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EDDS对铅镉复合胁迫下黑麦草幼苗生理生化的影响

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高师理科学刊 2020年第5期40卷 61-66页

作者：温昱晨郝宇解琳张东向莫继先刘本松金忠民齐齐哈尔大学生命科学与农林学院黑龙江齐齐哈尔161006 海南地质综合勘察设计院海南海口570100

以黑麦草为实验材料,通过盆栽实验模拟不同质量浓度铅镉污染,添加不同浓度乙二胺二琥珀酸(EDDS)后测定黑麦草幼苗的超氧化物歧化酶(SOD)活性、过氧化物酶(POD)活性、过氧化氢酶(CAT)活性、叶绿素(CHL)含量的变化,探讨EDDS对不同质量浓... 详细信息

以黑麦草为实验材料,通过盆栽实验模拟不同质量浓度铅镉污染,添加不同浓度乙二胺二琥珀酸(EDDS)后测定黑麦草幼苗的超氧化物歧化酶(SOD)活性、过氧化物酶(POD)活性、过氧化氢酶(CAT)活性、叶绿素(CHL)含量的变化,探讨EDDS对不同质量浓度铅镉污染下黑麦草幼苗的影响.结果表明,黑麦草对铅镉有一定的抗性.在铅镉质量浓度分别为600,60 mg/kg时,施加2.4 mmol/kg的EDDS时,SOD和POD的活性达到最高;在铅镉质量浓度分别为600,60mg/kg时,施加1.2 mmol/kg的EDDS时,CAT的活性达到最高;在不同铅镉质量浓度下,随EDDS浓度的增加,黑麦草幼苗叶绿素的含量均呈逐渐减少的趋势;在铅镉质量浓度分别为600,60mg/kg,EDDS浓度为2.4 mmol/kg时,黑麦草幼苗叶绿素含量最少.因此,根据不同铅镉污染程度的土壤应选择相适应的EDDS浓度,才能有利于缓解铅镉对黑麦草幼苗的危害.

关键词：铅镉 EDDS 黑麦草幼苗生理生化

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钴纳米环层叠阵列的厚度对磁特性的影响

计算物理 2024年第2期41卷 232-238页

作者：黄倩南何雨洁范春龙温昌林薛宇宸陈水源黄志高叶晴莹福建师范大学物理与能源学院福建福州350117 福建半导体光电材料及其高效转换器件协同创新中心福建厦门361005

基于蒙特卡罗(MC)方法与快速傅里叶变换微磁学(FFTM)方法,模拟不同厚度层叠阵列钴纳米环的磁化动力学特征。研究发现:厚度不同的钴纳米环的磁滞回线均出现“双稳态”特征,且系统的“涡旋态”的形成及稳定性与厚度明显相关。进一步研究表... 详细信息

基于蒙特卡罗(MC)方法与快速傅里叶变换微磁学(FFTM)方法,模拟不同厚度层叠阵列钴纳米环的磁化动力学特征。研究发现:厚度不同的钴纳米环的磁滞回线均出现“双稳态”特征,且系统的“涡旋态”的形成及稳定性与厚度明显相关。进一步研究表明:纳米环层叠阵列的厚度对系统达到饱和所需要的外磁场有较大的影响,磁滞回线的台阶宽度ΔH_(fc)也与厚度相关,模拟结果与实验事实接近。

关键词：蒙特卡罗方法快速傅里叶变换微磁学方法纳米环层叠阵列厚度磁特性

Recent advances in bacterial therapeutics based on sense and response

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1014-1027页

作者： Zhuo Feng yuchen Wang Haiheng Xu Yunfei Guo wen Xia Chenxuan Zhao Xiaozhi Zhao Jinhui Wu State Key Laboratory of Pharmaceutical Biotechnology Chemistry and Biomedicine Innovation CenterMedical School of Nanjing UniversityNanjing 210093China Jiangsu Key Laboratory for Nano Technology Nanjing UniversityNanjing 210093China Department of Andrology Drum Tower HospitalMedical School of Nanjing UniversityNanjing 210093China

Intelligent drug delivery is a promising strategy for cancer *** recent years,with the rapid development of synthetic biology,some properties of bacteria,such as gene operability,excellent tumor colonization ability,and host-independent structure,make them ideal intelligent drug carriers and have attracted extensive *** implanting condition-responsive elements or gene circuits into bacteria,they can synthesize or release drugs by sensing ***,compared with traditional drug delivery,the usage of bacteria for drug loading has better targeting ability and controllability,and can cope with the complex delivery environment of the body to achieve the intelligent delivery of *** review mainly introduces the development of bacterial-based drug delivery carriers,including mechanisms of bacterial targeting to tumor colonization,gene deletions or mutations,environment-responsive elements,and gene ***,we summarize the challenges and prospects faced by bacteria in clinical research,and hope to provide ideas for clinical translation.

