anodes. The improvement in the safety and cycle life of batteries creates conditions for further commercialization of ZIBs. Therefore, this work systematically introduces the research progress of zinc metal-free anodes in “rocking chair” ZIBs. Zinc metal-free anodes are mainly discussed in four categories: transition metal oxides,transition metal sulfides, MXene(two dimensional transition metal carbide) composites, and organic compounds, with discussions on their properties and zinc storage mechanisms. Finally, the outlook for the development of zinc metal-free anodes is proposed. This paper is expected to provide a reference for the further promotion of commercial rechargeable ZIBs.

关键词： zinc ion batteries anode zinc metal-free anode recent advances perspectives

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