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Efficacy of substances containing 3 types of active ingredients-saponins, flavones, and alkaloids in regulation of cytokines in autoimmune diseases a systematic review and Meta-analysis based on animal studies

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Journal of Traditional Chinese Medicine 2024年第3期44卷 417-426页

作者： ZHU Ruifang ZHANG Jun LYU Yaru chen yulu HAN Shifan WANG Hongwei Key Laboratory for Molecular Diagnosis and Treatment of Hematologic Diseases Second Hospital of Shanxi Medical UniversityShanxi 030001China School of Nursing Shanxi Medical UniversityShanxi 030001China Editorial Office First Hospital of Shanxi Medical UniversityShanxi 030001China

OBJECTIVE: To investigate the efficacy of substances containing 3 types of active ingredients-saponins,flavones, and alkaloids on experimental animals with autoimmune diseases(AIDs).METHODS: The protocol for this systematic review and Meta-analysis was prospectively registered with PROSPERO(CRD42023395741). Searches were conducted in the China National Knowledge Infrastructure, Wanfang, Chinese Science and Technology Journals, China Biomedical, Pub Med,Cochrane Library, and Embase databases to screen for animal studies investigating the therapeutic effects of saponins, flavones, or alkaloids on autoimmune diseases;consequently, corresponding data extraction tables were prepared. Systematic Review Centre for Laboratory Animal Experimentation was used to assess the risk of methodological bias in the included literature. RevMan 5.4 was used for the Meta-analysis on the 8 serum ***: A total of 31 studies were included, all of which were randomized controlled studies. Meta-analysis indicated that substances rich in saponins, flavones, and alkaloids reduced serum levels of interleukin(IL)-1β[standardized mean difference(SMD) =-1.94, 95%confidence interval(CI)(-2.99,-0.90), P = 0.0003], IL-6 [SMD =-1.65, 95% CI(-2.33,-0.97,) P < 0.000 01],IL-17 [SMD =-2.41, 95% CI(-3.61,-1.20), P <0.0001], tumor necrosis factor(TNF)-α [SMD =-1.84, 95%CI(-2.61,-1.06), P < 0.0001], and interferon(IFN)-γ[SMD =-1.54, 95% CI(-2.43,-0.65), P = 0.0007], but increased serum levels of IL-4 [SMD = 1.30, 95% CI(0.15,2.44), P = 0.03) and IL-10 [SMD = 2.05, 95% CI(1.39,2.70), P < 0.000 01) in animal models. However, no significant regulatory effect of these three active components was observed on serum levels of IL-2 [SMD =-0.63, 95% CI(-1.82, 0.57), P = 0.30].CONCLUTIONS: Substances containing saponins,flavones, and alkaloids regulated the changes of immunerelated cytokines, it may be a novel dietary substance to relieve and control autoimmune diseases in the future.

关键词： autoimmune diseases saponins flavones alkaloids system evaluation Meta-analysis

Optical manipulation of ratio-designable Janus microspheres

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Photonics Research 2024年第6期12卷 1239-1249页

作者： yulu chen CONG ZHAI XIAOQING GAO HAN WANG ZUZENG LIN XIAOWEI ZHOU CHUNGUANG HU State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China

Angular optical trapping based on Janus microspheres has been proven to be a novel method to achieve controllable *** contrast to natural birefringent crystals,Janus microspheres are chemically synthesized of two compositions with different refractive ***,their structures can be artificially regulated,which brings excellent potential for fine and multi-degree-of-freedom manipulation in the optical ***,it is a considerable challenge to model the interaction of heterogeneous particles with the optical field,and there has also been no experimental study on the optical manipulation of microspheres with such designable refractive index *** the specific structure affects the kinematic properties of Janus microspheres remains ***,we report systematic research on the optical trapping and rotating of various ratio-designable Janus *** employ an efficient T-matrix method to rapidly calculate the optical force and torque on Janus microspheres to obtain their trapped postures and rotational characteristics in the optical *** have developed a robust microfluidic-based scheme to prepare Janus *** experimental results demonstrate that within a specific ratio range,the rotation radii of microspheres vary linearly and the orientations of microsphere are always aligned with the light polarization *** is of great importance in guiding the design of Janus *** their orientations flip at a particular ratio,all consistent with the *** work provides a reliable theoretical analysis and experimental strategy for studying the interaction of heterogeneous particles with the optical field and further expands the diverse manipulation capabilities of optical tweezers.

