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通督调神针刺法联合认知功能训练对卒中后认知障碍患者肠道菌群和神经递质的影响

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现代生物医学进展 2024年第1期24卷 167-170页

作者：景亚丽顾晨丛魏凯刘杰王利春河北中医学院研究生学院河北石家庄050000 承德医学院中医学院河北承德067000 河北省沧州中西医结合医院神经重症康复科河北沧州061000

目的:观察通督调神针刺法联合认知功能训练对卒中后认知障碍患者神经递质、肠道菌群的影响。方法:按照随机数字表法将河北省沧州中西医结合医院2021年7月-2022年10月收治的124例卒中后认知障碍患者分为对照组(62例,认知功能训练)和观察... 详细信息

目的:观察通督调神针刺法联合认知功能训练对卒中后认知障碍患者神经递质、肠道菌群的影响。方法:按照随机数字表法将河北省沧州中西医结合医院2021年7月-2022年10月收治的124例卒中后认知障碍患者分为对照组(62例,认知功能训练)和观察组(62例,认知功能训练、通督调神针刺法联合治疗)。对比两组简易精神状态检查表(MMSE)、日常生活活动(ADL)、蒙特利尔认知评估量表(MoCA)、血清神经递质[去甲肾上腺素(NE)、神经递质乙酰胆碱(ACh)、5-羟色胺(5-HT)、多巴胺(DA)]、肠道菌群指标。结果:治疗30 d后,观察组MMSE、MoCA、ADL评分高于对照组同期(P<0.05)。治疗30 d后,观察组Ach、DA、NE、5-HT高于对照组同期(P<0.05)。治疗30 d后,观察组大肠埃希菌、肠球菌低于对照组同期,双歧杆菌、乳杆菌高于对照组同期(P<0.05)。结论:卒中后认知障碍患者在认知功能训练基础上结合通督调神针刺法,认知功能、肠道菌群和神经递质水平显著改善,从而有利于改善患者的日常生活活动能力。

关键词：通督调神针刺法认知功能训练卒中后认知障碍肠道菌群神经递质

Association between brain N-acetylaspartate levels and sensory and motor dysfunction in patients who have spinal cord injury with spasticity:an observational case-control study

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Neural Regeneration Research 2023年第3期18卷 582-586页

作者： Jia-Yi liu ya-jing li Xin-Ying Cong Zuliyaer Talifu Xin Zhang Feng Gao Jian-Jun li School of Rehabilitation Capital Medical UniversityBeijingChina Department of Spinal and Neural Function Reconstruction China Rehabilitation Research CenterBeijingChina China Rehabilitation Science Institute BeijingChina Beijing Key Laboratory of Neural Injury and Rehabilitation BeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Rehabilitation Department Shanghai Huashan HospitalShanghaiChina Department of Medical Imaging China Rehabilitation Research CenterBeijingChina

Spinal cord injury is a severe and devastating disease,and spasticity is a common and severe complication that is notoriously refractory to ***,the pathophysiological mechanisms underlying spasticity and its development remain largely *** goal of the present study was to find differences,if any,in metabolites of the left precentral gyrus and basal ganglia of patients who have spinal cord injury with or without spasticity,and to explore the relationship between the brain metabolite concentrations and clinical ***-six participants were recruited for magnetic resonance spectroscopic examination:23 with spinal cord injury(12 with spasticity and 11 without spasticity)and 13 healthy *** acquired localized proton spectra from the precentral gyrus and basal ganglia via 10 mm^(3) ***,univariate linear regression analysis demonstrated that the lower that the N-acetylaspartate concentration(a marker for neuronal loss)was in the precentral gyrus of the patients,the lower their ASIA(American Spinal Injury Association)light-touch scores,pinprick scores,and motor ***,longer durations of injury were associated with higher N-acetylaspartate levels in the precentral *** with the healthy participants and patients without spasticity,N-acetylaspartate levels in the patients with spasticity were significantly lower in both the precentral gyrus and basal *** N-acetylaspartate levels also correlated with greater sensory and motor dysfunction in the patients who had spinal cord injury with spasticity.

关键词： ASIA motor score ASIA sensory score basal ganglia central nervous system duration of injury magnetic resonance spectroscopy N-acetylaspartate precentral gyrus spasticity spinal cord injury

pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

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Chinese Journal of Polymer Science 2024年第1期42卷 7-13,I0005页

作者： jing-Yuan Xiang Wen-Long Zhang He-Ting li ya-Ning He Department of Chemical Engineering Key Laboratory of Advanced Materials(MOE)Tsinghua UniversityBejing 100084China

This work reported an AIE fluorescent probe for tumor imaging based on the p H induced self-assembly strategy. The fluorescent probe was composed of an acid-responsive soluble copolymer PEG-b-PAMA-DMMA with a maleic acid amide group and an anionic soluble aggregation-induced emission fluorogen(AIEgen) TPE-2SO_(3)^(-). The polymer could be transformed into a protonated amine-containing polymer after the hydrolysis of maleic acid amide in acidic tumor microenvironment, which would be further self-assembled with TPE-2SO_(3)^(-)to form aggregated nanoparticles. The transition of TPE-2SO_(3)^(-)from dispersed state to aggregated state led to an obvious increase in fluorescence intensity due to its AIE characteristics.