关键词： Cancer therapy Bacterial drug delivery system Synthetic biology Responsive elements Gene circuits Intelligential delivery

Internet of Things Intrusion Detection System Based on Convolutional Neural Network

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计算机、材料和连续体（英文） 2023年第4期75卷 2119-2135页

作者： Jie Yin Yuxuan Shi wen Deng Chang Yin Tiannan Wang yuchen Song Tianyao Li Yicheng Li Department of Computer Information and Cyber Security Jiangsu Police InstituteNanjingChina Engineering Research Center of Electronic Data Forensics Analysis NanjingChina Key Laboratory of Digital Forensics Department of Public Security of Jiangsu ProvinceNanjingChina

In recent years, the Internet of Things (IoT) technology has developedby leaps and bounds. However, the large and heterogeneous networkstructure of IoT brings high management costs. In particular, the low costof IoT devices exposes them to more serious security concerns. First, aconvolutional neural network intrusion detection system for IoT devices isproposed. After cleaning and preprocessing the NSL-KDD dataset, this paperuses feature engineering methods to select appropriate features. Then, basedon the combination of DCNN and machine learning, this paper designs acloud-based loss function, which adopts a regularization method to preventoverfitting. The model consists of one input layer, two convolutional layers,two pooling layers and three fully connected layers and one output ***, a framework that can fully consider the user’s privacy protection isproposed. The framework can only exchange model parameters or intermediateresults without exchanging local individuals or sample data. This paperfurther builds a global model based on virtual fusion data, so as to achievea balance between data privacy protection and data sharing computing. Theperformance indicators such as accuracy, precision, recall, F1 score, and AUCof the model are verified by simulation. The results show that the model ishelpful in solving the problem that the IoT intrusion detection system cannotachieve high precision and low cost at the same time.

关键词： Internet of things intrusion detection system convolutional neural network federated learning

Bottlebrush inspired injectable hydrogel for rapid prevention of postoperative and recurrent adhesion

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Bioactive Materials 2022年第10期7卷 27-46页

作者： Jushan Gao Jinpeng wen Datao Hu Kailai Liu yuchen Zhang Xinxin Zhao Ke Wang School of Pharmacy Health Science CenterXi’an Jiaotong UniversityXi’an710061China

Postsurgical adhesion is a common clinic disease induced by surgical trauma,accompanying serious subsequent *** non-surgical approaches of drugs treatment and biomaterial barrier administration only show limited prevention effects and couldn’t effectively promote peritoneum ***,inspired by bottlebrush,a novel self-fused,antifouling,and injectable hydrogel is fabricated by the free-radical polymerization in aqueous solution between the methacrylate hyaluronic acid(HA-GMA)and N-(2-hydroxypropyl)methacrylamide(HPMA)monomer without any chemical crosslinkers,termed as H-HPMA *** H-HPMA hydrogel can be tuned to perform excellent self-fused properties and suitable abdominal metabolism ***,the introduction of the ultra-hydrophilic HPMA chains to the H-HPMA hydrogel affords an unprecedented antifouling *** HPMA chains establish a dense hydrated layer that rapidly prevents the postsurgical adhesions and recurrent adhesions after adhesiolysis in *** H-HPMA hydrogel can repair the peritoneal wound of the rat model within 5 ***,an underlying mechanism study reveals that the H-HPMA hydrogel significantly regulated the mesothelial-to-mesenchymal transition(MMT)process dominated by the TGF-β-Smad2/3 signal ***,we developed a simple,effective,and available approach to rapidly promote peritoneum regeneration and prevent peritoneal adhesion and adhesion recurrence after adhesiolysis,offering novel design ideas for developing biomaterials to prevent peritoneal adhesion.

关键词： Bottlebrush polymer Rapid healing Antifouling MMT Postoperative adhesion prevention

Quantitative Evaluation of the Larval Density of Sea Potato Acaudina *** Mitochondrial Molecular Marker

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Journal of Ocean University of China 2021年第3期20卷 681-687页

作者： LI Xiang WANG Guilin LI Yunfan LIU Wei LU Chao GUO yuchen HUANG wen WANG Jinhui DONG Bo Laboratory for Morphogenesis&Evolution College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Ningde Marine Environment Monitoring Center Ningde 352100China Key Laboratory of Marine Ecological Monitoring and Restoration Technology Shanghai 200137China East China Sea Branch Ministry of Natural ResourcesShanghai 200137China

The sea potato Acaudina *** a species of sea cucumber,belonging to the class Holothuroidea under Phylum *** becomes blooming recently in the East Sea of China,causing serious ecological ***,until now there are no molecular data for its larval identification and population genetic *** this study,we firstly screened a mtDNA fragment and demonstrated that it was the species-specific molecular marker for the identification of Acaudina *** then developed a quantitative polymerase chain reaction(PCR)method to evaluate the larval density of Acaudina *** on this molecular *** this method,we examined 116 plankton samples collected in four seasons from 13 stations along the coastal region in Fu-jian province,*** results showed that the high larval density was presented at stations 1,2,and 3,which were near a quay in the *** larval density increased from April and reached the highest value in June and July,suggesting temperature might be the main environmental factor on the effects of its population distribution and *** work provides an important molecular tool for species identification and risk evaluation of a potentially invasive species.

