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miR-103-3p regulates the differentiation of bone marrow mesenchymal stem cells in myelodysplastic syndrome

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BIOCELL 2023年第1期47卷 133-141页

作者： NINGYU LI XIAOFANG CHEN SUXIA GENG PEILONG LAI LISI HUANG MINMING LI XIN HUANG CHENGXIN DENG yulian wang JIANYU WENG XIN DU School of Medicine South China University of TechnologyGuangzhou510006China Department of Hematology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of Hematology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou510180China

The pathogenesis of myelodysplastic syndrome(MDS)may be related to the abnormal expression of microRNAs(miRNAs),which could influence the differentiation capacity of mesenchymal stem cells(MSCs)towards adipogenic and osteogenic *** this study,exosomes from bone marrow plasma were successfully extracted and *** of miR-103-3p expression in exosomes isolated from BM in 34 MDS patients and 10 controls revealed its 0.52-fold downregulation in patients with MDS compared with controls(NOR)and was downregulated 0.55-fold in MDS-MSCs compared with *** of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro,while inhibition of miR-103-3p showed the opposite results in ***,the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs,significantly impacting MDS-MSCs *** miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation,thereby providing possible target for the treatment of MDS pathogenesis.

关键词： Myelodysplastic syndrome Mesenchymal stem cells miR-103-3p Osteogenic differentiation Adipogenic differentiation

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四苯基甲烷球磨法合成多孔碘蒸气吸附材料

中国粉体技术 2024年第3期30卷 158-169页

作者：张承昕王余莲苏峻樟董春阳王浩然肖坤富袁志刚苏德生沈阳理工大学材料科学与工程学院辽宁沈阳110159 辽宁丹炭科技集团有限公司辽宁丹东118100 辽宁省超高功率石墨电极材料专业技术创新中心辽宁丹东118100

【目的】避免在核能利用过程中产生的常见放射性污染核素129I和131I等碘蒸气泄漏对环境和生物产生危害,制备并探讨具有丰富孔道的有机多孔聚合物对碘蒸气的吸附性能。【方法】采用简便快捷的机械合成法,以具有正四面体结构的四苯基甲烷... 详细信息

【目的】避免在核能利用过程中产生的常见放射性污染核素129I和131I等碘蒸气泄漏对环境和生物产生危害,制备并探讨具有丰富孔道的有机多孔聚合物对碘蒸气的吸附性能。【方法】采用简便快捷的机械合成法,以具有正四面体结构的四苯基甲烷为单体,利用高能行星式球磨机球磨2 h制备3种具有较大比表面积和丰富孔道的有机多孔聚合物T-FDA、T-DCM和T-DCE,并利用碘单质在温度为75℃的密闭体系内升华模仿放射性碘蒸气,分别测试3种多孔材料的碘蒸气吸附性能。【结果】T-FDA、T-DCM、T-DCE的碘蒸气吸附质量分数分别可达461%、486%、444%,达到饱和吸附量的时间分别为5、8、6 h,且多孔材料在循环使用5次后碘吸附性能仅有轻微下降(≤6.8%)。【结论】以四苯基甲烷为单体,通过快速球磨法合成的多孔材料具有良好的碘蒸气吸附性能,有望在放射性碘蒸气吸附领域发挥重要作用。

关键词：四苯基甲烷球磨法有机多孔材料碘蒸气吸附

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Revealing the anti-sintering phenomenon on silica-supported nickel catalysts during CO_(2)hydrogenation

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Journal of Environmental Sciences 2024年第6期140卷 270-278页

作者： Liuqingqing Yang Tiancheng Pu Feixiang Tian yulian He Minghui Zhu State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The CO_(2)catalytic hydrogenation represents a promising approach for gas-phase CO_(2)utilization in a direct *** to its excellent hydrogenation ability,nickel has been widely studied and has shown good activities in CO_(2)hydrogenation reactions,in addition to its high availability and low ***,Ni-based catalysts are prone to sintering under elevated temperatures,leading to unstable catalytic *** the present study,various characterization techniques were employed to study the structural evolution of Ni/SiO_(2)during CO_(2)*** anti-sintering phenomenon is observed for both 9%Ni/SiO_(2)and 1%Ni/SiO_(2)during CO_(2)hydrogenation at 400℃.Results revealed that Ni species were re-dispersed into smaller-sized nanoparticles and formed Ni^(0)active *** interestingly,this anti-sintering phenomenon leads to distinct outcomes for two catalysts,with a gradual increase in both reactivity and CH_(4)selectivity for 9%Ni/SiO_(2)presumably due to the formation of abundant surface Ni°from redispersion,while an apparent decreasing trend of CH_(4)selectivity for 1%Ni/SiO_(2)sample,presumably due to the formation of ultra-small nanoparticles that diffuse and partially filled the mesoporous pores of the silica support over ***,the redispersion phenomenon was found relevant to the H_(2)gas in the reaction environment and enhanced as the H_(2)concentration *** finding is believed to provide in-depth insights into the structural evolution of Ni-based catalysts and product selectivity control in CO_(2)hydrogenation reactions.

