Association between brain N-acetylaspartate levels and sensory and motor dysfunction in patients who have spinal cord injury with spasticity:an observational case-control study

作     者：Jia-Yi Liu Ya-Jing Li Xin-Ying Cong Zuliyaer Talifu Xin Zhang Feng Gao Jian-Jun Li Jia-Yi Liu;Ya-Jing Li;Xin-Ying Cong;Zuliyaer Talifu;Xin Zhang;Feng Gao;Jian-Jun Li

作者机构：School of RehabilitationCapital Medical UniversityBeijingChina Department of Spinal and Neural Function ReconstructionChina Rehabilitation Research CenterBeijingChina China Rehabilitation Science InstituteBeijingChina Beijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and RepairBeijing Institute for Brain DisordersBeijingChina Rehabilitation DepartmentShanghai Huashan HospitalShanghaiChina Department of Medical ImagingChina Rehabilitation Research CenterBeijingChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第3期

页      面：582-586页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,Nos.82071400,81870979 the Scientific Research Foundation of China Rehabilitation Research Center,No.2020cz-01 the Special Capital Health Research and Development of China,No.2018-1-6011(all to JJL) 

主　　题：ASIA motor score ASIA sensory score basal ganglia central nervous system duration of injury magnetic resonance spectroscopy N-acetylaspartate precentral gyrus spasticity spinal cord injury 

摘      要：Spinal cord injury is a severe and devastating disease,and spasticity is a common and severe complication that is notoriously refractory to ***,the pathophysiological mechanisms underlying spasticity and its development remain largely *** goal of the present study was to find differences,if any,in metabolites of the left precentral gyrus and basal ganglia of patients who have spinal cord injury with or without spasticity,and to explore the relationship between the brain metabolite concentrations and clinical ***-six participants were recruited for magnetic resonance spectroscopic examination:23 with spinal cord injury(12 with spasticity and 11 without spasticity)and 13 healthy *** acquired localized proton spectra from the precentral gyrus and basal ganglia via 10 mm^(3) ***,univariate linear regression analysis demonstrated that the lower that the N-acetylaspartate concentration(a marker for neuronal loss)was in the precentral gyrus of the patients,the lower their ASIA(American Spinal Injury Association)light-touch scores,pinprick scores,and motor ***,longer durations of injury were associated with higher N-acetylaspartate levels in the precentral *** with the healthy participants and patients without spasticity,N-acetylaspartate levels in the patients with spasticity were significantly lower in both the precentral gyrus and basal *** N-acetylaspartate levels also correlated with greater sensory and motor dysfunction in the patients who had spinal cord injury with spasticity.