关键词： Acaudina spp. sea potato larval density population distribution molecular marker

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缝洞型油藏裂缝中泡沫辅助气驱运移特征

石油科学通报 2019年第3期4卷 300-309页

作者：屈鸣侯吉瑞闻宇晨梁拓马什希杨景斌中国石油大学(北京)非常规油气科学技术研究院北京102249 中国石油大学(北京)石油工程教育部重点实验室北京102249

泡沫辅助气驱是缝洞型油藏极具潜力的提高采收率技术。裂缝作为缝洞型油藏流体的主要流动通道,在岩溶成藏过程中以“等径”和“变径”形式发育。为了系统地研究泡沫辅助气驱在缝洞型碳酸盐岩油藏裂缝介质中的流动特征及驱油效果,本文设... 详细信息

泡沫辅助气驱是缝洞型油藏极具潜力的提高采收率技术。裂缝作为缝洞型油藏流体的主要流动通道,在岩溶成藏过程中以“等径”和“变径”形式发育。为了系统地研究泡沫辅助气驱在缝洞型碳酸盐岩油藏裂缝介质中的流动特征及驱油效果,本文设计了不同开度的等径、变径裂缝相似模型和微观可视化模型,开展泡沫辅助气驱物理模拟实验。结果表明:小开度裂缝中,泡沫辅助气驱容易形成气液段塞,气体被微小压缩后易突破泡沫段塞形成气体优势通道;大开度裂缝中,泡沫以多个微小段塞的形式堆积,产生堆积叠加效应,驱油效果优于比小开度裂缝;在变开度裂缝中,泡沫段塞随裂缝开度变化而发生形变,泡沫堆积程度越高,则稳定性越强,提高采收率效果越好。泡沫前缘有4种类型:微尺度泡沫伴随堆积型、小尺度泡沫堆积型、中尺度泡沫轻微变形型、大尺度泡沫严重变形型,它们的稳定性依次递减。在亲油性裂缝中,泡沫前缘气液界面的流动基本符合Poiseuille速度分布,随着弯曲液面附加压力不平衡逐渐加剧,气相逐渐突破气液界面的趋势明显。

关键词：可视化模型缝洞型油藏裂缝开度泡沫驱

2014—2021年北京市丰台区主要慢性病早死概率及早死寿命损失分析

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职业与健康 2024年第13期40卷 1793-1799页

作者：武宇晨信振江肖文陈黎黎马健桐谢俊卿北京市丰台区疾病预防控制中心信息科北京100070

目的分析2014—2021年北京市丰台区4类慢性病(心脑血管疾病、恶性肿瘤、慢性呼吸系统疾病及糖尿病,以下称主要慢性病)死亡率、早死概率及其变化趋势,为北京市丰台区慢性病防控提供数据支持。方法计算2014—2021年北京市丰台区户籍居民... 详细信息

目的分析2014—2021年北京市丰台区4类慢性病(心脑血管疾病、恶性肿瘤、慢性呼吸系统疾病及糖尿病,以下称主要慢性病)死亡率、早死概率及其变化趋势,为北京市丰台区慢性病防控提供数据支持。方法计算2014—2021年北京市丰台区户籍居民主要慢性病粗死亡率、标化死亡率、早死概率、减寿年数等指标,结合Joinpoint回归模型计算平均年度变化百分比(average annual percent change,AAPC)计算早死概率的平均增长速度,并以2025年和2030年的控制目标作为标准,预测和评估主要慢性病早死概率是否达标。结果2014—2021年北京市丰台区30~69岁人群主要慢性病粗死亡率呈上升趋势(AAPC=1.63%,P0.05),女性主要慢性病早死概率呈下降趋势(AAPC=-4.97%,P<0.05)。相同年份中,男性主要慢性病早死概率高于女性,恶性肿瘤和心脑血管疾病的早死概率高于慢性呼吸系统疾病和糖尿病。2014—2021年北京市丰台区30~69岁户籍居民因主要慢性病共造成潜在寿命损失(potential years of life lost,PYLL)379806.13人年,同一年份相同主要慢性病,男性的PYLL均高于女性;2014—2021年北京市丰台区30~69岁户籍居民主要慢性病的平均寿命损失(average years of life lost,AYLL)为22.47年,同一年份相同主要慢性病,女性的AYLL均高于男性。按照2014—2021年北京市丰台区早死概率的年均变化速度,2025年女性早死概率的预测值可达到“2025年慢性病中长期规划”目标值的要求,女性2030年早死概率的预测值可达到“健康中国2030”目标值的要求。全人群早死概率2030年的预测值可达到“健康北京2030”目标值的要求。结论男性是北京市丰台区主要慢性病的重点干预人群,应做好相关危险因素的监测和干预,降低早死概率。2014—2021年北京市丰台区30~69岁户籍居民主要慢性病的AYLL女性高于男性,应重点关注低年龄组女性。

关键词：主要慢性病早死概率早死寿命损失

An Improved Method for the Extraction of the X—Ray Absorption Atomic Background at the Zr K—Edge

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同步辐射装置用户科技论文集 1998年第1期 1-7页

作者： wen－CAIWANG yuchen