关键词： p H-responsive Self-assembly Fluorescent probe AIE Tumor imaging

Chain Dynamics Heterogeneity in Plasticized Poly(vinyl butyral)(PVB) as Elucidated by Solid-State NMR

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Chinese Journal of Polymer Science 2024年第1期42卷 113-124,I0010页

作者： jing Lv Xu Chen Zi-Shuo Wu ya-Hui li Wei Chen National Synchrotron Radiation Laboratory Anhui Provincial Engineering Laboratory of Advanced Functional Polymer FilmCAS Key Laboratory of Soft Matter ChemistryUniversity of Scienceand Technology of ChinaHefei 230026China

The chain dynamics heterogeneity of the poly(vinyl butyral)(PVB) plasticized by triethylene glycol bis(2-ethylhexa noate)(TEG-EH) was investigated by various solid-state NMR *** plasticized PVB shows two domains in distinct molecular dynamics differences,namely,rigid and soft domains,where the latter is the plasticizer-rich *** time domain low field NMR was first used to investigate the dynamics heterogeneity of the plasticized PVB,and the results show the decreasing activated energy of components in the soft domain of plasticized PVB(E_a=20.2 kJ/mol) as compared with that of the pristine one(E_a=24.3 kJ/mol).Detailed dynamics heterogeneity was obtained by high-field NMR with site-specific *** quadrupole-echo ~2H-NMR was adopted to elucidate the dynamics heterogeneity of the vinyl alcohol(VA) units,where only the hydroxyl group of VA is *** ~1H-^(13)C WISE NMR spectra show that there is not much difference in the mobility of the VB unit in PVB with and without plasticizer,whereas the glass transition temperature differed by approximately 53℃.This is further supported by Torchia's T_1 relaxation *** origin of such an unusual phenomenon is attributed to the critical role of the remaining VA(~22%) in the soft domain,where the VA units locally aggregate through hydrogen ***,the existence of a mobility gradient in the VB unit has been ***,the mobility difference for VB with different stereo-geometry(meso or racemic conformation) is observed for the first *** indicates the importance of modulating the ratio of meso over racemic VB for controlling the macroscopic perfo rmance of PVB.

关键词： Poly(vinyl butyral) Dynamics heterogeneity Plasticizer Solid state NMR

A new class of potent liver injury protective compounds: Structural elucidation, total synthesis and bioactivity study

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3414-3424页

作者： Kailong Ji Wei liu Weihang Yin Xiangrong Kong Honghong Xu Zeng-Wei Lai jing-ya li Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China

A new class of potent liver injury protective compounds,phychetins A-D(1-4)featuring an unique 6/6/5/6/5 pentacyclic framework,were isolated and structurally characterized from a Chinese medicinal plant Phyllanthus *** 2-4 are three pairs of enantiomers that were initially obtained in a racemic manner,and were further separated by chiral HPLC *** 1-4 were proposed to be originated biosynthetically from a coexisting lignan via an intramolecular Friedel-Crafts reaction as the key step.A bioinspired total synthesis strategy was thus designated,and allowed the effective syntheses of compounds 2-4 in high *** of compounds exhibited significant anti-inflammatory activities in vitro via suppressing the production of pro-inflammatory cytokine IL-1β.Notably,compound 4,the most active enantiomeric pair in vitro,displayed prominent potent protecting activity against liver injury at a low dose of 3 mg/kg in mice,which could serve as a promising lead for the development of acute liver injury therapeutic agent.

关键词： Phychetins Phyllanthusfranchetianus Structural elucidation Total synthesis liver injury protection Anti-inflammation

Discovery of Novel Long-Chain Alkenyl Diacid Derivatives as ACLY Inhibitors

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Chinese Journal of Chemistry 2022年第22期40卷 2663-2670页

作者： Gao-Lei Song Lei Cao Mei Zhang Yu-Rou yang Jie Ma Zhi-Fu Xie jing-ya li Fa-Jun Nan State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantaiShandong 264000China

ATP citrate lyase(ACLY)synthesizes cytosolic acetyl coenzyme A(acetyl-CoA),an essential biosynthetic precursor for lipid synthesis and the acetyl donor required for protein *** aberrant expression and activity of ACLY has been documented in multiple human ***-1002 is an indirect ACLY inhibitor,and it has recently been approved by the FDA as an additional therapeutic option in high-risk hypercholesterolemia patients unable to meet goals with standard *** this work,we identified a series of novel long-chain alkenyl diacids as potent direct ACLY inhibitors,and comprehensive structure-activity relationship analysis showed that compound 18f was the most potent ACLY inhibitor with an IC50 value of 1.5μmol/*** ester formation of 18f gave a new series of compounds such as 25f that maintained ACLY inhibitory activity and improved antitumor cell proliferation effects.