关键词： Carbon dioxide utilization CO_(2)hydrogenation Nickel-based catalysts Anti-sintering Structural evolution

Mechanistic understanding of Cu-based bimetallic catalysts

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Frontiers of Chemical Science and Engineering 2020年第5期14卷 689-748页

作者： You Han yulian wang Tengzhou Ma Wei Li Jinli Zhang Minhua Zhang School of Chemical Enginering and Technology Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin UniversityTianjin 300072China School of Chemistry and Chemical Engineering Shihezi UniversityShihezi 832003China Key Laboratory for Green Chemical Technology of Ministry of Education Research and Development Center for Petrochemical TechnologyTianjin UniversityTianjin 300072China

Copper has received extensive attention in the field of catalysis due to its rich natural reserves,low cost,and superior catalytic ***,we reviewed two modification mechanisms of co-catalyst on the coordination environment change of Cu-based catalysts:(1)change the electronic orbitals and geometric structure of Cu without any catalytic functions;(2)act as an additional active site with a certain catalytic function,as well as their catalytic mechanism in major reactions,including the hydrogenation to alcohols,dehydrogenation of alcohols,water gas shift reaction,reduction of nitrogenous compounds,electrocatalysis and *** influencing mechanisms of different types of auxiliary metals on the structure-activity relationship of Cu-based catalysts in these reactions were especially summarized and *** mechanistic understanding can provide significant guidance for the design and controllable synthesis of novel Cu-based catalysts used in many industrial reactions.

关键词： copper bimetallic catalyst coordination modification mechanism catalytic application

The“depict”strategy for discovering new compounds in complex matrices:Lycibarbarspermidines as a case

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Journal of Pharmaceutical Analysis 2024年第3期14卷 416-426页

作者： Chen Han Zhixin Zhang Zhiyang Feng Chuanjia Zhai Xuejiao Li yulian Shi Xiang Li Miao Li Ying wang Gan Luo Xiaoyan Gao Department of Chinese Medicine Analysis School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China

The comprehensive detection and identification of active ingredients in complex matrices is a crucial *** chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex ***,the LC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 *** are vital antioxidant active ingredients in Lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low *** comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this ***,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine ***,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target ***,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of ***,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly *** on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from Lycii Fructus,and in particular,170 potential new compounds were structurally *** integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds.

关键词： Mass spectrometric detection Weak response signals Complex matrices Novel lycibarbarspermidines

基于BP神经网络的三水碳酸镁晶须制备工艺优化

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中国粉体技术 2024年第1期30卷 103-113页

作者：于雨王余莲朱益斌张一帆李克卿关蕊孙浩然韩会丽袁志刚沈阳理工大学材料科学与工程学院辽宁沈阳110159

【目的】为了得到更大长径比的三水碳酸镁晶须,基于反向传播(back-propagation,BP)神经网络方法对三水碳酸镁的制备工艺进行优化。【方法】以菱镁矿为原料,MgCl_(2)为添加剂,采用正交试验和BP神经网络相结合的方法,对三水碳酸镁制备工... 详细信息

【目的】为了得到更大长径比的三水碳酸镁晶须,基于反向传播(back-propagation,BP)神经网络方法对三水碳酸镁的制备工艺进行优化。【方法】以菱镁矿为原料,MgCl_(2)为添加剂,采用正交试验和BP神经网络相结合的方法,对三水碳酸镁制备工艺中的反应时间、反应温度、搅拌速率、pH和MgCl_(2)用量等条件进行优化。【结果】正交试验优化后的条件是反应时间为80 min,反应温度为40℃,搅拌速率为500 r/min,pH为7±0.1,MgCl_(2)质量浓度为0.5 g/L,可获得长径比约为20的三水碳酸镁晶须;BP神经网络优化后的条件是反应时间为86 min,反应温度为44℃,搅拌速率为760 r/min、pH为7,MgCl_(2)质量浓度为1.6 g/L,可获得长径比约为25的三水碳酸镁晶须。【结论】利用BP神经网络优化工艺参数能制备更大长径比的三水碳酸镁晶须,优于传统工艺方法。

关键词：菱镁矿反向传播神经网络三水碳酸镁晶须

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桑沟湾海域表层沉积物重金属含量和污染评价

海洋地质前沿 2023年第9期39卷 87-93页

作者：王敬韩忠王玉莲山东省第六地质矿产勘查院威海264209 山东省深部金矿探测大数据应用开发工程实验室威海264209

分析了山东省荣成市东部桑沟湾及邻近海域200个站位的表层沉积物样品重金属元素(As、Cd、Cr、Cu、Hg、Pb、Zn)含量分布特征,采用不同的评价方法,研究了重金属元素对环境的污染情况。结果表明,桑沟湾及邻近海域表层沉积物中多数重金属元... 详细信息