关键词： polarization ratio refractive

Chlorfenapyr poisoning:mechanisms,clinical presentations,and treatment strategies

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World Journal of Emergency Medicine 2024年第3期15卷 214-219页

作者： Ji cheng yulu chen Weidong Wang Xueqi Zhu Zhenluo Jiang Peng Liu Liwen Du Emergency Department Ningbo No.2 HospitalNingbo 315010China

BACKGROUND:Chlorfenapyr is used to kill insects that are resistant to organophosphorus *** poisoning has a high mortality rate and is difficult to *** article aims to review the mechanisms,clinical presentations,and treatment strategies for chlorfenapyr *** RESOURCES:We conducted a review of the literature using PubMed,Web of Science,and SpringerLink from their beginnings to the end of October *** inclusion criteria were systematic reviews,clinical guidelines,retrospective studies,and case reports on chlorfenapyr poisoning that focused on its mechanisms,clinical presentations,and treatment *** references in the included studies were also examined to identify additional ***:We included 57 studies in this *** can be degraded into tralopyril,which is more toxic and reduces energy production by inhibiting the conversion of adenosine diphosphate to adenosine *** fever and altered mental status are characteristic clinical presentations of chlorfenapyr *** it occurs,respiratory failure occurs immediately,ultimately leading to cardiac arrest and *** poisoning is diflcult to treat,and there is no specific ***:Chlorfenapyr is a new pyrrole *** it has been identified as a moderately toxic pesticide by the World Health Organization(WHO),the mortality rate of poisoned patients is extremely *** is no specific antidote for chlorfenapyr ***,based on the literature review,future efforts to explore rapid and effective detoxification methods,reconstitute intracellular oxidative phosphorylation couplings,identify early biomarkers of chlorfenapyr poisoning,and block the conversion of chlorfenapyr to tralopyril may be helpful for emergency physicians in the diagnosis and treatment of this disease.

关键词： Chlorfenapyr poisoning Mechanism Clinical presentation Treatment

Numerical study on gas production via a horizontal well from hydrate reservoirs with different slope angles in the South China Sea

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Deep Underground Science and Engineering 2024年第2期3卷 171-181页

作者： Tingting Luo Jianlin Song Xiang Sun Fanbao cheng Madhusudhan Bangalore Narasimha Murthy yulu chen Yi Zhao Yongchen Song School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhouChina Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhanChina Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education Dalian University of TechnologyDalianChina Faculty of Engineering and the Environment University of SouthamptonSouthamptonUK

It is important to study the effect of hydrate production on the physical and mechanical properties of low-permeability clayey–silty reservoirs for the largescale exploitation of hydrate reservoirs in the South China *** this study,a multiphysical-field coupling model,combined with actual exploration drilling data and the mechanical experimental data of hydrate cores in the laboratory,was established to investigate the physical and mechanical properties of low-permeability reservoirs with different slope angles during 5-year hydrate production by the depressurization method via a horizontal *** result shows that the permeability of reservoirs severely affects gas production rate,and the maximum gas production amount of a 20-m-long horizontal well can reach186.8 m3/day during the 5-year hydrate *** with smaller slope angles show higher gas production *** depressurization propagation and hydrate dissociation mainly develop along the direction parallel to the ***,the mean effective stress of reservoirs is concentrated in the near-wellbore area with the on-going hydrate production,and gradually decreases with the increase of the slope *** from the effective stress distribution law,the total reservoir settlement amount first decreases and then increases with the increase of the slope *** maximum settlement of reservoirs with a 0°slope angle is up to 3.4 m,and the displacement in the near-wellbore area is as high as2.2 m after 5 years of hydrate *** is concluded that the pore pressure drop region of low-permeability reservoirs in the South China Sea is limited,and various slope angles further lead to differences in effective stress and strain of reservoirs during hydrate production,resulting in severe uneven settlement of reservoirs.