关键词： Alkenyl diacid derivatives Cancer ACLY inhibitors Acetyl-CoA Structure-activity relationships

cis-Clerodane Diterpenoids with Structural Diversity and Anti-inflammatory Activity from Tinospora crispa

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Chinese Journal of Chemistry 2022年第24期40卷 2882-2892,I0002页

作者： Jin-Qiu You Yi-Nan liu Jun-Su Zhou Xin-Yu Sun Chun Lei Qing Mu jing-ya li Ai-Jun Hou School of Pharmacy Fudan UniversityShanghai201203 China School of Pharmacy Shanghai Jiao Tong UniversityShanghai200240 China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai201203 China

Twelve new cis-clerodane diterpenoids, designated as crispinoids A—L (1—12), together with three known analogues (13—15), were isolated from Tinospora crispa. Their structures were fully assigned by comprehensive spectroscopic techniques, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) analyses. The isolated clerodanes displayed diverse heterocyclic frameworks including 6/6/6-, 6/5/6/6-, 6/6/5-, 6/6-, and 6/5/6-fused ring systems. Some of the isolates showed ATP-citrate lyase (ACLY) and nuclear factor kappa B (NF-κB) pathway inhibition. The NF-κB inhibitors further suppressed the lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 cells.

关键词： Natural products Structure elucidation Tinospora crispa ATP-citrate lyase Nuclear factor kappa B

Two-dimensional silica enhanced solid polymer electrolyte for lithium metal batteries

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Particuology 2024年第2期85卷 146-154页

作者： Zhihong Luo Weiyong li Chong Guo ya Song Mingxia Zhou yan Shi jing Xu Long li Bin Shi Quansheng Ouyang Jiao-jing Shao Guangmin Zhou School of Materials and Metallurgy Guizhou UniversityGuiyang550025China State Key Laboratory of Advanced Chemical Power Sources Zunyi563003China Graphene Materials Engineering Research Center of Guizhou Colleges and Universities Guiyang550025China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate Schoo Tsinghua UniversityShenzhen518055China

Solid polymer electrolytes(SPEs)are promising substitutes for current flammable liquid electrolytes to achieve high-safety and high-energy-density lithium metal *** oxide(PEO)based solid polymer electrolytes have attracted increasing attention because of their excellent flexibility,manufacturability,light weight,and low-cost processing,while they often suffer from low ionic con-ductivity at room temperature,low lithium transference number and unsatisfactory interfacial resis-tance,which largely restrain their practical ***,two-dimensional holey silica nanosheets(2D-HSN)as the fillers,together with liNO_(3) as the electrolyte additive,are introduced in a PEO/poly(-vinylidene fiuoride-co-hexafluoropropylene)(PVDF-HFP)blended polymer matrix to obtain a *** incorporation of HSN filler creates supplementary channels for lithium ion migration and lowers the crystallinity of the polymer,thereby facilitating the movement of lithium *** HSN-based SPE demonstrates higher ionic conductivity up to 3.7 x 10-4 S cm-1 at 30℃,larger li+transference number close to 0.34,and more stable lithium plating/stripping than that without the fillers,and HSN can promote the formation of more stable solid electrolyte interphase(SEI)*** as-assembled liFePO4||li batteries deliver a high specific capacity of 159 mA h g-1 with the capacity retention of 95.5%after 200 cycles at 30℃,as well as superior rate performance and cycling stability compared to that using the blank SPE.

关键词： Vermiculite nanosheets Two-dimensional silica Solid polymer electrolytes Fillerslithium metal batteries

Recovery and in-situ reduction of precious metals by graphdiyne and graphdiyne oxide for antibacterial use

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Rare Metals 2024年第4期43卷 1747-1757页

作者： Ming-Ji Jiang ya-Na Zhang ling-Shen Meng jing Kang Yong-Jun li Alideertu Dong College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot010021China Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityHohhot010021China Department of Chemistry University of ZurichCH-8057ZurichSwitzerland Laboratory of Organic Solids and Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing100190China

Based on the in-situ self-reduction and chemical stability,graphdiyne(GDY)and graphdiyne oxide(GDYO)are used as trapping agents to investigate the ability for recovering Au^(3+),Ag^+,and Pd^(2+)under different pH values and interfering *** strong acidity at pH=1,these two agents demonstrate high select recovery towards the three precious metal ions,which could be insitu reduced to nanoparticles(NPs).In addition,superparamagnetic Fe_(3)O_(4)NPs are deposited on the surfaces of GDY and *** magnetic responses enable GDYFe_(3)O_(4)to recover precious metals conveniently and efficiently by the aid of an external magnetic *** study also confirms the antibacterial activity of the as-recovered NPs deposited on GDY and GDYO against Escherichia coli and Staphylococcus aureus(1×10^(5)colony-forming unit(CFU)·mL^(-1)),and the antibacterial rates are 100%.This strategy of recovering precious metals and subsequently reusing to combat pathogens will be of great significance for environmental remediation and biomedical applications.

关键词： Graphdiyne In-situ reduction Recovery Precious metals Antibacterial