分析了山东省荣成市东部桑沟湾及邻近海域200个站位的表层沉积物样品重金属元素(As、Cd、Cr、Cu、Hg、Pb、Zn)含量分布特征,采用不同的评价方法,研究了重金属元素对环境的污染情况。结果表明,桑沟湾及邻近海域表层沉积物中多数重金属元素含量由湾内向周围降低,As、Cd、Cr、Cu、Hg、Pb、Zn平均含量分别为6.51、0.11、64.86、18.05、0.015、27.74、75.21μg/g。海底表层沉积物整体质量较好,重金属污染程度低,潜在生态风险程度低。

关键词：桑沟湾表层沉积物重金属污染评价

Continuous ambulatory peritoneal dialysis telemonitoring and education:A scoping review

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Journal of Integrative Nursing 2024年第1期6卷 62-68页

作者： Muhammad Syamsul BAKHRI yulian Wiji UTAMI Dina Dewi Sartika Lestari ISMAIL Nursing Department Faculty of Health SciencesBrawijaya UniversityMalangIndonesia Dialysis Department RSUD Dr.Saiful AnwarMalangIndonesia

The risk of peritonitis complications in continuous ambulatory peritoneal dialysis(CAPD)can be prevented or reduced by providing proper education and continuous *** and telemonitoring are methods that enable remote monitoring and patient *** study aimed to determine the success and factors affecting telemonitoring in CAPD patient *** study is a scoping review(ScR)using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-ScR *** searches were carried out on ProQuest,PubMed,and ScienceDirect with a time range of *** extraction was performed regarding knowledge level,quality of life,clinical outcomes(peritonitis),and risk of *** the 12 articles and studies included,6 articles were related to the effect of telemonitoring on CAPD patient outcomes,and 6 articles were associated with the effect of education on CAPD patient *** provided to patients can improve patient understanding of therapeutic modalities for renal disorders,reduce the potential for peritonitis and dialysis complications,and improve the quality of life of patients with *** patients who received telemonitoring had a better quality of life,good clinical outcomes,and a lower risk of hospitalization than those who did not receive telemonitoring and had fewer health-care *** summary,the implementation of telemonitoring and education in chronic kidney disease patients with CAPD modality therapy has been proven effective in improving quality of life and reducing dialysis-related risks.

关键词： Clinical outcome continuous ambulatory peritoneal dialysis education peritonitis quality of life telemonitoring chronic kidney disease

Effect and mechanism of ethanol extracts of muxiang(Radix Aucklandiae) on gastric ulcers in rats

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Journal of Traditional Chinese Medicine 2020年第1期40卷 59-66页

作者： Xu Yuannan Guo Peixin wang yulian Xia Tingting Shen Yue Zhang Qing Huang Jinhong Chen Haifeng Lei Na Xie Yuhuan School of Basic Medical Sciences Yunnan University of Chinese MedicineYunnan 650500China School of Traditional Chinese Pharmacy Yunnan University of Chinese MedicineYunnan 650500China School of Ethnic Medicine Yunnan University of Chinese MedicineYunnan 650500China International Education College Yunnan University of Chinese MedicineYunnan 650500China

OBJECTIVE:To investigate the effect of ethanol extracts of Muxiang(Radix Aucklandiae)(RA)on gastric ulcers in rats and explore the potential ***:A model was established by ethanol(0.75 m L/kg).According to body weight,rats were pretreated with RA extracts(2.5 or 5 g/kg).The rats were administered 95%ethanol orally after 1 *** effects of ethanol were evaluated by measuring the gastric secretion volume,p H,pepsin activity,and ulcer *** analysis and immunohistochemistry were also ***,the effect of the ethanol extract of RA on transiting activity of the gastrointestinal tract was observed in ***:Intragastric administration of RA extracts protected the gastric mucosa from ethanol-induced gastric ulcers,while reducing submucosal edema and preventing hemorrhagic ***,the extracts increased the production of gastric mucus,upregulated Bcl-2,and downregulated Bax ***,pretreated rats exhibited no significant change in the gastric secretion volume,gastric juice acidity,or ***,pretreatment prominently(P<0.05)enhanced propulsive movement of the gastrointestinal tract in normal mice and mice with gastrointestinal motility ***:Ethanol extracts of RA ameliorated gastric lesions in the gastric ulcer rat *** mechanisms of action were related to improvement of gastrointestinal dynamics,maintenance of mucus integrity,and inhibition of apoptosis by downregulating proapoptotic Bax protein and upregulating anti-apoptotic Bcl-2 protein.

关键词： Stomach ulcer Gastric mucosa Apoptosis Genes,Bcl-2 Gastrointestinal dynamics Muxiang(Radix Aucklandiae)