关键词： effective stress low‐permeability reservoirs natural gas hydrate production numerical simulation settlement slope angle the South China

基于孔压静力触探的大直径单桩p-y曲线分析

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水利水电技术（中英文） 2024年第8期55卷 141-151页

作者：陈雨露欧阳仲坤郑向远清华大学深圳国际研究生院广东深圳518055

【目的】水平受荷桩的p-y曲线法已广泛用于描述桩-土相互作用并预测桩在水平荷载下的行为,特别是在海上风电机大直径单桩的理论分析中。孔压静力触探试验(piezocone penetration test,简称CPTu)作为一种效率高、精确度好的原位测试手段... 详细信息

【目的】水平受荷桩的p-y曲线法已广泛用于描述桩-土相互作用并预测桩在水平荷载下的行为,特别是在海上风电机大直径单桩的理论分析中。孔压静力触探试验(piezocone penetration test,简称CPTu)作为一种效率高、精确度好的原位测试手段,克服了传统室内试验获得土工参数的过程中土样存在扰动、结果准确性较差的缺点。该试验可以通过测量三个基本参数(修正锥尖阻力qt、侧壁摩阻力fs以及孔隙水压力u2)随深度变化的连续剖面来解译土体的物理力学参数,从而在p-y曲线模型的建立中提供关键数据。【方法】利用渤海海域某场区的CPTu数据,完成了以下研究任务:(1)基于CPTu触探响应结果,对该场区海洋土体进行分类,以及物理与力学参数的反演,包括土体密度、弹性模量、有效内摩擦角及有效黏聚力;(2)将CPTu反演参数代入三维有限元分析模型中,模拟直径为5 m的钢管桩在最大荷载为20 MN时的水平受荷响应;(3)基于CPTu测试数据,提出一套土抗力计算公式;(4)将现有p-y曲线模型中相关参数通过CPTu触探响应结果进行反演,之后对比分析上述p-y曲线模型。【结果】形成了一套基于CPTu且适用于土体分层情况较为复杂的p-y曲线公式,该公式与有限元方法对比结果良好。【结论】结果表明,提出的基于CPTu的土抗力公式经过有限元模拟检验后能快速、准确地反映大直径单桩的水平受荷响应。该公式不仅为渤海海域内大直径单桩的工程实践提供了有力的理论支持,还为相似海洋环境的工程设计与分析提供了完全基于CPTu研究大直径单桩的新思路。

关键词： p-y曲线静力触探试验有限元方法水平受荷桩大直径单桩土抗力土体有效应力参数力学性能

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光伏-绿化复合屋面的研究现状与展望

太阳能学报 2024年第9期45卷 251-258页

作者：何旸于航陈雨露孟二林东华大学环境科学与工程学院上海201620 同济大学机械与能源工程学院上海201804 日本九州大学人间环境学府福冈819-0395 苏州科技大学环境科学与工程学院苏州215009

从屋面热湿环境和植被状态、光伏发电效率、水分平衡、能量平衡与热过程模型4个方面对光伏-绿化复合屋面的研究现状进行阐述。结果表明不同气候和空间配置条件下,光伏组件与植被间的相互作用存在动态变化,导致屋面综合性能存在一定的不... 详细信息

从屋面热湿环境和植被状态、光伏发电效率、水分平衡、能量平衡与热过程模型4个方面对光伏-绿化复合屋面的研究现状进行阐述。结果表明不同气候和空间配置条件下,光伏组件与植被间的相互作用存在动态变化,导致屋面综合性能存在一定的不确定性。最后对光伏-绿化复合屋面工程应用中面临的挑战以及未来的研究方向进行分析和展望,并指出掌握光伏组件与植被之间的相互作用机理是准确预测与优化光伏-绿化复合屋面综合性能的关键。

关键词：光伏组件植被传热性能发电效率水分与能量平衡

长牡蛎壳橙性状遗传参数评估及与生长性状的关联性

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水产学报 2024年第1期48卷 123-131页

作者：陈雨露徐成勋刘士凯孔令锋李琪中国海洋大学海水养殖教育部重点实验室青岛海洋科学与技术试点国家实验室海洋渔业科学与食物产出过程功能实验室

长牡蛎壳橙快速生长品系是结合群体选育与种内群体间杂交方法，以壳色性状和生长性状为选育指标，经过连续3代选育获得的新品系。本研究以第1代长牡蛎壳橙快速生长品系(G1)为亲本，采用巢式设计建立了48个混养家系，共获得863个个体。... 详细信息

长牡蛎壳橙快速生长品系是结合群体选育与种内群体间杂交方法，以壳色性状和生长性状为选育指标，经过连续3代选育获得的新品系。本研究以第1代长牡蛎壳橙快速生长品系(G1)为亲本，采用巢式设计建立了48个混养家系，共获得863个个体。利用微卫星标记对混养家系进行了系谱分析，并基于REML法评估了长牡蛎壳橙快速生长品系壳色性状的遗传参数及与生长性状的相关性。结果显示，863个个体中，有851个个体被准确鉴定其所属家系；长牡蛎壳橙快速生长品系壳色性状颜色参数指标a*(红绿轴色品指数)、b*(黄蓝轴色品指数)和ΔE (色差)等均具中高等遗传力，大小依次为0.47±0.23、0.42±0.21和0.56±0.29。4个颜色参数指标间的遗传相关和表型相关范围分别为-0.79～0.86和-0.45～0.48。壳色性状与各生长性状的遗传相关和表型相关较低，分别为-0.33～0.17和-0.04～0.11。研究表明，在长牡蛎壳橙快速生长品系育种过程中，对壳色性状进行选育可以得到预期的改良效果。此外，壳橙性状与生长性状应分别作为目标性状进行协同选择，以实现同时改良两个性状的目的。本研究可为长牡蛎壳橙快速生长品系选育提供基础资料。

关键词：长牡蛎壳色生长性状微卫星遗传参数

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护士工作场所语言暴力的概念分析

军事护理 2024年第10期41卷 26-30页

作者：齐建伟陈丽娟陈宇露赵庆华重庆医科大学附属第一医院急诊医学科重庆400016 重庆医科大学护理学院重庆400016 重庆医科大学附属第一医院护理部

目的分析并阐明护士工作场所语言暴力的概念内涵,为开发相应的测评工具、开展干预研究提供参考。方法系统检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、CINAHL、Embase、Web of Science和PsycINFO数据库中护士工作场... 详细信息

目的分析并阐明护士工作场所语言暴力的概念内涵,为开发相应的测评工具、开展干预研究提供参考。方法系统检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、CINAHL、Embase、Web of Science和PsycINFO数据库中护士工作场所语言暴力的相关研究,检索时限为建库至2023年8月。应用Walker和Avant概念分析法对纳入文献进行分析。结果护士工作场所语言暴力包括工作关系、言语性、伤害性等3个概念属性;前因包括施暴者因素、工作环境因素、政策及医院管理因素;后果包括影响护士的身心健康、影响护理质量及患者安全、影响护理队伍的稳定性。结论通过概念分析明确了护士工作场所语言暴力的概念属性,未来研究可结合护士工作场所语言暴力的概念内涵,对其进行多层次、多角度的研究。

关键词：护士工作场所暴力语言暴力概念分析

成渝地区双城经济圈经济空间格局演变研究——基于产业空间联系视角

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现代城市研究 2024年第3期39卷 47-53页

作者：张扬陈雨露王兴平李娟东南大学建筑学院自然资源部国土空间智能规划技术重点实验室成都理工大学地理与规划学院成都市经济发展研究院

文章从产业空间联系视角出发,基于投入产出模型测算成渝地区双城经济圈各城市的产业发展对外辐射能力,并应用引力模型和社会网络分析法研究2010年、2020年产业空间联系强度空间格局及演变特征。研究结果表明:(1)重庆市、成都市产业发展... 详细信息

文章从产业空间联系视角出发,基于投入产出模型测算成渝地区双城经济圈各城市的产业发展对外辐射能力,并应用引力模型和社会网络分析法研究2010年、2020年产业空间联系强度空间格局及演变特征。研究结果表明:(1)重庆市、成都市产业发展对外辐射能力和对外联系强度最大,且在研究期内提升幅度较大,14个地级市之间产业发展层级结构不明显;(2)产业空间联系网络表现为以重庆市、成都市为核心区,以14个地级市为边缘区的核心—边缘结构,且在研究期内重庆市、成都市的中心性得到加强;(3)在研究期内成渝地区双城经济圈经济一体化发展格局初步形成。在此基础上,从提升产业空间联系的角度给出促进成渝地区双城经济圈经济空间格局优化的相关对策建议。

关键词：成渝地区双城经济圈产业空间联系投入产出模型引力模型社会网络分析